Displaying publications 1 - 20 of 245 in total

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  1. Han WM, Jiamsakul A, Jantarapakde J, Yunihastuti E, Choi JY, Ditangco R, et al.
    HIV Med, 2021 Apr;22(4):294-306.
    PMID: 33200864 DOI: 10.1111/hiv.13017
    OBJECTIVES: We conducted a longitudinal cohort analysis to evaluate the association of pre-treatment body mass index (BMI) with CD4 recovery, virological failure (VF) and cardiovascular risk disease (CVD) markers among people living with HIV (PLHIV).

    METHODS: Participants who were enrolled between January 2003 and March 2019 in a regional Asia HIV cohort with weight and height measurements prior to antiretroviral therapy (ART) initiation were included. Factors associated with mean CD4 increase were analysed using repeated-measures linear regression. Time to first VF after 6 months on ART and time to first development of CVD risk markers were analysed using Cox regression models. Sensitivity analyses were done adjusting for Asian BMI thresholds.

    RESULTS: Of 4993 PLHIV (66% male), 62% had pre-treatment BMI in the normal range (18.5-25.0 kg/m2 ), while 26%, 10% and 2% were underweight ( 30 kg/m2 ), respectively. Both higher baseline and time-updated BMI were associated with larger CD4 gains compared with normal BMI. After adjusting for Asian BMI thresholds, higher baseline BMIs of 23-27.5 and > 27.5 kg/m2 were associated with larger CD4 increases of 15.6 cells/µL [95% confidence interval (CI): 2.9-28.3] and 28.8 cells/µL (95% CI: 6.6-50.9), respectively, compared with normal BMI (18.5-23 kg/m2 ). PLHIV with BMIs of 25-30 and > 30 kg/m2 were 1.27 times (95% CI: 1.10-1.47) and 1.61 times (95% CI: 1.13-2.24) more likely to develop CVD risk factors. No relationship between pre-treatment BMI and VF was observed.

    CONCLUSIONS: High pre-treatment BMI was associated with better immune reconstitution and CVD risk factor development in an Asian PLHIV cohort.

  2. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al.
    Autophagy, 2016;12(1):1-222.
    PMID: 26799652 DOI: 10.1080/15548627.2015.1100356
  3. Zhou W, Zeng S, Yu J, Xiang J, Zhang F, Takriff MS, et al.
    J Basic Microbiol, 2023 Feb;63(2):223-234.
    PMID: 36538731 DOI: 10.1002/jobm.202200528
    In this study, selected properties of protease and the complete genome sequence of Bacillus licheniformis NWMCC0046 were investigated, to discover laundry applications and other potential probiotic properties of this strain. Partial characterization of B. licheniformis NWMCC0046 showed that its protease has good activity both in alkaline environments and at low temperatures. Also, the protease is compatible with commercial detergents and can be used as a detergent additive for effective stain removal at low temperatures. The complete genome sequence of B. licheniformis NWMCC0046 is comprised of a 4,321,565 bp linear chromosome with a G + C content of 46.78% and no plasmids. It had 4504 protein-encoding genes, 81 transfer RNA (tRNA) genes, and 24 ribosomal RNA (rRNA) genes. Genomic analysis revealed genes involved in exocellular enzyme production and probiotic properties. In addition, genomic sequence analysis revealed specific genes encoding carbohydrate metabolism pathways, resistance, and cold adaptation capacity. Overall, protease properties show its potential as a detergent additive enzyme. The complete genome sequence information of B. licheniformis NWMCC0046 was obtained, and functional prediction revealed its numerous probiotic properties.
  4. Ma Z, Zhang F, Ma H, Chen X, Yang J, Yang Y, et al.
    PLoS One, 2021;16(4):e0248329.
    PMID: 33857162 DOI: 10.1371/journal.pone.0248329
    The elderly usually suffer from many diseases. Improving the quality of life of the elderly is an urgent social issue. In this present study, D-galactose treated aging mice models were used to reveal the effects of different animal sources and different doses of whey protein (WP) on the immune indexes organs and intestinal flora. A total of 9 groups were set up, including normal control (NC), negative control (NS), positive control (Vc), low-, medium- and high-doses of cow WP intervention groups (CL, CM and CH for short, correspondingly) and low-, medium- and high-doses of goat WP intervention groups (GL, GM and GH for short, correspondingly). The body weight gain, thymus/body weight ratio, superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, spleen immunoglobulins G (IgG), spleen interleukin-2 (IL-2) and spleen interleukin-2 (IL-6) were measured. Then, the intestinal contents were collected, and 16s genes of intestinal bacteria were sequenced to reveal the changes in bacterial flora structure. WP intervention significantly increased the weight gain, thymus/body ratio and SOD activity, but decrease the content of MDA. WP intervention increased some immune indicators. All the WP treated aging mice showed similar values of physiological indexes to that of the Vc group, even better. The relative abundance of Lactobacillus and Stenotrophomonas was increased and decreased, respectively, by both cow and goat WP. Lactobacillus may be involved in regulating the functional repair of organisms. In contrast, Stenotrophomonas might play a negative role in the immune and antioxidant capacity of the body. Combining physiological indicators and intestinal flora structure, low-concentration WP for cow and goat might be optimal for aging models.
  5. Chiou CF, Wang BC, Caldwell R, Furnback W, Lee JS, Kothandaraman N, et al.
    Neuropsychiatr Dis Treat, 2015;11:1989-94.
    PMID: 26346330 DOI: 10.2147/NDT.S86722
    Schizophrenia results in substantial health care utilization costs. Much of these costs can be attributed to health care use resulting from nonadherence to treatment, relapse, and hospitalization.
  6. Li H, Turkoz I, Zhang F
    Neuropsychiatr Dis Treat, 2016;12:15-24.
    PMID: 26730193 DOI: 10.2147/NDT.S83651
    INTRODUCTION: This single-group, open-label, prospective, noncomparative, multicenter, Phase IV study explored the efficacy and tolerability of paliperidone palmitate (PP) in hospitalized patients with acute exacerbation of schizophrenia.

    METHODS: Asian patients of either sex, between 18 and 65 years of age, diagnosed with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) with acute exacerbations within the previous 4 weeks, were enrolled. Intramuscular PP was initiated at doses of 150 milligram equivalent (mg eq) (day 1) and 100 mg eq (day 8), followed by a monthly maintenance dose between 75 mg eq and 150 mg eq (days 36 and 64). Primary efficacy endpoint was the change from baseline in the Positive and Negative Syndrome Scale (PANSS) total score (last-observation-carried-forward) at week 13.

    RESULTS: Of the 212 enrolled patients, 152 (71.7%) completed the 13-week treatment; withdrawal of consent (24 [11.3%] patients) was the most common reason for study discontinuation. Mean (standard deviation) PANSS total score from baseline (90.0 [17.41]) improved significantly at day 4 (-6.1 [9.27]; 95% confidence interval: -7.38, -4.85; P<0.001) and week 13 endpoint (-23.9 [23.24]; 95% confidence interval: -27.10, -20.78; P<0.001). Similarly, the secondary endpoints (Clinical Global Impression-Severity, Physical and Social Performance, each PANSS subscale, and Marder factor scores) improved significantly from baseline to week 13 endpoint (P<0.001 for all). At week 13, 112/210 (53.3%) patients had a 40% improvement in the PANSS total score (responder rate), and 133/212 (62.7%) patients were ready for hospital discharge. Overall, 139 (65.6%) patients experienced at least one treatment-emergent adverse event (TEAE). Most common (>5%) TEAEs were hyperprolactinemia, constipation, nasopharyngitis, insomnia, increased weight, and tremor. Worsening of schizophrenia (3.3%) and sinus bradycardia (2.0%) were serious TEAEs; no deaths were reported.

    CONCLUSION: PP was generally tolerable and efficacious in a hospital setting for the treatment of acute exacerbated schizophrenia with significant improvements in psychotic symptoms, social functioning, and severity of illness.
  7. Hu T, Qiu W, He B, Zhang Y, Yu J, Liang X, et al.
    BMC Microbiol, 2014;14:293.
    PMID: 25433675 DOI: 10.1186/s12866-014-0293-4
    In recent years novel human respiratory disease agents have been described for Southeast Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with a strong phylogenetic relationship to orthoreoviruses of bat origin.
  8. Hu T, Zheng Y, Zhang Y, Li G, Qiu W, Yu J, et al.
    BMC Microbiol, 2012;12:305.
    PMID: 23268691 DOI: 10.1186/1471-2180-12-305
    The identification of new virus strains is important for the study of infectious disease, but current (or existing) molecular biology methods are limited since the target sequence must be known to design genome-specific PCR primers. Thus, we developed a new method for the discovery of unknown viruses based on the cDNA--random amplified polymorphic DNA (cDNA-RAPD) technique. Getah virus, belonging to the family Togaviridae in the genus Alphavirus, is a mosquito-borne enveloped RNA virus that was identified using the Virus-Discovery-cDNA RAPD (VIDISCR) method.
  9. Zhang BS, Zhang F
    Zookeys, 2018.
    PMID: 30344434 DOI: 10.3897/zookeys.789.24261
    Three new species of the genus Asceua Thorell, 1887, from the natural forests of Malaysia, are described as Asceuabifurcasp. n. (♂♀), A.curvasp. n. (♂), and A.trimaculatasp. n. (♀). The genus Asceua is reported from Malaysia for the first time.
  10. Zhang BS, Zhang F
    Zootaxa, 2019 Mar 20;4568(2):zootaxa.4568.2.2.
    PMID: 31715856 DOI: 10.11646/zootaxa.4568.2.2
    Four new species of the genus Mallinella Strand, 1906, from the natural forests of Malaysia, are described as Mallinella bicanaliculata sp. n. (♂♀), M. calautica sp. n. (♂♀), M. laxa sp. n. (♂♀), and M. obliqua sp. n. (♂♀). The four new species belong to four species groups and were collected from the forest litter in Sabah state by sieving.
  11. Zhou X, Tian X, Song L, Luo L, Ma Z, Zhang F
    Food Sci Nutr, 2023 Feb;11(2):752-764.
    PMID: 36789044 DOI: 10.1002/fsn3.3111
    The prolongation of life span has attracted more and more attention in the current world. Gut microbiota is considered one of the most critical elements and is essential in regulating life span and quality. The effects of donkey whey protein (DWP) and donkey whey hydrolysate (DWPP) on physiological functions and gut microbiota of D-galactose-induced aging mice were investigated to find new strategies for resisting aging. Our results showed that DWP and DWPP could increase the body weight gain velocity, superoxide dismutase (SOD) activity, and thymus index, whereas decrease the level of reactive oxygen species (ROS) and malondialdehyde (MDA), and improve the aging of the body in the liver congestion, oozy draw focal sclerosis of chronic inflammation. The effects of medium and high concentrations of DWP and low and medium concentrations of DWPP were the same as the vitamin C (Vc)-positive control group. It was found that both DWP and DWPP could change α-diversity; the relative abundance of Lactobacillus increased, whereas the relative abundance of Helicobacter and Stenotrophomonas decreased after being treated with DWP and DWPP. The correlation between intestinal microflora and physiological indexes showed that chao1, ACE, and observed species indexes in the α index were positively correlated with weight gain velocity, SOD activity, and thymus index. The relative abundance of Lactobacillus was positively correlated with SOD and thymus index but negatively correlated with MDA. The relative abundance of Stenotrophomonas was opposite to that of Lactobacillus. The Anaerobiospirillum, Fusobacterium, and Dubosiella had a significant positive correlation with the weight gain velocity. The study provided a deeper more profound understanding of the potential use of DWP and DWPP in senescence delays.
  12. Zhang L, Mu Y, Zhang F
    Biodivers Data J, 2022;10:e96594.
    PMID: 36761594 DOI: 10.3897/BDJ.10.e96594
    BACKGROUND: The genus Aetius O. Pickard-Cambridge, 1897 has been discovered in Sri lanka, India, Malaysia (Borneo), Thailand and Ivory Coast and comprises four species: A.bicuspidatus Yamasaki, 2020, A.decollatus O. Pickard-Cambridge, 1897, A.nocturnus Deeleman-Reinhold, 2001 and A.tuberculatus (Haddad, 2013).

    NEW INFORMATION: The genus Aetius O. Pickard-Cambridge, 1897 is reported for the first time in China (Yunnan Province) and includes three species: one new species and two newly-recorded species. One new species is described, based on both sexes: A.maculatus sp. n. Additionally, A.bicuspidatus Yamasaki, 2020 and A.nocturnus Deeleman-Reinhold, 2001, are newly recorded from China, with photographs of habitus and genitalia being provided.

  13. Wang G, Guo Q, Zhou X, Zhang F
    Environ Sci Pollut Res Int, 2023 Jan;30(1):2315-2328.
    PMID: 35930151 DOI: 10.1007/s11356-022-22337-w
    Agricultural carbon emission is an important cause of climate change, and the carbon transfer caused by agricultural trade is a key area related to carbon emissions of all countries. Based on the Eora database, this paper aims to constructs a multi-region input-output database of 185 countries or regions, analyzes a spatial correlation network of embodied net carbon transfer in global agricultural trade by using UCINET, selects multi-dimensional network measurement indicators, and comprehensively studies the global evolution characteristics and functional features of network plate role of embodied carbon transfer in the global agricultural trade. The result shows that the embodied net carbon transfer network of global agricultural trade is densely connected, the spatial correlation spillover effect is significant, and the edge of the network core structure is clear. On the one hand, the top four countries or regions in terms of embodied carbon outflow in agricultural trade are the USA, Australia, Vietnam, and China. On the other hand, the top four countries or regions of embodied carbon inflow are Malaysia, Central Africa, Singapore, and Serbia. From the perspective of outdegree, indegree, proximity centrality, and intermediary centrality, Cambodia, the Netherlands, Vietnam, Ghana, and South Africa, with the high frequency of the shortest path of the globally embodied net carbon transfer network, have a strong influence and linking facility in spatial correlation and have a strong control ability to the spatial correlation of other countries or regions. The embodied carbon emission network of global agricultural trade can be divided into four sectors: main spillover, two-way spillover, broker, and main benefit. The main spillover segment, constituted by the USA, India, Germany, and China, has significant embodied carbon spillover effects on the internal segment and other segments. It is the main embodied carbon spillover sector of embodied net carbon transfer of global agricultural trade. Countries should reasonably allocate the responsibility of carbon reduction according to the trading embodied carbon transfer and made efforts to optimize the export structure of agricultural products.
  14. Zhang L, Zhang F
    Biodivers Data J, 2023;11:e99980.
    PMID: 38327341 DOI: 10.3897/BDJ.11.e99980
    BACKGROUND: Prior to this study, the genus Serendib Deeleman-Reinhold, 2001 has been discovered in Indonesia, Thailand and Laos and comprises three species: S.muadai Jäger, Nophaseud & Praxaysombath, 2012, S.suthepica Deeleman-Reinhold, 2001 and S.volans Deeleman-Reinhold, 2001.

    NEW INFORMATION: The genus Serendib Deeleman-Reinhold, 2001 is reviewed. A new species, S.hispida sp. n. (male and female), representing the first record of genus Serendib from Malaysia, is described. Descriptions and illustrations of the females of S.volans (Malaysia) and S.suthepica (China) are also provided. The latter represents the first record of the genus in China.

  15. Su Y, Ma T, Wang Z, Dong B, Tai C, Wang H, et al.
    ESC Heart Fail, 2020 Dec;7(6):4465-4471.
    PMID: 32945150 DOI: 10.1002/ehf2.12997
    AIMS: Elevated heart rate (HR) in heart failure (HF) is associated with worse outcomes, particularly in acute HF (AHF). HR reduction with ivabradine reduces cardiovascular events in HF patients with reduced ejection fraction. The present trial aimed to test the hypothesis that the early HR reduction using ivabradine improves clinical outcomes in patients with AHF.

    METHODS AND RESULTS: SHIFT-AHF is a prospective, multi-centre, double-blind, randomized, placebo-controlled trial to evaluate the efficacy and safety of ivabradine when adding to standard therapy in AHF patients (SHIFT-AHF). The trial will include 674 AHF patients with left ventricular ejection fraction 

  16. CMS Collaboration, Sirunyan AM, Tumasyan A, Adam W, Ambrogi F, Bergauer T, et al.
    Eur Phys J C Part Fields, 2020;80(3):189.
    PMID: 32226948 DOI: 10.1140/epjc/s10052-020-7739-7
    A search is presented for τ slepton pairs produced in proton-proton collisions at a center-of-mass energy of 13 TeV . The search is carried out in events containing two τ leptons in the final state, on the assumption that each τ slepton decays primarily to a τ lepton and a neutralino. Events are considered in which each τ lepton decays to one or more hadrons and a neutrino, or in which one of the τ leptons decays instead to an electron or a muon and two neutrinos. The data, collected with the CMS detector in 2016 and 2017, correspond to an integrated luminosity of 77.2 fb - 1 . The observed data are consistent with the standard model background expectation. The results are used to set 95% confidence level upper limits on the cross section for τ slepton pair production in various models for τ slepton masses between 90 and 200 GeV and neutralino masses of 1, 10, and 20 GeV . In the case of purely left-handed τ slepton production and decay to a τ lepton and a neutralino with a mass of 1 GeV , the strongest limit is obtained for a τ slepton mass of 125 GeV at a factor of 1.14 larger than the theoretical cross section.
  17. Jiamsakul A, Polizzotto M, Wen-Wei Ku S, Tanuma J, Hui E, Chaiwarith R, et al.
    J Acquir Immune Defic Syndr, 2019 03 01;80(3):301-307.
    PMID: 30531303 DOI: 10.1097/QAI.0000000000001918
    BACKGROUND: Hematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence of, risk factors for, and outcomes of hematological and nonhematological malignancies in PLHIV in Asia.

    METHODS: Incidence of malignancy after cohort enrollment was evaluated. Factors associated with development of hematological and nonhematological malignancy were analyzed using competing risk regression and survival time using Kaplan-Meier.

    RESULTS: Of 7455 patients, 107 patients (1%) developed a malignancy: 34 (0.5%) hematological [0.08 per 100 person-years (/100PY)] and 73 (1%) nonhematological (0.17/100PY). Of the hematological malignancies, non-Hodgkin lymphoma was predominant (n = 26, 76%): immunoblastic (n = 6, 18%), Burkitt (n = 5, 15%), diffuse large B-cell (n = 5, 15%), and unspecified (n = 10, 30%). Others include central nervous system lymphoma (n = 7, 21%) and myelodysplastic syndrome (n = 1, 3%). Nonhematological malignancies were mostly Kaposi sarcoma (n = 12, 16%) and cervical cancer (n = 10, 14%). Risk factors for hematological malignancy included age >50 vs. ≤30 years [subhazard ratio (SHR) = 6.48, 95% confidence interval (CI): 1.79 to 23.43] and being from a high-income vs. a lower-middle-income country (SHR = 3.97, 95% CI: 1.45 to 10.84). Risk was reduced with CD4 351-500 cells/µL (SHR = 0.20, 95% CI: 0.05 to 0.74) and CD4 >500 cells/µL (SHR = 0.14, 95% CI: 0.04 to 0.78), compared to CD4 ≤200 cells/µL. Similar risk factors were seen for nonhematological malignancy, with prior AIDS diagnosis showing a weak association. Patients diagnosed with a hematological malignancy had shorter survival time compared to patients diagnosed with a nonhematological malignancy.

    CONCLUSIONS: Nonhematological malignancies were common but non-Hodgkin lymphoma was more predominant in our cohort. PLHIV from high-income countries were more likely to be diagnosed, indicating a potential underdiagnosis of cancer in low-income settings.

  18. Fu X, Song X, Li X, Wong KK, Li J, Zhang F, et al.
    PMID: 28191021 DOI: 10.1155/2017/4365715
    Traditional Chinese Marine Medicine (TCMM) represents one of the medicinal resources for research and development of novel anticancer drugs. In this study, to investigate the presence of anticancer activity (AA) displayed by cold or hot nature of TCMM, we analyzed the association relationship and the distribution regularity of TCMMs with different nature (613 TCMMs originated from 1,091 species of marine organisms) via association rules mining and phylogenetic tree analysis. The screened association rules were collected from three taxonomy groups: (1) Bacteria superkingdom, Phaeophyceae class, Fucales order, Sargassaceae family, and Sargassum genus; (2) Viridiplantae kingdom, Streptophyta phylum, Malpighiales class, and Rhizophoraceae family; (3) Holothuroidea class, Aspidochirotida order, and Holothuria genus. Our analyses showed that TCMMs with closer taxonomic relationship were more likely to possess anticancer bioactivity. We found that the cluster pattern of marine organisms with reported AA tended to cluster with cold nature TCMMs. Moreover, TCMMs with salty-cold nature demonstrated properties for softening hard mass and removing stasis to treat cancers, and species within Metazoa or Viridiplantae kingdom of cold nature were more likely to contain AA properties. We propose that TCMMs from these marine groups may enable focused bioprospecting for discovery of novel anticancer drugs derived from marine bioresources.
  19. Wang Z, Zhang F, Zhang X, Chan NW, Kung HT, Ariken M, et al.
    Sci Total Environ, 2021 Feb 12;775:145807.
    PMID: 33618298 DOI: 10.1016/j.scitotenv.2021.145807
    Soil salinization is an extremely serious land degradation problem in arid and semi-arid regions that hinders the sustainable development of agriculture and food security. Information and research on soil salinity using remote sensing (RS) technology provide a quick and accurate assessment and solutions to address this problem. This study aims to compare the capabilities of Landsat-8 OLI and Sentinel-2A MSI in RS prediction and exploration of the potential application of derivatives to RS prediction of salinized soils. It explores the ability of derivatives to be used in the Landsat-8 OLI and Sentinel-2A MSI multispectral data, and it was used as a data source as well as to address the adaptability of salinity prediction on a regional scale. The two-dimensional (2D) and three-dimensional (3D) optimal spectral indices are used to screen the bands that are most sensitive to soil salinity (0-10 cm), and RS data and topographic factors are combined with machine learning to construct a comprehensive soil salinity estimation model based on gray correlation analysis. The results are as follows: (1) The optimal spectral index (2D, 3D) can effectively consider possible combinations of the bands between the interaction effects and responding to sensitive bands of soil properties to circumvent the problem of applicability of spectral indices in different regions; (2) Both the Landsat-8 OLI and Sentinel-2A MSI multispectral RS data sources, after the first-order derivative techniques are all processed, show improvements in the prediction accuracy of the model; (3) The best performance/accuracy of the predictive model is for sentinel data under first-order derivatives. This study compared the capabilities of Landsat-8 OLI and Sentinel-2A MSI in RS prediction in finding the potential application of derivatives to RS prediction of salinized soils, with the results providing some theoretical basis and technical guidance for salinized soil prediction and environmental management planning.
  20. Wang Z, Zhang F, Liang Y, Zheng K, Gu C, Zhang W, et al.
    Microbiol Spectr, 2021 10 31;9(2):e0046321.
    PMID: 34643440 DOI: 10.1128/Spectrum.00463-21
    Alteromonas is a ubiquitous, abundant, copiotrophic and phytoplankton-associated marine member of the Gammaproteobacteria with a range extending from tropical waters to polar regions and including hadal zones. Here, we describe a novel Alteromonas phage, ZP6, that was isolated from surface coastal waters of Qingdao, China. ZP6 contains a linear, double-stranded, 38,080-bp DNA molecule with 50.1% G+C content and 47 putative open reading frames (ORFs). Three auxiliary metabolic genes were identified, encoding metal-dependent phosphohydrolase, diaminopurine synthetase, and nucleotide pyrophosphohydrolase. The first two ORFs facilitate the replacement of adenine (A) by diaminopurine (Z) in phage genomes and help phages to evade attack from host restriction enzymes. The nucleotide pyrophosphohydrolase enables the host cells to stop programmed cell death and improves the survival rate of the host in a nutrient-depleted environment. Phylogenetic analysis based on the amino acid sequences of whole genomes and comparative genomic analysis revealed that ZP6 is most closely related to Enhodamvirus but with low similarity (shared genes, <30%, and average nucleotide sequence identity, <65%); it is distinct from other bacteriophages. Together, these results suggest that ZP6 could represent a novel viral genus, here named Mareflavirus. Combining its ability to infect Alteromonas, its harboring of a diaminopurine genome-biosynthetic system, and its representativeness of an understudied viral group, ZP6 could be an important and novel model system for marine virus research. IMPORTANCE Alteromonas is an important symbiotic bacterium of phytoplankton, but research on its bacteriophages is still at an elementary level. Our isolation and genome characterization of a novel Alteromonas podovirus, ZP6, identified a new viral genus of podovirus, namely, Mareflavirus. The ZP6 genome, with a diaminopurine genome-biosynthetic system, is different from those of other isolated Alteromonas phages and will bring new impetus to the development of virus classification and provide important insights into novel viral sequences from metagenomic data sets.
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