Displaying all 3 publications

Abstract:
Sort:
  1. Hermawan A, Amrillah T, Riapanitra A, Ong WJ, Yin S
    Adv Healthc Mater, 2021 10;10(20):e2100970.
    PMID: 34318999 DOI: 10.1002/adhm.202100970
    A fully integrated, flexible, and functional sensing device for exhaled breath analysis drastically transforms conventional medical diagnosis to non-invasive, low-cost, real-time, and personalized health care. 2D materials based on MXenes offer multiple advantages for accurately detecting various breath biomarkers compared to conventional semiconducting oxides. High surface sensitivity, large surface-to-weight ratio, room temperature detection, and easy-to-assemble structures are vital parameters for such sensing devices in which MXenes have demonstrated all these properties both experimentally and theoretically. So far, MXenes-based flexible sensor is successfully fabricated at a lab-scale and is predicted to be translated into clinical practice within the next few years. This review presents a potential application of MXenes as emerging materials for flexible and wearable sensor devices. The biomarkers from exhaled breath are described first, with emphasis on metabolic processes and diseases indicated by abnormal biomarkers. Then, biomarkers sensing performances provided by MXenes families and the enhancement strategies are discussed. The method of fabrications toward MXenes integration into various flexible substrates is summarized. Finally, the fundamental challenges and prospects, including portable integration with Internet-of-Thing (IoT) and Artificial Intelligence (AI), are addressed to realize marketization.
  2. Setyawan D, Amrillah T, Abdullah CAC, Ilhami FB, Dewi DMM, Mumtazah Z, et al.
    J Drug Target, 2023 Apr;31(4):369-389.
    PMID: 36721905 DOI: 10.1080/1061186X.2023.2175833
    The development of two-dimensional (2D) materials for biomedical applications has accelerated exponentially. Contrary to their bulk counterparts, the exceptional properties of 2D materials make them highly prospective for contrast agents for bioimage, drug, and heat delivery in biomedical treatment. Nevertheless, empty space in the integration and utilisation of 2D materials in living biological systems, potential toxicity, as well as required complicated synthesis and high-cost production limit the real application of 2D materials in those advance medical treatments. On the other hand, green technology appears to be one of strategy to shed a light on the blurred employment of 2D in medical applications, thus, with the increasing reports of green technology that promote advanced technologies, here, we compile, summarise, and synthesise information on the biomedical technology of 2D materials through green technology point of view. Beginning with a fundamental understanding, of crystal structures, the working mechanism, and novel properties, this article examines the recent development of 2D materials. As well as 2D materials made from natural and biogenic resources, a recent development in green-related synthesis was also discussed. The biotechnology and biomedical-related application constraints are also discussed. The challenges, solutions, and prospects of the so-called green 2D materials are outlined.
  3. Aminatun, Hanum S F, Izak R D, Hadi S, Amrillah T, Che Abdullah CA
    RSC Adv, 2023 Apr 03;13(16):10459-10467.
    PMID: 37021102 DOI: 10.1039/d2ra07756f
    Knee injuries are musculoskeletal system injuries, including the Anterior Cruciate Ligament (ACL). ACL injuries are most common in athletes. This ACL injury necessitates biomaterial replacement. It is sometimes taken from the patient's tendon and a biomaterial scaffold is used. The use of biomaterial scaffolds as artificial ACLs remains to be investigated. The purpose of this study is to determine the properties of an ACL scaffold made of polycaprolactone (PCL)-hydroxyapatite (HA) and collagen with various composition variations of (50 : 45 : 5), (50 : 40 : 10), (50 : 35 : 15), (50 : 30 : 20), and (50 : 25 : 25) wt%. The scaffold was created using the electrospinning method with a voltage of 23 kV, a needle-collector distance of 15 cm, and a solution flow rate of 2 mL h-1. The average fiber diameter in all samples was less than 1000 nm. The model with the best characterization was PCL : HA : collagen with a weight-to-weight (wt%) ratio of 50 : 45 : 5 and an average fiber diameter of 488 ± 271 nm. The UTS and modulus of elasticity for braided samples were 2.796 MPa and 3.224 MPa, respectively, while the non-braided samples were 2.864 MPa and 12.942 MPa. The estimated time of degradation was 9.44 months. It was also revealed to be non-toxic, with an 87.95% viable cell percentage.
Related Terms
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links