Displaying publications 1 - 20 of 925 in total

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  1. Danaraj TJ, LaBrooy EB
    Singapore Med J, 1960 Mar;1(1):16-32.
    PMID: 13719549
    Six cases of Ebstein's malformation are reported. The notable clinical features seen in four patients were gross enlargement of the
    heart, venous congestion and marked hepatosplenomegaly. There was complete heart block in one patient and auricular fibrillation in the remaining three. The unusual pathologic features in the four cases that came to necropsy were the large pericardial effusions associated with the cardiomegaly, the absence of an atrial septal defect or patent foramen ovale, the gross enlargement of liver with cirrhotic changes and the large spleen. Histologic examination of heart muscle revealed certain unusual features which are described.
  2. Fernando A, Fernando CH
    Singapore Med J, 1961 Jun;2(2):78-80.
    PMID: 13698986
    A second case of a gordian worm (hairworm) "parasitic" in man is recorded from Malaya. A previous literature is critically discussed especially in regard to the mode of human infection. It is suggested that water-borne larvae reach the gut, invade the tissues and are finally voided with the faeces or passed with urine. Other modes of infection are considered less likely by the authors.
  3. Gwee AL
    Singapore Med J, 1963 Jun;4(2):68-80.
    PMID: 14046966
    A double-blind study with control was done to assess the effect of mono-amine-oxidase inhibitors and anticoagulant therapy in the mortality of acute myocardial infarction, in the first 4 weeks. The results show that no effect whether beneficial or adverse was seen with the use of monoamine inhibitor. On the other hand, there is a distinct decrease in mortality amongst cases not on anticoagulants. It is believed that the rarity of phlebothrombosis in local patients is the cause of the difference between local and foreign results so far as anticoagulant therapy goes. It is postulated too that one of the reasons for the difference may be due to the fact that patients are not on so strict a bed rest as elsewhere. There appears to be a definite increase of incidence in Indians, and also at least a third of myocardial infarction cases had low normal serum cholesterol readings.
  4. Pettit JHS
    Singapore Med J, 1963 Mar;4(1):18-21.
    PMID: 13942989
    Attention is drawn to a number of recently described skin conditions and a number of new treatments which, in the opinion of the writer, warrant more extensive publicity
  5. Tang KY, Khoo OT, Tan KK
    Singapore Med J, 1964 Sep;4(3):115-21.
    PMID: 14232046
    A case of sarcoidosis is reported in the hope that this seemingly rare disease in Malaysia will be better recognised. A brief review of the literature is made and various points regarding the aetiology, pathology, clinical features and diagnosis are discussed.
  6. SANDOSHAM AA, BENNETT GF, FONG YL, OMAR EI
    Singapore Med J, 1965 Mar;6(1):47-8.
    PMID: 14306412
    An immature Glossy Tree-Starling (Aplonis panayensis strigatus), also known as ‘burong perling’ in Malay, was captured in the vicinity of the Institute for Medical Research, Kuala Lumpur. It was found to harbour a small malaria parasite which showed the characteristics of the sub-genus Novyella (Corradetti et al, 1963) viz:
    1. Trophozoites small with little cytoplasm, relatively large nuclear elements, the parasite usually applied to the host-cell nucleus.
    2. Schizonts with usually less than eight merozoites. 3. Pigment small and difficult to see except in the schizonts and in the gametocytes where the pigment granules are large and usually clustered at one end.
    4. The parasite rarely distorts the host erythrocyte. Unfortunately the bird died a few days later before detailed work on duration of the schizogonic cycle and experimental transmission could be done. The parasite has the following morphological features and most of the larger forms, asexual and sexual, assume the characteristic position proximal to the nucleus of the avian erythrocyte. Trophozoites: The earliest forms are ‘rings’ with a fairly marked vacuole. As the organism grows older, it produces a grain or two of pigment. The parasite at this stage tends to occupy a polar position in the host erythrocyte. Schizonts: The segmenting forms are usually attached to the pole end of the host-cell nucleus. The number of chromatin segments varies from 3 to 8, with a prevalent range of 4 to 6. The cytoplasm is scanty and pale with a prominent little mass of blackish-brown pigment or a close collection of granules. A rare mature schizont with 8 merozoites was seen in which the nucleus of the parasitised erythrocyte was displaced somewhat similar to figure 20 of Plate I portrayed in the original paper by Manwell (1935). Gametocytes: The sexual forms are often narrow and elongate, and are closely applied to the nucleus of the host erythrocyte. The outline of the parasite is frequently irregular. The cytoplasm is pale and vacuolated with coarse conspicuous granules of blackish-brown pigment usually collected at one end; sometimes either one or both ends curved around the host-cell nucleus. Although this parasite has some affinites to both P. nucleophiltim and P. hexamerium the lack of adequate study of the avian malarias of South-East Asia precludes even provisional identification of this parasite. On two occasions numerous gametocytes were seen in the peripheral blood of the bird and four species of laboratory-reared culicines (three indigenous to Malaya) were allowed to feed on it. Ten Andes togoi, 19 Culex sitiens and seven Culex fatigans were completely refractory to development of the parasite. Two of 17 Aedes aegypti had a single small oocyst each; both oocysts appeared to be degenerating. A Giemsa-stained thin blood film together with drawings made from the microscope showing the different forms of the parasite were demonstrated. REFERENCES
    Corradetti, A., Garnham, P. C. & Laird, M. (i963). Parassitologia, 5, 1-4.
    Manwell, R. D. (l935). Amer. J. Trop. Med 15, 265-283.
    ...(1938). Ibid., 18, 565-575
  7. Phoon WO, Alfred ER
    Singapore Med J, 1965 Sep;6(3):158-63.
    PMID: 5851268
    The circumstances, clinical features, complications and progress of eighty-one cases of stonefish stings are described. There were no fatalities, few complications and no lasting ill-effects. The various forms of treatment are discussed. The venomous fishes of Malaysia are briefly reviewed. It is concluded that stonefish stings occur fairly frequently in this country and that they are attended by appreciable morbidity, but that fatal cases or cases with lasting ill-health are probably rare.
  8. Snelling MRJ, Kam CM
    Singapore Med J, 1966 Dec;7(4):240-3.
    PMID: 6036643
    Three cases of intrathoracic sarcoidosis are described, one in a Malay from Brunei and two in Indians from Malaya
  9. Kan SP, Cheah JS
    Singapore Med J, 1970 Dec;11(4):283-6.
    PMID: 5511861
    300 patients (185 males, 115 females) were examined for intestinal parasites. About 40% of these patients was infected, 14% of which was heavily infected. The highest prevalence and intensity of infection with soil-transmitted helminths was found among Malays and Indians of different ages. Heavy infections with these helminths were also frequently encountered in young Chinese. Helminthic infections in patients over 60 years of age was significantly lower. There was no significant differences in the prevalence and degree of infection among males and females. The commonest helminth encountered was Trichuris trichiura, which usually occurred as trace single infections. Mixed infections with Ascaris and Trichuris, usually with the former as the predominating parasite, were also frequently observed.
  10. Jayaratnam FJ, Tan KK, Jacob E, Seah CS, Kho KM
    Singapore Med J, 1970 Dec;11(4):275-82.
    PMID: 5511860
    Investigations in 30 healthy control subjects of Indian, Chinese and Malay ethnic origin, revealed that all the Chinese and about two thirds of the Indians and Malays had a normal capacity to absorb D—xylose, Vitamin A, Co58 labelled Vitamin B12 and dietary fat. About a third of the Indians and Malays were unable to absorb one or two of the four test substances used in the absorption studies. Jejunal biopsies did not differ in the 3 ethnic groups and were normal or mildly abnormal. 27 patients presenting with anorexia, a sore tongue and pallor were also investigated. Indians formed the majority of the patients. Diarrhoea occurred in only 51 % of the patients. All had a megaloblastic anaemia. Absorption studies revealed malabsorption of xylose, Vitamin A and Vitamin B12 in the majority but steatorrhoea occurred in only 26% of the patients. Jejunal biopsies were mildly abnormal in 8% and moderately or severely abnormal in 92 % of the patients. All responded to folic acid or Vitamin B12 therapy. 16 patients were restudied after 5 to 24 months therapy and the majority were found to have improved. Results of investigations and response to therapy indicate that these patients were suffering from tropical sprue. These studies indicate that tropical sprue in Singapore affects Indians mainly and can often present without diarrhoea and steatorrhoea.
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