Displaying publications 1 - 20 of 30 in total

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  1. Samsudin S, Sakinah SNS, Malina O, Norliza BA, Noh MA, Fairuz A, et al.
    Trop Med Int Health, 2018 03;23(3):327-333.
    PMID: 29356240 DOI: 10.1111/tmi.13033
    OBJECTIVE: The high prevalence of leptospirosis in humans is of great public health concern, particularly in tropical and subtropical regions. This study aimed to determine the seroprevalence of leptospiral antibodies and distribution of serovars, and to assess the usefulness of enzyme-linked immunosorbent assay (ELISA) as a screening method for leptospiral antibodies in a high-risk healthy community.

    METHODS: Cross-sectional study of 231 market workers and food handlers in wet markets and food premises from two localities in central Malaysia. Respondents' background information was obtained using a questionnaire. Serum samples were tested for leptospiral antibodies using ELISA and microscopic agglutination test (MAT).

    RESULTS: Seroprevalence of leptospirosis among healthy workers was 46.3%. Detection of seropositivity was higher by MAT (46%) than ELISA (15%). We observed high seropositivity among local workers (49%), food handlers (49.5%), females (60.8%) and those aged 34 years and older (46.3%). Local strain LEP175 was the predominant serovar, followed by WHO strain Patoc.

    CONCLUSION: Overall seroprevalence among healthy food handlers and market workers was high in this study. The workplace places susceptible individuals at risk of leptospirosis.

  2. Gasibat Q, Abdullah B, Samsudin S, Alexe DI, Alexe CI, Tohănean DI
    Sports (Basel), 2023 Aug 30;11(9).
    PMID: 37755841 DOI: 10.3390/sports11090164
    The high-intensity demands of overhead sports exert significant stress on the bilateral shoulder complex, triggering adaptive kinematics and a distinct strength imbalance between internal and external rotators. The imbalance being referred to in the given statement poses a potential risk for humeral head displacement and puts nearby tendons under tension, heightening the vulnerability to injury. This study aims to assess muscle imbalances in badminton athletes. The first hypothesis (H1) suggests that there are differences in internal and external shoulder rotation movements between dominant and non-dominant segments in badminton players. The second hypothesis (H2) proposes that there are variations in muscle imbalances based on gender among elite badminton players. The objectives are to analyze these differences and explore potential gender-related variations in muscle imbalances. The study seeks to contribute to the understanding of muscle imbalances in badminton athletes and potentially guide training and injury prevention strategies in the sport. Using a cutting-edge Hand-Held Dynamometer (HHD), a cohort of 30 elite badminton players underwent an assessment to uncover any bilateral shoulder rotation strength imbalances during a challenging five second isometric maximum contraction. The participants boasted an average age of 17.4 years and a mean playing experience of 7.23 years. The study revealed a notable difference in the ratio of external and internal strength between the dominant and non-dominant shoulders (p = 0.000). This discrepancy amounted to a striking 27.93% muscle imbalance in external rotation/internal rotation strength ratios, favoring the dominant shoulder. Moreover, gender-specific differences were detected, with male players exhibiting a 24.54% muscle imbalance in favor of the dominant shoulder, while female players showcased a more substantial 31.33% imbalance (p = 0.000). In light of these findings, it became evident that elite badminton players possess considerably stronger dominant shoulders compared with their non-dominant counterparts. Furthermore, the study revealed that male players experience less muscular imbalance than their female counterparts.
  3. Wang X, Soh KG, Samsudin S, Deng N, Liu X, Zhao Y, et al.
    PLoS One, 2023;18(12):e0295531.
    PMID: 38064433 DOI: 10.1371/journal.pone.0295531
    OBJECTIVE: This study aims to meta-analyze the impact of high-intensity functional training on athletes' physical fitness and sport-specific performance.

    METHODS: A systematic search was conducted in five well-known academic databases (PubMed, Scopus, Web of Science, EBSCOhost, and the Cochrane Library) up to July 1, 2023. The literature screening criteria included: (1) studies involving healthy athletes, (2) a HIFT program, (3) an assessment of outcomes related to athletes' physical fitness or sport-specific performance, and (4) the inclusion of randomized controlled trials. The Physical Therapy Evidence Database (PEDro) scale was used to evaluate the quality of studies included in the meta-analysis.

    RESULTS: 13 medium- and high-quality studies met the inclusion criteria for the systematic review, involving 478 athletes aged between 10 and 24.5 years. The training showed a small to large effect size (ES = 0.414-3.351; all p < 0.05) in improving upper and lower body muscle strength, power, flexibility, and sport-specific performance.

    CONCLUSION: High-intensity functional training effectively improves athletes' muscle strength, power, flexibility, and sport-specific performance but has no significant impact on endurance and agility. Future research is needed to explore the impact of high-intensity functional training on athletes' speed, balance, and technical and tactical performance parameters.

  4. Samsudin S, Chui PL, Kamar ABA, Abdullah KL
    Nurs Open, 2023 Jan;10(1):349-357.
    PMID: 36514142 DOI: 10.1002/nop2.1311
    AIM: To assess the effectiveness of the maternal kangaroo care education programme over 1 month and 3 months on the mother's perception, knowledge, perceived barriers and stress.

    DESIGN: A quasi-experimental and longitudinal study was conducted among mothers with premature infants.

    METHODS: Forty-eight mother-infant dyads were enrolled per arm in the control and experimental groups. The control group received standard routine care, while the experimental group received a maternal kangaroo care education program. Data were collected through self-administered Kangaroo Care Questionnaires. Chi-square, the general linear model and repeated measures ANOVA were used to analyse data.

    RESULTS: The demographics are a majority of Malay mothers with multipara, a caesarean delivery with prematurity. At 3 months post-intervention, the experimental group reported a significant reduction in stress, a positive perception and good knowledge towards kangaroo care implementation. The mothers' perceived barriers towards kangaroo care significantly decreased after 3 months in the experimental group.

  5. Samsudin S, Tan KCH
    MyJurnal
    Mental health is an integral component to the formation of human capital performance. Human capital with high productivity is the key factor to the growth of a country. Thus, this study aims to investigate the relationship between the level of mental health of undergraduate students in Universiti Utara Malaysia (UUM) with their performance. Mental health was measured using the General Health Questionnaire 12-item (GHQ-12) and the performance was based on the Cumulative Grade Point Average (CGPA). A total of 316 undergraduate students at UUM had answered questionnaires that were distributed. The data were analysed descriptively and the effect of the level of mental health on performance was tested using probit model. Based on GHQ-12, 48% respondents were found to have a good mental health status. A total of 67.21% of the students who obtain CGPA 3.67 and above have a good level of health compared with only 36.08% for those with CGPA under 3.67. Based on the probit model, the level of mental health was found to be significant at 1% level in influencing the CGPA. These findings provide indication to policy makers of the importance of mental health in influencing the students’ performance. Mental health education programs should be implemented or enhanced to raise awareness of the importance of good mental health state among students in higher education institution.
    Keywords: CGPA; GHQ-12; mental health; productivity; Kedah; Malaysia
  6. Al-Salih M, Samsudin S, Arshad SS
    J Genet Eng Biotechnol, 2021 May 18;19(1):76.
    PMID: 34003402 DOI: 10.1186/s43141-021-00161-y
    BACKGROUND: Environmental contamination by microbes is a major public health concern. A damp environment is one of the potential sources for microbe proliferation. Smart synthesis nanocatalytic coatings on surfaces, food, and material from different pathogen bacteria can inhibit using the Fe3O4/CNTs as anti-microbial growth can effectively curb this growing threat. In this present work, the anti-microbial efficacy of synthesis of a compound nanoparticle-containing iron oxide-multi-walled carbon nanotube was combined by laser ablation PLAL and explored the anti-bacterial action of colloidal solution of Fe3O4/CNTs NPs that was evaluated against bacteria which is classified as gram-negative (Escherichia coli (E. coli), Klebsiella pneumonia (K. pneumonia), and also that is identified as gram-positive (Streptococcus pyogenes (S .pyogenes) and Staphylococcus aureus (S. aureus) under visible light irradiation.

    RESULTS: Doping of a minute fraction of iron(III) salt (0.5 mol%) in a volatile solvent (ethanol) was carried out via the sol-gel technique. Fe3O4 was further calcined at various temperatures (in the range of 500-700 °C) to evaluate the thermal stability of the Fe3O4 nanoporous oxidizer nanoparticles. The physicochemical properties of the samples were characterized through X-ray diffraction (XRD), atomic force microscopy (AFM), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and UV-Visible spectroscopy techniques. XRD results revealed that the nanoparticles framework of Fe3O4 was maintained well up to 650 °C by the Fe dopant. UV-Vis results suggested that absorption property of combination Fe3O4/CNTs nanopowder by PLAL was enhanced and the band gap is reduced into 2.0 eV.

    CONCLUSIONS: Density functional theory (DFT) studies emphasize the introduction of Fe+ and Fe2+ ions by replacing other ions in the CNT lattice, therefore creating oxygen vacancies. These further promoted anti-microbial efficiency. A significantly high bacterial inactivation that indicates results was evaluated and that the mean estimations of restraint were determined from triple assessment in every appraisal at 400 ml which represent the best anti-bacterial action against gram-positive and gram-negative microbes.

  7. Samsudin S, Chui PL, Ahmad Kamar A, Abdullah KL, Yu CW, Mohamed Z
    J Multidiscip Healthc, 2023;16:1023-1035.
    PMID: 37077560 DOI: 10.2147/JMDH.S403206
    PURPOSE: Kangaroo care is a complementary humanistic intervention based on a family-centered care model. This study investigated the effects of a locally contextualized, structured kangaroo care education program on weight gain, breastfeeding rate and length of hospitalization for premature infants.

    PATIENTS AND METHODS: This longitudinal quasi-experimental study with pre- and post-intervention design involved 96 infants born between 28 and 37 weeks of gestation for three months, and was carried out at a neonatal intensive care unit in Malaysia. The experimental group received a structured education program and careful monitoring of their kangaroo care practices, while the control group received routine care without a structured education program. The institutional review board approved the study design and registered at ClinicalTrials.gov (NCT04926402).

    RESULTS: The kangaroo care hours performed by mothers at baseline in the experimental and control group was 4.12 and 0.55 hours per week, respectively. At three months post-discharge, the experimental group had significantly higher weight gain, higher breastfeeding rates and shorter lengths of hospitalization than the control group.

    CONCLUSION: A locally contextualized and structured kangaroo care education program is effective in the performance of kangaroo care. One hour per day of kangaroo care is positively associated with an extended period of breastfeeding, improved weight gain and shorter hospitalization of premature infants.

  8. Samsudin S, Adwan S, Arof H, Mokhtar N, Ibrahim F
    J Digit Imaging, 2013 Apr;26(2):361-70.
    PMID: 22610151 DOI: 10.1007/s10278-012-9483-5
    Standard X-ray images using conventional screen-film technique have a limited field of view that is insufficient to show the full bone structure of large hands on a single frame. To produce images containing the whole hand structure, digitized images from the X-ray films can be assembled using image stitching. This paper presents a new medical image stitching method that utilizes minimum average correlation energy filters to identify and merge pairs of hand X-ray medical images. The effectiveness of the proposed method is demonstrated in the experiments involving two databases which contain a total of 40 pairs of overlapping and non-overlapping hand images. The experimental results are compared with that of the normalized cross-correlation (NCC) method. It is found that the proposed method outperforms the NCC method in classifying and merging the overlapping and non-overlapping medical images. The efficacy of the proposed method is further indicated by its average execution time, which is about five times shorter than that of the other method.
  9. Samsudin S, Abdullah N
    J Cross Cult Gerontol, 2017 Jun;32(2):223-237.
    PMID: 28493065 DOI: 10.1007/s10823-017-9318-4
    Determining factors that affect healthcare utilization by the elderly is vital for the health system to be more responsive in providing care to this vulnerable group. The main objective of this paper is to identify the effect of the predisposing, enabling, and need factors on doctor visits and in-patient care for the elderly residing in the northern region of Malaysia. A multistage cluster sampling was used in selecting the sample for the study. A total of 1414 respondents aged 60 and over were interviewed face-to-face using a structured questionnaire. A probit model was used in estimating the utilization equations. At a significance level of 0.05, except for age, all predisposing and enabling factors were not statistically significant in affecting the doctor visits. On the other hand, being a male, smoker, medical insurance holder or had not actively involved in social interaction within the reference period increases the likelihood of being in-patient. Health-related variables remain the most significant factors that determine healthcare utilization, including both doctor visits and in-patient stays, in the area of study, which suggests that government policies to improve population health may influence the level of healthcare use in the future.
  10. Samsudin S, Dulasi M, Sany S, Balanathan K, Chong SE, Ali A
    Int J Womens Health, 2020;12:1259-1270.
    PMID: 33408531 DOI: 10.2147/IJWH.S281826
    OBJECTIVE: This study aimed to compare the efficacy, side effects, and clinical outcomes between parenteral iron sucrose complex (ISC) and low-molecular-weight iron dextran (LMWID) for iron deficiency anemia (IDA) in pregnancy.

    METHODS: The study was conducted in a Malaysian tertiary hospital for a period of 1 year. Forty pregnant women with IDA between 24 and 38 weeks of gestation were randomized into two groups receiving treatment with either ISC or LMWID.

    RESULTS: No significant difference was found between the groups in terms of demographic data, parity, and mean gestational age. A mean total of 835 ± 150 mg doses of ISC and 656 ± 382 mg doses of LMWID were administered (P = 0.0001). Adverse events were reported in five patients who received LMWID and none in those treated with ISC (P = 0.024). The mean hemoglobin (Hb) level increment 2 weeks post treatment was higher among those who received ISC than in those who received LMWID. The ISC group demonstrated an increase of 1.91 ± 1.10 g/dL (from 8.43 ± 1.03 g/dL to 10.29 ± 0.90 g/dL) compared with the LMWID group at 1.39 ± 0.54 g/dL (from 8.61 ± 0.70 g/dL to 9.92 ± 0.88 g/dL, P = 0.023). All participants in both groups delivered at term. The estimated blood loss during delivery was significantly higher in the LMWID group (359 ± 247 mL) than in the ISC group (280 ± 100 mL, P = 0.026). Otherwise, no significant difference was observed in terms of Hb level during delivery and the perinatal outcomes for both groups.

    CONCLUSION: Parenteral ISC is more effective than LMWID in treating maternal IDA, and it is associated with fewer adverse events.

  11. Nozmi N, Samsudin S, Sukeri S, Shafei MN, Wan Mohd WMZ, Idris Z, et al.
    PMID: 29642390 DOI: 10.3390/ijerph15040693
    Little is known on the knowledge, attitudes and preventive practices (KAP) of leptospirosis worldwide. This study embarked on assessing the KAP of leptospirosis among rural communities in Malaysia. A total of 444 participants (223 male; 221 female) aged between 18 and 81 years old were surveyed by using a self-administered questionnaire. A majority of participants had poor knowledge level (57.0%), unacceptable attitudes (90.3%) and unacceptable preventive practices (69.1%) on leptospirosis, and only 29.7% knew "rat-urine disease" as leptospirosis. Only 34.2% of the participants knew the bacteria could enter via wound lesions. Ethnicity and income were strongly associated with knowledge level and preventive practices, respectively (p-values < 0.05). As for attitudes, ethnicity, income and education type were significantly associated (p-values < 0.05). Only 36.5% of the participants were willing to see a doctor and did not mind if their house or surrounding area is dirty (59.7%). Surprisingly, only 32.9% had used rubber boots during floods. By logistic regression analysis, ethnicity was the only significant predictor for both knowledge level (an odds ratio (AOR) = 0.39, 95% confidence interval (CI) = 0.222-0.680) and preventive practices (AOR = 1.81, 95% CI = 1.204-2.734). Ethnicity (AOR = 0.40, 95% CI = 0.239-0.665), income (AOR = 1.58, 95% CI = 1.041-2.385) and education type (AOR = 3.69, 95% CI = 1.237-10.986) were strong predictors for attitudes. Among the KAP variables, attitude (AOR = 4.357, 95% CI = 2.613-7.264) was the only predictor for the preventive practices by logistic regression analysis. The KAP elements on leptospirosis are still lacking and poor health seeking behavior and attitudes are of our utmost concern. Thus, effective strategies should be planned to impart knowledge, and develop proactive approaches and good preventive modules on leptospirosis to this leptospirosis-prone community.
  12. Samsudin S, Saudi SNS, Masri NS, Ithnin NR, T Z M T J, Hamat RA, et al.
    PMID: 32093098 DOI: 10.3390/ijerph17041346
    Leptospirosis has been reported as an endemic in most tropical countries. Among high risk occupations, leptospirosis includes workers in agriculture and domestic animal industries. Environmental hygiene in the wet market has established a link between the presence of rodents with probability of leptospirosis infection. This study was aimed to compare the level of knowledge, attitude and preventive practice against leptospirosis between healthy Malaysian and non-Malaysian wet market workers in selected wet markets in urban areas of Selangor. A cross-sectional study in the determined area was conducted with the participation of 147 respondents. The respondents were randomly chosen from the list provided by the state agency that regulates these markets. A self-administered bilingual validated questionnaire (English and Bahasa Melayu) was distributed to the selected respondents. There were 68 (48.3%) Malaysian respondents and 79 (53.7%) non-Malaysian respondents. The majority of them were males, who attained formal education and were less than 40 years old. Meanwhile, the respondents earned less than RM3000. Among the Malaysian respondents, 80.9% were aware of leptospirosis as compared to 17.7% of the non-Malaysian colleagues (p < 0.05). All items of knowledge showed that the Malaysian respondents scored higher as compared to non-Malaysian respondents. On attitude towards infection prevention, most Malaysian respondents had a positive attitude, while most non-Malaysian respondents had undecided perception on the majority of crucial attitude items. In practicing preventive measures, there was a marked significant difference in proportion between Malaysian and non-Malaysian respondents for items on "Specific Protection and Isolation at Source." There was a significant gap on knowledge, attitude and preventive practice among Malaysian workers as compared to non-Malaysian workers. Therefore, it was highly recommended the health promotion implementation should also provide specific focus on non-Malaysian workers.
  13. Yuan Y, Ji X, Yang X, Wang C, Samsudin S, Omar Dev RD
    Int J Environ Res Public Health, 2022 Sep 12;19(18).
    PMID: 36141724 DOI: 10.3390/ijerph191811451
    The effect of persistence of physical exercise on the psychological and emotional aspects of primary school students is studied to improve the comprehensive quality of current Chinese primary school students and explore the effect of physical exercise on students' emotions under the science, technology, engineering, art, mathematics (STEAM) education concept. First, students in a primary school in Nanchang are taken as the survey participants. Second, by formulating a physical exercise scale and a psychological and emotional scale, the current situation of physical exercise of primary school students is investigated by means of mathematical statistics. Finally, the current situation of physical exercise and the overall situation of positive psychological emotions of primary school students are analyzed, and the effect of physical exercise on the positive psychological emotions of primary school students is studied. The data show that there are significant differences in the amount of exercise and its three dimensions of intensity, time, and frequency, as well as the scores of positive emotions in the gender dimension, with the boys scoring higher than the girls. In terms of grades, students in grades 1, 2, and 6 are higher than students in grades 3, 4, and 5 on the level of a small amount of exercise, while students in grades 3, 4, and 5 are higher than the other three grades in terms of a moderate amount of exercise. Moreover, in the aspect of positive psychological emotions, the lower-grade students are obviously higher than the upper-grade students, and the second- and third-grade students present marginal significance, p = 0.058. The correlation and regression between physical exercise and positive psychological emotions are calculated and analyzed, and it is found that there is a significant positive correlation between physical exercise indicators and positive psychological emotions, with a correlation coefficient of 0.297. Physical exercise explains 8.8% of positive emotions. This research also makes relevant recommendations for students and schools and has played a role in strengthening the physical exercise and mental health of primary and secondary school students. Greater attention to the physical exercise of primary school students is recommended.
  14. Folasayo AT, Oluwasegun AJ, Samsudin S, Saudi SN, Osman M, Hamat RA
    PMID: 28208724 DOI: 10.3390/ijerph14020159
    This study was done to assess the knowledge, attitudes, risky behaviors and preventive practices related to sexually-transmitted diseases (STDs) among health and non-health sciences university students as future healthcare providers in Malaysia. A total of 700 health and non-health sciences university students (255 male; 445 female) aged between 17 and 30 years were surveyed by using a self-administered questionnaire. The majority (86.6%) had heard of STDs, and 50.4% knew STDs could present without symptoms. HIV remains the best known STD (83.6%) by the students, while chlamydia (26%) and trichomoniasis (21.0%) were rarely known. Gender, age group, educational level and faculty type were strongly associated with knowledge level (p-values < 0.05). Most of them (88.8%) were aware that STD screening was important while use of condoms was protective (63.8%). The majority of them strongly felt that treatment should be sought immediately if they (85.5%) and their partners (87.4%) have symptoms. Among the sexually-active students, 66.7% and 18% had sexual intercourse with multiple partners and commercial sex workers, while 17.4% and 9.4% took alcohol and drugs before having sex, respectively. By logistic regression analysis, students aged 24-30 years old (an odds ratio (AOR) = 0.57, 95% confidence interval (CI) = 0.377-0.859) and faculty type (AOR = 5.69, 95% CI = 4.019-8.057) were the significant predictors for the knowledge level. Knowledge on the non-HIV causes of STDs is still lacking, and the risky behavior practiced by the sexually-active students in this study is alarming. There is a need to revisit the existing STD education curriculum in both schools and universities so that appropriate intervention on STDs can be implemented.
  15. Samsudin S, Mohd Hashim S, Nawi A
    MyJurnal
    Introduction: Osteoporosis has frequently been regards as a disease of women only. However, men are also at risk of developing osteoporosis. We aimed to evaluate the knowledge of osteoporosis among men and its associated factors.
    Materials and method: A cross-sectional study of 245 male patients aged 50 and above was conducted in the primary care clinic, University Kebangsaan Malaysia Medical Centre. The research instrument used in this study was a validated self-administered questionnaire which consists of socio-demographic data and 16 items of knowledge of osteoporosis among men.
    Results: The mean score for knowledge was 7.78± 3.32 out of 16 points. Most of the subjects (83 percent) knew the definition of osteoporosis but were not aware that osteoporosis was a silent disease. Only a quarter of subjects (38 percent) recognized family history as a risk factors for osteoporosis. Despite 78 percent of subjects answer correctly regarding importance of calcium intake in their diet however only 7 percent
    of them knew the recommended dosage of daily calcium intake. Knowledge of osteoporosis was found to be significantly associated with education and total monthly household income.
    Conclusion: Findings indicate limited knowledge of osteoporosis among the subjects. Public education of osteoporosis among men is important to increase their knowledge. Meanwhile, primary care doctors should also emphasize and educate men regarding osteoporosis to enhance their knowledge of the disease.
  16. Md Hadis ND, Draman S, Samsudin S, Yusuf MZ, Md Rosli AN, Abd Rahman NS
    IIUM Medical Journal Malaysia, 2019;18(102):31-0.
    MyJurnal
    Transgender is an umbrella term for persons whose gender identity, gender expression or behaviour does not conform to that typically associated with the sex to which they were assigned at birth. Transgender individuals are particularly vulnerable to mental health concerns and psychological distress. Objective: This study aims to assess the prevalence of depression and associated risk factors among transgender male to female in Kuantan, Pahang. Material and method: This was a cross-sectional study conducted among 96 transgender male to female in Kuantan, Pahang. A convenient type of sampling was used as a mean of data collection. A selfadministered validated Malay version of Beck Depression Inventory(BDI) was used to screen for depression. Result: Majority of the respondent were Malay (82.3%), Muslim (99%), unmarried (93.8%) and monthly income <RM2300 (91.7%). Prevalence of depression among transgender male to female in Kuantan is 37.5%. There is no significant association between sociodemographic data of participants and depression. Conclusion: This study shows that almost one third of transgender male to female are at risk of depression. Therefore, screening for mental health assessment is recommended so that important measures can be taken to prevent depression among this high-risk group.
  17. Somchit N, Hassim SM, Samsudin SH
    Hum Exp Toxicol, 2002 Jan;21(1):43-8.
    PMID: 12046723
    This current study was to investigate the in vitro cytotoxicity of rat hepatocytes induced by the antifungal drugs, itraconazole and fluconazole. Both antifungal drugs caused dose-dependent cytotoxicity. In vitro incubation of hepatocytes with itraconazole revealed significantly higher lactate dehydrogenase (LDH) leakage when compared to fluconazole. Phenobarbital pretreated hepatocytes contained significantly higher total cytochrome P450 content than the control hepatocytes. P450 content was reduced approximately 30% for both types of hepatocytes after 6 hours incubation. Interestingly, cytotoxicity of itraconazole was reduced significantly by phenobarbital pretreatment. Phenobarbital did not have any effect on the cytotoxicity induced by fluconazole. These results demonstrate the in vitro toxicity of hepatocytes induced by itraconazole and fluconazole that were expressed in a dose- and time-dependent manner. Phenobarbital plays a role in the cytoprotection of hepatocytes to itraconazole-induced but not fluconazole-induced cytotoxicity in vitro.
  18. Wang X, Soh KG, Deng N, Zhang D, Cao S, Samsudin S
    Heliyon, 2024 Jan 30;10(2):e24087.
    PMID: 38293332 DOI: 10.1016/j.heliyon.2024.e24087
    This study aims to analyse the effects of functional training on muscle strength, jumping, and functional movement screen in wushu athletes.

    METHODS: This study followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A systematic search of electronic databases was also conducted, including EBSCOhost, Scopus, PubMed, Web of Science, CNKI, Google Scholar, and Wanfang. The Physiotherapy Evidence Database (PEDro) scale was an effective indicator to evaluate the quality of studies included in the systematic review.

    RESULTS: This systematic review included 474 participants aged 8-24 years old. The intervention period for most studies was 12 weeks. Among the included studies, 6 focused on muscle strength, 4 on jumping performance, and 11 on functional movement screen.

    CONCLUSION: These articles have been analysed, and the positive impact of functional training interventions on muscle strength, jumping, and functional movement screen of wushu athletes has been verified.

  19. Wang X, Yang X, Juzaily Bin Mohd Nasiruddin N, Wei S, Dong D, Bin Samsudin S
    Health Educ Behav, 2024 Feb 02.
    PMID: 38305027 DOI: 10.1177/10901981231216735
    Although physical activity (PA) has a profound impact on health, many college and university students are still physically inactive. There is some evidence to suggest that social support (SS) could impact the PA levels of students, but the internal relationship and specific effects are not very clear. The purpose of this review was to determine the strength of the relationship between SS and PA and examine whether any potential associations differed in terms of age, gender, and region among college and university students. Studies were identified using the following electronic databases: PubMed, SPORTDiscus, Web of Science, and Sociological Abstracts. Moderator analyses investigating the effects of students' age, gender, and region (nation) were performed. This review included 19 articles. The results showed total SS was significantly associated with PA (r = 0.30, 95% confidence interval [CI]: [0.22, 0.37], p < .001). With respect to different types of support, friend support was more strongly associated with PA than family support. Gender factors had a significant moderating effect on the correlation between SS and PA (QM = 17.433, p < .001). Separate analyses examining the moderating effects of gender (percentage of females) found that the association between SS and PA was stronger with the increase in female percentage. In conclusion, SS is an important factor associated with PA levels and should foster SS within intervention programs according to types of SS and gender differences to increase PA levels among college and university students.
  20. Sun W, Chee C, Kok L, Lim F, Samsudin S
    Front Sports Act Living, 2022;4:1052909.
    PMID: 36506722 DOI: 10.3389/fspor.2022.1052909
    INTRODUCTION: This study aimed to explore common characteristics among top basketball teams, differentiate attacking and defensive performance between top and bottom teams, and correlate attacking and defensive performance with final competition rankings during the 2019 Men's Basketball World Cup, as well as to determine the relationship between performance indicators and the attacking and defensive performance. In addition, the study aimed to determine the attacking and defensive level of the top and bottom eight teams and find their existing problems and shortcomings, to further improve their competitive basketball strength, and also provided valid and reliable information for coaches to conduct targeted training in the future.

    METHODS: The rank-sum ratio (RSR) was employed to evaluate the attack, defense, and overall attacking and defensive performance between the top and bottom teams during the 2019 Men's Basketball World Cup. Additionally, an independent sample T-test was conducted to test the difference in performance indicators of attack and defense between the top eight and bottom eight teams. Spearman Rho Correlation was conducted to determine the relationship between the attacking and defensive RSR value and the final competition ranking at the 0.05 confidence level. Pearson Correlation was employed to test the relationship between the performance indicators and the attacking and defensive RSR value at the 0.05 confidence level. According to Spearman and Pearson Correlation, the indicators which contributed most to the attacking and defensive performance, as well as the correlation between attack and defense and the final ranking, can thus be determined.

    RESULTS: The results showed that the attacking performance of the top eight teams was far better than the bottom eight teams in terms of average points (p = 0.000), 2-point shoot percentage (p = 0.001), 3-point shoot percentage (p = 0.003), free throw percentage (p = 0.001), turnovers (p = 0.012), and assists (p = 0.000), and there was a significant difference (p < 0.05). However, second attack (p = 0.484), fast-break (p = 0.174), and offensive rebounds (p = 0.261) showed no significant difference between the two cohorts (P > 0.05), and the offensive rebounds of the bottom eight teams were better than the top eight teams. Additionally, there was a large gap between the top eight teams and the bottom eight teams in lost points (p = 0.001) and defensive rebounds (p = 0.000), with a very significant difference (p < 0.01). However, steals (p = 0.760), blocks (p = 0.166), and fouls (p = 0.686) had no significant difference between the two cohorts (P > 0.05). Additionally, there was a very significant difference between attack RSR (p = 0.000), defense RSR (p = 0.006), and the overall attack-defense RSR (p = 0.000) of the top eight and bottom eight teams (p < 0.01), and most top teams focused on developing both attack and defense and paid attention to improve the overall attacking and defensive ability. Moreover, there was a significant relationship between the overall attack-defense performance and assists (p = 0.832), rebounds (p = 0.762), turnovers (p = 0.702), 2-point shoot percentage (p = 0.704), defensive rebounds (p = 0.809), fast-break points (p = 0.577), blocks (p = 0.600), and free throw percentage (p = 0.575).

    CONCLUSIONS: This study showed that the top basketball teams focused on developing both attack and defense, and have the common characteristics of strong attack and defense. Whether it was the attack, defense, or overall attacking and defensive ability, there was a significant relationship with the final ranking. Additionally, this study showed that there were very significant differences in both attacking and defensive abilities between the top eight and bottom eight teams, as well as highlighted their respective advantages and disadvantages in attacking and defensive indicators. Besides that, this study found that performance indicators such as assists, defensive rebounds, 2P%, turnovers, FT%, fast-breaks, and blocks were the main factors that distinguish the top and bottom teams, and they had a significant relationship with overall attacking and defensive performance. The above information allows coaches and players to learn the latest developments in competitive basketball, as well as their advantages and disadvantages, to help them organize targeted training in the future.

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