Displaying publications 1 - 20 of 164 in total

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  1. Tehami M, Imam HT, Abdullah I, Hosford J, Wong XJ, Rahman NA, et al.
    ACS Sustain Chem Eng, 2024 Feb 19;12(7):2678-2685.
    PMID: 38389905 DOI: 10.1021/acssuschemeng.3c06758
    1,4-Benzoxazines are important motifs in many pharmaceuticals and can be formed by a reaction sequence involving the oxidation of o-aminophenols to their corresponding quinone imine followed by an in situ inverse electron demand Diels-Alder (IEDDA) cycloaddition with a suitable dienophile. Reported herein is the development of a reaction sequence that employs horseradish peroxidase to catalyze the oxidation of the aminophenols prior to the IEDDA as a more sustainable alternative to the use of conventional stoichiometric oxidants. The synthesis of 10 example benzoxazines is demonstrated in this "one-pot, two-step" procedure with yields between 42% and 92%. The green chemistry metrics, including the E-factor and generalized reaction mass efficiency, for this biocatalytic reaction were compared against the conventional chemical approach. It was found that the reported biocatalytic route was approximately twice as green by these measures.
  2. Ghazali N, Rahman NA, Kannan TP, Ahmad A, Sulong S
    BMC Oral Health, 2023 Nov 29;23(1):945.
    PMID: 38031027 DOI: 10.1186/s12903-023-03464-3
    BACKGROUND: Nonsyndromic cleft lip and/or without cleft palate (NSCL/P) with or without hypodontia is a common developmental aberration in humans and animals. This study aimed to identify the loss of heterozygosity (LOH) involved in hypodontia and NSCL/P pathogenesis.

    METHODS: This is a cross-sectional study that conducted genome-wide copy number analysis using CytoScan 750K array on salivary samples from Malay subjects with NSCL/P with or without hypodontia aged 7-13 years. To confirm the significant results, simple logistic regression was employed to conduct statistical data analysis using SPSS software.

    RESULTS: The results indicated the most common recurrent copy neutral LOH (cnLOH) observed at 1p33-1p32.3, 1q32.2-1q42.13 and 6p12.1-6p11.1 loci in 8 (13%), 4 (7%), and 3 (5%) of the NSCL/P subjects, respectively. The cnLOHs at 1p33-1p32.3 (D1S197), 1q32.2-1q42.13 (D1S160), and 6p12.1-6p11.1 (D1S1661) were identified observed in NSCL/P and noncleft children using microsatellite analysis markers as a validation analysis. The regions affected by the cnLOHs at 1p33-1p32.3, 1q32.2-1q42.13, and 6p12.1-6p11.1 loci contained selected genes, namely FAF1, WNT3A and BMP5, respectively. There was a significant association between the D1S197 (1p33-32.3) markers containing the FAF1 gene among NSCL/P subjects with or without hypodontia compared with the noncleft subjects (p-value = 0.023).

    CONCLUSION: The results supported the finding that the genetic aberration on 1p33-32.3 significantly contributed to the development of NSCL/P with or without hypodontia. These results have an exciting prospect in the promising field of individualized preventive oral health care.

  3. Du X, Rashid SA, Abdullah LC, Rahman NA
    Environ Sci Pollut Res Int, 2023 Nov;30(51):110417-110430.
    PMID: 37783997 DOI: 10.1007/s11356-023-30213-4
    Separation materials have received increasing attention given their broad applications in the management of environmental pollution. It is desired to balance the contradiction between high separation efficiency and selectivity of separation materials. The integration of ball-milled bone chars with electrospun membranes might achieve this balance. In this study, electrospun cellulose/chitosan/ball-milled bone char (CL/CS/MB) membranes were by well-dispersing ball-milled bone chars with nanoscale size (98.9-167.5 nm) and developed porosity (40.2-373.1 m2/g) in the electrospinning solvent. The synergistic integration of distributed MBs (5.4-31.5 wt.% of loading hydroxyapatite on the membrane matrix) allowed the efficient sorption of Pb(II) with fast kinetics (20.0 min), excellent capacity (219.9 mg/g at pH 5.0, T 298 K), and favorable selectivity coefficients (2.76-6.79). The formation of minerals was dominant for the selective sorption of Pb(II) by combining the spectral analysis and quantitative determination. The surface complexation with O-/reductive N-species, the cation exchange with inorganic Ca2+, the electrostatic attraction with deprotonated O-, and the cation-π coordination with the aromatic carbon via the π-electrons should be not ignored for the capture of Pb(II). This work demonstrated the feasibility of electrospun CL/CS/MB membranes as a promising candidate for the remediation of aquatic pollutants.
  4. Abd Rahman NA, Mohamed Sahari KS, Baharuddin MZ
    Appl Radiat Isot, 2023 Oct;200:110968.
    PMID: 37544032 DOI: 10.1016/j.apradiso.2023.110968
    The sensor coverage problem aims to maximize the coverage of a target area with a fixed or minimum number of sensors. However, the sampling point coverage for radiation mapping has yet to be specified or adequately established. When dealing with unknown radiation fields, it is critical that the placements of sampling points will ensure that all hotspots are detected and accurately identified. Therefore, the concept of coverage and detection limit for a sampling point in radiation mapping is proposed in this paper. The proposed concept relates the angular dependency of the radiation measurement instruments with the detector detection limit or minimum detectable amount (MDA). To demonstrate the implementation, the concept is used to compute the sensitivity of the radiation map for coverage radiation mapping with mobile robot. Simulation results showed that hotspots with intensity equal to or above the sampling point detection limit were successfully detected regardless of their position within the coverage circle. Moreover, the experimental results of coverage radiation mapping showed that the concept can be used to compute the resolution of the radiation map. This will help the user to efficiently configure the appropriate grid size that suit their mapping situation and requirements.
  5. Ab Razak A, Rahman NA, Zulkifly MFM, Sapiai NA, Phoa PKA, Mohamed Mustafar MF, et al.
    Malays J Med Sci, 2023 Oct;30(5):1-6.
    PMID: 37928788 DOI: 10.21315/mjms2023.30.5.1
    Improving healthcare and living conditions has led to an increase in life expectancies and challenges of population aging in Malaysia. The Advanced Memory and Cognitive Service builds on integrated healthcare among multidisciplinary specialists to provide holistic and patient-centred healthcare. The service treats older adults experiencing neurocognitive impairment as well as young individuals with complex neurocognitive disorders and thoroughly screens asymptomatic individuals at high risk of developing neurocognitive disorders. This early intervention strategy is a preventive effort in the hope of reducing disease burden and improving quality of life to prepare Malaysia for the forthcoming population aging.
  6. Chockalingam K, A Rahman NA, Idris Z, Theophilus SC, Abdullah JM, Ghani ARI, et al.
    Malays J Med Sci, 2023 Aug;30(4):71-84.
    PMID: 37655152 DOI: 10.21315/mjms2023.30.4.7
    BACKGROUND: Traumatic brain injury (TBI) is the third leading cause of death and disability worldwide in 2020. For patients with TBI with significant intracranial bleeds, urgent surgical intervention remains the mainstay treatment. This study aims to evaluate the time to definite surgical intervention since admission and its association with patient outcomes in a neurosurgery referral centre in Malaysia.

    METHODS: This retrospective study was conducted at Hospital Sultanah Aminah Johor Bahru from 1 January 2019 to 31 December 2019. All patients with TBI requiring urgent craniotomy were identified from the operating theatre registry, and the required data were extracted from their clinical notes, including the Glasgow Outcome Score (GCS) at discharge and 6 months later. Logistic regression was performed to identify the factors associated with poor outcomes.

    RESULTS: A total of 154 patients were included in this study. The median door-to-skin time was 605 (interquartile range = 494-766) min. At discharge, 105 patients (68.2%) had poor outcomes. At the 6-month follow-up, only 58 patients (37.7%) remained to have poor outcomes. Simple logistic regression showed that polytrauma, hypotensive episode, ventilation, severe TBI, and the door-to-skin time were significantly associated with poor outcomes. After adjustments for the clinical characteristics in the analysis, the likelihood of having poor outcomes for every minute delay in the door-to-skin time increased at discharge (adjusted odds ratio [AOR] = 1.005; 95% confidence interval [CI] = 1.002-1.008) and the 6-month follow-up (AOR = 1.008; 95% CI = 1.005-1.011).

    CONCLUSION: The door-to-skin time is directly proportional to poor outcomes in patients with TBI. Concerted efforts from all parties involved in trauma care are essential in eliminating delays in surgical interventions and improving outcomes.

  7. Abdul Rahman NA, Mohd Desa MN, Masri SN, Taib NM, Sulaiman N, Hazman H, et al.
    Pol J Microbiol, 2023 Jun 01;72(2):103-115.
    PMID: 37314355 DOI: 10.33073/pjm-2023-023
    Streptococcus pneumoniae (pneumococcus) belongs to the Gram-positive cocci. This bacterium typically colonizes the nasopharyngeal region of healthy individuals. It has a distinct polysaccharide capsule - a virulence factor allowing the bacteria to elude the immune defense mechanisms. Consequently, it might trigger aggressive conditions like septicemia and meningitis in immunocompromised or older individuals. Moreover, children below five years of age are at risk of morbidity and mortality. Studies have found 101 S. pneumoniae capsular serotypes, of which several correlate with clinical and carriage isolates with distinct disease aggressiveness. Introducing pneumococcal conjugate vaccines (PCV) targets the most common disease-associated serotypes. Nevertheless, vaccine selection pressure leads to replacing the formerly dominant vaccine serotypes (VTs) by non-vaccine types (NVTs). Therefore, serotyping must be conducted for epidemiological surveillance and vaccine assessment. Serotyping can be performed using numerous techniques, either by the conventional antisera-based (Quellung and latex agglutination) or molecular-based approaches (sequetyping, multiplex PCR, real-time PCR, and PCR-RFLP). A cost-effective and practical approach must be used to enhance serotyping accuracy to monitor the prevalence of VTs and NVTs. Therefore, dependable pneumococcal serotyping techniques are essential to precisely monitor virulent lineages, NVT emergence, and genetic associations of isolates. This review discusses the principles, associated benefits, and drawbacks of the respective available conventional and molecular approaches, and potentially the whole genome sequencing (WGS) to be directed for future exploration.
  8. Abd Rahman NA, Noor SK, Ibrahim IM, Yasin MNM, Ismail AM, Osman MN, et al.
    Micromachines (Basel), 2023 Apr 13;14(4).
    PMID: 37421074 DOI: 10.3390/mi14040841
    This paper presents the generation of orbital angular momentum (OAM) vortex waves with mode +1 using dielectric resonator antenna (DRA) array. The proposed antenna was designed and fabricated using FR-4 substrate to generate OAM mode +1 at 3.56 GHz (5G new radio band). The proposed antenna consists of 2 × 2 rectangular DRA array, a feeding network, and four cross slots etched on the ground plane. The proposed antenna succeeded in generating OAM waves; this was confirmed by the measured radiation pattern (2D polar form), simulated phase distribution, and intensity distribution. Moreover, mode purity analysis was carried out to verify the generation of OAM mode +1, and the purity obtained was 53.87%. The antenna operates from 3.2 to 3.66 GHz with a maximum gain of 7.3 dBi. Compared with previous designs, this proposed antenna is low-profile and easy to fabricate. In addition, the proposed antenna has a compact structure, wide bandwidth, high gain, and low losses, thus meeting the requirements of 5G NR applications.
  9. Shahid F, Nowrin SA, Alam MK, Khamis MF, Husein A, Rahman NA
    Healthcare (Basel), 2023 Mar 15;11(6).
    PMID: 36981521 DOI: 10.3390/healthcare11060864
    This study aimed to assess the outcomes of low-level laser therapy (LLLT) with the conventional bracket (CB) and self-ligating (SL) bracket systems on root resorption (RR) during orthodontic treatment. A total of 32 patients were included in this randomized clinical trial. All the patients were randomly divided into four individual groups (SLL: self-ligating laser, CBL: conventional bracket laser, SLNL: self-ligating non-laser, CBNL: conventional bracket non-laser). RR was measured from the cone-beam computed tomography (CBCT) radiographs which were taken at two stages of the orthodontic treatment: pre-treatment (T1) and after leveling and alignment stage (T2). Wilcoxon rank test for the comparison was conducted to compare the RR at T1 and T2 stages within each group and showed a significant difference (p < 0.05) for various variables. Mann Whitney test compared the RR in laser and non-laser groups irrespective of the bracket systems and exhibited no significant differences except the left lateral incisor. Moreover, CB and SL groups showed no significant difference in RR among any tooth. Kruskal Wallis test was performed to compare the RR among all groups which presented no significant differences. LLLT and bracket systems have no consequences on RR until the leveling and alignment stage of orthodontic treatment.
  10. Airak S, Sukor NSA, Rahman NA
    Transp Res Interdiscip Perspect, 2023 Mar;18:100784.
    PMID: 36844954 DOI: 10.1016/j.trip.2023.100784
    The COVID-19 pandemic has disrupted travel behaviours due to the need for movement restrictions. The restrictions adversely affected various aspects of health and the economy. This study aimed to investigate factors affecting trip frequency during the recovery period of the COVID-19 pandemic in Malaysia. An online national cross-sectional survey was conducted to collect data in conjunction with different movement restriction policies. The questionnaire includes socio-demographics, experience with COVID-19, risk perception of COVID-19, and trip frequency on several activities during the pandemic. Mann Whitney U was conducted to determine whether there were statistically significant differences between the socio-demographic factors for the respondents in the first and second surveys. Results show no significant difference in socio-demographic factors except for the level of education. The results indicate that the respondents from both surveys were comparable. Next, Spearman correlation analyses were conducted to find significant correlations between trip frequencies toward socio-demographics, experience with COVID-19 and risk perception. There was a correlation between the frequency of travel and risk perception for both surveys. Regression analyses were performed based on the findings to investigate trip frequency determinants during the pandemic. Perceived risk, gender, and occupation influenced the trip frequencies for both surveys. By understanding the influence of risk perception on the frequency of travel, the government can identify the appropriate policy during a pandemic or health emergency to avoid impeding normal travel behaviour. Thus, people's mental and psychological well-being are not negatively affected.
  11. Abd Rahman NA, Li S, Schmid S, Shaharudin S
    Phys Ther Sport, 2023 Jan;59:60-72.
    PMID: 36516512 DOI: 10.1016/j.ptsp.2022.11.011
    Low back pain (LBP) can result in increased direct medical and non-medical costs to patients, employers, and health care providers. This systematic review aimed to provide a better understanding of the biomechanical factors associated with chronic non-specific LBP in adults. SCOPUS, ScienceDirect, MEDLINE, and Web of Science databases were searched. In total, 26 studies were included and significant differences were noted between healthy controls and LBP patients in various motion. Biomechanical factors among adults with non-specific LBP were altered and differed as compared to healthy controls in various motion might be to compensate the pain during those motions. This review highlighted the biomechanical differences across those with non-specific LBP and healthy adults. Both groups showed a similar level of pain during functional tasks but LBP patients suffered from a moderate level of disability. Future studies should not rely on questionnaire-based pain scale only. The biomechanical factors summarized in this review can be used to diagnose non-specific LBP accurately, and as modifiable targets for exercise-based intervention.
  12. Hameed MM, Razali SFM, Mohtar WHMW, Rahman NA, Yaseen ZM
    PLoS One, 2023;18(10):e0290891.
    PMID: 37906556 DOI: 10.1371/journal.pone.0290891
    The Great Lakes are critical freshwater sources, supporting millions of people, agriculture, and ecosystems. However, climate change has worsened droughts, leading to significant economic and social consequences. Accurate multi-month drought forecasting is, therefore, essential for effective water management and mitigating these impacts. This study introduces the Multivariate Standardized Lake Water Level Index (MSWI), a modified drought index that utilizes water level data collected from 1920 to 2020. Four hybrid models are developed: Support Vector Regression with Beluga whale optimization (SVR-BWO), Random Forest with Beluga whale optimization (RF-BWO), Extreme Learning Machine with Beluga whale optimization (ELM-BWO), and Regularized ELM with Beluga whale optimization (RELM-BWO). The models forecast droughts up to six months ahead for Lake Superior and Lake Michigan-Huron. The best-performing model is then selected to forecast droughts for the remaining three lakes, which have not experienced severe droughts in the past 50 years. The results show that incorporating the BWO improves the accuracy of all classical models, particularly in forecasting drought turning and critical points. Among the hybrid models, the RELM-BWO model achieves the highest level of accuracy, surpassing both classical and hybrid models by a significant margin (7.21 to 76.74%). Furthermore, Monte-Carlo simulation is employed to analyze uncertainties and ensure the reliability of the forecasts. Accordingly, the RELM-BWO model reliably forecasts droughts for all lakes, with a lead time ranging from 2 to 6 months. The study's findings offer valuable insights for policymakers, water managers, and other stakeholders to better prepare drought mitigation strategies.
  13. Abd Rahman NA, Mohd Yasin MN, Ibrahim IM, Jusoh M, Noor SK, Ekscalin Emalda Mary MR, et al.
    Micromachines (Basel), 2022 Dec 08;13(12).
    PMID: 36557477 DOI: 10.3390/mi13122178
    A comprehensive review on recent developments and applications of circularly polarized (CP) dielectric resonator antennas (DRAs) is proposed in this paper. DRAs have received more considerations in various applications due to their advantages such as wide bandwidth, high gain, high efficiency, low losses, and low profile. A broad justification for circular polarization and DRAs is stated at the beginning of the review. Various techniques such as single feed, dual, or multiple feeds used by different researchers for generating circular polarization in DRAs are briefly studied in this paper. Multiple-input-multiple-output (MIMO) CP DRAs, which can increase channel capacity, link reliability, and data rate, have also been analyzed. Additionally, innovative design solutions for broadening the circular polarization bandwidth and reducing mutual coupling are studied. Several applications of DRA are also discussed comprehensively. This paper finishes with concluding remarks.
  14. Das P, Samad N, Sapkota A, Al-Banna H, A Rahman NA, Ahmad R, et al.
    Cureus, 2021 Dec;13(12):e20326.
    PMID: 35028222 DOI: 10.7759/cureus.20326
    Background Caesarian sections (CS) are life-saving management for a pregnant mother and fetus subject to obstetric complications. The World Health Organization (WHO) expected CS rates not to exceed 10 to 15 per 100 live births in any country. This study aimed to assess the prevalence of CS and its associated factors from the 2016 Nepal Demographic and Health Survey (NDHS), building on previous studies mentioned in detail in the latter part of the paper. Methods This study analyzed the secondary data from the 2016 Nepal Demographic and Health Survey (NDHS), conducted from June 19, 2016, to January 31, 2017. The survey is undertaken every five years; consequently, the data capture the information in the previous five years from the data collection period. We used the 2016 NDHS, which is implemented by the new Enumeration Area (EA) under the support of the Ministry of Health (MOH) and funded by the U.S. Agency for International Development (USAID). In the rural areas, the sample is stratified and selected in two stages. In the first stage, wards are selected as the primary sampling units (PSU), with households subsequently chosen from the PSUs. In the urban areas, the sample is nominated in three stages. In the first stage, wards are selected as PSUs; in the second stage, one EA is chosen from each PSU, and finally, households are selected from the EAs. Then data were collected from the women in the reproductive age group within the selected households. Results The prevalence of CS in Nepal conforms to the WHO standard with 7.8, 7.5, and 8.1 per 100 deliveries, or 9.8, 8.9, and 9.1 per women's last births in the previous one, three, and five years, respectively. Older mothers of 30 years old or more, having high incomes, being overweight and obese, using the internet, ante-natal care (ANC) visits of more than four times, ANC by doctors, twin delivery, and having babies of 4 kg or more, had higher odds for a CS while having two or more children seemed to be protective towards CS. Conclusion These findings can be used to update health policies surrounding CS delivery to limit unnecessary CS and ensure better health as CS is not without complications.
  15. Sukumaran SD, Nasir SB, Tee JT, Buckle MJC, Othman R, Rahman NA, et al.
    J Enzyme Inhib Med Chem, 2021 Dec;36(1):130-137.
    PMID: 33243025 DOI: 10.1080/14756366.2020.1847100
    A series of C4-substituted tertiary nitrogen-bearing 2'-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Majority of the 2'-hydroxychalcone analogues displayed a better inhibition against acetylcholinesterase (AChE) than butyrylcholinesterase (BuChE). Among them, compound 4c was identified as the most potent AChE inhibitor (IC50: 3.3 µM) and showed the highest selectivity for AChE over BuChE (ratio >30:1). Molecular docking studies suggested that compound 4c interacts with both the peripheral anionic site (PAS) and catalytic anionic site (CAS) regions of AChE. ADMET analysis confirmed the therapeutic potential of compound 4c based on its blood-brain barrier penetrating. Overall, the results suggest that this 2'-hydroxychalcone deserves further investigation into the therapeutic lead for Alzheimer's disease (AD).
  16. Al-Thiabat MG, Gazzali AM, Mohtar N, Murugaiyah V, Kamarulzaman EE, Yap BK, et al.
    Molecules, 2021 Aug 31;26(17).
    PMID: 34500740 DOI: 10.3390/molecules26175304
    Drug targeting is a progressive area of research with folate receptor alpha (FRα) receiving significant attention as a biological marker in cancer drug delivery. The binding affinity of folic acid (FA) to the FRα active site provides a basis for recognition of FRα. In this study, FA was conjugated to beta-cyclodextrin (βCD) and subjected to in silico analysis (molecular docking and molecular dynamics (MD) simulation (100 ns)) to investigate the affinity and stability for the conjugated system compared to unconjugated and apo systems (ligand free). Docking studies revealed that the conjugated FA bound into the active site of FRα with a docking score (free binding energy < -15 kcal/mol), with a similar binding pose to that of unconjugated FA. Subsequent analyses from molecular dynamics (MD) simulations, root mean square deviation (RMSD), root mean square fluctuation (RMSF), and radius of gyration (Rg) demonstrated that FA and FA-βCDs created more dynamically stable systems with FRα than the apo-FRα system. All systems reached equilibrium with stable RMSD values ranging from 1.9-2.4 Å and the average residual fluctuation values of the FRα backbone atoms for all residues (except for terminal residues ARG8, THR9, THR214, and LEU215) were less than 2.1 Å with a consistent Rg value of around 16.8 Å throughout the MD simulation time (0-100 ns). The conjugation with βCD improved the stability and decreased the mobility of all the residues (except residues 149-151) compared to FA-FRα and apo-FRα systems. Further analysis of H-bonds, binding free energy (MM-PBSA), and per residue decomposition energy revealed that besides APS81, residues HIS20, TRP102, HIS135, TRP138, TRP140, and TRP171 were shown to have more favourable energy contributions in the holo systems than in the apo-FRα system, and these residues might have a direct role in increasing the stability of holo systems.
  17. Gautam V, Nimmanpipug P, Zain SM, Rahman NA, Lee VS
    Molecules, 2021 Jul 27;26(15).
    PMID: 34361694 DOI: 10.3390/molecules26154540
    Extracellular signal-regulated kinases 1 and 2 (ERK1/2) play key roles in promoting cell survival and proliferation through the phosphorylation of various substrates. Remarkable antitumour activity is found in many inhibitors that act upstream of the ERK pathway. However, drug-resistant tumour cells invariably emerge after their use due to the reactivation of ERK1/2 signalling. ERK1/2 inhibitors have shown clinical efficacy as a therapeutic strategy for the treatment of tumours with mitogen-activated protein kinase (MAPK) upstream target mutations. These inhibitors may be used as a possible strategy to overcome acquired resistance to MAPK inhibitors. Here, we report a class of repeat proteins-designed ankyrin repeat protein (DARPin) macromolecules targeting ERK2 as inhibitors. The structural basis of ERK2-DARPin interactions based on molecular dynamics (MD) simulations was studied. The information was then used to predict stabilizing mutations employing a web-based algorithm, MAESTRO. To evaluate whether these design strategies were successfully deployed, we performed all-atom, explicit-solvent molecular dynamics (MD) simulations. Two mutations, Ala → Asp and Ser → Leu, were found to perform better than the original sequence (DARPin E40) based on the associated energy and key residues involved in protein-protein interaction. MD simulations and analysis of the data obtained on these mutations supported our predictions.
  18. Jahan I, Begum M, Akhter S, Islam MZ, Jahan N, Samad N, et al.
    Ann Afr Med, 2021 7 3;20(2):69-77.
    PMID: 34213471 DOI: 10.4103/aam.aam_114_20
    Introduction: Alternate nostril breathing (ANB) is an effective breathing exercise with therapeutic benefits on cardiorespiratory functions for healthy and diseased individuals. This study was conducted to assess the effects of ANB exercise on cardiorespiratory tasks in healthy adults.

    Materials and Methods: This randomized experimental study was conducted in the Department of Physiology, Chittagong Medical College, Chattogram, from July 2017 to June 2018. A total of 100 1st-year students, aged between 18 and 20 years, were included by a random sampling method. Fifty participants (25 males and 25 females) were enrolled in the experimental group, while age- and body mass index-matched another 50 participants (25 males and 25 females) served as the control group. Experimental group participants performed ANB exercise for 4 weeks. Cardiorespiratory parameters (pulse rate, blood pressure, forced vital capacity, forced expiratory volume in 1st s [FEV1], and peak expiratory flow rate [PEFR] were measured. Data were taken at the start and after 4 weeks in both groups.

    Results: Independent t-test showed no significant differences in the cardiorespiratory functions between the experimental and control groups among the male and female participants, except for the females' PEFR which showed small differences. On the other hand, repeated measure ANOVA shows significant improvement in the experimental groups among males (P < 0.001-0.028) and females (P < 0.001-0.001) in all the cardiorespiratory functions measured, except for the FEV1 and PEFR among males.

    Conclusion: The results of this study suggest that cardiorespiratory functions were improved after breathing exercise, and therefore, ANB can be recommended for increasing cardiorespiratory efficiency.

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