MyMedR

Fulltext "Miotic-induced retinal detachment": a case report

Singh M

Med J Malaysia, 1985 Jun;40(2):136-8.

A rare case of pilocarpine-induced retinal detachment occurring in the only useful myopic eye of a young Chinese woman is described. Problems of treating raised intraocular pressure in high-risk cases of retinal detachment are discussed.

A Central Spiral Split Rectangular-Shaped Metamaterial Absorber Surrounded by Polarization-Insensitive Ring Resonator for S-Band Applications

Sakib S, Hoque A, Rahim SKBA, Singh M, Sahar NM, Islam MS, et al.

Materials (Basel), 2023 Jan 30;16(3).

PMID: 36770180 DOI: 10.3390/ma16031172

This paper reports a central spiral split-rectangular-shaped metamaterial absorber surrounded by a polarization-insensitive ring resonator for s-band applications. The rated absorption is 99.9% at 3.1 GHz when using a three-layer structure where the top and ground are made of copper and the center dielectric material is a commonly used FR-4 substrate. The central split gaps have an impact on the unit cell by increasing high absorption, and an adequate electric field is apparent in the outer split ring gap. At 3.1 GHz, the permittivity and permeability are negative and positive, respectively, so the proposed unit cell acts as an epsilon negative (ENG) metamaterial absorber. In a further analysis, Roger4450B was used as a substrate and obtained excellent absorption rates of 99.382%, 99.383%, 99.91%, and 95.17% at 1.44, 3.96, 4.205, and 5.025 GHz, respectively, in the S- and C-band regions. This unit cell acts as a single negative metamaterial (SNG) absorber at all resonance frequencies. The S11 and S21 parameters for FR-4 and Rogers4450B were simulated while keeping the polarization angle (θ and φ) at 15, 30, 45, 60, 75, and 90 degrees to measure, permittivity, permeability, reflective index, absorption, and reflection. The values of the reflective index are near zero. Near-zero reflective indexes (NZRI) are widely used in antenna gain propagation. The unit cell fabricated for the FR-4 substrate attained 99.9% absorption. S-band values in the range of (2-4) GHz can be applied for low-frequency radar detection.

Fulltext A Polarization Independent Quasi-TEM Metamaterial Absorber for X and Ku Band Sensing Applications

Hoque A, Tariqul Islam M, Almutairi AF, Alam T, Jit Singh M, Amin N

Sensors (Basel), 2018 Nov 30;18(12).

PMID: 30513675 DOI: 10.3390/s18124209

In this paper, a dual-band metamaterial absorber (MMA) ring with a mirror reflexed C-shape is introduced for X and Ku band sensing applications. The proposed metamaterial consists of two square ring resonators and a mirror reflexed C-shape, which reveals two distinctive absorption bands in the electromagnetic wave spectrum. The mechanism of the two-band absorber particularly demonstrates two resonance frequencies and absorption was analyzed using a quasi-TEM field distribution. The absorption can be tunable by changing the size of the metallic ring in the frequency spectrum. Design and analysis of the proposed meta-absorber was performed using the finite-integration technique (FIT)-based CST microwave studio simulation software. Two specific absorption peaks value of 99.6% and 99.14% are achieved at 13.78 GHz and 15.3 GHz, respectively. The absorption results have been measured and compared with computational results. The proposed dual-band absorber has potential applications in sensing techniques for satellite communication and radar systems.

A new record of Platynosomum proxilliciens in Malaysian crows (Trematoda: Dicrocoeliidae)

Singh M, Sinniah B

Southeast Asian J. Trop. Med. Public Health, 1980 Mar;11(1):148.

PMID: 7403950

A study on the prevalence of antibodies to Toxoplasma gondii in Singapore

Lim KC, Pillai R, Singh M

Southeast Asian J. Trop. Med. Public Health, 1982 Dec;13(4):547-50.

PMID: 6763354

The indirect fluorescence antibody technique has been employed to study the prevalence of toxoplasma antibodies in Singapore. 42.5% of clinically suspected cases of toxoplasmosis showed antibody titres. Of these, 17.5% had titres greater than or equal to 1.64. Malays and Indians have higher positive rates compared to the main ethnic group, the Chinese. Antibody titres are found in both males and females and span through the various age groups. The possible mode of transmission is discussed and the importance of congenital toxoplasmosis is indicated.

A survey on the prevalence of toxoplasmic antibodies in animal sera

Singh M, Zaman V, Goh TK, Kheng CS

Med J Malaya, 1967 Dec;22(2):115-7.

PMID: 4231976

Actinomycetic corneal ulcer

Singh M, Kaur B

Eye (Lond), 1989;3 ( Pt 4):460-2.

PMID: 2606221

A rare case of keratoactinomycosis developing in the absence of any known ocular trauma is described. It showed a dramatic response to penicillin therapy. Steroids should be cautiously used in the presence of active corneal disease. This case highlights the importance of repeated examination of corneal scrapings.

Fulltext Acute Paraplegia in a Toddler: A Diagnostic Journey Compounding the Challenge in Management: A Case Report

Goh JH, Fazir M, Zainal-Abidin NA, Amir D, Singh M

Malays Orthop J, 2016 Jul;10(2):56-60.

PMID: 28435564 MyJurnal DOI: 10.5704/MOJ.1607.012

Spinal tuberculosis is not common in the paediatric age group. Initial clinical features are often vague and non specific until the disease progresses to later stages. We highlight the diagnostic difficulties and management challenges of a complicated extradural tuberculoma with neurological deficits in a very young girl.

Alginate-based bipolymeric-nanobioceramic composite matrices for sustained drug release

Hasnain MS, Nayak AK, Singh M, Tabish M, Ansari MT, Ara TJ

Int J Biol Macromol, 2016 Feb;83:71-7.

PMID: 26608007 DOI: 10.1016/j.ijbiomac.2015.11.044

Alginate-based bipolymeric-nanobioceramic composite matrices for sustained drug release were developed through incorporation of nano-hydroxyapatite [nHAp] powders within ionotropically-gelled calcium ion-induced alginate-poly (vinyl pyrrolidone) blends polymeric systems. nHAp powders were synthesized by precipitation technique using calcium hydroxide [Ca(OH)2] and orthophosphoric acid [H3PO4] as raw materials. The average particle size of these was synthesized. nHAp powders was found as 19.04 nm and used to prepare nHAp-alginate-PVP beads containing DS. These beads exhibited drug entrapment efficiency (%) of 65.82±1.88 to 94.45±3.72% and average bead sizes of 0.98±0.07 to 1.23±0.15 mm. These beads were characterized by scanning electron microscopy (SEM) and Fourier transform-infra red (FTIR) spectroscopy analyses. Various nHAp-alginate-PVP beads containing DS exhibited prolonged sustained drug release and followed the Koresmeyer-Peppas model of drug release (R2=0.9908-0.9978) with non-Fickian release (anomalous transport) mechanism (n=0.73-0.84) for drug release over 8 h.

Analysis of differentially expressed proteins in cancerous and normal colonic tissues

Gam LH, Leow CH, Man CN, Gooi BH, Singh M

World J Gastroenterol, 2006 Aug 21;12(31):4973-80.

PMID: 16937492

AIM: To identify and analyze the differentially expressed proteins in normal and cancerous tissues of four patients suffering from colon cancer.

METHODS: Colon tissues (normal and cancerous) were homogenized and the proteins were extracted using three protein extraction buffers. The extraction buffers were used in an orderly sequence of increasing extraction strength for proteins with hydrophobic properties. The protein extracts were separated using the SDS-PAGE method and the images were captured and analyzed using Quantity One software. The target protein bands were subjected to in-gel digestion with trypsin and finally analyzed using an ESI-ion trap mass spectrometer.

RESULTS: A total of 50 differentially expressed proteins in colonic cancerous and normal tissues were identified.

CONCLUSION: Many of the identified proteins have been reported to be involved in the progression of similar or other types of cancers. However, some of the identified proteins have not been reported before. In addition, a number of hypothetical proteins were also identified.

Analysis of differentially expressed proteins in colorectal cancer using hydroxyapatite column and SDS-PAGE

Lim SR, Gooi BH, Singh M, Gam LH

Appl Biochem Biotechnol, 2011 Nov;165(5-6):1211-24.

PMID: 21863284 DOI: 10.1007/s12010-011-9339-3

Limitation on two dimensional (2D) gel electrophoresis technique causes some proteins to be under presented, especially the extreme acidic, basic, or membrane proteins. To overcome the limitation of 2D electrophoresis, an analysis method was developed for identification of differentially expressed proteins in normal and cancerous colonic tissues using self-pack hydroxyapatite (HA) column. Normal and cancerous colon tissues were homogenized and proteins were extracted using sodium phosphate buffer at pH 6.8. Protein concentration was determined and the proteins were loaded unto the HA column. HA column reduced the complexity of proteins mixture by fractionating the proteins according to their ionic strength. Further protein separation was accomplished by a simple and cost effective sodium dodecyl sulfate-polyacrylamide gel electrophoresis method. The protein bands were subjected to in-gel digestion and protein analysis was performed using electrospray ionization (ESI) ion trap mass spectrometer. There were 17 upregulated proteins and seven downregulated proteins detected with significant differential expression. Some of these proteins were low abundant proteins or proteins with extreme pH that were usually under presented in 2D gel analysis. We have identified brain mitochondrial carrier protein 1, T-cell surface glycoprotein CD1a, SOSS complex subunit B2, and Protein Jade 1 which were previously not detected in 2D gel analysis method.

Fulltext Anterior leprotic retinitis of trantas: a case report

Singh M

Med J Malaysia, 1985 Jun;40(2):139-41.

PMID: 3841732

A case of rare retinal lesion occurring in a young girl suffering from lepromatous leprosy is described. Fundus lesions in leprosy are extremely rare but do occur in some cases without causing any threat to vision. Their response to antileprotic treatment is not clearly known.

Argon laser trabeculoplasty in Asian eyes

Singh M, Kaur B

Int Ophthalmol, 1987 Jun;10(3):161-5.

PMID: 3596909

Twenty two Asian eyes suffering from open angle glaucoma were treated by argon laser trabeculoplasty and were followed for an average of eleven months. 77.27% of eyes were controlled with ALT alone. The pressure lowering effect of argon laser trabeculoplasty in this series was found to be consistent. Argon laser trabeculoplasty may become the preferred method of treating open angle glaucoma in the Asian population.

Fulltext Automatic Annotation of Unlabeled Data from Smartphone-Based Motion and Location Sensors

Pius Owoh N, Mahinderjit Singh M, Zaaba ZF

Sensors (Basel), 2018 Jul 03;18(7).

PMID: 29970823 DOI: 10.3390/s18072134

Automatic data annotation eliminates most of the challenges we faced due to the manual methods of annotating sensor data. It significantly improves users’ experience during sensing activities since their active involvement in the labeling process is reduced. An unsupervised learning technique such as clustering can be used to automatically annotate sensor data. However, the lingering issue with clustering is the validation of generated clusters. In this paper, we adopted the k-means clustering algorithm for annotating unlabeled sensor data for the purpose of detecting sensitive location information of mobile crowd sensing users. Furthermore, we proposed a cluster validation index for the k-means algorithm, which is based on Multiple Pair-Frequency. Thereafter, we trained three classifiers (Support Vector Machine, K-Nearest Neighbor, and Naïve Bayes) using cluster labels generated from the k-means clustering algorithm. The accuracy, precision, and recall of these classifiers were evaluated during the classification of “non-sensitive” and “sensitive” data from motion and location sensors. Very high accuracy scores were recorded from Support Vector Machine and K-Nearest Neighbor classifiers while a fairly high accuracy score was recorded from the Naïve Bayes classifier. With the hybridized machine learning (unsupervised and supervised) technique presented in this paper, unlabeled sensor data was automatically annotated and then classified.

Fulltext Bacteriology of healthy conjunctivae in Malaysians

Singh M, Lim VKE

Med J Malaysia, 1987 Mar;42(1):50-2.

PMID: 3431502

The eye harbours bacteria from the time of birth throughout life. Owing to its antibacterial properties, the normal conjunctival flora plays a significant role in the defence against superficial ocular infections. In view of its protective action as well as its probable role in causing ocular disease under certain circumstances, the study of the normal flora and its pattern of antibiotic susceptibility could provide useful information in the prevention and treatment of post-surgical infections. While several such surveys have been reported from various parts of the world, no data is available for the Malaysian population. This survey seeks to establish the pattern of bacterial flora in healthy conjunctivae of Malaysians. In addition, the bacterial flora of a nondiabetic population was compared to that of a diabetic population to see if there were any differences.

Blood gene signature for early hepatocellular carcinoma detection in patients with chronic hepatitis B

Omar H, Lim CR, Chao S, Lee MM, Bong CW, Ooi EJ, et al.

J Clin Gastroenterol, 2015 Feb;49(2):150-7.

PMID: 25569223 DOI: 10.1097/MCG.0000000000000112

Up to 25% of chronic hepatitis B (CHB) patients eventually develop hepatocellular carcinoma (HCC), a disease with poor prognosis unless detected early. This study identifies a blood-based RNA biomarker panel for early HCC detection in CHB.

Fulltext Brain volumetric changes in menopausal women and its association with cognitive function: a structured review

Ramli NZ, Yahaya MF, Mohd Fahami NA, Abdul Manan H, Singh M, Damanhuri HA

Front Aging Neurosci, 2023;15:1158001.

PMID: 37818479 DOI: 10.3389/fnagi.2023.1158001

The menopausal transition has been proposed to put women at risk for undesirable neurological symptoms, including cognitive decline. Previous studies suggest that alterations in the hormonal milieu modulate brain structures associated with cognitive function. This structured review provides an overview of the relevant studies that have utilized MRI to report volumetric differences in the brain following menopause, and its correlations with the evaluated cognitive functions. We performed an electronic literature search using Medline (Ovid) and Scopus to identify studies that assessed the influence of menopause on brain structure with MRI. Fourteen studies met the inclusion criteria. Brain volumetric differences have been reported most frequently in the frontal and temporal cortices as well as the hippocampus. These regions are important for higher cognitive tasks and memory. Additionally, the deficit in verbal and visuospatial memory in postmenopausal women has been associated with smaller regional brain volumes. Nevertheless, the limited number of eligible studies and cross-sectional study designs warrant further research to draw more robust conclusions.

Fulltext Breast Self-Examination System Using Multifaceted Trustworthiness: Observational Study

Khana R, Mahinderjit Singh M, Damanhoori F, Mustaffa N

JMIR Med Inform, 2020 Sep 23;8(9):e21584.

PMID: 32965225 DOI: 10.2196/21584

BACKGROUND: Breast cancer is the leading cause of mortality among women worldwide. However, female patients often feel reluctant and embarrassed about meeting physicians in person to discuss their intimate body parts, and prefer to use social media for such interactions. Indeed, the number of patients and physicians interacting and seeking information related to breast cancer on social media has been growing. However, a physician may behave inappropriately on social media by sharing a patient's personal medical data excessively with colleagues or the public. Such an act would reduce the physician's trustworthiness from the patient's perspective. The multifaceted trust model is currently most commonly used for investigating social media interactions, which facilitates its enhanced adoption in the context of breast self-examination. The characteristics of the multifaceted trust model go beyond being personalized, context-dependent, and transitive. This model is more user-centric, which allows any user to evaluate the interaction process. Thus, in this study, we explored and evaluated use of the multifaceted trust model for breast self-examination as a more suitable trust model for patient-physician social media interactions in breast cancer screening.

OBJECTIVE: The objectives of this study were: (1) to identify the trustworthiness indicators that are suitable for a breast self-examination system, (2) design and propose a breast self-examination system, and (3) evaluate the multifaceted trustworthiness interaction between patients and physicians.

METHODS: We used a qualitative study design based on open-ended interviews with 32 participants (16 outpatients and 16 physicians). The interview started with an introduction to the research objective and an explanation of the steps on how to use the proposed breast self-examination system. The breast self-examination system was then evaluated by asking the patient to rate their trustworthiness with the physician after the consultation. The evaluation was also based on monitoring the activity in the chat room (interactions between physicians and patients) during daily meetings, weekly meetings, and the articles posted by the physician in the forum.

RESULTS: Based on the interview sessions with 16 physicians and 16 patients on using the breast self-examination system, honesty had a strong positive correlation (r=0.91) with trustworthiness, followed by credibility (r=0.85), confidence (r=0.79), and faith (r=0.79). In addition, belief (r=0.75), competency (r=0.73), and reliability (r=0.73) were strongly correlated with trustworthiness, with the lowest correlation found for reputation (r=0.72). The correlation among trustworthiness indicators was significant (P

Breinlia booliati sp. n. (Filaroidea: Onchocercidae), a filaria of the Malayan forest rat, Rattus sabanus (Thos.)

Singh M, Ho BC

J Helminthol, 1973;47(2):127-33.

PMID: 4724312

Fulltext Chemometrics of differentially expressed proteins from colorectal cancer patients

Yeoh LC, Dharmaraj S, Gooi BH, Singh M, Gam LH

World J Gastroenterol, 2011 Apr 28;17(16):2096-103.

PMID: 21547128 DOI: 10.3748/wjg.v17.i16.2096

To evaluate the usefulness of differentially expressed proteins from colorectal cancer (CRC) tissues for differentiating cancer and normal tissues.

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