Displaying publications 1 - 20 of 29 in total

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  1. Teo BSX, Gan RY, Abdul Aziz S, Sirirak T, Mohd Asmani MF, Yusuf E
    J Cosmet Dermatol, 2021 Mar;20(3):993-1001.
    PMID: 32659861 DOI: 10.1111/jocd.13624
    BACKGROUND: Eucheuma Cottonii is a type of red algae obtained from Sabah with main active component, sulfated polysaccharide or k-carrageenan.

    AIMS: The objective of this research was to evaluate the antioxidant, antibacterial and potential wound-healing properties in aqueous extraction of E cottonii in order to meet the increasing demand for halal and natural cosmeceutical products.

    METHODS AND RESULTS: Aqueous extract of E cottonii was investigated for active compounds by phytochemical screening and IR spectroscopy. Antioxidant activity was carried out using DPPH method, and the IC50 value was 1.99 mg/mL. Antibacterial activity was examined against Staphylococcus Aureus using Kirby-Bauer disk diffusion method and showed 10.03 ± 0.06 mm zone of inhibition, achieved by 200 mg/mL of extracts. A wound was made by skin excision of area around 100 mm2 on each mouse. Test group was treated with aqueous extract gel (10% w/w); meanwhile, the mice that were treated with honey acted as the positive control group and the untreated mice as negative control group. Results showed that the wound contraction rate inclined to aqueous extracts as compared to untreated group (P 

  2. Lim TS, Wanitphakdeedecha R, Yi KH
    J Cosmet Dermatol, 2024 Feb 18.
    PMID: 38369859 DOI: 10.1111/jocd.16244
    INTRODUCTION: Facial fillers and injectables have transformed the landscape of cosmetic procedures, offering rejuvenation possibilities. However, the emergence of "Facial Overfilled Syndrome (FOS)" presents a concerning trend attributed to excessive filler use and suboptimal injection techniques. Understanding the interplay between facial aging and augmentation techniques is crucial in addressing and preventing FOS.

    MATERIAL AND METHODS: Facial overfilled syndrome is characterized by the excessive use of fillers, resulting in a distorted and heavy appearance. It manifests in various forms, including 'flowerhorn' foreheads, 'sunset' eyes, 'chipmunk' cheeks, 'witch' chins, and 'pillow' faces. The syndrome arises from attempts to combat anatomical aging with dramatic filler treatments, causing rapid volume changes and skin tightening. Skeletal structures and soft tissue distribution across different ethnicities play a significant role in FOS development.

    RESULTS: Understanding the aging process across facial tissues is essential, as fillers cannot entirely reverse aging manifestations. Tailored assessment and treatment plans should precede filler injections, involving muscle assessment, observation of facial movements during injection, and ultrasound imaging of fat layers. Attention should be given to filler pressure and migration risks, particularly in areas with elevated pressure. Additionally, alternative approaches like energy-based devices and polymer reinforcement of facial ligaments should be considered to minimize filler use. Ethnic variations in facial anatomy require careful consideration to avoid overcorrection.

    CONCLUSION: FOS predominantly affects individuals of East Asian descent due to specific facial characteristics. Prevention strategies involve minimizing filler use, addressing underlying bone changes, and considering ethnic and gender differences in facial anatomy. Recent MRI and ultrasound studies challenge the notion of filler breakdown, emphasizing the importance of filler selection and injection techniques. Education, individualized treatments, and a holistic understanding of facial anatomy are key to preventing and managing FOS and ensuring natural and harmonious facial aesthetics.

  3. Yap FB
    J Cosmet Dermatol, 2017 Sep;16(3):348-352.
    PMID: 27539948 DOI: 10.1111/jocd.12268
    INTRODUCTION: Low-dose isotretinoin is used to reduce side effects albeit higher relapse. This study aimed to determine the efficacy and safety of fixed-dose 10 mg daily isotretinoin for the treatment of acne.

    METHODS: This prospective study was performed between 2011 and 2015. All 150 patients were given 10 mg daily isotretinoin until a cumulative dose of 90-110 mg/kg.

    RESULTS: The mean age was 26.6 years with 64.7% moderate acne, 29.3% severe, and 6% very severe. The mean cumulative dose was 98.8 ± 6.05 mg/kg. All 150 patients had total clearance with a mean time to clearance of 24.0 weeks. Patients with severe/very severe acne had higher cumulative dosage (102.1 vs. 97.0, P 

  4. Hadi H, Wilkinson CM
    J Cosmet Dermatol, 2017 Jun;16(2):180-185.
    PMID: 28145033 DOI: 10.1111/jocd.12305
    Ensuring uniformity in the nomenclature standardization of facial creases is important to enable the scholarly community to follow and debate the advancements in research. This review highlights the prevailing disparity in the nomenclature that refers to the same facial crease by researchers and laypeople, and suggests uniform names for the facial creases based on available literature. The previous and current trends in facial crease classification are also discussed. The nomenclature of the facial creases considered for this review include the following: the nasolabial fold, corner of the mouth lines, upper and lower lip creases around the mouth region, the mandibular folds, the bifid nose, the transverse nasal line, the vertical glabellar line, chin crease, the mental crease, four type of creases around the eyes, forehead creases, and periauricular creases. A figure illustrating the above facial creases is included as reference. It is hoped that the proposed standardization of nomenclature would ensure a more scientific referencing of facial creases enabling more effective scientific interaction among the scholarly community as well as the laypeople interested in the research and application of facial creases.
  5. Nordin FNM, Aziz A, Zakaria Z, Wan Mohamed Radzi CWJ
    J Cosmet Dermatol, 2021 Apr;20(4):1050-1060.
    PMID: 32854162 DOI: 10.1111/jocd.13691
    BACKGROUND: Skin-whitening products are in the high trend of demand for skin beautifying and lightening. Sources of ingredients for cosmetics could be natural, semi-synthetic, and synthetic that may affect the halal status of a product. The lack of scientific evidence on the safety and risks of such ingredients is a major concern to many consumers.

    OBJECTIVE: This review paper aimed to shed light on the skin-whitening ingredients and their issues related to safety, health risk, and halal status.

    METHODOLOGY: Based on the reviews scientific publications published from January 2015 to July 2020 using Web of Science and Scopus engines.

    FINDINGS: Based on the review, most of the common ingredients in the skin-whitening products are originated from plants, animals, microbes, and heavy metals. Health risk of the ingredients was evaluated based on the usage, chronic or acute adverse effect, frequency of incidence, and the hazardous chemical contents of a halal cosmetics. The halal status of the ingredients was investigated based on the sources of origin, safety evaluation, and associated health risk of the ingredients.

    ORIGINALITY: This review shows that ingredients play a vital role in the halal status decision-making of a cosmetic product. Therefore, the categories of Halal-Safe, Haram-Prohibited, and Critical-Need further evaluation were suggested to integrate the sources of ingredients with safety.

  6. Packirisamy V, Sadacharan CM
    J Cosmet Dermatol, 2021 Dec;20(12):3991-4000.
    PMID: 33706422 DOI: 10.1111/jocd.14062
    BACKGROUND: Eyebrows are an important esthetic feature of the face. In cosmetic surgery, knowledge about the patient's preference of eyebrow apex position is important to achieve agreeable esthetic results.

    AIM: To study the preference of eyebrow apex positions on the different facial shapes in the Malaysian population.

    METHODS: A frontal view photograph of a female model was morphed into oval, square, round, and long facial shapes. Four types of brow apex were created on each facial shape, A. above the midpupil (A-MP), B. above the lateral limbus (A-LL), C. halfway between the lateral limbus and lateral canthus (A-HF) and D. above the lateral canthus (A-LC). Out of the four brow apexes, the respondent selected one esthetically appealing brow apex for each facial shape. A total of 441 Malaysians completed the survey questionnaire. Differences in preference between the ethnic groups were analyzed by the chi-square test.

    RESULTS: The majority of Malaysian Chinese (MC) and Malaysian Indians (MI) subjects found A-LL as attractive on the oval (MC-73%, MI-52%), square (MC-42%, MI-42%), round (MC-45%, MI-40%) and long (MC-39%, MI-44%) shape, but the Malaysian Malays preferred more the A-HF on long (42%) and round (42%) face. While the Malaysian Indians least preferred the A-MP on the oval (4%), square (5%), round (6%), and long (5%). A significant difference in preference of apex position was observed between MC versus MI and MC versus MM in both oval and square faces. On the round face, the difference was noted between all the ethnic groups. However, on the long face, a significant difference was noted only between MI and MM.

    CONCLUSIONS: Significant interethnic differences exist in the preference of eyebrow apex position on the facial shapes.

  7. Wan Mohamed Radzi CWJ, Nordin FNM
    J Cosmet Dermatol, 2022 Dec;21(12):6875-6882.
    PMID: 36181345 DOI: 10.1111/jocd.15429
    BACKGROUND: Concern on cosmetic safety has been a subject of interest in recent years and is commonly associated with the exposure of the consumers to chemicals and impurities such as mercury contamination. Moreover, cancellations of notified cosmetic products were recurrently being reported by the Malaysia authority, namely the National Pharmaceutical Regulatory Authority (NPRA). Among the cosmetic categories was skin whitening product, which is still in high demand whilst reported to cause health risks. Besides, low number of studies on cosmetic safety and mercury contamination were recorded in Malaysia. The lack of scientific evidence on the safety and risks of the ingredients used in cosmetic formulation is a major concern to many consumers.

    OBJECTIVE: The aim of this study was to identify the presence of mercury in skin whitening products, and to identify products containing mercury with the concentration exceeding the limitation of 1 ppm.

    METHODOLOGY: A total of 104 whitening products were selected from the market via random sampling technique. The mercury concentration was determined by accredited laboratory, and the results were later compared with the cosmetic guideline of Malaysia and the list of banned products issued by NPRA.

    RESULTS: A total of 51.9% (n = 54) whitening products were found registered under the NPRA Quest system and remaining 48.1% (n = 50) were non-registered products. None of the whitening products listed mercury as an ingredient, but laboratory analysis showed 15.4% (n = 16) of the products contained mercury with the concentration exceeding the maximum limit of 1 ppm. A total of 87.5% of the whitening products (14 out of 16) containing high mercury concentration were non-registered products which were not registered in NPRA Quest system. The exceeded concentration recorded ranged between 1.81 ppm and 838 123 ppm. Besides that, 50% (8 out of 16) of the products were found in the list of banned products issued by the NPRA of Malaysia.

    CONCLUSIONS: This study presents the status of cosmetic products, particularly the skin whitening products available in Malaysia market. Concern arises when some of the products were found to have presence of harmful substances such as mercury. Even though the presence of mercury in a cosmetic product can either be non-intentional or intentionally used by the manufacturer in the cosmetic formulation, the impact of the ingredient can cause health risk to the users.

  8. Bae SH, Park JJ, Song EJ, Lee JA, Byun KS, Kim NS, et al.
    J Cosmet Dermatol, 2016 Jul 1.
    PMID: 27369004 DOI: 10.1111/jocd.12234
    The skin brightness is determined according to the amount and type of melanin. People with darker skin have a greater amount of melanin that makes their skin less susceptible to UV damages. They live in lower latitude and receive a greater amount of the intensity of the UV radiation.
  9. Shahinuzzaman M, Yaakob Z, Moniruzzaman M
    J Cosmet Dermatol, 2016 Jun;15(2):185-93.
    PMID: 26777540 DOI: 10.1111/jocd.12209
    Soap is the most useful things which we use our everyday life in various cleansing and cosmetics purposes. Jatropha oil is nonedible oil which has more benefits to soap making. It has also cosmetics and medicinal properties. But the presence of toxic Phorbol esters in Jatropha oil is the main constrains to use it. So it is necessary to search a more suitable method for detoxifying the Jatropha oil before the use as the main ingredient of soap production. This review implies a more suitable method for removing phorbol esters from Jatropha oil. Several parameters such as the % yield of pure Jatropha oil soap, TFM value of soap, total alkali content, free caustic alkalinity content, pH, the antimicrobial activity, and CMC value of general soap should be taken into consideration for soap from detoxified Jatropha oil.
  10. de Maio M, Chatrath V, Hart S, Hoo AJS, Marchac A, Sykianakis D, et al.
    J Cosmet Dermatol, 2021 Jul;20(7):2069-2082.
    PMID: 33977669 DOI: 10.1111/jocd.14216
    BACKGROUND: Comprehensive patient assessment and planning are central to esthetic treatment with injectables. MD ASA™ (Multi-Dimensional Aesthetic Scan Assessment) is a novel tool developed for this purpose.

    AIMS: To describe the MD ASA technique and present its preliminary application.

    METHODS: MD ASA breaks down the face into five hierarchies (H1-H5). H1 shifts patients' focus from "distractions" (individual lines and folds) toward the overall messages their face portrays, based on eight Emotional Attributes: four negative (tired, sad, angry, and saggy); four positive (youthful, attractive, contoured, and feminine/masculine). Three priority Emotional Attributes are selected for each patient. This is followed by a process of narrowing down through facial thirds (H2), periorbital and perioral dynamics (H3), facial units (H4), and subunits (H5), to arrive at a final assessment. Based on the key facial signs identified, this can be translated into MD Codes equations and thus a treatment formula. A retrospective analysis was performed based on 12 female patients injected by expert clinicians at an educational event. All patients were selected for, and treated using, a single MD Codes formula derived from a common MD ASA work-up.

    RESULTS: There were substantial differences between patients and clinicians in their views of which anatomical areas needed treatment-but good alignment on priority Emotional Attributes. Patients were treated only for three negative Emotional Attributes, but improvements were observed across all eight attributes.

    CONCLUSIONS: MD ASA provides a practical method for translating facial messages into actionable injectable treatment plans and facilitates greater patient-clinician alignment. Prospective studies are warranted.

  11. How KN, Chang HW, Lai OM
    J Cosmet Dermatol, 2023 Oct;22(10):2746-2754.
    PMID: 37143441 DOI: 10.1111/jocd.15793
    BACKGROUND: Little is known about antioxidant efficacy of topical vitamin E on atopic dermatitis (AD) due to lack of controlled clinical studies.

    AIM: The study evaluates the effectiveness and safety of a topical moisturizer containing tocotrienol-rich composition over 12 weeks on patients aged between 1 month and 12 years with mild to moderate AD.

    METHODS: We conducted a 12 weeks, prospective, open-label clinical study on the effect of tocotrienol as an adjunct to conventional treatment. This study was approved by the Ethics Committee for Research Involving Human Subject. JKEUPM-2019-274 (NMMR-19-1588-49234).

    RESULTS: Thirty AD patients with a mean age of 2.77 ± 3.05 were enrolled in the study. At week-12, significant reduction of investigator global assessment (63.4%), Patient-Oriented Scoring Atopic Dermatitis Index (PO-SCORAD) (65%), and SCORAD (52.3%) was noted (p 

  12. Leeyaphan C, Varothai S, Trakanwittayarak S, Suphatsathienkul P, Pattaravadee S, Matthapan L, et al.
    J Cosmet Dermatol, 2022 Feb;21(2):679-688.
    PMID: 33811776 DOI: 10.1111/jocd.14125
    BACKGROUND: Intertrigo is an inflammatory skin-fold condition. Candida infections may occur concurrently or afterward. Topical corticosteroids may reduce inflammation but exacerbate Candida infections. The treatment is contentious.

    OBJECTIVE: To evaluate the efficacies and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin for the treatment of mild-to-moderate intertrigo, relative to 1% hydrocortisone cream.

    METHODS: This randomized, double-blinded study enrolled 40 intertrigo patients. Twice daily, 20 patients applied adsorbent lotion while the remainder used 1% hydrocortisone cream. Efficacy evaluation, skin biophysical measurements, skin tolerability, safety, and visual analog scale (VAS) patient-satisfaction scores were evaluated at baseline and Week 2.

    RESULTS: The adsorbent lotion showed higher complete cure rates for color, partial epidermal loss, papules/pustules/vesicles/patches, dryness, and scaling than the corticosteroid without statistical significance. Adsorbent lotion demonstrated significantly higher reduction in pruritus than the corticosteroid treatment. Reduction of erythema level using Mexameter and VAS patient-satisfaction scores were not statistically different between adsorbent lotion and hydrocortisone cream. No adverse effects or superimposed infections were reported.

    CONCLUSIONS: The anti-inflammatory efficacies of adsorbent lotion and low-potency steroid were equivalent. The lotion was safe and produced excellent pruritus reduction. Patient satisfaction was high.

  13. Mohammed AH, Blebil A, Dujaili J, Hassan BAR
    J Cosmet Dermatol, 2021 Jul;20(7):1992-2000.
    PMID: 33834600 DOI: 10.1111/jocd.14147
    BACKGROUND: The use of cosmetics is growing among both male and female consumers due to the availability of different brands. While there is an increase in the usage of cosmetic products, it is concerning whether the consumers are aware of the safety of the products.

    AIMS: This study aimed to widely explore consumers' perceptions and attitudes toward cosmetics within the context of the COVID-19 pandemic.

    METHODS: A cross-sectional study was carried out among adults in Selangor, Malaysia. Thirty-three questions divided into three dimensions (socio-demographic parameters, assessment of perception, and assessment of attitude) were developed and validated to be answered by cosmetics consumers. Descriptive and inferential statistical analysis was done using SPSS.

    RESULTS: A response rate of 87% was achieved, and the mean age of participants was 33 ± 7.2. The overall perception of consumers indicates low levels of perception and moderate level of attitude toward cosmetic products. There was a positive correlation and high relationship between participants' perception and attitude (p = 0.001, r = 0.72). A significant association was observed between demographic data of respondents and their attitude and perception toward cosmetic products. Participants were unaware that sharing of cosmetic products could lead to bacterial infection and possibly increased the chance of contracting COVID-19.

    CONCLUSION: This study displayed a nonchalant perception and attitude of Malaysian adults toward cosmetic products by focusing on aesthetics rather than health safety. Therefore, it is recommended to raise awareness on the composition and effects of cosmetic products, increase the practice of hygiene and dissuade the sharing of cosmetics to reduce transmissions of COVID-19.

  14. Baleg SM, Bidin N, Suan LP, Ahmad MF, Krishnan G, Johari AR, et al.
    J Cosmet Dermatol, 2015 Sep;14(3):246-53.
    PMID: 25817596 DOI: 10.1111/jocd.12142
    The aim of this study was to evaluate the effects of multiple pulses on the depth of injury caused by CO2 laser in an in vivo rat model.
  15. Lim T, Frank K, Hadjab B
    J Cosmet Dermatol, 2022 Jan;21(1):207-219.
    PMID: 34255904 DOI: 10.1111/jocd.14342
    Injectable rejuvenation treatments used in Caucasians might not always suit Asians as the visible signs of aging manifest differently, underscoring a need for Asian-specific strategies that correct underlying structural deficiencies and cumulative age-related changes. The presented Target-Specific Sandwich Technique (TSST) aims to simultaneously restore, rejuvenate, and enhance faces through the distribution of minute amounts of different fillers with different rheologies, using a minimal number of entry points in strategic facial areas and different soft tissue layers in Asians. A total of 14 patients underwent the presented TSST and were subsequently assessed for satisfaction with the treatment and the outcome of the treatment. With 3 cc of fillers, patients experienced a rejuvenated appearance with brow support, brow ridge softening, less severe nasolabial folds, and corrected tear trough hollows. Fillers in the lateral canthal and mandibular angles lifted mouth corners, improved submandibular jowls, and defined the lower face. Although the prejowl sulcus received minimal filler, it appeared subtler, relaxed, and had fewer lines visible while smiling. Overall, patients appeared less tense, rejuvenated, and had improved light reflection and firmer skin. These were due to tissues being supported upward and laterally by fillers in areas of bone resorption-induced volume loss.
  16. Ng SY, Eh Suk VR, Gew LT
    J Cosmet Dermatol, 2022 Nov;21(11):5409-5444.
    PMID: 35723888 DOI: 10.1111/jocd.15170
    BACKGROUND: Excessive exposure to ultraviolet radiation has harmful effects on human skin. At present, synthetic and mineral types of sunscreens used to protect against these harmful damages have been reported to cause negative health and environmental effects. The studies involving characterization and isolation of phytoconstituents from natural botanical sources are important to discover their potential beneficial effects on sunscreen development AIM: This systematic review provides specific and compiled information on the photoprotective properties of natural botanical sources for sunscreen development. The efforts in research and innovation are essential to ensure the safety and sustainability of plant-based sunscreen products.

    METHODS: In this review, a total of 35 articles were selected using the Scopus database based on the inclusion and exclusion criteria RESULT: The significant correlation between total phenolic content, total flavonoid content, antioxidant activities, and sun protection factor were shown in these studies which confirmed the potential benefits of natural plants in sunscreen development.

    CONCLUSIONS: In addition, natural botanical sources also exhibit excellent anti-tyrosinase, anti-aging, and anti-inflammatory activities. However, the biological activities of plants were dependent on the solvents used for extraction.

  17. Lim MW, Yow YY, Gew LT
    J Cosmet Dermatol, 2023 Oct;22(10):2810-2815.
    PMID: 37313630 DOI: 10.1111/jocd.15794
    BACKGROUND: Application of natural resources from the marine environment in the cosmeceutical industry is gaining great attention.

    AIM: This study pursues to discover the cosmeceutical potential of two Malaysian algae, Sargassum sp. and Kappaphycus sp. by determining their antioxidant capacity and assessing the presence of their secondary metabolites with cosmeceutical potential using non-targeted metabolite profiling.

    METHODS: Metabolite profiling using Quadrupole Time-of-Flight (Q-TOF) liquid chromatography-mass spectrometry (LC-MS) in the Electrospray Ionization (ESI) mode resulted in 110 putative metabolites in Sargassum sp. and 47 putative metabolites in Kappaphycus sp. and were grouped according to their functions. To the best of our knowledge, the bioactive compounds of both algae have not been studied in any great detail. This is the first report to explore their cosmeceutical potential.

    RESULTS: Six antioxidants were detected in Sargassum sp., including fucoxanthin, (3S, 4R, 3'R)-4-Hydroxyalloxanthin, enzacamene N-stearoyl valine, 2-hydroxy-hexadecanoic acid, and metalloporphyrins. Meanwhile, three antioxidants detected in Kappahycus sp., namely Tanacetol A, 2-fluoro palmitic acid and idebenone metabolites. Three antioxidants are found in both algae species, namely, 3-tert-Butyl-5-methylcatechol, (-)-isoamijiol, and (6S)-dehydrovomifoliol. Anti-inflammatory metabolites such as 5(R)-HETE, protoverine, phytosphingosine, 4,5-Leukotriene-A4, and 5Z-octadecenoic acid were also found in both species. Sargassum sp. possesses higher antioxidant capacity as compared to Kappahycus sp. which may be linked to its number of antioxidant compounds found through LC-MS.

    CONCLUSIONS: Hence, our results conclude that Malaysian Sargassum sp. and Kappaphycus sp. are potential natural cosmeceutical ingredients as we aim to produce algae cosmeceutical products using native algae.

  18. Kuek WN, Tiang YR, Yow HY, Tan LKS, How CW, Looi QHD, et al.
    J Cosmet Dermatol, 2024 Feb 17.
    PMID: 38366687 DOI: 10.1111/jocd.16234
    OBJECTIVE: Despite the demonstrated anti-melanogenic and UV protective effects of Zerumbone (ZER) in vitro, there is a lack of clinical trials that have been done to assess these properties. The primary objective of this study was to assess the effectiveness of ZER in lightening the skin tone of human participants with a single-blind approach.

    METHODS: Twenty-six participants were randomly assigned to two groups to investigate the application location (left or right volar forearm) for the placebo and ZER creams. Both creams were topically administered to the volar forearms twice daily over a duration of 4 weeks. Initial skin irritation was assessed before and 30 min after applying creams. The melanin and erythema levels were quantified with Mexameter MX 18.

    RESULTS: Twenty participants were included in the analysis. The cream formulation had excellent physical properties and was well-received by the participants. The initial skin irritation study results indicated that neither of the creams elicited an allergic reaction. The administration of ZER cream resulted in a statistically significant reduction in melanin levels (p 

  19. Gupta G, Singh Y, Chellappan D, Dua K
    J Cosmet Dermatol, 2020 Sep;19(9):2447-2448.
    PMID: 32365277 DOI: 10.1111/jocd.13466
  20. Shah S, Chew SK
    J Cosmet Dermatol, 2018 Oct;17(5):830-839.
    PMID: 29193788 DOI: 10.1111/jocd.12435
    BACKGROUND: Skin hyperpigmentation is the darkening of skin due to the increased production of melanin in the body.

    OBJECTIVES: To evaluate the efficacy and safety of a botanical-based Rosa E pigmentation serum in healthy fair skin female volunteers with wrinkles, skin tone, and pigmentation.

    METHODS: This was a single-arm, open label study conducted in healthy Indian females; 18 subjects aged 30-55, having fair Caucasian-like skin with at least 2 dark skin pigments with facial wrinkles diagnosed by dermatologist were selected. Rosa E pigmentation serum was applied twice a day for 84 days. Effect was evaluated by (i) instrumental technique (spectrophotometer® 2600D), (ii) clinically by dermatologist regarding product efficacy (skin tone, antiwrinkle, pigmentation), and (iii) volunteers self-evaluation.

    RESULTS: The L* value of spectrophotometer reading represents lightness in the skin pigment. Reduction in the pigment was reported from day 14, with significant reductions observed till day 84 compared with baseline. Significant (P < .0001) skin pigmentation lightening was seen on day 14 (1.11) vastly improving on day 84 (1.94) based on photographic assessments. The significant reduction in skin pigment was 76.85%, Felix von Luschan skin color score was 30.24% (P < .0001) with a 7.38-fold reduction in skin tone and 57% reduction in facial wrinkles at day 84 from baseline.

    CONCLUSIONS: Rosa E pigmentation serum was found safe and effective in significant reduction in skin pigments, improvement of skin tone, and antiwrinkle properties instrumentally, clinically, and self-evaluation by volunteers. In these evaluations, best results were seen the longer the Rosa E was used.

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