MyMedR

Fulltext Chordoid meningioma, part of a multiple intracranial meningioma: a case report & review

Sriram PR

Malays J Med Sci, 2013 Jul;20(4):91-4.

Chordoid meningioma, classified as atypical meningioma according to the World Health Organisation (WHO) classification, is a rare subtype, which represents only 0.5% of all meningiomas and is associated with a high incidence of recurrence. Multiple intracranial meningiomas are rare in non-neurofibromatosis patients. We present a female patient with both of these rare types of meningioma. The patient presented with two concurrent intracranial meningiomas, with one a meningotheliomatous subtype and the other a chordoid meningioma. Given the wide array of histological differential diagnoses in chordoid meningioma, immunohistochemistry has a significant role to play in differentiating them. Recurrence in chordoid meningioma can be generally predicted based on the extent of resection, the percentage of chordoid element, and proliferation indices.

Fulltext Human adipose tissue derived stem cells as a source of smooth muscle cells in the regeneration of muscular layer of urinary bladder wall

Salem SA, Hwie AN, Saim A, Chee Kong CH, Sagap I, Singh R, et al.

Malays J Med Sci, 2013 Jul;20(4):80-7.

PMID: 24044001 MyJurnal

Adipose tissue provides an abundant source of multipotent cells, which represent a source of cell-based regeneration strategies for urinary bladder smooth muscle repair. Our objective was to confirm that adipose-derived stem cells (ADSCs) can be differentiated into smooth muscle cells.

Fulltext Drug utilization review of potassium chloride injection formulations available in a private hospital in kuching, sarawak, malaysia

Melissa MH, Azmi S

Malays J Med Sci, 2013 Jul;20(4):47-55.

PMID: 24043996 MyJurnal

The concentrated potassium chloride injection is a high-alert medication and replacing it with a pre-mixed formulation can reduce the risks associated with its use. The aim of this study was to determine the clinical characteristics of patients receiving different potassium chloride formulations available at a private institution. The study also assessed the effectiveness and safety of pre-mixed formulations in the correction of hypokalaemia.

Fulltext Prevalence of oral mucosal lesions in patients with type 2 diabetes attending hospital universiti sains malaysia

Al-Maweri SA, Ismail NM, Ismail AR, Al-Ghashm A

Malays J Med Sci, 2013 Jul;20(4):39-46.

PMID: 24043995 MyJurnal

Diabetes mellitus is associated with a greater likelihood of developing certain oral mucosal disorders. This study was aimed at assessing the prevalence of oral mucosal lesions (OMLs) in patients with type 2 diabetes (DM2) and to investigate the association of such lesions with metabolic control of the disease.

Fulltext MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above

Embong MF, Yaacob R, Abdullah MS, Abdul Karim AH, Ghazali AK, Jalaluddin WM

Malays J Med Sci, 2013 Jul;20(4):25-31.

PMID: 24043993 MyJurnal

Hippocampal volume is affected by several psychiatric illnesses of old age, as well as by normal aging. It is important to have a normal data in a population to assist in diagnosis. The aim of this study is to determine hippocampal volume in normal Malay people aged 50 years old and older.

Fulltext Uterine arteriovenous malformation

Hashim H, Nawawi O

Malays J Med Sci, 2013 Mar;20(2):76-80.

PMID: 23983582 MyJurnal

Uterine arteriovenous malformation (AVM) is a rare condition, with fewer than 100 cases reported in the literature. Despite it being rare, it is a potentially life-threatening condition. This case report describes a 33-year-old woman who presented with secondary post-partum hemorrhage. Transabdominal ultrasound (US) of the pelvis showed increased vascularity with multidirectional flow of the uterus and a prominent vessel, located on the left lateral wall. She also had retained product of conception, which complicated the diagnosis. A uterine artery angiogram confirmed an AVM in the fundal region with an early draining vein. Embolisation of the AVM was performed successfully.

Fulltext Percutaneous catheter-based rheolytic thrombectomy for massive pulmonary embolism: a case report

Nguyen D, Yaacob Y, Muda S, Mohamed Z

Malays J Med Sci, 2013 Mar;20(2):70-5.

PMID: 23983581 MyJurnal

Pulmonary thromboembolism is a life-threatening cardiovascular condition. The mortality rate is high in its current management. Besides supportive treatments, systemic thrombolysis and surgical thrombectomy play important roles in the comprehensive management of pulmonary embolism (PE). The percutaneous catheter-based rheolytic thrombectomy is a promising alternative for management of massive pulmonary emboli, particularly, when patients have contraindication with systemic thrombolysis or are not suitable for surgery. We present the case of a 36-year-old Somalian man who came to our center for a total knee replacement (TKR). Three days after TKR, he developed sudden shortness of breath and decreased oxygen saturation. Computed tomography of pulmonary arteriogram showed extensive thrombi within the main pulmonary trunk, right and left pulmonary arteries, bilateral ascending and bilateral descending pulmonary arteries in keeping with massive PE. Because the patient was contraindicated for systemic thrombolysis, percutaneous, catheter-based rheolytic thrombectomy was chosen as the alternative treatment. His clinical symptoms improved immediately post-treatment. In conclusion, catheter-based rheolytic thrombectomy can serve as an alternative treatment for massive PE with a good clinical outcome.

Fulltext Knowledge, practices and attitudes towards adverse drug reaction reporting by private practitioners from klang valley in malaysia

Agarwal R, Daher AM, Mohd Ismail N

Malays J Med Sci, 2013 Mar;20(2):52-61.

PMID: 23983578 MyJurnal

The study aimed to determine current status of knowledge, practices, and attitudes towards adverse drug reaction (ADR) reporting among private practitioners in Klang region of Malaysia.

Fulltext Preliminary study: effects of social instability stress on depressive behaviours in ovariectomised rats

Al-Rahbi B, Zakaria R, Muthuraju S, Othman Z, Hassan A

Malays J Med Sci, 2013 Mar;20(2):35-40.

PMID: 23983575 MyJurnal

Depression is one of the common post-menopausal symptoms. In addition to estrogen deficiency, social instability stress may contribute as an additional underlying factor in the development of depressive behaviour in females. Therefore, this study was aimed at examining the influence of social instability stress on depressive behaviour in ovariectomized rats.

Fulltext Apoptotic activities in soft tissue sarcoma: immunohistochemical study and their association with tumour characteristics

Win TT, Yusuf Y, Jaafar H

Malays J Med Sci, 2013 Mar;20(2):10-6.

PMID: 23983572 MyJurnal

Many studies on the role of apoptosis in cancer development and management have been undertaken. Apoptotic activity depends partly on the balance between anti-apoptotic (Bcl-2) and pro-apoptotic (Bax) activities. This study compared Bcl-2 and Bax expression in the tumour cells and endothelial cells of tumour blood vessels in soft tissue sarcoma, and examined the association of these with tumour characteristics.

Fulltext The influence of colour on memory performance: a review

Dzulkifli MA, Mustafar MF

Malays J Med Sci, 2013 Mar;20(2):3-9.

PMID: 23983571 MyJurnal

Human cognition involves many mental processes that are highly interrelated, such as perception, attention, memory, and thinking. An important and core cognitive process is memory, which is commonly associated with the storing and remembering of environmental information. An interesting issue in memory research is on ways to enhance memory performance, and thus, remembering of information. Can colour result in improved memory abilities? The present paper highlights the relationship between colours, attention, and memory performance. The significance of colour in different settings is presented first, followed by a description on the nature of human memory. The role of attention and emotional arousal on memory performance is discussed next. The review of several studies on colours and memory are meant to explain some empirical works done in the area and related issues that arise from such studies.

Proteomics technology - a powerful tool for the biomedical scientists

Noordin R, Othman N

Malays J Med Sci, 2013 Mar;20(2):1-2.

PMID: 23983570

"Proteomics" refers to the systematic analysis of proteins. It complements other "omics" technologies such as genomics and transcriptomics in elucidating the identity of proteins of an organism, and understanding their functions. Proteomics is used in many areas of research such as discovery of markers for diagnosis and vaccine candidates, understanding pathogenic mechanisms, in the study of expression patterns at different time points and in response to different stimuli, and in elucidating functional protein networks. Proteomics analysis involves sample preparation, protein separation, and protein identification. The 'heart' of current proteomics is mass-spectrometry, with LC-MS/MS and MALDI-TOF/TOF being commonly used equipment. However, the high costs of the equipment, software, databases, and the need for skilled personnel limit the wide utilization of this technology in the less developed countries. Therefore, there need to be sharing of facilities, better networking and collaborations among our scientists and laboratories to take advantage of this powerful technology.

Fulltext Lymphocytic mastitis mimicking breast carcinoma, radiology and pathology correlation: review of two cases

Alhabshi SM, Rahmat K, Westerhout CJ, Md Latar NH, Chandran PA, Aziz S

Malays J Med Sci, 2013 May;20(3):83-7.

PMID: 23966831 MyJurnal

Lymphocytic mastitis, or diabetic mastopathy, is an unusual finding in early-onset and long-standing diabetes. It can presents as a non-tender or tender palpable breast mass. Mammogram and ultrasound frequently demonstrate findings suspicious of malignancy, thus biopsy and histological confirmation is usually required. We reviewed two cases of lymphocytic mastitis with characteristics findings on mammogram, ultrasound, and histopathology. Diagnoses were confirmed with excision biopsy.

Fulltext Mesenchymal chondrosarcoma: a case report

Nguyen DV, Muda AS, Yaacob Y

Malays J Med Sci, 2013 May;20(3):71-7.

PMID: 23966829 MyJurnal

Mesenchymal chondrosarcoma is a rare disease with poor prognosis. Treatment including wide or radical excision is very important. Radiotherapy and chemotherapy are additional treatment options, but no conclusive results for their efficacy have been shown until date. Imaging modalities can give important clues for diagnosis and management planning. Angioembolization before surgery could be useful as prophylaxis to control intraoperative bleeding, increasing the likelihood of complete resection.

Fulltext Survey on maternal satisfaction in receiving spinal anaesthesia for caesarean section

Dharmalingam TK, Ahmad Zainuddin NA

Malays J Med Sci, 2013 May;20(3):51-4.

PMID: 23966825 MyJurnal

This study was undertaken to evaluate patient satisfaction after spinal anaesthesia, which is the most frequently administered anaesthesia in obstetric patients.

Isolation of Extended Spectrum β-lactamase (ESBL) Producing Bacteria from Urban Surface Waters in Malaysia

Tissera S, Lee SM

Malays J Med Sci, 2013 May;20(3):14-22.

PMID: 23966820

This was a preliminary study to test for the presence of multiple antibiotic-resistant extended spectrum β-lactamase (ESBL) producing bacteria in Malaysian urban surface waters. Although the literature review revealed several published papers on clinical ESBL isolates in Malaysia, none were found on ESBL isolates obtained from local surface waters.

Fulltext Review of the medicinal effects of tualang honey and a comparison with manuka honey

Ahmed S, Othman NH

Malays J Med Sci, 2013 May;20(3):6-13.

PMID: 23966819 MyJurnal

Tualang honey (TH) is a Malaysian multifloral jungle honey. In recent years, there has been a marked increase in the number of studies published in medical databases regarding its potential health benefits. The honey is produced by the rock bee (Apis dorsata), which builds hives on branches of tall Tualang trees located mainly in the north-western region of Peninsular Malaysia. This review collates the results of the various studies of TH that range from research on tissue culture to randomised control clinical trials. Findings thus far show that, TH has antimicrobial, anti-inflammatory, antioxidant, antimutagenic, antitumor, and antidiabetic properties, in addition to wound-healing attributes. Some of its properties are similar to the well-researched Manuka honey (New Zealand and/or Australian monofloral honey). Distinct differences include higher phenolics, flavonoids, and 5-(hydroxymethyl) furfural (HMF). Compared with Manuka honey, TH is also more effective against some gram-negative bacterial strains in burn wounds.

A Psychometric Properties of the Malay-version Police Stress Questionnaire

Irniza R, Emilia ZA, Muhammad Saliluddin S, Nizam Isha AS

Malays J Med Sci, 2014 Jul;21(4):42-50.

PMID: 25977621 MyJurnal

BACKGROUND: Police Stress Questionnaire (PSQ) was developed to measure police-specific stressors. The present study was the first to have translated the PSQ to Malay. This study aims to test the reliability, construct validity, and component structure of the Malay-version PSQ.

METHODS: A set of survey consisted of the Malay-version PSQ, General Health Questionnaire (GHQ-12), Job Content Questionnaire (JCQ), Global Stress Questionnaire (GSQ) and General Self-rated Health (GSRH) were distributed to 300 traffic police officers in Kuala Lumpur and all traffic police officers in a few districts of Pahang and Negeri Sembilan.

RESULTS: The response rate was 65.5% (N = 262). The reported Cronbach's alpha coefficient was 0.93 for Operational PSQ (PSQ-Op) and 0.94 for Organisational PSQ (PSQ-Org). Findings indicated that the PSQ had positive construct validity with the GSRH, GSQ, and GHQ. After excluding four factors related to lifestyles, all police-specific stressors were highly loaded (0.50) in one component.

CONCLUSION: It is confirmed that the Malay-version PSQ, excluding the four factors related to lifestyle, was uni-dimensional, reliable, and a valid questionnaire. This study proffers a potentially better instrument for assessing the stressors among Malaysian police.

Fulltext An outcome of Surgically Treated Head and Neck Cancer in one of the tertiary Referral Center in the East Coast of Malaysia: A 6-year Retrospective Analysis

Abdullah K, Raja Lope Ahmad RA, Asha'ari ZA, Razali MS, Leman WI

Malays J Med Sci, 2014 Jul;21(4):28-36.

PMID: 25977619 MyJurnal

Surgical management of head and neck cancer is undoubtedly challenging, and we would like to see the outcome of managing such cases at one of the tertiary referral center in the East Coast of Malaysia.

Fulltext Searching for the Origin through Central Nervous System: A Review and Thought which Related to Microgravity, Evolution, Big Bang Theory and Universes, Soul and Brainwaves, Greater Limbic System and Seat of the Soul

Idris Z

Malays J Med Sci, 2014 Jul;21(4):4-11.

PMID: 25977615 MyJurnal

Cerebrospinal fluid (CSF) serves buoyancy. The buoyancy thought to play crucial role in many aspects of the central nervous system (CNS). Weightlessness is produced mainly by the CSF. This manuscript is purposely made to discuss its significance which thought contributing towards an ideal environment for the CNS to develop and function normally. The idea of microgravity environment for the CNS is supported not only by the weightlessness concept of the brain, but also the noted anatomical position of the CNS. The CNS is positioned in bowing position (at main cephalic flexure) which is nearly similar to an astronaut in a microgravity chamber, fetus in the amniotic fluid at early gestation, and animals and plants in the ocean or on the land. Therefore, this microgravity position can bring us closer to the concept of origin. The hypothesis on 'the origin' based on the microgravity were explored and their similarities were identified including the brainwaves and soul. Subsequently a review on soul was made. Interestingly, an idea from Leonardo da Vinci seems in agreement with the notion of seat of the soul at the greater limbic system which has a distinctive feature of "from God back to God".

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