Displaying publications 1 - 20 of 156 in total

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  1. Adi O, Ahmad AH, Fong CP, Ranga A, Panebianco N
    Ultrasound J, 2021 Apr 15;13(1):22.
    PMID: 33856577 DOI: 10.1186/s13089-021-00225-7
    BACKGROUND: Pericardial effusion is a known complication of post-open cardiac surgery which can progress to life-threatening cardiac tamponade. Classical signs of tamponade such as hypotension and pulsus paradoxus are often absent. Diagnosing acute cardiac tamponade with transthoracic echocardiography (TTE) can be challenging in post-cardiac surgical patients due to distorted anatomy and limited scanning windows by the presence of surgical dressings or scar. Additionally, this patient population is more likely to have a loculated pericardial effusion, or an effusion that is isoechoic in appearance secondary to clotted blood. These findings can be challenging to visualize with traditional TTE. Missed diagnosis of cardiac tamponade due to loculated pericardial clot can result in delayed diagnosis and clinical management.

    CASE PRESENTATION: We report a case series that illustrates the diagnostic challenge and value of resuscitative transesophageal echocardiography (TEE) in the emergency department (ED) for the diagnosis of cardiac tamponade due to posterior loculated pericardial clot in post-surgical coronary artery bypass graft (CABG) patients.

    CONCLUSIONS: Cardiac tamponade due to loculated posterior pericardial clot post-CABG requires prompt diagnosis and appropriate management to avoid the potential for hemodynamic instability. Transesophageal echocardiography allows a rapid diagnosis, early appropriate referral and an opportunity to institute appropriate therapeutic measures.

    Matched MeSH terms: Bandages
  2. Ruznan WS, Laing RM, Lowe BJ, Wilson CA, Jowett TJ
    Int J Low Extrem Wounds, 2021 Sep;20(3):244-250.
    PMID: 32248708 DOI: 10.1177/1534734620912093
    Bandages are common in many health-related treatments, including management of edema of the lower limb where they may remain in place for several days. The behavior of 2 bandage fabrics was investigated after exposure for up to 5 days to a multiaxial extension laboratory setup on a tensile tester in compression mode. The fabrics were extended 20% and remained under that machine setting. Stress-relaxation over time was determined by analyzing the rate of change over 24 hours and over 5 days. Most change, a rapid drop in force, occurred during the first 15 minutes; thereafter, for the next 12-hour period, a slower rate of decrease was observed. Both fabrics continued to relax gradually during the next 12 hours and continued to do so for up to 5 days. Little further change was evident during the last 12 hours or so. This phenomenon suggests that rewrapping may be appropriate (albeit not practical) after 12 hours of compression therapy to optimize the compression given to the lower leg. Relaxation behavior of these 2 fabrics can be explained using the generalized Maxwell-Wiechert model.
    Matched MeSH terms: Bandages*
  3. Nair HKR
    Int J Low Extrem Wounds, 2018 Mar;17(1):54-61.
    PMID: 29564953 DOI: 10.1177/1534734618762225
    The management of chronic nonhealing ulcers pose a great challenge because they are associated with morbidity and increased costs. This report presents the observations of standard management along with application of modified collagen with glycerin (MCG) in the periwound area for management of nonhealing wounds. This observational report included 50 patients (33 male, 17 female) aged 24 to 94 years having nonhealing wounds. All wounds were treated using standard treatment protocols (TIME concept), whereas the periwound severity was assessed using the Harikrishna Periwound Skin Classification (HPSC). All patients received once-daily application of MCG lotion directly in the periwound areas and compression bandaging until there was complete wound healing. Patient compliance was ensured by regular follow-up and counseling. All diabetic patients were counseled to ensure glycemic control during the entire follow-up period. The criteria used for wound healing were based on clinical observation, and proper epithelialization of the wound was the end point. The median age of the wounds was 12.0 weeks (95% CI = 8.00 - 58.08). Majority of the non-healing wounds were diabetic foot ulcers with age of wound between 4 weeks to 15 years. The median time to complete wound healing was 12.71 (95% CI = 10.00-16.67) weeks. Standard treatment protocol of TIME principle with periwound area assessment based on HPSC 2015 and treatment accordingly with topical application of MCG along with additional measures has shown complete healing of nonhealing wounds. However, further large-scale comparative studies are needed to substantiate these effects on a larger population.
    Matched MeSH terms: Compression Bandages*
  4. Nair HKR, Lew X, Liew KY, Kamis SA, Nik Kub NMH, Zakaria AM, et al.
    Int J Low Extrem Wounds, 2023 Dec;22(4):759-766.
    PMID: 34806457 DOI: 10.1177/15347346211058273
    Background: Venous leg ulcers severely affect patients' quality of life due to its high morbidity and recurrent nature. Currently, compression therapy is the first-line treatment for venous leg ulcers. Aim: This study sought to evaluate the efficacy of the Mobiderm® technology developed by Thuasne in a prospective case series of venous leg ulcers. Methods: Nine patients (N  =  9) with venous leg ulcers were enrolled into this case series. Mobiderm® bandage was applied on to the affected limbs of the patients in the multi-component bandages system. The bandages were changed as frequent as the patients had their wound dressing for their standard treatment in a 12-week duration. Wound size and calf circumference were measured at week 0 and week 12. Paired sample t-test was used to compare the mean values of wound size and calf circumference pre- and post-treatment. Results: Reductions in wound size and calf circumference were observed in all nine patients (100%). Five patients were evaluable at week 12. The wound sizes significantly reduced by 27.2% to 53.2% (p  =  0.02), and the calf circumferences significantly reduced by 3.2% to 26.0% (p  =  0.02) after 12 weeks (N  =  5). Safety was unremarkable, with no occurrence of treatment-emergent-related adverse event. Conclusion: Mobiderm® bandage was reported to be effective in promoting wound healing and reducing swelling, suggesting it to be integrated in the compression therapy for the management of venous leg ulcers.
    Matched MeSH terms: Bandages
  5. Shukrimi A, Sulaiman AR, Halim AY, Azril A
    Med J Malaysia, 2008 Mar;63(1):44-6.
    PMID: 18935732 MyJurnal
    Honey dressing has been used to promote wound healing for years but scanty scientific studies did not provide enough evidences to justify it benefits in the treatment of diabetic foot ulcers. We conducted a prospective study to compare the effect of honey dressing for Wagner's grade-II diabetic foot ulcers with controlled dressing group (povidone iodine followed by normal saline). Surgical debridement and appropriate antibiotics were prescribed in all patients. There were 30 patients age between 31 to 65-years-old (mean of 52.1 years). The mean healing time in the standard dressing group was 15.4 days (range 9-36 days) compared to 14.4 days (range 7-26 days) in the honey group (p < 0.005). In conclusion, ulcer healing was not significantly different in both study groups. Honey dressing is a safe alternative dressing for Wagner grade-II diabetic foot ulcers.
    Matched MeSH terms: Bandages*
  6. Lau CP, Chee EK, Thirumal M
    Med J Malaysia, 2006 Dec;61 Suppl B:32-6.
    PMID: 17600990
    Antibiotic pouch technique is commonly used due to the high local antibiotic concentration and moist environment for wound healing. We used locally made gentamicin impregnated Plaster of Paris discs in treating wounds with exposed deep structures like tendons and bones. Out of 22 patients treated with this method, 19 completed treatment. Granulation tissue formed quickly and effectively covered the exposed structures. All wounds either healed by secondary intention or became suitable for split skin grafting. Gentamicin impregnated Plaster of Paris disc pouch dressing is safe, cost saving, and effective for management of deep open wounds.
    Matched MeSH terms: Bandages*
  7. Saw A, Chan CK, Penafort R, Sengupta S
    Med J Malaysia, 2006 Feb;61 Suppl A:62-5.
    PMID: 17042233
    Patients treated with external fixation for limb reconsturciton or fracture stabilization equire regular and prolongedperiod of pin-tract care involving frequent visits to clinic and dressing traditionally carried out by trained nurses or medical assistants. A simple method of do-it-yourself dressing was introduced in our institution and this study was undertaken to evaluate the effectiveness of the protocol. Sixty patients (40 trauma-related problems and 20 congenital or developmental disorders) were enrolled into the study. Following application of external fixation, the patients and/or their caretakers were taught on how to do pin-site dressing using normal saline or drinking water as cleansing solution on daily basis. Patients were discharged on the second or third post-operative day and were followed-up every two weeks for an average 182 days (range 66 to 379 days) with special attention on identifying pin-tract infection. A simple grading system for pin-tract infections was proposed. Of 40 patients with trauma-related problems. 65% were post-traumatic infections. There were 788 metal-skin interfaces (239 half-pin fixations and 549 tensioned wire fixations. A total 143 metal-skin interface infections (18.1%) involving half-pin sites (41.3%) and tensioned wire sites (58.7%) was noted. Majority were grade I infections (79.7%), 18.8% grade II and only 1.4% grade III. Most infections (81%)were caused by Staphylococcus aureus. Grade I infections were successfully treated with frequent dressing, grade II by adjunctive oral antibiotic but grade III infections required removal of fixator. All eventually healed. Do yourself non-sterile dressing of metal-skin interfaces is a cost-effective method of pin-site care with a low infection rate. The infections were sucessfully treated using guidelines according to the proposed classification of pin-tract infections.
    Matched MeSH terms: Bandages*
  8. Sow YL, Tang IP, Kho JPY, Prepageran N
    Med J Malaysia, 2018 08;73(4):244-248.
    PMID: 30121688
    INTRODUCTION: Endoscopic sinus surgery (ESS) is the mainstay for treatment of chronic rhinosinusitis versus maximal medical therapy. We propose a more economical option, by using steroid-impregnated Gelfoam instead of Nasopore post ESS, as it is less expensive and has showed effectiveness in preventing post-operative bleeding.

    MATERIALS AND METHODS: A randomised, double-blinded, placebo-controlled trial was carried out in eight patients with chronic rhinosinusitis or nasal polyposis who were planned for bilateral endoscopic sinus surgery. A Peri-operative Sinus Endoscopy (POSE) Score and Lund-Kennedy Endoscopic Score (LKES) were recorded. The use of hydrocortisone-impregnated Gelfoam dressing versus normal saline-impregnated Gelfoam dressing were compared. Scores were repeated post-operatively at one week, three weeks and three months interval.

    RESULTS: For LKES, at the end of three months, 50% of the patients had the same score difference, 37.5% had better results on the study side while 12.5% had better results on the control side. Meanwhile, for POSE Score, at the end of three months, 75% of the patients had better score difference on the study side while 12.5% had better results on the control side.

    CONCLUSION: Gelfoam can be used as nasal packing material to deliver topical steroid after endoscopic sinus surgery. Steroid-impregnated nasal dressing after endoscopic sinus surgery may not provide better long-term outcome.

    Matched MeSH terms: Bandages*
  9. Steffi W, Zaliana B, Amreen A, Nasirudin N
    Med J Malaysia, 2017 10;72(5):316-317.
    PMID: 29197891 MyJurnal
    Chronic exudative malodorous fungating wound of four years at the right arm due to diffuse large B cell lymphoma managed with silver dressings. In two months of application with nanocrystalline silver coated dressings, there was significant improvement in wound.
    Matched MeSH terms: Bandages*
  10. Shaariyah MM, Marina MB, Mohd Razif MY, Mazita A, Primuharsa Putra SH
    Malays J Med Sci, 2010 Apr;17(2):51-5.
    PMID: 22135538 MyJurnal
    Necrotizing fasciitis of the head and neck is a rare, rapidly progressive infection involving the skin, subcutaneous tissue and fascia. We report three cases of necrotizing fasciitis that differ in their presentation and outcome. The first case involves a patient who presented with progressively enlarging anterior neck swelling that was later complicated by dehydration and reduced consciousness. The second case is a patient with neck swelling and ipsilateral otorrhea. The third case concerns a patient with a buccal ulcer complicated by ipsilateral facial swelling. All of them underwent a fasciotomy with wound debridement with the addition of a cortical mastoidectomy in the second case. Two of these patients recovered well. Unfortunately, the third case succumbed to death due to airway compromise and septicaemia. We advocate the importance of eradicating the source of infection followed by frequent, meticulous wound dressing and strict blood sugar control to obtain better outcomes in managing necrotizing fasciitis of the head and neck. However, involvement of the airway carries a grave prognosis despite aggressive treatment.
    Matched MeSH terms: Bandages
  11. Julia PE, Sa'ari MY, Hasnan N
    Spinal Cord, 2011 Nov;49(11):1138-42.
    PMID: 21577218 DOI: 10.1038/sc.2011.53
    STUDY DESIGN: A cross-sectional experimental study.
    OBJECTIVE: The purpose of this study is to examine the benefit of elastic abdominal binders on voluntary cough in persons with spinal cord injury.
    SETTING: Spinal rehabilitation unit in a teaching hospital.
    METHODS: We measured voluntary cough peak expiratory flow rate (in 21 subjects with spinal cord injury, (18 tetraplegia, 3 paraplegia) under three conditions: without abdominal binder as the baseline, with single-strap abdominal binder and triple-strap abdominal binder.
    RESULTS: The results showed that the mean cough peak expiratory flow rate in all subjects without abdominal binder was 277.1 l per min. There was a significant increase in flow rate with the use of abdominal binders: 325.7 l per min with single-strap abdominal binder and 345.2 l per min with triple-strap abdominal binder (P<0.05, paired t-test). The mean cough peak expiratory flow rate in tetraplegic subjects using triple-strap abdominal binders was significantly higher compared with those using single-strap abdomina
    l binders (322.1 l per min and 299.4 l per min, respectively).
    CONCLUSION: Abdominal binders can be used as an effective method to improve cough ability in spinal cord injured patients, with triple-strap abdominal binder achieving greater cough peak expiratory flows.

    Comment in: Frisbie JH. Question of stamina for the diaphragm. Spinal Cord. 2012 Jun;50(6):480. doi: 10.1038/sc.2011.164. Epub 2012 Jan 17. PubMed PMID: 22249332.
    Matched MeSH terms: Compression Bandages*
  12. Sawalmeh A, Othman NS, Shakhatreh H
    Sensors (Basel), 2018 Oct 26;18(11).
    PMID: 30373204 DOI: 10.3390/s18113640
    In this paper, the efficient 3D placement of UAV as an aerial base station in providing wireless coverage for users in a small and large coverage area is investigated. In the case of providing wireless coverage for outdoor and indoor users in a small area, the Particle Swarm Optimization (PSO) and K-means with Ternary Search (KTS) algorithms are invoked to find an efficient 3D location of a single UAV with the objective of minimizing its required transmit power. It was observed that a single UAV at the 3D location found using the PSO algorithm requires less transmit power, by a factor of 1/5 compared to that when using the KTS algorithm. In the case of providing wireless coverage for users in three different shapes of a large coverage area, namely square, rectangle and circular regions, the problems of finding an efficient placement of multiple UAVs equipped with a directional antenna are formulated with the objective to maximize the coverage area and coverage density using the Circle Packing Theory (CPT). Then, the UAV efficient altitude placement is formulated with the objective of minimizing its required transmit power. It is observed that the large number of UAVs does not necessarily result in the maximum coverage density. Based on the simulation results, the deployment of 16, 19 and 26 UAVs is capable of providing the maximum coverage density of 78.5%, 82.5% and 80.3% for the case of a square region with the dimensions of 2 km × 2 km, a rectangle region with the dimensions of 6 km × 1.8 km and a circular region with the radius of 1.125 km, respectively. These observations are obtained when the UAVs are located at the optimum altitude, where the required transmit power for each UAV is reasonably small.
    Matched MeSH terms: Bandages
  13. Ebrahim M, Chia WC, Adil SH, Raza K
    Sensors (Basel), 2019 May 19;19(10).
    PMID: 31109154 DOI: 10.3390/s19102309
    Devices in a visual sensor network (VSN) are mostly powered by batteries, and in such a network, energy consumption and bandwidth utilization are the most critical issues that need to be taken into consideration. The most suitable solution to such issues is to compress the captured visual data before transmission takes place. Compressive sensing (CS) has emerged as an efficient sampling mechanism for VSN. CS reduces the total amount of data to be processed such that it recreates the signal by using only fewer sampling values than that of the Nyquist rate. However, there are few open issues related to the reconstruction quality and practical implementation of CS. The current studies of CS are more concentrated on hypothetical characteristics with simulated results, rather than on the understanding the potential issues in the practical implementation of CS and its computational validation. In this paper, a low power, low cost, visual sensor platform is developed using an Arduino Due microcontroller board, XBee transmitter, and uCAM-II camera. Block compressive sensing (BCS) is implemented on the developed platform to validate the characteristics of compressive sensing in a real-world scenario. The reconstruction is performed by using the joint multi-phase decoding (JMD) framework. To the best of our knowledge, no such practical implementation using off the shelf components has yet been conducted for CS.
    Matched MeSH terms: Bandages
  14. Abudula T, Gauthaman K, Mostafavi A, Alshahrie A, Salah N, Morganti P, et al.
    Sci Rep, 2020 11 24;10(1):20428.
    PMID: 33235239 DOI: 10.1038/s41598-020-76971-w
    Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core-shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications.
    Matched MeSH terms: Bandages
  15. Ng CL, Reaz MBI, Crespo ML, Cicuttin A, Chowdhury MEH
    Sci Rep, 2020 09 10;10(1):14891.
    PMID: 32913303 DOI: 10.1038/s41598-020-71709-0
    A capacitive electromyography (cEMG) biomedical sensor measures the EMG signal from human body through capacitive coupling methodology. It has the flexibility to be insulated by different types of materials. Each type of insulator will yield a unique skin-electrode capacitance which determine the performance of a cEMG biomedical sensor. Most of the insulator being explored are solid and non-breathable which cause perspiration in a long-term EMG measurement process. This research aims to explore the porous medical bandages such as micropore, gauze, and crepe bandage to be used as an insulator of a cEMG biomedical sensor. These materials are breathable and hypoallergenic. Their unique properties and characteristics have been reviewed respectively. A 50 Hz digital notch filter was developed and implemented in the EMG measurement system design to further enhance the performance of these porous medical bandage insulated cEMG biomedical sensors. A series of experimental verifications such as noise floor characterization, EMG signals measurement, and performance correlation were done on all these sensors. The micropore insulated cEMG biomedical sensor yielded the lowest noise floor amplitude of 2.44 mV and achieved the highest correlation coefficient result in comparison with the EMG signals captured by the conventional wet contact electrode.
    Matched MeSH terms: Bandages*
  16. Nor Azlan AYH, Katas H, Habideen NH, Mh Busra MF
    Saudi Pharm J, 2020 Nov;28(11):1420-1430.
    PMID: 33250649 DOI: 10.1016/j.jsps.2020.09.007
    Diabetic wounds are difficult to treat due to multiple causes, including reduced blood flow and bacterial infections. Reduced blood flow is associated with overexpression of prostaglandin transporter (PGT) gene, induced by hyperglycaemia which causing poor vascularization and healing of the wound. Recently, gold nanoparticles (AuNPs) have been biosynthesized using cold and hot sclerotium of Lignosus rhinocerotis extracts (CLRE and HLRE, respectively) and capped with chitosan (CS) to produce biocompatible antibacterial nanocomposites. The AuNPs have shown to produce biostatic effects against selected gram positive and negative bacteria. Therefore, in this study, a dual therapy for diabetic wound consisting Dicer subtract small interfering RNA (DsiRNA) and AuNPs was developed to improve vascularization by inhibiting PGT gene expression and preventing bacterial infection, respectively. The nanocomposites were incorporated into thermoresponsive gel, made of pluronic and polyethylene glycol. The particle size of AuNPs synthesized using CLRE (AuNPs-CLRE) and HLRE (AuNPs-HLRE) was 202 ± 49 and 190 ± 31 nm, respectively with positive surface charge (+30 to + 45 mV). The thermoresponsive gels containing DsiRNA-AuNPs gelled at 32 ± 1 °C and released the active agents in sufficient amount with good texture and rheological profiles for topical application. DsiRNA-AuNPs and those incorporated into thermoresponsive pluronic gels demonstrated high cell viability, proliferation and cell migration rate via in vitro cultured cells of human dermal fibroblasts, indicating their non-cytotoxicity and wound healing properties. Taken together, the thermoresponsive gels are expected to be useful as a potential dressing that promotes healing of diabetic wounds.
    Matched MeSH terms: Bandages
  17. Aswir Abd Rashed, Mohd Fairulnizal Md Noh, Norhayati Mustafa Khalid, Mohd Naeem Mohd Nawi, Mohd Azerulazree Jamilan, Nurul `Izzah Ab Rahman, et al.
    Sains Malaysiana, 2017;46:139-147.
    Mayonnaise and salad dressing are fast becoming popular condiments for Malaysian. The aim of this study was to
    obtain the nutritional composition of mayonnaise and salad dressing commercially available in the Malaysian market.
    The data will be used to update the Malaysian Food Composition Database which was last updated in 1997. A total of
    six brands from each type of mayonnaise and salad dressing were sampled from local supermarkets in the Klang Valley
    and analysed using standard methods. The validity of test data was monitored with the application of internal quality
    controls in line with the requirements of ISO 17025. The energy contents of mayonnaise and salad dressings were up to
    626.40 kcal/100 g. Our findings were also in agreement with the energy labelling on the packaging. Sodium was high in
    mayonnaise and salad dressing because it is used in the final mixture of both condiments to improve their characteristics
    for certain reasons. Mayonnaise and salad dressing have been identified as potent sources of vitamin A and vitamin
    E and both condiments were found to contain high levels of these antioxidants. It can be concluded that this study are
    useful not only in providing information on the nutritional content of several commercial types of mayonnaise and salad
    dressing, but also in improving the public understanding of healthy food choices.
    Matched MeSH terms: Bandages
  18. N Amirrah I, Mohd Razip Wee MF, Tabata Y, Bt Hj Idrus R, Nordin A, Fauzi MB
    Polymers (Basel), 2020 Sep 22;12(9).
    PMID: 32972012 DOI: 10.3390/polym12092168
    Diabetic foot ulcer (DFU) is a chronic wound frequently delayed from severe infection. Wound dressing provides an essential barrier between the ulcer and the external environment. This review aimed to analyse the effectiveness of antibacterial collagen-based dressing for DFU treatment in a clinical setting. An electronic search in four databases, namely, Scopus, PubMed, Ovid MEDLINE(R), and ISI Web of Science, was performed to obtain relevant articles published within the last ten years. The published studies were included if they reported evidence of (1) collagen-based antibacterial dressing or (2) wound healing for diabetic ulcers, and (3) were written in English. Both randomised and non-randomised clinical trials were included. The search for relevant clinical studies (n) identified eight related references discussing the effectiveness of collagen-based antibacterial wound dressings for DFU comprising collagen impregnated with polyhexamethylene biguanide (n = 2), gentamicin (n = 3), combined-cellulose and silver (n = 1), gentian violet/methylene blue mixed (n = 1), and silver (n = 1). The clinical data were limited by small sample sizes and multiple aetiologies of chronic wounds. The evidence was not robust enough for a conclusive statement, although most of the studies reported positive outcomes for the use of collagen dressings loaded with antibacterial properties for DFU wound healing. This study emphasises the importance of having standardised clinical trials, larger sample sizes, and accurate reporting for reliable statistical evidence confirming DFU treatment efficiency.
    Matched MeSH terms: Bandages
  19. Jaganathan SK, Mani MP, Khudzari AZM
    Polymers (Basel), 2019 Apr 01;11(4).
    PMID: 30960571 DOI: 10.3390/polym11040586
    The ultimate goal in tissue engineering is to fabricate a scaffold which could mimic the native tissue structure. In this work, the physicochemical and biocompatibility properties of electrospun composites based on polyurethane (PU) with added pepper mint (PM) oil and copper sulphate (CuSO₄) were investigated. Field Emission Electron microscope (FESEM) study depicted the increase in mean fiber diameter for PU/PM and decrease in fiber diameter for PU/PM/CuSO₄ compared to the pristine PU. Fourier transform infrared spectroscopy (FTIR) analysis revealed the formation of a hydrogen bond for the fabricated composites as identified by an alteration in PU peak intensity. Contact angle analysis presented the hydrophobic nature of pristine PU and PU/PM while the PU/PM/CuSO₄ showed hydrophilic behavior. Atomic force microscopy (AFM) analysis revealed the increase in the surface roughness for the PU/PM while PU/PM/CuSO₄ showed a decrease in surface roughness compared to the pristine PU. Blood compatibility studies showed improved blood clotting time and less toxic behavior for the developed composites than the pristine PU. Finally, the cell viability of the fabricated composite was higher than the pristine PU as indicated in the MTS assay. Hence, the fabricated wound dressing composite based on PU with added PM and CuSO₄ rendered a better physicochemical and biocompatible nature, making it suitable for wound healing applications.
    Matched MeSH terms: Bandages
  20. Arshad R, Sohail MF, Sarwar HS, Saeed H, Ali I, Akhtar S, et al.
    PLoS One, 2019;14(6):e0217079.
    PMID: 31170179 DOI: 10.1371/journal.pone.0217079
    Post-operative surgical site infections (SSI) present a serious threat and may lead to complications. Currently available dressings for SSI lack mucoadhesion, safety, efficacy and most importantly patient compliance. We aimed to address these concerns by developing a bioactive thiolated chitosan-alginate bandage embedded with zinc oxide nanoparticles (ZnO-NPs) for localized topical treatment of SSI. The FTIR, XRD, DSC and TGA of bandage confirmed the compatibility of ingredients and modifications made. The porosity, swelling index and lysozyme degradation showed good properties for wound healing and biodegradation. Moreover, in-vitro antibacterial activity showed higher bactericidal effect as compared to ZnO-NPs free bandage. In-vivo wound healing in murine model showed significant improved tissue generation and speedy wound healing as compared to positive and negative controls. Over all, thiolated bandage showed potential as an advanced therapeutic agent for treating surgical site infections, meeting the required features of an ideal surgical dressing.
    Matched MeSH terms: Bandages*
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