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  1. A Bilayer Engineered Skin Substitute for Wound Repair in an Irradiation-Impeded Healing Model on Rat
    Mohd Hilmi AB, Hassan A, Halim AS
    Adv Wound Care (New Rochelle), 2015 May 1;4(5):312-320.
    PMID: 26005597
    Objective: An engineered skin substitute is produced to accelerate wound healing by increasing the mechanical strength of the skin wound via high production of collagen bundles. During the remodeling stage of wound healing, collagen deposition is the most important event. The collagen deposition process may be altered by nutritional deficiency, diabetes mellitus, microbial infection, or radiation exposure, leading to impaired healing. This study describes the fabrication of an engineered bilayer skin substitute and evaluates its effectiveness for the production of collagen bundles in an impaired healing model. Approach: Rats were exposed to 10 Gy of radiation. Two months postirradiation, the wounds were excised and treated with one of three skin replacement products: bilayer engineered skin substitutes, chitosan skin templates, or duoderm(©). The collagen deposition was analyzed by hematoxylin and eosin staining. Results: On day 21 postwound, the irradiated wounds displayed increased collagen bundle deposition after treatment using bilayer engineered skin substitutes (3.4±0.25) and chitosan skin templates (3.2±0.58) compared with duoderm (2.0±0.63). Innovation: We provide the first report on the fabrication of bilayer engineered skin substitutes using high density human dermal fibroblasts cocultured with HFSCs on chitosan skin templates. Conclusion: The high density of fibroblasts significantly increases the penetration of cells into chitosan skin templates, contributing to the fabrication of bilayer engineered skin substitute.
  2. A Comprehensive Review of Friction Stir Additive Manufacturing (FSAM) of Non-Ferrous Alloys
    Hassan A, Pedapati SR, Awang M, Soomro IA
    Materials (Basel), 2023 Mar 29;16(7).
    PMID: 37049016 DOI: 10.3390/ma16072723
    Additive manufacturing is a key component of the fourth industrial revolution (IR4.0) that has received increased attention over the last three decades. Metal additive manufacturing is broadly classified into two types: melting-based additive manufacturing and solid-state additive manufacturing. Friction stir additive manufacturing (FSAM) is a subset of solid-state additive manufacturing that produces big area multi-layered components through plate addition fashion using the friction stir welding (FSW) concept. Because of the solid-state process in nature, the part produced has equiaxed grain structure, which leads to better mechanical properties with less residual stresses and solidification defects when compared to existing melting-based additive manufacturing processes. The current review article intends to highlight the working principle and previous research conducted by various research groups using FSAM as an emerging material synthesizing technique. The summary of affecting process parameters and defects claimed for different research materials is discussed in detail based on open access experimental data. Mechanical properties such as microhardness and tensile strength, as well as microstructural properties such as grain refinement and morphology, are summarized in comparison to the base material. Furthermore, the viability and potential application of FSAM, as well as its current academic research status with technology readiness level and future recommendations are discussed meticulously.
  3. A Review of Bacterial Colonization on Dental Implants With Various Hygiene Instruments
    Chen A, Ghaffar H, Taib H, Hassan A
    Cureus, 2023 Oct;15(10):e47483.
    PMID: 38021779 DOI: 10.7759/cureus.47483
    Peri-implant diseases can still develop despite oral hygiene practices being maintained. Consequently, regular debridement must be carried out to ensure the implant is sustained. This review evaluated bacterial colonization on implants following the use of different hygiene instruments. A literature search was conducted in PubMed, ScienceDirect, and Scopus databases for articles published from 2012 to 2022. A total of 19 full-text papers were selected. The number of bacteria colonized was most commonly evaluated with a scanning electron microscope (SEM) or by colony-forming unit (CFU) counts, crystal violet assays, plaque index, probing depth, bleeding on probing, turbidity test, and live-dead assays. Rubber cup polishing with an abrasive paste showed a significantly greater reduction in biofilm formation compared with air abrasion with glycine powder, while the air abrasion treatment was found to be more efficient than piezoelectric, carbon, and stainless steel scalers. Surface treatment with Er, Cr: YSGG laser, and Er: YAG laser resulted in statistically significant superior dental biofilm removal compared with titanium curettes and photodynamic therapy. Air abrasion, plastic curette, titanium curette, and ultrasonic scaler showed no significant differences in bacterial colonization, but air abrasion and plastic curette were safer for zirconia implant decontamination. Furthermore, the titanium brush showed better results in decontaminating the implant surface than the Er: YAG laser. Although no single instrument or method could be considered as offering a gold standard in treating peri-implant diseases, the use of air abrasion with glycine powder, laser therapies, rubber cup polishing with an abrasive paste, and a titanium brush had high levels of cleaning efficacy and acceptance by patients.
  4. A Scoping Review of Effective Teaching Strategies in Surface Anatomy
    Abu Bakar YI, Hassan A, Yusoff MSB, Kasim F, Abdul Manan Sulong H, Hadie SNH
    Anat Sci Educ, 2021 Mar 01.
    PMID: 33650315 DOI: 10.1002/ase.2067
    To become skilled physicians, medical students must master surface anatomy. However, the study of surface anatomy is less emphasized in medical and allied health science curricula, and the time devoted to direct engagement with the human body is limited. This scoping review was designed to answer one research question: "What are the elements and strategies that are effective in teaching surface anatomy?" The review was performed using a five-stage scoping review framework, including research question identification, relevant study identification, study selection, data charting, and result collating and reporting. Three databases were searched using two search terms combined with a Boolean operator: "teaching" and "surface anatomy." The initial pool of 3,294 sources was assessed for duplication, and study eligibility was evaluated using inclusion and exclusion criteria. Data were abstracted from 26 original articles by one researcher and verified by two other researchers. A thematic analysis was performed, and several elements of effective teaching strategies for surface anatomy were identified, namely contextualized teaching, embracing experiential learning, and learning facilitation. This review revealed that a multimodal approach was most commonly used in surface anatomy instruction. Hence, future research should explore the effectiveness of multimodal teaching strategies that adopt the three aforementioned primary elements of effective teaching in an authentic learning environment. It is pertinent to clarify the effectiveness of these teaching strategies by evaluating their impact on student learning, organizational changes, and benefits to other stakeholders.
  5. Fulltext A cross-sectional assessment of health-related quality of life among type 2 diabetes patients in Riyadh, Saudi Arabia
    Al-Aboudi IS, Hassali MA, Shafie AA, Hassan A, Alrasheedy AA
    SAGE Open Med, 2015;3:2050312115610129.
    PMID: 26770806 DOI: 10.1177/2050312115610129
    This study aimed to describe the health-related quality of life profile among type 2 diabetes patients in Riyadh, Saudi Arabia.
  6. Fulltext A preliminary study on the decomposition and dipteran associated with exposed carcasses in an oil palm plantation in Bandar Baharu, Kedah, Malaysia
    Azwandi A, Abu Hassan A
    Trop Biomed, 2009 Apr;26(1):1-10.
    PMID: 19696721 MyJurnal
    This study was carried out in an oil palm plantation in Bandar Baharu, Kedah using monkey carcasses and focuses in documenting the decomposition and dipteran colonization sequences in 50 days. This is the first study of Diptera associated with the exploitation of carcasses conducted in the north of peninsular Malaysia during the dry and wet seasons thereat. During the process of decomposition in both seasons, five phases of decay were recognized namely fresh, bloated, active decay, advance decay and dry remain. In this decomposition study, biomass loss of carcass occurred rapidly during the fresh to active decay stage due to the colonization and feeding activity of the Diptera larvae. The duration of the fresh and bloated stages of decay were the same in wet and dry seasons but later stages of decay were markedly shorter during the wet season. Twenty one species of adult Diptera were identified colonizing carcasses in the study period. Among the flies from the family Calliphoridae, Chrysomya megacephala Fabricius and Chrysomya nigripes Aubertin were recognized as the earliest arrivals on the first day of exposure. Adult Ch. nigripes was abundant for approximately two weeks after placement of the carcasses. By comparing the percentages of adults collected during the study period, the calliphorids abundance in percentages in wet season was 50.83%, but in dry season, the abundance was only about 35.2%. In contrast, the percentage of Sphaeroceridae in wet season was only 3.33%, but in the dry season, the abundance was 20.8%. Dipteran in family Phoridae, Piophilidae, Sepsidae, Drosophilidae and Dolichopodidae colonized the carcasses for a long period of time and were categorized as long term colonizers.
  7. Fulltext A prospective study of tracheal intubation in an academic emergency department in Malaysia
    Fathil SM, Mohd Mahdi SN, Che'man Z, Hassan A, Ahmad Z, Ismail AK
    Int J Emerg Med, 2010;3(4):233-7.
    PMID: 21373289 DOI: 10.1007/s12245-010-0201-0
    BACKGROUND: Airway management is an important part of the management of the critically ill and injured patients in the Emergency Department (ED). Numerous studies from developed countries have demonstrated the competency of emergency doctors in intubation. To date there have been no published data on intubations performed in EDs in Malaysia.
    METHODS: Data on intubations from 7 August 2007 till 28 August 2008 were prospectively collected.
    RESULTS: There were 228 intubations included in the study period. Cardiopulmonary arrest was the main indication for intubation (35.5%). The other indications were head injury (18.4%), respiratory failure (15.4%), polytrauma (9.6%) and cerebrovascular accident (7.0%). All of the 228 patients were successfully intubated. Rapid sequence intubation (RSI) was the most frequent method (49.6%) of intubation. A total of 223 (97.8%) intubations were done by ED personnel. In 79.8% of the cases, intubations were successfully performed on the first attempt. Midazolam was the most common induction agent used (97 patients), while suxamethonium was the muscle relaxant of choice (109 patients). There were 34 patients (14.9%) with 38 reported immediate complications. The most common complication was oesophageal intubation.
    CONCLUSION: Emergency Department UKMMC personnel have a high competency level in intubation with an acceptable complication rate. RSI was the most common method for intubation.
    KEYWORDS: Airway; Intubation; Orotracheal intubation; Rapid sequence intubation
  8. Fulltext A report of Anopheles (Diptera: Culicidae) attracted to cow bait in a malaria endemic village in Peninsular Malaysia near the Thailand border
    Rahman WA, Abu Hassan A, Adanan CR, Mohd Razha R
    Southeast Asian J. Trop. Med. Public Health, 1995 Jun;26(2):359-63.
    PMID: 8629076
    Twelve species of Anopheles were collected by using cow-baited net trap in a malarial endemic village in northern Peninsular Malaysia. Anopheles maculatus which is the main malaria vector with its densities were related to drought. An. aconitus, An. kochi and An. philippinensis were less susceptible to P. falciparum and P. vivax infection, and are not considered important in falciparum or vivax malaria transmission. Biting activities of An. kochi and An. vagus were primarily active after dusk and steadily declined after midnight. An. maculatus and An. aconitus showed biting activities throughout the night but An. maculatus showed two peaks of biting activity in the first half of the night.
  9. Fulltext A report on the pupae of Desmometopa sp. (Diptera: Milichiidae) recovered from a human corpse in Malaysia
    Kumara TK, Abu Hassan A, Che Salmah MR, Bhupinder S
    Trop Biomed, 2010 Apr;27(1):131-3.
    PMID: 20562823
    The pupae of Desmometopa sp. (Diptera: Milichiidae) were collected from a human corpse found indoor in active decay stage together with the larvae of Sarcophagidae, Synthesiomyia nudiseta (Wulp), Chrysomya megacephala (Fabricius) and Chrysomya rufifacies (Macquart). This research note is the first report of the Desmometopa sp. recovered from a human corpse in Malaysia.
  10. Fulltext A study on some aspects of the epidemiology of malaria in an endemic district in northern Peninsular Malaysia near Thailand border
    Rahman WA, Adanan CR, Abu Hassan A
    Southeast Asian J. Trop. Med. Public Health, 1998 Sep;29(3):537-40.
    PMID: 10437952
    A study on the distribution of malaria in Hulu Perak district, Peninsular Malaysia was carried out between January and December 1993. The study encompassed the distribution of malaria cases according to sex, age and profession. A total of 332 cases were recorded, with 182 cases occurring in males. The highest infection was observed in the above 15 years old age group. Forest workers (loggers, rattan collectors and forest product gatherers) were the group most exposed to the disease (32.8%), followed by both plantantion workers (32.2%) and aboriginal communities (32.2%). Army and police personnels (2.1%) were also infected. Plasmodium falciparum was the most common species of malaria in the area.
  11. A study on the optimal hydraulic loading rate and plant ratios in recirculation aquaponic system
    Endut A, Jusoh A, Ali N, Wan Nik WB, Hassan A
    Bioresour Technol, 2010 Mar;101(5):1511-7.
    PMID: 19819130 DOI: 10.1016/j.biortech.2009.09.040
    The growths of the African catfish (Clarias gariepinus) and water spinach (Ipomoea aquatica) were evaluated in recirculation aquaponic system (RAS). Fish production performance, plant growth and nutrient removal were measured and their dependence on hydraulic loading rate (HLR) was assessed. Fish production did not differ significantly between hydraulic loading rates. In contrast to the fish production, the water spinach yield was significantly higher in the lower hydraulic loading rate. Fish production, plant growth and percentage nutrient removal were highest at hydraulic loading rate of 1.28 m/day. The ratio of fish to plant production has been calculated to balance nutrient generation from fish with nutrient removal by plants and the optimum ratio was 15-42 gram of fish feed/m(2) of plant growing area. Each unit in RAS was evaluated in terms of oxygen demand. Using specified feeding regime, mass balance equations were applied to quantify the waste discharges from rearing tanks and treatment units. The waste discharged was found to be strongly dependent on hydraulic loading rate.
  12. Fulltext Absorbed dose rate levels around amang plant buildings
    Omar, M., Sulaiman, I., Hassan, A.
    Journal of Nuclear and Related Technologies, 2008;2008(2):73-76.
    MyJurnal
    The measurements of absorbed dose rate in air around amang plant buildings were carried out using a scintillation detector. It was found that the mean radiation levels at seven amang plants were in the range of 1.6 – 5.5 µGy h -1. The individual maximum value measured was 56 µGy h -1. The annual dose to a worker transporting the minerals to the plant was estimated to be 1.5 mSv y -1.
  13. An interconnected duplicated femoral vein and its clinical significance
    Khan AA, Asari MA, Hassan A, Aiman N
    Folia Morphol (Warsz), 2013 Feb;72(1):82-5.
    PMID: 23749717
    Anatomical variations in the femoral vein are of great clinical importance especially in cases of deep vein thrombosis (DVT). Knowledge of the variable anatomy of the femoral vein is important to minimise false-negative findings on ultrasound examination in patients with DVT and help to explain the 'silent' DVT. Furthermore, the presence of a duplicated femoral vein itself is associated with higher incidence of DVT. These venous anomalies are usually due to the truncular venous malformation. In the present study, while dissecting the right lower limb, we found a case of variation of the femoral vein. In this case, besides a duplicated femoral vein, we also noticed a 3rd interconnecting channel near the apex of the femoral triangle joining the two veins. This variation has not been reported previously by other authors. Considering its uniqueness and clinical importance, we decided to report this case.
  14. An ionic liquid process for mercury removal from natural gas
    Abai M, Atkins MP, Hassan A, Holbrey JD, Kuah Y, Nockemann P, et al.
    Dalton Trans, 2015 May 14;44(18):8617-24.
    PMID: 25722100 DOI: 10.1039/c4dt03273j
    Efficient scrubbing of mercury vapour from natural gas streams has been demonstrated both in the laboratory and on an industrial scale, using chlorocuprate(II) ionic liquids impregnated on high surface area porous solid supports, resulting in the effective removal of mercury vapour from natural gas streams. This material has been commercialised for use within the petroleum gas production industry, and has currently been running continuously for three years on a natural gas plant in Malaysia. Here we report on the chemistry underlying this process, and demonstrate the transfer of this technology from gram to ton scale.
  15. Fulltext Anatomy Education Environment Measurement Inventory (AEEMI): a cross-validation study in Malaysian medical schools
    Hadie SNH, Yusoff MSB, Arifin WN, Kasim F, Ismail ZIM, Asari MA, et al.
    BMC Med Educ, 2021 Jan 14;21(1):50.
    PMID: 33446203 DOI: 10.1186/s12909-020-02467-w
    BACKGROUND: The Anatomy Education Environment Measurement Inventory (AEEMI) evaluates the perception of medical students of educational climates with regard to teaching and learning anatomy. The study aimed to cross-validate the AEEMI, which was previously studied in a public medical school, and proposed a valid universal model of AEEMI across public and private medical schools in Malaysia.

    METHODS: The initial 11-factor and 132-item AEEMI was distributed to 1930 pre-clinical and clinical year medical students from 11 medical schools in Malaysia. The study examined the construct validity of the AEEMI using exploratory and confirmatory factor analyses.

    RESULTS: The best-fit model of AEEMI was achieved using 5 factors and 26 items (χ 2 = 3300.71 (df = 1680), P

  16. Anatomy education environment measurement inventory: A valid tool to measure the anatomy learning environment
    Hadie SNH, Hassan A, Ismail ZIM, Asari MA, Khan AA, Kasim F, et al.
    Anat Sci Educ, 2017 Sep;10(5):423-432.
    PMID: 28135037 DOI: 10.1002/ase.1683
    Students' perceptions of the education environment influence their learning. Ever since the major medical curriculum reform, anatomy education has undergone several changes in terms of its curriculum, teaching modalities, learning resources, and assessment methods. By measuring students' perceptions concerning anatomy education environment, valuable information can be obtained to facilitate improvements in teaching and learning. Hence, it is important to use a valid inventory that specifically measures attributes of the anatomy education environment. In this study, a new 11-factor, 132-items Anatomy Education Environment Measurement Inventory (AEEMI) was developed using Delphi technique and was validated in a Malaysian public medical school. The inventory was found to have satisfactory content evidence (scale-level content validity index [total] = 0.646); good response process evidence (scale-level face validity index [total] = 0.867); and acceptable to high internal consistency, with the Raykov composite reliability estimates of the six factors are in the range of 0.604-0.876. The best fit model of the AEEMI is achieved with six domains and 25 items (X2  = 415.67, P 
  17. Fulltext Aquaponics production of catfish and pumpkin: Comparison with conventional production systems
    Oladimeji SA, Okomoda VT, Olufeagba SO, Solomon SG, Abol-Munafi AB, Alabi KI, et al.
    Food Sci Nutr, 2020 May;8(5):2307-2315.
    PMID: 32405388 DOI: 10.1002/fsn3.1512
    Aquaponics is known to be a smart way of producing fish and crops simultaneously; however, there is a paucity of information about the extents of this system's efficiency over other conventional methods of food production. Thus, this study was designed to evaluate the performance of a catfish-pumpkin aquaponics system in comparison with recirculatory and static aquaculture systems (for fish performance), as well as irrigated and nonirrigated systems (for pumpkin performance). Results obtained showed that the production of fish in the aquaponics system was 29% and 75% more efficient than recirculatory and static aquaculture systems, respectively. The survival of the fish was also significantly improved probably due to better water quality in the aquaponics system. With respect to pumpkin production, yield in the aquaponics system was about five times the performance in irrigated land and eleven times those in nonirrigated land. This study gives definitive evidence to support the efficiency of the aquaponics system over other conventional food production methods.
  18. Fulltext BRAF V600E and Mismatch Repair Proteins Expression in Sporadic Young-onset Colorectal Cancer in Kelantan, Malaysia
    Saizul Z, Siti-Azrin AH, Zakaria AD, Hassan A, Abdul Rahman WFW, Jalil NAC
    Oman Med J, 2021 Jul;36(4):e284.
    PMID: 34367685 DOI: 10.5001/omj.2021.83
    Objectives: We sought to determine the immunohistochemistry expression of mismatch repair (MMR) and BRAF V600E proteins in sporadic young-onset colorectal cancer (CRC) and their association with clinicopathological features in the Kelantan population.

    Methods: This was a cross-sectional study of sporadic young-onset CRC over 11 years from 1 January 2006 to 31 December 2017 in Kelantan. Formalin-fixed paraffin-embedded tissue blocks were immunohistochemically stained with antibodies for MMR (MLH1, MSH2, MSH6, and PMS2) and BRAF V600E. These expressions were correlated with clinicopathological parameters.

    Results: Our patient sample included 31 patients with a mean age of 31.5 years. More than half (61.3%) of the patients were women. The majority presented with abdominal pain (41.9%), and 71.0% had a tumor located on the right side of the colon, with 83.9% being moderately differentiated adenocarcinoma. The majority of patients presented at stage IV (54.8%). The most frequent pattern was all MMR protein expressions, which constituted patients in the microsatellite stable group (64.5%). Nine (29.0%) were microsatellite instability (MSI-high), and two (6.5%) were MSI-low. Positive BRAF V600E expression was observed in 83.9% of patients. Only histopathological subtypes revealed a significant association with BRAF V600E positive expression (p = 0.015).

    Conclusions: The majority of sporadic young-onset CRC presented with abdominal pain and advanced cancer stage. Most were microsatellite stable, and most cases showed positive expressions in all MMR markers and BRAF V600E by immunohistochemistry method. This finding will pave the way for further research on this disease.

  19. Be Careful Where You Smile: Culture Shapes Judgments of Intelligence and Honesty of Smiling Individuals
    Krys K, -Melanie Vauclair C, Capaldi CA, Lun VM, Bond MH, Domínguez-Espinosa A, et al.
    Journal of nonverbal behavior, 2015 12 30;40:101-116.
    PMID: 27194817
    Smiling individuals are usually perceived more favorably than non-smiling ones-they are judged as happier, more attractive, competent, and friendly. These seemingly clear and obvious consequences of smiling are assumed to be culturally universal, however most of the psychological research is carried out in WEIRD societies (Western, Educated, Industrialized, Rich, and Democratic) and the influence of culture on social perception of nonverbal behavior is still understudied. Here we show that a smiling individual may be judged as less intelligent than the same non-smiling individual in cultures low on the GLOBE's uncertainty avoidance dimension. Furthermore, we show that corruption at the societal level may undermine the prosocial perception of smiling-in societies with high corruption indicators, trust toward smiling individuals is reduced. This research fosters understanding of the cultural framework surrounding nonverbal communication processes and reveals that in some cultures smiling may lead to negative attributions.
  20. Fulltext Bilateral Optic Atrophy in a Young Patient With Chronic Anaemia Secondary to End-Stage Renal Disease
    Ab Gani NH, Ibrahim M, Wan Hitam WH, Masnon NA, Hassan A
    Cureus, 2021 Mar 18;13(3):e13969.
    PMID: 33884230 DOI: 10.7759/cureus.13969
    End-stage renal disease (ESRD) is associated with a number of serious complications, including increased cardiovascular disease, anaemia and metabolic bone disease. Optic atrophy secondary to chronic anaemia in ESRD is rare. We report a case of bilateral optic atrophy in a young patient with chronic anaemia secondary to ESRD. A 23-year-old lady with ESRD, presented with progressive blurring of vision in her left eye for a period of six months. Visual acuity in the left eye was counting finger and the right eye was 6/6. Left optic nerve functions were significantly reduced. Bilateral anterior segments and intraocular pressure were normal. Funduscopy showed bilateral pale disc with arteriolar attenuation. The infective, autoimmune and demyelinating screening were negative. Serial full blood count indicated low haemoglobin and haematocrit value. The full blood picture revealed normocytic normochromic anaemia. Neuroimaging was normal. The patient was diagnosed as having bilateral optic atrophy secondary to chronic anaemia due to ESRD. Chronic anaemia is a potential cause of optic atrophy in a young patient with chronic disease. Management of anaemia in such cases is crucial to prevent irreversible complications including optic atrophy and blindness.
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