Displaying publications 1 - 20 of 64 in total

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  1. Polunin I
    Med J Malaya, 1951;5.
    1. Observations on filariasis made during medical travels in the Malay Peninsula are described. 2. The tentative diagnosis of endemic filariasis was made when cases typical of filarial elephantiasis were found in members of the indigenous population who have never resided in a previously known filariasis area, and was confirmed by finding microfilariae of Wuchereria malayi in bloods from that population. 3. Endemic filariasis has previously been reported associated with jungle swamp along the lower reaches of some of the larger rivers, and in certain coastal ricefield areas. It is reported in this paper in undeveloped inland areas of Perak, Pahang and Selangor, far distant from the previously described foci. This data has been summarized in maps and an Appendix. 4. In most inland areas where a search has been made, it has been possible to find evidence of endemic filariasis and sometimes the parasite rate has been over 50%. 5. The geographical distribution of the disease has not yet been defined, but is certainly more extensive than that described in this paper. 6. Infection probably takes place at an altitude of 1,500 feet in mountain valleys in Malaya.
    Matched MeSH terms: Brugia malayi
  2. EDESON JF, WHARTON RH
    Trans R Soc Trop Med Hyg, 1958 Jan;52(1):25-38; discussion 39-45.
    PMID: 13507120
    Matched MeSH terms: Brugia malayi*
  3. WHARTON RH, EDESON JF, WILSON T, REID JA
    Ann Trop Med Parasitol, 1958 Jul;52(2):191-205.
    PMID: 13559957
    Matched MeSH terms: Brugia malayi*
  4. LAING AB, EDESON JF, WHARTON RH
    Ann Trop Med Parasitol, 1960 Apr;54:92-9.
    PMID: 14413482
    Matched MeSH terms: Brugia malayi*
  5. Edeson JFB
    Bull World Health Organ, 1962;27(4-5):529-41.
    PMID: 20604131
    The author reviews the distribution, epidemiology, and treatment of filarial infection due to Brugia malayi, with special reference to Malaya. B. malayi infection in man is confined to the Far East between longitudes 75 degrees E and 140 degrees E and is essentially rural. The chief vectors are Mansonia spp., Anopheles hyrcanus group, A. barbirostris group, and Aëdes togoi. The epidemiological picture is complicated by the fact that B. malayi and other closely related species have now been found in several species of animals. The existence of an animal reservoir of infection might have important implications for filariasis control. As to the treatment of B. malayi infection, diethylcarbamazine has been found to reduce the microfilaria count and to kill the adult worms; the severe febrile reactions of microfilaria carriers to the initial doses of this drug may be reduced by administration of the steroid prednisolone.
    Matched MeSH terms: Brugia malayi
  6. Seo BS
    Kisaengchunghak Chapchi, 1974 Dec;12(2):95-100.
    PMID: 12913470
    The periodicity of the microfilariae of Brugia malayi was studied in 9 human carriers from Shin-san Ri, Seong-san Myon, Cheju Island. The periodicity pattern was markedly nocturnal and the peaks were observed between 21:30 p.m. and 5:30 a.m. The average peak count was 1:30 a.m. and the percentage of peak count at this time was 95.3. The ratio of minimum of the average peak count percentage to the maximum was 8.3. The periodicity pattern of B.malayi in Cheju Island was compared with that in Inland and no differences were found between two forms. From the above observations, it was concluded that the periodicity of B. malayi in Korea is markedly nocturnal and closely resembles that in the strain of Penang, Malaya.
    Matched MeSH terms: Brugia malayi
  7. Mak JW
    Family Practitioner, 1982;5(3):23-26.
    Brugia malayi and Wuchereria bancrofti infections cause lymphatic filariasis in Malaysia. About 2.5 million people live in endemic areas of filariasis, of whom 5% have microfilaraemia and probably twice as many are infected. There is a wide clinical spectrum of response to the infection. While some have asymptomatic microfilaraemia, others have episodic attacks of fever, lymphadenitis, retrograde lymphangitis and lymphoedema. Elephantiasis is a late complication. Tropical pulmonary eosinophilia and other forms of occult filariasis are due to hyper allergic reactions to microfilarial antigens. Parasitological and serological tests aid in confirming the clinical diagnosis. The drug of choice is diethylcarbamazine citrate.
    Matched MeSH terms: Brugia malayi
  8. Mak JW, Navaratnam V, Grewel JS, Mansor SM, Ambu S
    Am J Trop Med Hyg, 1993 Apr;48(4):591-6.
    PMID: 8480868
    A clinical trial on the efficacy of a single oral dose of ivermectin at 20, 50, 100, and 200 micrograms/kg was carried out in 40 subjects with subperiodic Brugia malayi microfilaremia. There was no significant difference in the clearance of microfilaremia in the four treatment groups, and the lowest geometric mean microfilarial count (GMC) achieved in the 40 subjects was 8.8/ml or 8.3% of the initial count (106.1/ml), at two weeks post-treatment. The GMC started to increase at one month post-treatment and by six months was 22.2% of the initial GMC. Only 27.5%, 23.1%, 15.0%, and 18.9% of subjects were amicrofilaremic at two, four, 12, and 24 weeks post-treatment, respectively. Mild fever in 35% of the subjects was the primary side reaction and was more common in those with microfilarial counts > or = 500/ml (85.7%) than in those with counts < 500/ml (32%). The clearance of B. malayi microfilaremia by ivermectin was less rapid than that reported for Wuchereria bancrofti. The smaller number of side reactions encountered in the present study compared with those reported for bancroftian filariasis is probably related to the lower microfilarial density in the present subjects. Since ivermectin at a single oral dose of 20-200 micrograms/kg can reduce the GMC to less than 10% at two weeks and maintain it below 25% of the initial level even at six months post-treatment, it is recommended that the drug be seriously evaluated for use in the control of brugian filariasis.
    Matched MeSH terms: Brugia malayi*
  9. Ramanathan S, Nair NK, Mansor SM, Navaratnam V
    J. Chromatogr., 1993 Jun 02;615(2):303-7.
    PMID: 8335708
    A rapid and selective high-performance liquid chromatographic assay for simultaneous quantitative determination of a new antifilarial drug (UMF-058, I) and mebendazole (MBZ) is described. After a simple extraction from whole blood, both compounds were analysed using a C18 Nova Pak reversed-phase column and a mobile phase of methanol-0.05 M ammonium dihydrogenphosphate (50:50, v/v) adjusted to pH 4.0, with ultraviolet detection at 291 nm. The average recoveries of I and MBZ over a concentration range of 25-250 ng/ml were 92.0 +/- 7.7 and 84.4 +/- 4.4%, respectively. The minimum detectable concentrations in whole blood for I and MBZ were 7 and 6 ng/ml, respectively. This method was found to be suitable for pharmacokinetic studies.
    Matched MeSH terms: Brugia malayi
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