MyMedR

Fulltext Clonal distribution and possible microevolution of methicillin-resistant Staphylococcus aureus strains in a teaching hospital in Malaysia

Tan XE, Neoh HM, Hussin S, Zin NM

Asian Pac J Trop Biomed, 2013 Mar;3(3):224-8.

PMID: 23620843 DOI: 10.1016/S2221-1691(13)60055-6

OBJECTIVE: To genotypically characterize methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from medical and surgical wards in Universiti Kebangsaan Malaysia Medical Centre (UKMMC) in 2009.

METHODS: MRSA strains were collected and molecularly typed by pulsed-field gel electrophoresis (PFGE).

RESULTS: PFGE typing on 180 MRSA isolated in UKMMC identified 5 pulsotypes (A-E) and 6 singletons, where pulsotypes B and C were suspected to be divergent clones originating from a single ancestor. This study also showed that most MRSA strains were isolated from swab (119 isolates), followed by blood (22 isolates), tracheal aspirate (11 isolates) and sputum (10 isolates). On the other hand, urine and bone isolates were less, which were 4 and 1 isolates, respectively. The distribution of different pulsotypes of MRSA among wards suggested that MRSA was communicated in surgical and medical wards in UKMMC, with pulsotype B MRSA as the dominant strain. Besides, it was found that most deceased patients were infected by pulsotype B MRSA, however, no particular pulsotype could be associated with patient age, underlying disease, or ward of admittance.

CONCLUSIONS: Five pulsotypes of MRSA and 6 singletons were identified, with pulsotype B MRSA as the endemic strains circulating in these wards, which is useful in establishment of preventive measures against MRSA transmission.

Fulltext A case report of ocular toxocariasis

Azira NM, Zeehaida M

Asian Pac J Trop Biomed, 2011 Apr;1(2):164-5.

PMID: 23569750 DOI: 10.1016/S2221-1691(11)60018-X

Ocular toxocariasis is prevalent among children. The symptoms and signs may mimic other ocular pathologies such as malignancies and other infectious diseases (such as toxoplasmosis and syphilis). We presented a case of progressive blurring of vision in a single eye of a 9-year-old boy. The presence of anti-toxocara antibody in serum samples helps to confirmation the diagnosis in our patient. Despite of treatment, the boy had lost his vision on the affected eye.

Fulltext Antimicrobial drug resistance of Staphylococcus aureus in dairy products

Sasidharan S, Prema B, Yoga LL

Asian Pac J Trop Biomed, 2011 Apr;1(2):130-2.

PMID: 23569742 DOI: 10.1016/S2221-1691(11)60010-5

To evaluate the prevalence of multidrug resistant Staphylococcus aureus (S. aureus) in dairy products.

Fulltext Prevalence of potential drug-drug interactions among internal medicine ward in University of Gondar Teaching Hospital, Ethiopia

Bhagavathula AS, Berhanie A, Tigistu H, Abraham Y, Getachew Y, Khan TM, et al.

Asian Pac J Trop Biomed, 2014 May;4(Suppl 1):S204-8.

PMID: 25183081 DOI: 10.12980/APJTB.4.2014C1172

To determine the prevalence, clinical significance and the associated risk factors of potential drug-drug interactions (DDIs) at internal medicine ward of University of Gondar (UOG) hospital.

Fulltext Isolation and identification of salmonella from curry samples and its sensitivity to commercial antibiotics and aqueous extracts of Camelia sinensis (L.) and Trachyspermum ammi (L.)

Gunasegaran T, Rathinam X, Kasi M, Sathasivam K, Sreenivasan S, Subramaniam S

Asian Pac J Trop Biomed, 2011 Aug;1(4):266-9.

PMID: 23569772 DOI: 10.1016/S2221-1691(11)60040-3

To isolate Salmonella from curry samples and to evaluate the drug sensitivity of the food-borne Salmonella and its susceptibility to specific plant extracts.

Fulltext Correlation between lipid profile and troponin I test results in patients with chest pain in Nepal

Kumar A, Sathian B

Asian Pac J Trop Biomed, 2013 Jun;3(6):487-91.

PMID: 23730563 DOI: 10.1016/S2221-1691(13)60101-X

To study the usefulness of traditional lipid profile levels in screening subjects who had developed chest pain due to cardiac event as indicated by a positive troponin I test.

Fulltext Cytotoxicity and genotoxicity assessment of Euphorbia hirta in MCF-7 cell line model using comet assay

Ping KY, Darah I, Chen Y, Sasidharan S

Asian Pac J Trop Biomed, 2013 Sep;3(9):692-6.

PMID: 23998008 DOI: 10.1016/S2221-1691(13)60140-9

To evaluate the cytotoxicity and genotoxicity activity of Euphorbia hirta (E. hirta) in MCF-7 cell line model using comet assay.

Fulltext Antioxidant activity of methanol extracts of different parts of Lantana camara

Mahdi-Pour B, Jothy SL, Latha LY, Chen Y, Sasidharan S

Asian Pac J Trop Biomed, 2012 Dec;2(12):960-5.

PMID: 23593576 DOI: 10.1016/S2221-1691(13)60007-6

To investigate the antioxidant activity of methanolic extracts of Lantana camara (L. camara) various parts and the determination of their total phenolics content.

Fulltext Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines

Vijayarathna S, Sasidharan S

Asian Pac J Trop Biomed, 2012 Oct;2(10):826-9.

PMID: 23569855 DOI: 10.1016/S2221-1691(12)60237-8

To investigate the cytotoxic effect of Elaeis guineensis methanol extract on MCF-7 and Vero cell.

Fulltext Antioxidant and antibacterial activity of different parts of Leucas aspera

Chew AL, Jessica JJ, Sasidharan S

Asian Pac J Trop Biomed, 2012 Mar;2(3):176-80.

PMID: 23569893 DOI: 10.1016/S2221-1691(12)60037-9

To evaluate antioxidant, antimicrobial and cytotoxic activity of different parts (root, flower, leaf and stem) of Leucas aspera (L. aspera) (Labiatae).

Fulltext In vivo toxicity study of Lantana camara

Pour BM, Sasidharan S

Asian Pac J Trop Biomed, 2011 Jun;1(3):230-2.

PMID: 23569765 DOI: 10.1016/S2221-1691(11)60033-6

To investigate the toxicity of methanol extract of various parts (Root, Stem, Leaf, Flower and Fruit) of Lantana camara (L. Camara) in Artemia salina.

Fulltext A transmission electron microscopy study of the diversity of Candida albicans cells induced by Euphorbia hirta L. leaf extract in vitro

Basma AA, Zuraini Z, Sasidharan S

Asian Pac J Trop Biomed, 2011 Jan;1(1):20-2.

PMID: 23569719 DOI: 10.1016/S2221-1691(11)60062-2

To determine the major changes in the microstructure of Candida albicans (C. albicans) after treatment with Euphorbia hirta (E. hirta) L. leaf extract.

Fulltext Pharmacological screening of methanolic extract of Ixora species

Latha LY, Darah I, Jain K, Sasidharan S

Asian Pac J Trop Biomed, 2012 Feb;2(2):149-51.

PMID: 23569886 DOI: 10.1016/S2221-1691(11)60210-4

OBJECTIVE: To investigate the antimicrobial activity of methanolic extracts of different parts of Ixora species.

METHODS: Antimicrobial activity was carried out using disc diffusion assay against fungi, gram-positive and gram-negative bacteria.

RESULTS: All methanolic extracts of different parts of Ixora species showed a broad-spectrum of antibacterial and antiyeast activities, which inhibited the growth of at least one bacterium or yeast. There was no remarkable difference between different Ixora species observed in this study.

CONCLUSIONS: The significant antimicrobial activity shown by this Ixora species suggests its potential against infections caused by pathogens. The extract may be developed as an antimicrobial agent.

Fulltext Polyketide and benzopyran compounds of an endophytic fungus isolated from Cinnamomum mollissimum: biological activity and structure

Santiago C, Sun L, Munro MH, Santhanam J

Asian Pac J Trop Biomed, 2014 Aug;4(8):627-32.

PMID: 25183332 DOI: 10.12980/APJTB.4.2014APJTB-2014-0030

To study bioactivity and compounds produced by an endophytic Phoma sp. fungus isolated from the medicinal plant Cinnamomum mollissimum.

Fulltext Cytotoxicity screening of Melastoma malabathricum extracts on human breast cancer cell lines in vitro

Roslen NA, Alewi NA, Ahamada H, Rasad MS

Asian Pac J Trop Biomed, 2014 Jul;4(7):545-8.

PMID: 25183274 DOI: 10.12980/APJTB.4.2014C658

To screen the cytotoxic activity of Melastoma malabathricum (M. malabathricum) against human breast cancer cell line (MCF-7) in vitro.

Fulltext Blood meal analysis of tabanid fly after it biting the rare Sumatran rhinoceros

Rovie-Ryan JJ, Zainuddin ZZ, Marni W, Ahmad AH, Ambu LN, Payne J

Asian Pac J Trop Biomed, 2013 Feb;3(2):95-9.

PMID: 23593586 DOI: 10.1016/S2221-1691(13)60031-3

To demonstrate a noninvasive large mammalian genetic sampling method using blood meal obtained from a tabanid fly.

Fulltext Acaricidal activity of Cymbopogon citratus and Azadirachta indica against house dust mites

Hanifah AL, Awang SH, Ho TM, Abidin SZ, Omar MH

Asian Pac J Trop Biomed, 2011 Oct;1(5):365-9.

PMID: 23569794 DOI: 10.1016/S2221-1691(11)60081-6

To examine the acaricidal effects of the essential oil of Cymbopogon citratus leaf extract (lemongrass) and ethanolic Azadirachta indica leaf extract (neem) against house dust mites Dermatophagoides farinae (D. farinae) and Dermatophagoides pteronyssinus (D. pteronyssinus).

Fulltext Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines

Wong YH, Tan WY, Tan CP, Long K, Nyam KL

Asian Pac J Trop Biomed, 2014 May;4(Suppl 1):S510-5.

PMID: 25183141 DOI: 10.12980/APJTB.4.2014C1090

To examine the cytotoxic properties of both the kenaf (Hibiscus cannabinus L.) seed extract and kenaf seed oil on human cervical cancer, human breast cancer, human colon cancer and human lung cancer cell lines.

Fulltext The biology and demographic parameters of Aedes albopictus in northern peninsular Malaysia

Aida HN, Dieng H, Ahmad AH, Satho T, Nurita AT, Salmah MR, et al.

Asian Pac J Trop Biomed, 2011 Dec;1(6):472-7.

PMID: 23569816 DOI: 10.1016/S2221-1691(11)60103-2

OBJECTIVE: To generate life table characteristics for the dengue vector Aedes albopictus (A. albopictus) under uncontrolled conditions, incorporating both the aquatic and the adult stages.

METHODS: Ten females derived from wild pupae were allowed to fully blood-feed on restrained mice. 774 eggs were hatched in seasoned water. F1 larvae were followed for development until their F2 counterparts emerged as adults. Some population parameters were monitored (F1) or estimated (F2).

RESULTS: A. albopictus exhibited increased fecundity and egg hatch success. Immature development was quick. Immature survival was high, with lowest rate in the pupal stage. Adult emergence was about 81% and sex ratio was close to 1:1. Generational mortality (K) was about 28%. A high proportion of females completed a reproductive cycle and the obtained parity rate was predicted to lead to higher fecundity in the next generation.

CONCLUSIONS: It can be concluded that natural A. albopictus populations in Penang seem largely determined by quick development in combination with low immature loss and increased oviposition.

Fulltext Bilateral atypical optic neuritis associated with tuberculosis in an immunocompromised patient

Jaafar J, Hitam WH, Noor RA

Asian Pac J Trop Biomed, 2012 Jul;2(7):586-8.

PMID: 23569976 DOI: 10.1016/S2221-1691(12)60102-6

A 27 year-old lady, presented with sudden loss of vision in the right eye for a week. It was followed by poor vision in the left eye after 3 days. It involved the whole entire visual field and was associated with pain on eye movement. She was diagnosed to have miliary tuberculosis and retroviral disease 4 months ago. She was started on anti-TB since then but defaulted highly active anti-retroviral therapy (HAART). On examination, her visual acuity was no perception of light in the right eye and 6/120 (pinhole 3/60) in the left eye. Anterior segment in both eyes was unremarkable. Funduscopy showed bilateral optic disc swelling with presence of multiple foci of choroiditis in the peripheral retina. The vitreous and retinal vessels were normal. Chest radiography was normal. CT scan of orbit and brain revealed bilateral enhancement of the optic nerve sheath that suggest the diagnosis of bilateral atypical optic neuritis. This patient was managed with infectious disease team. She was started on HAART and anti-TB treatment was continued. She completed anti-TB treatment after 9 months without any serious side effects. During follow up the visual acuity in both eyes was not improved. However, funduscopy showed resolving of disc swelling and choroiditis following treatment.

Displaying publications 1 - 20 of 53 in total