Displaying publications 1 - 20 of 33 in total

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  1. Lopez JB, Balasegaram M, Thambyrajah V, Timor J
    Malays J Pathol, 1996 Dec;18(2):95-9.
    PMID: 10879229
    This study was undertaken to see if liver function tests (LFT) served a worthwhile purpose in the investigation of hepatocellular carcinoma (HCC). Sera from 80 HCC, 76 benign liver disease (BLD) and 152 healthy adult (HA) subjects were assayed for alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase and lactate dehydrogenase, bilirubin and albumin. Cut-off values were determined from the HA. ALP, GGT, AST and albumin were abnormal in about 90% of the HCC. With the exception of bilirubin, the LFT were abnormal more frequently in HCC than in chronic hepatitis and cirrhosis, the conditions which preceed it. Raised ALP in the presence of normal bilirubin was more often a feature of HCC than BLD although this relationship was not statistically significant. It seems unlikely that LFT serve a useful function in HCC.
  2. Balasegaram M, Devanand MR, Singh B
    Med J Malaysia, 1980 Sep;35(1):68-72.
    PMID: 6265744
    Cefotaxime [HR 756], a third generation cephalosporin with pronounced antibacterial activity
    against the Enterobacteriaceae, was assessed in serious and problem antibiotic resistant infection. Good clinical success was achieved without observed untoward effects. The study suggests that due to its properties, cefotaxime could be used as a first-line antibiotic provided that the clinical situation warrants the use of a cephalosporin or aminoglycoside.
    Key words - cefotaxime [HR 756], serious surgical infection, antibiotic resistant infection.
  3. Hari Rajah S, Balasegaram M
    Med J Malaysia, 1980 Dec;35(2):155-61.
    PMID: 7266410
  4. Balasegaram M
    S Afr J Surg, 1972 Jun;10(2):79-87.
    PMID: 4546544
  5. Lopez JB, Balasegaram M, Thambyrajah V
    Int. J. Biol. Markers, 1996 Jul-Sep;11(3):178-82.
    PMID: 8915714
    This study was undertaken to investigate whether serum CA 125 could complement alpha-fetoprotein (AFP) to improve the diagnosis of hepatocellular carcinoma (HCC). CA 125 showed a sensitivity of 92% for HCC against the 58.8% sensitivity of AFP at the cutoff value of 200 ng/ml. However, the former was less specific (48.5% versus 97.4%) in relation to benign liver diseases (BLD). CA 125 had a higher negative predictive value (NPV) of 84.6% compared to 69.2% for AFP; when both markers were combined, however, the NPV rose to 91.7%. Overall, AFP was more efficient than CA 125 for the diagnosis of HCC. While a positive AFP result was highly indicative of HCC, a negative result did not rule out the disease; however, negative AFP and CA 125 meant that the likelihood of the disease was low. In situations of low HCC prevalence, CA 125 could serve as a first-line screening test followed by confirmation of positives by AFP.
  6. Ramanathan K, Ahmad UD, Kutty MK, Dutt AK, Balasegaram M, Singh H, et al.
    Med J Malaya, 1968 Jun;23(4):276-84.
    PMID: 4235590
  7. Lie-Injo LE, Lopez CG, Latu J, Lim ML, Balasegaram M
    Cytobios, 1987;50(201):101-6.
    PMID: 3036422
    Hepatitis B virus (HBV) DNA in the serum of 31 patients with histologically confirmed primary hepatocellular carcinoma (PHC) from Malaysia and Indonesia was quantitated by densitometric scanning of autoradiograms obtained by Southern blot DNA hybridization, after electrophoresis using a 32P DNA cloned into plasmid pBR325 as a probe. This quantitation after electrophoresis is more informative than the usual spot hybridization technique. Five of the 31 sera were positive for HBV DNA. Levels ranged between 1.36 pq and 143.18 pq per ml of serum, and the levels of HBsAg, anti-HBs, anti-HBc, HBeAg and anti-HBe in the serum were serologically determined. All five sera positive for HBV DNA were also positive for HBsAg. Three of the five positive for HBV DNA were positive for HBeAg and negative for anti-HBe. Two of the sera positive for HBV DNA were negative for HBeAg but positive for anti-HBe. All sera negative for HBV DNA were also negative for HBeAg. Many sera which were negative for HBV DNA and HBeAg were positive for HBsAg. Of the 31 sera from PHC patients, 23 had at least one HBV marker positive (74.2%).
  8. Joishy SK, Leela MP, Balasegaram M
    Am J Surg, 1979 Nov;138(5):716-20.
    PMID: 495861
    We report for the first time from Malaysia a patient with Peutz-Jeghers syndrome complicated by successive intussusceptions requiring extensive small bowel resection. Our experience is compared with that of other authors by a review of the literature highlighting important points in the diagnosis and management of complications in Peutz-Jeghers syndrome.
  9. Ramanathan K, Ungku Dato OA, Kannan Kutty M, Dutt AK, Balasegaram M, Singh H, et al.
    Dent J Malaysia Singapore, 1969 May;9(1):27-39.
    PMID: 5258332
  10. Balasegaram M
    Ann Surg, 1972 Apr;175(4):528-34.
    PMID: 4259839
  11. Balasegaram M
    Am J Surg, 1975 Jul;130(1):33-7.
    PMID: 50750
    A review of 352 patients with primary liver cell carcinoma treated by the author is presented. The poor rate of resectability (7 per cent) has necessitated various forms of treatment over the years. These are described in detail. Based on this experience, the current form of treatment for nonresectable carcinoma is summarized. Although it is too early to assess this form of treatment, initial results appear to be promising. A second report in the near future is planned.
  12. Kutty MK, Balasegaram M
    J R Coll Surg Edinb, 1972 Mar;17(2):102-7.
    PMID: 5021743
  13. Balasegaram M
    J R Coll Surg Edinb, 1971 Jul;16(4):192-6.
    PMID: 4328298
  14. Balasegaram M, Burkitt DP
    Lancet, 1976 Jan 17;1(7951):152.
    PMID: 54670
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