Displaying publications 1 - 20 of 769 in total

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  1. Nor ANM, Corstanje R, Harris JA, Grafius DR, Siriwardena GM
    Heliyon, 2017 Jun;3(6):e00325.
    PMID: 28706999 DOI: 10.1016/j.heliyon.2017.e00325
    Urban expansion increases fragmentation of the landscape. In effect, fragmentation decreases connectivity, causes green space loss and impacts upon the ecology and function of green space. Restoration of the functionality of green space often requires restoring the ecological connectivity of this green space within the city matrix. However, identifying ecological corridors that integrate different structural and functional connectivity of green space remains vague. Assessing connectivity for developing an ecological network by using efficient models is essential to improve these networks under rapid urban expansion. This paper presents a novel methodological approach to assess and model connectivity for the Eurasian tree sparrow (Passer montanus) and Yellow-vented bulbul (Pycnonotus goiavier) in three cities (Kuala Lumpur, Malaysia; Jakarta, Indonesia and Metro Manila, Philippines). The approach identifies potential priority corridors for ecological connectivity networks. The study combined circuit models, connectivity analysis and least-cost models to identify potential corridors by integrating structure and function of green space patches to provide reliable ecological connectivity network models in the cities. Relevant parameters such as landscape resistance and green space structure (vegetation density, patch size and patch distance) were derived from an expert and literature-based approach based on the preference of bird behaviour. The integrated models allowed the assessment of connectivity for both species using different measures of green space structure revealing the potential corridors and least-cost pathways for both bird species at the patch sites. The implementation of improvements to the identified corridors could increase the connectivity of green space. This study provides examples of how combining models can contribute to the improvement of ecological networks in rapidly expanding cities and demonstrates the usefulness of such models for biodiversity conservation and urban planning.
  2. Rahman MR, Hamdan S, Lai JCH, Jawaid M, Yusof FABM
    Heliyon, 2017 Jul;3(7):e00342.
    PMID: 28725868 DOI: 10.1016/j.heliyon.2017.e00342
    In this study, the physical, morphological, mechanical and thermal properties of furfuryl alcohol/2-ethylhexyl methacrylate/halloysite nanoclay wood polymer nanocomposites (FA-co-EHMA-HNC WPNCs) were investigated. FA-co-EHMA-HNC WPNCs were prepared via an impregnation method and the properties of the nanocomposites were characterized through the weight percent gain, Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), three-point flexural test, dynamic mechanical thermal analysis (DMTA), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) analysis and moisture absorption test. The weight percent gain in the 50:50 FA-co-EHMA-HNC WPNC was the highest compared with the raw wood (RW) and other WPNCs. The FT-IR results confirmed that polymerization took place in the nanocomposites, especially 50:50 FA-co-EHMA-HNC WPNC, which had a reduced amount of hydroxyl groups. The SEM results revealed that the 50:50 FA-co-EHMA-HNC WPNC had the smoothest and most uniform surface among all of the nanocomposites. The 50:50 FA-co-EHMA-HNC WPNC showed the highest flexural strength and modulus of elasticity. The results revealed that the storage modulus and loss modulus of the FA-co-EHMA-HNC WPNCs were higher and the tan δ of FA-co-EHMA-HNC WNPCs was lower compared with the RW. The FA-co-EHMA-HNC WPNCs exhibited the higher thermal stability in the TGA and DSC analysis. The 50:50 FA-co-EHMA-HNC WPNC exhibited remarkably lower moisture absorption compared with the RW. Overall, this study proved that the ratio 50:50 FA-co-EHMA ratio was the most suitable for introduction in the in the RW.
  3. Rodriguez O, Stone W, Schemitsch EH, Zalzal P, Waldman S, Papini M, et al.
    Heliyon, 2017 Oct;3(10):e00420.
    PMID: 29034340 DOI: 10.1016/j.heliyon.2017.e00420
    In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects. Atomic Absorption Spectroscopy confirmed the release of zinc ions (Zn(2+)), which has been linked to the antibacterial abilities of glasses SRT0, BRT0 and BRT3, with inhibition effectively achieved at concentrations lower than 0.7 ppm. In vitro cytotoxicity studies using MC3T3-E1 osteoblasts confirmed that cell proliferation was affected by all glasses in this study, with decreased proliferation attributed to a faster release of sodium ions over calcium ions in both glass series, factor known to slow cell proliferation in vitro.
  4. Noor AF, Soo TCC, Ghani FM, Goh ZH, Khoo LT, Bhassu S
    Heliyon, 2017 Dec;3(12):e00446.
    PMID: 29322096 DOI: 10.1016/j.heliyon.2017.e00446
    Background: Dystrophin, an essential protein functional in the maintenance of muscle structural integrity is known to be responsible for muscle deterioration during white spot syndrome virus (WSSV) infection among prawn species. Previous studies have shown the upregulation of dystrophin protein in Macrobrachium rosenbergii (the giant freshwater prawn) upon white spot syndrome virus (WSSV) infection. The literature has also suggested the important role of calcium ion alterations in causing such muscle diseases. Thus, the interest of this study lies within the linkage between dystrophin functioning, intracellular calcium and white spot syndrome virus (WSSV) infection condition.

    Methods: In this study, the dystrophin gene from M. rosenbergii (MrDys) was first characterised followed by the characterization of dystrophin gene from a closely related shrimp species, Penaeus monodon (PmDys). Dystrophin sequences from different phyla were then used for evolutionary comparison through BLAST analysis, conserved domain analysis and phylogenetic analysis. The changes in mRNA expression levels of dystrophin and the alteration of intracellular calcium concentrations in WSSV infected muscle cells were then studied.

    Results: A 1246 base pair long dystrophin sequence was identified in the giant freshwater prawn, Macrobrachium rosenbergii (MrDys) followed by 1082 base pair long dystrophin sequence in P. monodon (PmDys). Four conserved domains were identified from the thirteen dystrophin sequences compared which were classified into 5 different phyla. From the phylogenetic analysis, aside from PmDys, the characterised MrDys was shown to be most similar to the invertebrate phylum of Nematoda. In addition, an initial down-regulation of dystrophin gene expression followed by eventual up-regulation, together with an increase in intracellular calcium concentration [Ca2+]
    i
    were shown upon WSSV experimental infection.

    Discussion: Both the functionality of the dystrophin protein and the intracellular calcium concentration were affected by WSSV infection which resulted in progressive muscle degeneration. An increased understanding of the role of dystrophin-calcium in MrDys and the interactions between these two components is necessary to prevent or reduce occurrences of muscle degeneration caused by WSSV infection, thereby reducing economic losses in the prawn farming industry from such disease.

  5. Cheng WY, Liu MT
    Heliyon, 2018 Feb;4(2):e00518.
    PMID: 29560442 DOI: 10.1016/j.heliyon.2018.e00518
    Sixteen mumps virus (MuV) sequences collected in Taiwan between 2006 and 2016 were characterized as genotype F (n = 1), G (n = 7), H (n = 4), J (n = 2), and K (n = 2). Mumps genotype F strain was imported from China in 2008 which was in accordance with the epidemic genotype in China. The Philippines was indicated as export country of three genotype H strains in 2007-2010 and Vietnam as export country of one genotype K strain in 2016 that matched with genotypes described in previous reports. Four strains of genotype G were imported from Japan, Thailand, Malaysia and Myanmar individually indicated that genotype G spreads widely in Asia as well as in the global. In this study, mumps strains of genotype G was first reported in relation to import from Malaysia and Myanmar. Furthermore, Indonesia was referred to export MuV of genotype J in 2007 for the first time. Molecular genotyping benefits the differentiation of circulating mumps viruses and can be used to investigate the transmission pathways. The dynamic genotypes of imported cases revealed the epidemic genotypes in nearby countries.
  6. Gul Y, Sultan Z, Jokhio GA
    Heliyon, 2018 Aug;4(8):e00715.
    PMID: 30094383 DOI: 10.1016/j.heliyon.2018.e00715
    It has been reported in the literature that the perception of crime at the neighbourhood level inversely affects the walking behaviour of individuals. On the other hand, the gated neighbourhoods are considered safe from crime, however, there is a lack of research on the association of the perception of crime and walking in gated neighbourhoods. Therefore, the objectives of the study reported in this paper were to investigate the association between the perception of crime and walking in gated and non-gated neighbourhoods. A questionnaire was used to collect the data on walking and the perception of crime in 16 neighbourhoods of Karachi Pakistan, 8 out of which were gated. Independent sample t-test and gamma tests were used for the data analysis. The results show that although there is a lower perception of crime in the gated neighbourhoods, yet the inhabitants of gated neighbourhoods engage in less physical activity comprising of walking. In spite of a greater perception of crime in non-gated neighbourhoods, higher values of walking were reported by the residents of those neighbourhoods. Therefore, it has been concluded that there does not exist a definite relationship between the perception of crime and walking behaviour at the neighbourhood level and the perceived safety from crime claimed by the proponents of the gated neighbourhoods does not encourage walking among the residents.
  7. Shaari N, Kamarudin SK, Basri S
    Heliyon, 2018 Sep;4(9):e00808.
    PMID: 30246163 DOI: 10.1016/j.heliyon.2018.e00808
    The influence of methanol as a solvent on the properties of sodium alginate/sulfonated graphene oxide (SA/SGO) membranes was explored in water-methanol mixed conditions with various methanol concentrations and temperatures through molecular dynamics simulations. The methanol uptake of the membrane showed an isolation phase determined from the simulation results. The distance between the sulfonic acid groups increased in higher methanol concentrations, as observed from S-S RDFs. Furthermore, the distance between the SA-chain RDFs and the solvent molecules was analysed to determine a) the affinity of water towards the sulfonic acid groups and b) the affinity of the aromatic backbone of the SA towards methanol molecules. A decrease in water molecule diffusion led to an increase in methanol diffusion and uptake. SA/SGO membranes exhibited a smaller diffusion coefficient than that for the Nafion membranes, as calculated from simulation results and compared to the experimental work. Additionally, the diffusion ability increased at higher temperatures for all permeants. The interaction information obtained is useful for DMFC applications.
  8. Tagiling N, Ab Rashid R, Azhan SNA, Dollah N, Geso M, Rahman WN
    Heliyon, 2018 Oct;4(10):e00864.
    PMID: 30364574 DOI: 10.1016/j.heliyon.2018.e00864
    Proper dosimetry settings are crucial in radiotherapy to ensure accurate radiation dose delivery. This work evaluated scanning parameters as affecting factors in reading the dose-response of EBT2 and EBT3 radiochromic films (RCFs) irradiated with clinical photon and electron beams. The RCFs were digitised using Epson® Expression® 10000XL flatbed scanner and image analyses of net optical density (netOD) were conducted using five scanning parameters i.e. film type, resolution, image bit depth, colour to grayscale transformation and image inversion. The results showed that increasing spatial resolution and deepening colour depth did not improve film sensitivity, while grayscale scanning caused sensitivity reduction below than that detected in the Red-channel. It is also evident that invert and colour negative film type selection negated netOD values, hence unsuitable for scanning RCFs. In conclusion, choosing appropriate scanning parameters are important to maintain preciseness and reproducibility in films dosimetry.
  9. Lim BH, Majlan EH, Daud WRW, Rosli MI, Husaini T
    Heliyon, 2018 Oct;4(10):e00845.
    PMID: 30338304 DOI: 10.1016/j.heliyon.2018.e00845
    The flow distribution of a proton exchange membrane fuel cell within a manifold plays an important role on its performance. This study presents a numerical analysis of the flow distribution behavior within different manifold configurations. A two-dimensional model with 75 cells was employed to study the flow behavior. The variation in the stoichiometry and number of cells was also studied. Three different flow configurations were considered with different numbers of flow inlets and outlets. The flow characteristics, such as the pressure and velocity variations in the manifold and cells, were measured to determine the effects of the different flow configurations. The results indicated that the double inlet/outlet configuration had the best flow distribution when using 75 cells. Moreover, increasing the stoichiometry resulted in a better flow distribution to the cells in a stack.
  10. You HW
    Heliyon, 2018 Oct;4(10):e00848.
    PMID: 30386825 DOI: 10.1016/j.heliyon.2018.e00848
    The side sensitive group runs (SSGR) chart is better than both the Shewhart and synthetic charts in detecting small and moderate process mean shifts. In practical circumstances, the process parameters are seldom known, so it is necessary to estimate them from in-control Phase-I samples. Research has discovered that a large number of in-control Phase-I samples are needed for the SSGR chart with estimated process parameters to behave similarly to a chart with known process parameters. The common metric to evaluate the performance of the control chart is average run length (ARL). An assumption for the computation of the ARL is that the shift size is assumed to be known. In reality however, the practitioners may not know the following shift size in advance. In light of this, the expected average run length (EARL) will be considered to measure the performance of the SSGR chart. Moreover, the standard deviation of the ARL (SDARL) will be studied, which is used to quantify the between-practitioner variability in the SSGR chart with estimated process parameters. This paper proposes the optimal design of the estimated process parameters SSGR chart based on the EARL criterion. The application of the optimal SSGR chart with estimated process parameters is demonstrated with actual data taken from a manufacturing company.
  11. Mutafi A, Yidris N, Ishak MR, Zahari R
    Heliyon, 2018 Nov;4(11):e00937.
    PMID: 30839801 DOI: 10.1016/j.heliyon.2018.e00937
    Steel sections are normally shaped via cold work manufacturing processes. The extent of cold work to shape the steel sections might induce residual stresses in the region of bending. Previously, researchers had performed studies on the influences of local buckling on the failure behavior of steel compression members which shown that failure will happen when most of the yielding has extended to the middle surface in the bend region of the sections. Therefore, these cold work methods may have major effect on the behavior of the steel section and also its load-bearing capability. In addition, another factor may play significant role in formed section's load-bearing capacity which is the longitudinal residual strain. The longitudinal residual strain raised during forming procedure can be used to define the section imperfection of the formed section and its relation to the existence of defects. Therefore, the main motivation of this research paper is to perform three-dimensional finite element (3D-FE) to investigate peak longitudinal residual strains of a thin-walled steel plate with large bending angle along member length. A 3D finite element simulation in ABAQUS has been employed to simulate this forming process. The study concluded that the longitudinal residual strain at the section corner edge was higher than those at the rest of the corner region. These strains at the edge were higher than the yield strain


    (



    ε


    y



    )


    of the formed section which occurred due to the lack of transverse restraint. This made the plate edge tended to bend toward the normal direction when it was under a high transverse bending. This causes a significant difference in longitudinal strain at the plate edge.
  12. Abiodun OI, Jantan A, Omolara AE, Dada KV, Mohamed NA, Arshad H
    Heliyon, 2018 Nov;4(11):e00938.
    PMID: 30519653 DOI: 10.1016/j.heliyon.2018.e00938
    This is a survey of neural network applications in the real-world scenario. It provides a taxonomy of artificial neural networks (ANNs) and furnish the reader with knowledge of current and emerging trends in ANN applications research and area of focus for researchers. Additionally, the study presents ANN application challenges, contributions, compare performances and critiques methods. The study covers many applications of ANN techniques in various disciplines which include computing, science, engineering, medicine, environmental, agriculture, mining, technology, climate, business, arts, and nanotechnology, etc. The study assesses ANN contributions, compare performances and critiques methods. The study found that neural-network models such as feedforward and feedback propagation artificial neural networks are performing better in its application to human problems. Therefore, we proposed feedforward and feedback propagation ANN models for research focus based on data analysis factors like accuracy, processing speed, latency, fault tolerance, volume, scalability, convergence, and performance. Moreover, we recommend that instead of applying a single method, future research can focus on combining ANN models into one network-wide application.
  13. Dawood ET, Mohammad YZ, Abbas WA, Mannan MA
    Heliyon, 2018 Dec;4(12):e01103.
    PMID: 30603721 DOI: 10.1016/j.heliyon.2018.e01103
    This study has been undertaken to investigate the evaluation of Fiber-reinforced Foamed Concrete (FRFC) performance by the use of toughness and non-destructive tests. These tests cover the workability, density, static modulus of elasticity, toughness, ultrasonic pulse velocity and absorption tests. Different FRFC mixes using carbon fibers in the order of 0.5, 1 and 1.5% carbon fibers were used. Also, the combinations of carbon fibers (C) and polypropylene fibers (PP) as 1% C+ 0.5% PP, and 0.5% C+1% PP were prepared. Lastly, the inclusion of polypropylene fibers with the order of 1.5% PP was used to strengthen the foamed concrete mix. The results showed that the use of 1.5% of C has affected the modulus of elasticity and flexural toughness of foamed concrete. On the other hand, a strong relationship is found between compressive strength and ultrasonic pulse velocity for FRFC.
  14. Abduraman MA, Hariono M, Yusof R, Rahman NA, Wahab HA, Tan ML
    Heliyon, 2018 Dec;4(12):e01023.
    PMID: 30560214 DOI: 10.1016/j.heliyon.2018.e01023
    Background: Dengue infection is an endemic infectious disease and it can lead to dengue fever, dengue hemorrhagic fever, and/or dengue shock syndromes. Dengue NS2B/NS3 protease complex is essential for viral replication and is a primary target for anti-dengue drug development. In this study, a NS2B/NS3 protease inhibition assay was developed using AlphaScreen® beads and was used to screen compounds for their protease inhibition activities.

    Methods: The assay system utilized a known NS2B/NS3 peptide substrate, a recombinant of NS2B/NS3 protease with proprietary StrepTactin® donor and nickel chelate acceptor beads in 384-well format.

    Results: The optimized assay to screen for NS2B/NS3 protease inhibitors was demonstrated to be potentially useful with reasonable z' factor, coefficient variance and signal to background ratio. However, screening of synthesized thioguanine derivatives using the optimized AlphaScreen® assay revealed weak NS2B/NS3 inhibition activities.

    Conclusion: The AlphaScreen® assay to screen for NS2B/NS3 protease inhibitors is potentially applicable for high throughput screening.

  15. Tso CP, Hor CH, Chen GM, Kok CK
    Heliyon, 2018 Dec;4(12):e01085.
    PMID: 30627676 DOI: 10.1016/j.heliyon.2018.e01085
    The synovial fluid motion in an artificial hip joint is important in understanding the thermo-fluids effects that can affect the reliability of the joint, although it is difficult to be studied theoretically, as the modelling involves the viscous fluid interacting with a moving surface. A new analytical solution has been derived for the maximum induced fluid motion within a spherical gap with an oscillating lower surface and a stationary upper surface, assuming one-dimensional incompressible laminar Newtonian flow with constant properties, and using the Navier-Stokes equation. The resulting time-dependent motion is analysed in terms of two dimensionless parameters R and β, which are functions of geometry, fluid properties and the oscillation rate. The model is then applied to the conditions of the synovial fluid enclosed in the artificial hip joint and it is found that the motion may be described by a simpler velocity variation, whereby laying the foundation to thermal studies in the joint.
  16. Abdul Halim ND, Latif MT, Ahamad F, Dominick D, Chung JX, Juneng L, et al.
    Heliyon, 2018 Dec;4(12):e01054.
    PMID: 30603693 DOI: 10.1016/j.heliyon.2018.e01054
    This study aims to evaluate the air quality on Langkawi Island, a famous tourist destination in Malaysia, using 13 years of data (1999-2011) recorded by the Malaysian Department of Environment. Variations of seven air pollutants (O3, CO, NO, NO2, NOx, SO2 and PM10) and three meteorological factors (temperature, humidity and wind speed) were analysed. Statistical methods used to analyse the data included principal component regression (PCR) and sensitivity analysis. The results showed PM10 was the dominant air pollutant in Langkawi and values ranged between 5.0 μg m-3 and 183.2 μg m-3. The patterns of monthly values showed that the concentrations of measured air pollutants on Langkawi were higher during the south-west monsoon (June-September) due to seasonal biomass burning activities. High CO/NOx ratio values (between 28.3 and 43.6), low SO2/NOx ratio values (between 0.04 and 0.12) and NO/NO2 ratio values exceeding 2.2 indicate the source of air pollutants in this area was motor vehicles. PCR analysis grouped the seven variables into two factor components: the F1 component consisted of SO2, NO and NOx and the F2 component consisted of PM10. The F1 component (R2 = 0.931) indicated a stronger standardized coefficient value for meteorological variables compared to the F2 component (R2 = 0.059). The meteorological variables were statistically significant (p < 0.05) in influencing the distribution of the air pollutants. The status of air quality on the island could be improved through control on motor vehicle emissions as well as collaborative efforts to reduce regional air pollution, especially from biomass burning.
  17. Danaei M, Kalantari M, Raji M, Samareh Fekri H, Saber R, Asnani GP, et al.
    Heliyon, 2018 Dec;4(12):e01088.
    PMID: 30603716 DOI: 10.1016/j.heliyon.2018.e01088
    There has been a steady increase in the interest towards employing nanoliposomes as colloidal drug delivery systems, particularly in the last few years. Their biocompatibility nature along with the possibility of encapsulation of lipid-soluble, water-soluble and amphipathic molecules and compounds are among the advantages of employing these lipidic nanocarriers. A challenge in the successful formulation of nanoliposomal systems is to control the critical physicochemical properties, which impact their in vivo performance, and validating analytical techniques that can adequately characterize these nanostructures. Of particular interest are the chemical composition of nanoliposomes, their phase transition temperature, state of the encapsulated material, encapsulation efficiency, particle size distribution, morphology, internal structure, lamellarity, surface charge, and drug release pattern. These attributes are highly important in revealing the supramolecular arrangement of nanoliposomes and incorporated drugs and ensuring the stability of the formulation as well as consistent drug delivery to target tissues. In this article, we present characterization of nanoliposomal formulations as an example to illustrate identification of key in vitro characteristics of a typical nanotherapeutic agent. Corresponding analytical techniques are discussed within the context of nanoliposome assessment, single particle analysis and ensuring uniform manufacture of therapeutic formulations with batch-to-batch consistency.
  18. Tang CY, Zulhairun AK, Wong TW, Alireza S, Marzuki MSA, Ismail AF
    Heliyon, 2019 Jan;5(1):e01142.
    PMID: 30723824 DOI: 10.1016/j.heliyon.2019.e01142
    Ultrafiltration grade polysulfone-based mixed matrix membranes (MMMs) incorporated with two-dimensional boron nitride nanosheet (BNNS) was prepared via phase inversion method. The amount of BN incorporated was varied and the influence on membrane morphology, contact angle, surface charge, as well as water permeability and humic acid rejection were investigated. Results revealed that the addition of BN to the membrane matrix resulted in profound increase in water permeability (almost tripled to that of neat PSf) and humic acid rejection due to the increase in pore size and surface negative charge. Beyond the morphological changes imparted by the inclusion of BNNS, we postulated that the presence of BNNS within the membrane matrix also contribute to the enhancement in flux and rejection based on surface-slip and selective interlayer transport. Despite the favourable augmentation of water transport and filtration performance, the MMMs suffered with fouling problem due to the entrapment of foulant within the enlarged pores and the membrane valleys. Its inherent adsorptive character could be a disadvantage when utilized as membrane filler.
  19. Seetharaman, Moorthy K, Patwa N, Saravanan, Gupta Y
    Heliyon, 2019 Jan;5(1):e01166.
    PMID: 30723834 DOI: 10.1016/j.heliyon.2019.e01166
    Several economic, institutional, technical and socio-cultural barriers hinder countries from moving from the high to the low emission pathway. The objective of this research is to find out the impacts of social, economic, technological and regulatory barriers in the deployment of renewable energy. Data were collected through an online questionnaire responded to by 223 professionals working in the energy sector all over the globe. This research shows that social, technological and regulatory barriers have a strong influence on the deployment of renewable energy, while economic barriers significantly influence it indirectly. By breaking research and development-related barriers, organizations will be able to invest greatly in developing advanced technologies that can optimize usage of renewable energy and make renewable energy appear more lucrative. With less polluting and lower tariff energy solutions being made available to local people, and higher profits for manufacturers, this will create an atmosphere where all stakeholders are satisfied.
  20. Som AM, Ahmat N, Abdul Hamid HA, Azizuddin N
    Heliyon, 2019 Feb;5(2):e01244.
    PMID: 30828665 DOI: 10.1016/j.heliyon.2019.e01244
    Hylocereus undatus foliage is believed to contain antioxidants similar to its peel. Numerous studies have been conducted to determine the total phenolic content (TPC) and antioxidant activity on the Hylocereus undatus pulps and peels; however, similar studies on its foliage have yet to be investigated. In this study, Hylocereus undatus foliage and peels were extracted using two different solvents namely; chloroform and methanol through Folin-Ciocalteu method and Diphenyl-1-Ipicrylhydrazyl (DPPH) free radical scavenging assay for TPC and antioxidant activity, respectively. As for TPC, results revealed that the peels gave higher TPC in both methanol (48.15 mg GAE/100g extract) and chloroform (18.89 mg GAE/100g extract) extractions than foliage (30.3 mg GAE/100g extract and 5.92 mg GAE/100g extract, respectively). However, when a comparison was made between foliage and peels in terms of its scavenging effects in DPPH assay, the peels contained more antioxidants (18.71%) than foliage (38.3%) in the chloroform solvent extracts. This study shows that Hylocereus undatus foliage has a similar antioxidant activity as its peels and is potentially a natural antioxidant in food applications.
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