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Use of traditional and complementary medicine in Malaysia: a baseline study

Siti ZM, Tahir A, Farah AI, Fazlin SM, Sondi S, Azman AH, et al.

Complement Ther Med, 2009 Oct-Dec;17(5-6):292-9.
PMID: 19942109 DOI: 10.1016/j.ctim.2009.04.002

The increasing popularity and use of traditional and complementary medicine (TCAM) in both developed and developing countries, including Malaysia, have raised significant public health policy issues. However, currently, there is a paucity of baseline data on such usage by the Malaysian community.
Fulltext A Qualitative Analysis of the Coping Strategies of Female Victimisation After Separation

Yusof MM, Azman A, Singh PSJ, Yahaya M

J Hum Rights Soc Work, 2021 Oct 25.
PMID: 34722858 DOI: 10.1007/s41134-021-00199-5

Victims of high-risk domestic violence in Malaysia return to their husbands if they lack the necessary support to face life challenges, especially after separation. Violence against women is part of the violation of human rights. Therefore, several action strategies are essential to counteract the various pressures of the social injustice they have endured. This qualitative study identifies how victims of domestic violence use coping strategies to face various challenges and pressures after deciding to break up with their spouse. In-depth interviews using purposive sampling and snowball techniques were conducted on 15 female respondents in Penang, Malaysia. Actions including filling in time, positive thinking, seeking formal services assistance, religious approaches, and sharing problems with informal systems successfully reduced the stress and concerns of victims of domestic violence. Enhancing and empowering domestic violence victims about their rights is vital for them to exit the abusive cycle. It is hoped that by understanding their rights as a person, they will be able to resort to better social support systems to overcome their current challenges to better social functioning. Hence, social workers must continuously provide the source of support, including empowering/allowing victims to continuously aware of their rights, which are the most fundamental elements of professional social work practice.
Fulltext Detection of tetrodotoxin and saxitoxin in dried salted yellow puffer fish (Xenopterus naritus) eggs from Satok Market, Kuching, Sarawak

Mohd Nor Azman, A., Wan Norhana, M.N.

International Food Research Journal, 2013;20(5):2963-2966.
MyJurnal

The detection of tetrodotoxin (TTX) and saxitoxin (STX) in dried salted yellow puffer fish (Xenopterus naritus) eggs bought from Satok Market, Kuching, Sarawak was carried out by mouse bioassay method. The amount of TTX and STX detected in the samples ranged from 95.6-195.5 Mouse Unit (MU)/g and 1.72-3.58 MU/g respectively. The results indicate that the dried salted eggs samples were found to contain TTX 9-20 times above the regulatory limit for human consumption (10 MU/g). Although detected, the amount of STX in salted eggs extract was slightly below the accepted threshold limit (4 MU/g). The local public in Sarawak should be educated on the potential danger of consuming dried salted puffer fish eggs in addition to the current warnings on puffer fish.
Barriers to enrolling in voluntary treatment programs in Malaysia: a study of women who use methamphetamine (WWUM)

Singh D, Anandan A, Narayanan S, Athirah Daud NA, Azman A, Vicknasingam B

J Ethn Subst Abuse, 2022 Nov 21.
PMID: 36409777 DOI: 10.1080/15332640.2022.2147116

Women with substance use disorders (SUDs) have been widely reported to face barriers in seeking treatment. We sought to identify barriers that prevented women who use methamphetamine (WWUM) from accessing the decade-old Voluntary Treatment Centers (VTCs) in Malaysia. A total of 153 WWUM who were undergoing rehabilitation for methamphetamine use at a compulsory drug detention center (CDDC) were recruited for this cross-sectional study. Data were collected by canvasing a structured questionnaire through face-to-face meetings. Of the total sample, 131 (86%) were Malays, with a mean age of 32.1 years. The commonly cited treatment barriers were the belief that methamphetamine use was not problematic (42%), not knowing how to seek treatment (38%), feeling embarrassed to seek treatment (33%), the lack of family support (24%), and the long waiting time for enrollment (23%). Logistic analyses indicated that a longer duration of use increased the odds of not acknowledging methamphetamine use as a problem while older participants had lower odds of holding a similar view. A longer duration of use also increased the odds of claiming treatment was not needed but lowered the odds of asserting a lack of confidence in treatment. Furthermore, Malays had higher odds of lacking family support in seeking treatment while being employed lowered the odds of not wanting treatment. Addressing these concerns will hopefully encourage higher participation of WWUM in voluntary treatment programs.
Fulltext Quality of life of the Malaysian general population: results from a postal survey using the SF-36

Azman AB, Sararaks S, Rugayah B, Low LL, Azian AA, Geeta S, et al.

Med J Malaysia, 2003 Dec;58(5):694-711.
PMID: 15190656 MyJurnal

Population norms for Health Related Quality of Life using SF-36 are described. A national sample was canvassed in 2000 using a self-administered SF-36 in Bahasa Malaysia and English. Response rate was 30.6%, with 3072 usable data. Male: Female ratio was 1.04 and mean age was 39.8 years. Quality of life was affected by age and sex. Older population and women had a poorer quality of life. Population norms for Malaysia differed from those of US, Canada and Australia. The malaysian general population norm described is useful as reference point for studies in Malaysia. Variability in scores by age and sex emphasize the need to use appropriate age- or sex-specific normative data.
Fulltext Racial differences in the fasting lipid profile of healthy Malaysians

Zaraihan S, Azman AB, Tariq AR

Med J Malaysia, 1994 Dec;49(4):355-63.
PMID: 7674971

The fasting lipid profile of a sample of Malays, Chinese and Indians in Peninsular Malaysia was studied to see whether these might explain differences in the rate of coronary heart disease mortality amongst the three ethnic groups. Fifty healthy subjects were studied from each of the three groups. They were matched for age, body mass index, gender and smoking habits, if any. The total cholesterol/HDL-cholesterol ratio and LDL-cholesterol/HDL-cholesterol ratio were found to be statistically higher in the Indians than in the Malays and the Chinese. The differences between the Indians and the Chinese were statistically more significant than the differences between the Indians and the Malays. Our findings may partially explain the higher predisposition of the Indian community in Malaysia to CHD mortality and are consistent with those of other studies performed on Indian communities living outside the Indian subcontinent.
Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers

Fathil MF, Md Arshad MK, Gopinath SC, Hashim U, Adzhri R, Ayub RM, et al.

Biosens Bioelectron, 2015 Aug 15;70:209-20.
PMID: 25841117 DOI: 10.1016/j.bios.2015.03.037

Acute myocardial infarction or myocardial infarction (MI) is a major health problem, due to diminished flow of blood to the heart, leads to higher rates of mortality and morbidity. Data from World Health Organization (WHO) accounted 30% of global death annually and expected more than 23 million die annually by 2030. This fatal effects trigger the need of appropriate biomarkers for early diagnosis, thus countermeasure can be taken. At the moment, the most specific markers for cardiac injury are cardiac troponin I (cTnI) and cardiac troponin T (cTnT) which have been considered as 'gold standard'. Due to higher specificity, determination of the level of cardiac troponins became a predominant indicator for MI. Several ways of diagnostics have been formulated, which include enzyme-linked immunosorbent assay, chemiluminescent, fluoro-immunoassays, electrical detections, surface plasmon resonance, and colorimetric protein assay. This review represents and elucidates the strategies, methods and detection levels involved in these diagnostics on cardiac superior biomarkers. The advancement, sensitivity, and limitations of each method are also discussed. In addition, it concludes with a discussion on the point-of care (POC) assay for a fast, accurate and ability of handling small sample measurement of cardiac biomarker.
Fulltext Screening of optimization parameters for mixing process via CFD

Othman, N., Kamarudin, S.K., Mamat, M.R., Azman, A., Rosli, M.I., Takrif, M.S.

Journal of Nuclear and Related Technologies, 2013;2013(2):21-29.
MyJurnal

In this study, the numerical simulation in a mixing vessel agitated by a six bladed Rushton turbine has
been carried out to investigate the effects of effective parameters to the mixing process. The study is intended to screen the potential parameters which affect the optimization process and to provide the detail insights into the process. Three-dimensional and steady-state flow has been performed using the fully predictive Multiple Reference Frame (MRF) technique for the impeller and tank geometry. Process optimization is always used to ensure the optimum conditions are fulfilled to attain industries’ satisfaction or needs (ie; increase profit, low cost, yields, etc). In this study, the range of recommended speed to accelerate optimization is 100, 150 and 200rpm respectively and the range of recommended clearance is 50, 75 and 100mm respectively for dual Rushton impeller. Thus, the computer fluid dynamics (CFD) was introduced in order to screen the suitable parameters efficiently and to accelerate optimization. In this study,
Caregiver coping with the mentally ill: a qualitative study

Azman A, Jamir Singh PS, Sulaiman J

J Ment Health, 2017 Apr;26(2):98-103.
PMID: 26732363 DOI: 10.3109/09638237.2015.1124395

BACKGROUND: Mental illness is a disease that affects millions of people every year. It not only causes stress to the mentally ill patients, but also for the family members who provide them the care. The family caregivers, therefore need some form of coping strategies in dealing with their mentally ill family members.
AIMS: This qualitative study aims at identifying and analysing the coping strategies adopted by the family caregivers in dealing with their mentally ill family members.
METHOD: A total of 15 family caregivers from the state of Kedah, Malaysia participated in the face-to-face semi structured interview.
RESULTS: The study findings identified an array of coping strategies used by the family caregivers, including religious coping, emotional coping, acceptance, becoming engaged in leisure activities, and the use of traditional healing to help them cope with their mentally ill members. Suggestions and conclusions: Study suggests that the family caregivers should engage themselves in social support groups to learn about and obtain the positive coping strategies used by other caregivers who have similar experiences in caring for the mentally ill. Study also suggests that they should get appropriate training from the mental health professionals in order to enhance the caregivers' coping skills.
Fulltext Chondrosarcoma of the nasal septum

Indudharan R, Das PK, Azman AA, Suhaiza S

Singapore Med J, 1998 Aug;39(8):376-9.
PMID: 9844502

A case of chondrosarcoma of the nasal septum is presented with the result of treatment. The patient was admitted for a growth in the nose of four years' duration. Fine needle aspiration for cytological examination was suggestive of squamous cell carcinoma. She was treated with lateral rhinotomy and wide excision followed by septorhinoplasty. Histological examination showed that the lesion was chondrosarcoma. The patient remained free of disease 26 months after surgery.
Fulltext The Spetzler-Martin Grading System and management of patients with intracranial arteriovenous malformation in a tertiary referral hospital

Al-Edrus, S. A., Suhaimi, S. N., Noor Azman, A. R., Latif, A. Z., Sobri, M.

Malaysian Journal of Medicine and Health Sciences, 2010;6(1):91-99.
MyJurnal

Introduction: An arteriovenous malformation (AVM) is an abnormal collection of blood vessels in which arterial blood flows directly into the draining vein without the normal interposed capillaries. The Spetzler-Martin grading system has been widely accepted worldwide to estimate the pretreatment risks and predict the outcome of patients with intracranial AVM. In Malaysia, we still do not have the baseline data of this grading system. Methods: A total of 33 patients from a tertiary referral hospital diagnosed with intracranial AVM based on neuroimaging findings over a 4-year period were studied. Medical
records were traced and neuroimaging findings were analysed. The AVMs were graded according to the Spetzler-Martin grading system and Fisher’s exact test was used to assess statistical difference between the grades of the AVM and management plan for the patients. Results: Four patients were graded as Grade 1, 9 patients as Grade II, 10 patients as Grade III, 6 patients as Grade IV and 4 patients as Grade V. Ten patients were treated conservatively; six patients underwent surgery and embolisation respectively. Four patients underwent radiosurgery and a combination of embolisation while surgery and radiosurgery were given to 5 patients and 2 patients respectively. Statistically significant difference (p=0.016) was found between the Spetzler-Martin grading system and the management of intracranial AVMs. Conclusion: The management decision was not made based on the
grading of the AVMs. It is recommended that all AVM patients be routinely graded according to this system prior to treatment.
Factors associated with drug use during pregnancy and breastfeeding among females who use drugs (FWUDs) in Malaysia

Anandan A, Athirah Daud NA, Vicknasingam B, Narayanan S, Azman A, Singh D

J Ethn Subst Abuse, 2023;22(4):766-781.
PMID: 34965841 DOI: 10.1080/15332640.2021.2019162

Females who use drugs (FWUDs) are at risk of continuing illicit substance use during pregnancy and breastfeeding. We investigated the prevalence rates and factors associated with these practices in a sample of 200 FWUDs recruited from a publicly-run drug rehabilitation center. A semi-structured questionnaire was used to collect the data. The majority (86%) was Malay (n = 171/200), currently single (71%, n = 141/200), and 51% had nine years of education. The mean age of respondents was 32.2 years (SD = 8.61). Thirty-eight percent (n = 75/200) reported ever using illicit substances during pregnancy, while 15% (n = 30/200) had used them during breastfeeding. Higher odds of using drugs during pregnancy were associated with having an intimate male drug-using partner and with persons who reported abandoning an infant in the past. Lower odds were linked with women who used heroin with ATS (relative to those who used only ATS), and shorter-term ATS (≤3 years) relative to long term ATS users. At a lower level of significance (p = 0.054), being married also lowered the odds. Higher odds of drug use during breastfeeding were associated with having an intimate male drug-using partner, and previous methadone use history, while lower odds were associated with short-term ATS use and being employed. The findings highlight the need for timely and targeted interventions to inform, engage and promote the participation of FWUDs in pre- and post-natal care services.
Growth and thermal maturation of the Toba magma reservoir

Liu PP, Caricchi L, Chung SL, Li XH, Li QL, Zhou MF, et al.

Proc Natl Acad Sci U S A, 2021 11 09;118(45).
PMID: 34725149 DOI: 10.1073/pnas.2101695118

The Toba volcanic system in Indonesia has produced two of the largest eruptions (>2,000 km3 dense-rock equivalent [DRE] each) on Earth since the Quaternary. U-Pb crystallization ages of zircon span a period of ∼600 ky before each eruptive event, and in the run-up to each eruption, the mean and variance of the zircons' U content decrease. To quantify the process of accumulation of eruptible magma underneath the Toba caldera, we integrated these observations with thermal and geochemical modeling. We show that caldera-forming eruptions at Toba are the result of progressive thermal maturation of the upper crustal magma reservoir, which grows and chemically homogenizes, by sustained magma influx at average volumetric rates between 0.008 and 0.01 km3/y over the past 2.2 My. Protracted thermal pulses related to magma-recharge events prime the system for eruption without necessarily requiring an increased magma-recharge rate before the two supereruptions. If the rate of magma input was maintained since the last supereruption of Toba at 75 ka, eruptible magma is currently accumulating at a minimum rate of ∼4.2 km3 per millennium, and the current estimate of the total volume of potentially eruptible magma available today is a minimum of ∼315 km3 Our approach to evaluate magma flux and the rate of eruptible magma accumulation is applicable to other volcanic systems capable of producing supereruptions and thereby could help in assessing the potential of active volcanic systems to feed supereruptions.
Fulltext Big data-driven public health policy making: Potential for the healthcare industry

Chao K, Sarker MNI, Ali I, Firdaus RBR, Azman A, Shaed MM

Heliyon, 2023 Sep;9(9):e19681.
PMID: 37809720 DOI: 10.1016/j.heliyon.2023.e19681

The use of healthcare data analytics is anticipated to play a significant role in future public health policy formulation. Therefore, this study examines how big data analytics (BDA) may be methodically incorporated into various phases of the health policy cycle for fact-based and precise health policy decision-making. So, this study explores the potential of BDA for accurate and rapid policy-making processes in the healthcare industry. A systematic review of literature spanning 22 years (from January 2001 to January 2023) has been conducted using the PRISMA approach to develop a conceptual framework. The study introduces the emerging topic of BDA in healthcare policy, goes over the advantages, presents a framework, advances instances from the literature, reveals difficulties and provides recommendations. This study argues that BDA has the ability to transform the conventional policy-making process into data-driven process, which helps to make accurate health policy decision. In addition, this study contends that BDA is applicable to the different stages of health policy cycle, namely policy identification, agenda setting as well as policy formulation, implementation and evaluation. Currently, descriptive, predictive and prescriptive analytics are used for public health policy decisions on data obtained from several common health-related big data sources like electronic health reports, public health records, patient and clinical data, and government and social networking sites. To effectively utilize all of the data, it is necessary to overcome the computational, algorithmic and technological obstacles that define today's extremely heterogeneous data landscape, as well as a variety of legal, normative, governance and policy limitations. Big data can only fulfill its full potential if data are made available and shared. This enables public health institutions and policymakers to evaluate the impact and risk of policy changes at the population level.
Fulltext Simulation framework for connected vehicles: a scoping review

Abdul Razak SF, Yogarayan S, Azman A, Abdullah MFA, Muhamad Amin AH, Salleh M

F1000Res, 2021;10:1265.
PMID: 36852011 DOI: 10.12688/f1000research.73398.2

Background: V2V (Vehicle-to-Vehicle) is a booming research field with a diverse set of services and applications. Most researchers rely on vehicular simulation tools to model traffic and road conditions and evaluate the performance of network protocols. We conducted a scoping review to consider simulators that have been reported in the literature based on successful implementation of V2V systems, tutorials, documentation, examples, and/or discussion groups. Methods: Simulators that have limited information were not included. The selected simulators are described individually and compared based on their requirements and features, i.e., origin, traffic model, scalability, and traffic features. This scoping review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). The review considered only research published in English (in journals and conference papers) completed after 2015. Further, three reviewers initiated the data extraction phase to retrieve information from the published papers. Results: Most simulators can simulate system behaviour by modelling the events according to pre-defined scenarios. However, the main challenge faced is integrating the three components to simulate a road environment in either microscopic, macroscopic or mesoscopic models. These components include mobility generators, VANET simulators and network simulators. These simulators require the integration and synchronisation of the transportation domain and the communication domain. Simulation modelling can be run using a different types of simulators that are cost-effective and scalable for evaluating the performance of V2V systems in urban environments. In addition, we also considered the ability of the vehicular simulation tools to support wireless sensors. Conclusions: The outcome of this study may reduce the time required for other researchers to work on other applications involving V2V systems and as a reference for the study and development of new traffic simulators.
Edge computing for Vehicle to Everything: a short review

Abdullah MFA, Yogarayan S, Abdul Razak SF, Azman A, Muhamad Amin AH, Salleh M

F1000Res, 2021;10:1104.
PMID: 38595984 DOI: 10.12688/f1000research.73269.4

Vehicle to Everything (V2X) communications and services have sparked considerable interest as a potential component of future Intelligent Transportation Systems. V2X serves to organise communication and interaction between vehicle to vehicle (V2V), vehicle to infrastructure (V2I), vehicle to pedestrians (V2P), and vehicle to networks (V2N). However, having multiple communication channels can generate a vast amount of data for processing and distribution. In addition, V2X services may be subject to performance requirements relating to dynamic handover and low latency communication channels. Good throughput, lower delay, and reliable packet delivery are the core requirements for V2X services. Edge Computing (EC) may be a feasible option to address the challenge of dynamic handover and low latency to allow V2X information to be transmitted across vehicles. Currently, existing comparative studies do not cover the applicability of EC for V2X. This review explores EC approaches to determine the relevance for V2X communication and services. EC allows devices to carry out part or all of the data processing at the point where data is collected. The emphasis of this review is on several methods identified in the literature for implementing effective EC. We describe each method individually and compare them according to their applicability. The findings of this work indicate that most methods can simulate the EC positioning under predefined scenarios. These include the use of Mobile Edge Computing, Cloudlet, and Fog Computing. However, since most studies are carried out using simulation tools, there is a potential limitation in that crucial data in the search for EC positioning may be overlooked and ignored for bandwidth reduction. The EC approaches considered in this work are limited to the literature on the successful implementation of V2X communication and services. The outcome of this work could considerably help other researchers better characterise EC applicability for V2X communications and services.
Current status of infectious diseases among migrants and non-citizens in Malaysia

Mohd Putera NWS, Azman AS, Mohd Zain SN, Yahaya H, Lewis JW, Sahimin N

Trop Biomed, 2023 Jun 01;40(2):138-151.
PMID: 37650399 DOI: 10.47665/tb.40.2.003

The mass movement of migrants to Malaysia for employment is one of the factors contributing to the emergence and re-emergence of infectious diseases in this country. Despite mandatory health screening for migrants seeking employment, prevalence records of infectious diseases amongst migrant populations in Malaysia are still within negligible proportions. Therefore, the present review highlights the incidence, mortality and overall status of infectious diseases amongst migrants' populations in Malaysia, which maybe be useful for impeding exacerbation of inequalities among them and improving our national health system thru robust and effective emergency responses in controlling the prevalent diseases found among these populations and maybe, Malaysian citizens too. Peer-reviewed articles from January 2016 to December 2020 were searched through online platform including SCOPUS, PubMed, Science Direct, and Google Scholar. Non-peer-reviewed reports and publications from ministry and government websites including data from related agencies were also scoured from in order to ensure that there are no cases being overlooked, as most published articles did not have migrants as the research subjects. A total of 29 studies had been selected in the final analysis. Migrants in Malaysia were at higher risk for tuberculosis, malaria, lymphatic filariasis, cholera, leprosy and leptospirosis. Lymphatic filariasis was still endemic among this population while thousand cases of TB and cholera had been reported among them due to cramp living conditions and poor sanitation in their settlements respectively. While malaria had gradually decreased and become sporadic, the influx of migrant workers had led to the rising of imported malaria cases. Low cases of leprosy had been recorded in Malaysia but a significant proportion of it was contributed by migrant workers. As for leptospirosis, studies found that there are prominent cases among migrant workers, which particularly highest within workers with lower educational attainment. Infectious diseases are still prevalent among migrants in Malaysia due to various interplay factors including their working sectors, country of origin, immunization status, type of settlement, impoverished living conditions, and language and cultural barriers that impeding access to health facilities.
Fulltext Ocular involvement in acute lymphoblastic leukaemia

Tan AK, Azman A, Hoe TS, Rohana T

Med J Malaysia, 1994 Dec;49(4):409-11.
PMID: 7674978

A six-year-old boy, a known case of acute lymphoblastic leukaemia (ALL) on remission since 1991 presented with leukocoria and poor vision of the left eye for two days' duration. Examination revealed endophthalmitis in the left eye with raised intraocular pressure. Anterior chamber paracentesis with vitreous biopsy confirmed a diagnosis of ocular involvement. Further investigation revealed that he also had bone marrow and central nervous system relapse. Clinical manifestation and treatment modalities of ocular involvement in leukaemia are discussed.
Fulltext Guillain-Barré syndrome

Payus AO, Jan TH, Raymond AA

Clin Med (Lond), 2020 11;20(6):e281.
PMID: 33199345 DOI: 10.7861/clinmed.Let.20.6.6
Fulltext Brain Lipopolysaccharide Preconditioning-Induced Gene Reprogramming Mediates a Tolerance State in Electroconvulsive Shock Model of Epilepsy

Amini E, Golpich M, Farjam AS, Kamalidehghan B, Mohamed Z, Ibrahim NM, et al.

Front Pharmacol, 2018;9:416.
PMID: 29765321 DOI: 10.3389/fphar.2018.00416

There is increasing evidence pointing toward the role of inflammatory processes in epileptic seizures, and reciprocally, prolonged seizures induce more inflammation in the brain. In this regard, effective strategies to control epilepsy resulting from neuroinflammation could be targeted. Based on the available data, preconditioning (PC) with low dose lipopolysaccharide (LPS) through the regulation of the TLR4 signaling pathway provides neuroprotection against subsequent challenge with injury in the brain. To test this, we examined the effects of a single and chronic brain LPS PC, which is expected to lead to reduction of inflammation against epileptic seizures induced by electroconvulsive shock (ECS). A total of 60 male Sprague Dawley rats were randomly assigned to five groups: control, vehicle (single and chronic), and LPS PC (single and chronic). We first recorded the data regarding the behavioral and histological changes. We further investigated the alterations of gene and protein expression of important mediators in relation to TLR4 and inflammatory signaling pathways. Interestingly, significant increased presence of NFκB inhibitors [Src homology 2-containing inositol phosphatase-1 (SHIP1) and Toll interacting protein (TOLLIP)] was observed in LPS-preconditioned animals. This result was also associated with over-expression of IRF3 activity and anti-inflammatory markers, along with down-regulation of pro-inflammatory mediators. Summarizing, the analysis revealed that PC with LPS prior to seizure induction may have a neuroprotective effect possibly by reprogramming the signaling response to injury.

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