Displaying publications 1 - 20 of 833 in total

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  1. Soon SH, Chai Kim Kai
    Med J Malaya, 1969 Dec;24(2):145-6.
    PMID: 4244140
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  2. Chai KH, Soo-Hoo TS
    Med J Malaya, 1970 Sep;25(1):43-5.
    PMID: 4249494
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology
  3. Sng EH, Lam S
    Med J Malaya, 1971 Jun;25(4):301-4.
    PMID: 4261307
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  4. Puthucheary SD, Chen ST, Dugdale AE
    Med J Malaya, 1972 Jun;26(4):262-5.
    PMID: 5069415
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  5. Jegathesan M, Singh RB, Kanaganayagy M, Soon LE
    PMID: 1096307
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology
  6. Jamal F, Aziz AH, Shafie MS
    Med J Malaysia, 1982 Jun;37(2):128-31.
    PMID: 7132831
    Two hundred strains of Klebsiella species isolated from clinical specimens over a four-month period were biotyped as Klebsiella aerogenes (173 strains), Klebsiella ozaenae (15 strains), Klebsiella edwardsii (5 strains), Klebsiella atlantae (2 strains) and Klebsiella oxytoca (1 strain). Klebsiella aerogenes and Klebsiella ozaenae were more resistant towards antibiotics when compared with other species. Colonial morphology on eosin methylene blue agar (Oxoid) was not found useful for differentiations of Klebsiella biotypes.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  7. Koh CL, Lim ME, Wong YH
    PMID: 6362015
    Six independent isolates of Klebsiella from hospital environmental sources in Malaysia were found to be resistant to at least ampicillin, carbenicillin, cefoperazone, chloramphenicol, gentamicin and tetracycline. On the basis of their antibiograms, they were divided into four antibiogroups. They transferred all or part of their multiple antibiotic resistance traits to E. coli by conjugation. The results suggest that these Klebsiella strains harbour self-transmissible R plasmids. The significance of these findings are discussed.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  8. Koh CL, Kok CH
    PMID: 6377513
    Fifteen independent E. coli strains of avian, bovine and porcine origin in Peninsular Malaysia were tested for antibiotic resistance and conjugative R plasmids. Eight (53%) isolates were found to be antibiotic resistant. Among them, 37.5% were mono-resistant and 62.5% were resistant to three or more antibiotics, i.e., multi-resistant. All of them were resistant to Tc and sensitive to Gm and Nx. Three of the eight antibiotic resistant strains were able to transfer all or part of their resistance to an E. coli K12 recipient by conjugation. The transfer frequencies of Km, Sm and Tc resistance of the three donors varied between 4.5 X 10(-8) to 6.8 X 10(-7). Analysis of the plasmid profiles of all the three donors and their respective transconjugants after agarose gel electrophoresis provided conclusive evidence that the transferable resistance traits were plasmid-mediated.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  9. Koh CL, Kok CH
    PMID: 6395350
    Four of the five veterinary E. coli strains, which were unable to transfer their antibiotic resistance by conjugation, were found to harbour plasmids. Evidence from transformation, agarose gel electrophoresis and curing experiments showed that in strains KE-3, KE-4 and KE-14 a nonconjugative R plasmid carried the gene for resistance to tetracycline. The plasmids in KE-9 were cryptic.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology
  10. Koh CL, Tay SH
    Singapore Med J, 1984 Oct;25(5):300-3.
    PMID: 6523137
    A clinical isolate of Proteus sp., resistant to ampicillin, carbenicillin, cephaloridine, chloramphenicol, cotrimoxazole, gentamicin,
    kanamycin and tetracycline, was examined for the presence of conjugative R plasmids. Results from conjugation, agarose gel
    electrophoresis and transformation experiments showed that it harboured a large self-transmissible R plasmid which coded for all
    the resistance traits.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  11. Ngeow YS, Puthucheary SD, Lai PS
    Med J Malaysia, 1985 Sep;40(3):196-201.
    PMID: 3939567
    170 clinical isolates of Pseudomonas aeruginosa were tested for in vitro susceptibility to gentamicin, amikacin, tobramycin, netilmicin, kanamycin, streptomycin, cefotaxime, ceftriaxone, cefoperazone, ceftazidime, moxalactam, azlocillin, piperacillin and ticarcillin. Against 93 gentamicin-sensitive strains, the most active antibiotics were in descending order, ceftazidime, tobramycin, gentamicin, amikacin, and the ureidopenicillins. Against 77 gentamicin-resistant strains, only ceftazidime, amikacin and moxalactam had mode minimum inhibitory concentrations within achievable peak serum levels after standard therapeutic dosage. There was no correlation between cephalosporin resistance and aminoglycoside resistance except for cefoperazone, which, together with the ureidopenicillins and ticarcillin, showed marked decrease in activity against gentamicin-resistant strains.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology
  12. Tan HS, Ngeow YF, Jamal F
    Med J Malaysia, 1986 Mar;41(1):24-9.
    PMID: 3796343
    55% of a sample of patients in a rural
    community, and 76% of a sample of patients and
    staff in the local district hospital were found to
    be nasal carriers for Staphylococcus aureus. The
    in vitro antibiotic susceptibility patterns of 46
    strains of S. aureus isolated in nasal carriers as
    well as of 43 strains in community-acquired skin
    infections were characterised. High levels of
    resistance were expressed to penicillin (73%),
    cephalexin (64%) and tetracycline (46%).
    Resistance to erythromycin (18%) was moderate.
    A few strains showed resistance to methicillin
    (5 isolates), vancomycin (4), [usidic acid (3),
    cotrimoxazole (1), and none to gentamicin.
    Penicillin can no longer be recommended for
    treating community-acquired S. aureus infections.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  13. Koh CL
    Trans R Soc Trop Med Hyg, 1986;80(1):158-61.
    PMID: 3726978
    Twenty-five strains of enterobacteria, isolated from man in Peninsular Malaysia and consisting of seven Enterobacter spp., five Escherichia coli, five Salmonella spp., four Klebsiella spp., two Shigella spp., one Proteus sp. and and one Providencia sp., were tested for antibiotic resistance and conjugative R plasmids. They were all sensitive to nalidixic acid and resistant to at least three antibiotics. The number of resistances ranged from 3 to 11 antibiotics, including cefoperazone and sisomicin (two) newly released antibiotics), in addition to common drugs of current use. Of the 25 isolates, 19 (76%) conjugally transferred, at varied frequencies, at least two resistance determinants. Results from equilibrium density gradient centrifugation, agarose gel electrophoresis and transformation experiments provided proof that the transferable resistances were plasmid-mediated. Restriction endonuclease cleavage patterns showed that the plasmids from Proteus strain K005 and Providencia strain K001 may be identical.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  14. Dillon JR, Bygdeman SM, Sandström EG
    Genitourin Med, 1987 Jun;63(3):160-8.
    PMID: 3111978
    One hundred and thirty eight penicillinase producing Neisseria gonorrhoeae (PPNG) and 239 non-PPNG strains were characterised serologically using a panel of seven monoclonal antibodies directed against protein 1A and seven against protein 1B. An association between serovar and susceptibility to antimicrobial agents, auxotype, and plasmid content was observed. Serogroup WI strains were more sensitive to penicillin, ampicillin, tetracycline, erythromycin, cefoxitin, and cefuroxime. Sixty five (82%) of the 79 WI strains were typed as being serovar Aedgkih, and 47 (72%) of these strains required arginine, uracil, and hypoxanthine for growth (AUH-). Seventy one (44%) of 160 WII/WIII strains were serovar Bacejk, and 42 (59%) of these required proline, citrulline, and uracil for growth (PCU-) and were plasmid free. Serovars Bcgk, Beghjk, Bacjk, and Bajk were associated with resistance to antimicrobial agents. Analysis of PPNG isolates showed a new serovar, Af, which was associated with strains imported from Malaysia and Singapore that required proline and ornithine for growth (Pro-Orn-) and carried the 24.5 megadalton transfer plasmid, the 2.6 megadalton cryptic plasmid, and the 4.5 megadalton penicillinase producing plasmid. Other associations between serovar and geographical location were noted.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology
  15. Puthucheary SD, Parasakthi N
    Med J Malaysia, 1987 Dec;42(4):248-51.
    PMID: 3454397
    Fifty seven strains of Pseudomonas pseudomallei were tested for in vitro susceptibility to 15 antimicrobial agents. Amongst the generally recommended antibiotics for therapy of melioidosis, only 86%, 84% and 58% of the strains were found to be sensitive to trimethoprim-sulphamethoxazole, chloramphenicol and tetracycline respectively. Of the newer B-Iactams, in descending order of activity were, ceftazidime, ceftriaxone, cefotaxime, cefoperazone and cefuroxime. But on a weight for weight basis, ceftazidime was the most active agent and as such, may be considered in the therapy of acute septicaemic melioidosis."
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  16. Cheong YM, Jegathesan M, Henrichsen J, Wong YH, Ng AJ, Louis A
    J Trop Pediatr, 1988 08;34(4):182-5.
    PMID: 3172328 DOI: 10.1093/tropej/34.4.182
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  17. Williams JD, Moosdeen F, Teoh-Chan CH, Lim VK, Jayanetra P
    Eur J Epidemiol, 1989 Jun;5(2):207-13.
    PMID: 2504618
    Antibiotic resistance in Gram-negative bacteria, particularly Salmonella and Shigella, requires surveillance worldwide. This study describes results of surveys in Hong Kong, Bangkok and Kuala Lumpur. All strains were isolated in hospitals which have large community catchment areas in addition to specialised hospital units. The prevalence of resistant strains was high in all areas. Gram-negative bacteria such as Enterobacter associated with hospital infections were resistant to penicillins and cephalosporins, with gentamicin resistance ranging from about 20% in Kuala Lumpur and Hong Kong, to 35% in Bangkok. Ninety-seven percent of Shigella isolated in Thailand were resistant to ampicillin. About 10% of Salmonella were resistant to chloramphenicol in all three centres.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
  18. Palillo ES, Salleh MA
    Microbiol. Immunol., 1992;36(11):1195-200.
    PMID: 1491621
    Four hundred and ninety-eight predominantly pyocin-type 10 clinical strains of Pseudomonas aeruginosa were analyzed for resistance to carbenicillin, cefoperazone, cefotaxime, ceftazidime, gentamicin, amikacin and netilmicin. Based on NCCLS-recommended MIC breakpoints, 245 strains were found to be resistant, of which 41.6% were resistant to carbenicillin, 38% to gentamicin, 37.8% to netilmicin, 26.3% to cefoperazone, 17.9% to cefotaxime, 0.6% to amikacin and none to ceftazidime. Quadruple resistance to carbenicillin, cefoperazone, gentamicin and netilmicin was the most frequent pattern observed. Resistance to older antibiotics (kanamycin, streptomycin and tetracycline) and to mercuric chloride were also common. Conjugation experiments suggested that self-transmissible and non-transmissible plasmids occurred in at least 66 strains.
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology
  19. Mahalingam S, Cheong YM, Kan SK, Pang T
    PMID: 7939959
    Matched MeSH terms: Anti-Bacterial Agents/pharmacology*
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