Displaying publications 1 - 20 of 343 in total

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  1. van Roekel EH, Trijsburg L, Assi N, Carayol M, Achaintre D, Murphy N, et al.
    Nutrients, 2018 May 22;10(5).
    PMID: 29789452 DOI: 10.3390/nu10050654
    Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72 metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.
    Matched MeSH terms: Alcohol Drinking/adverse effects; Alcohol Drinking/blood*; Alcohol Drinking/epidemiology*
  2. Zawawi N, Ismail M
    Malays J Med Sci, 2018 Nov;25(6):46-58.
    PMID: 30914878 MyJurnal DOI: 10.21315/mjms2018.25.6.5
    Background: Strobilanthes crispus (S. crispus) leaves were traditionally consumed for its body weight lowering effect. In this study, we investigated the anti-obesity effect of S. crispus leaves extract (SCE).

    Methods: Mice (n = 48) were fed high-fat diet (HFD) for 25 weeks to induce obesity, after which half were maintained on HFD and half switched to low-fat diet (LFD)while they were given normal water (H2O) or 0.1% (w/v) SCE in water at week 0-4 which was increased to 1% (w/v) at week 5-9. Effects of treatment with SCE were compared between HFDH2O, HFDSCE, LFDH2O and LFDSCE groups. Respiratory exchange ratios (RER) were measured at weeks 0, 5 and 10. Food, water intake and body weight were measured weekly. Plasma lipid profile and organ weights were determined at week 10.

    Results: SCE had significantly reduced RER at week 9 (P = 0.011). Food intake, body weight, and abdominal adipose tissue weight were not altered by SCE at weeks 5 and 10. However, significant increase in plasma and liver cholesterol (P < 0.050) was observed.

    Conclusion: Our findings suggest that SCE induced lipolysis and body fat oxidation and increased energy expenditure. Further studies in other animal models should be done to confirm the consistency of these results.

    Matched MeSH terms: Drinking
  3. Zainuddin N, Mohd Kornain NK
    Malays Fam Physician, 2016;11(2-3):35-37.
    PMID: 28461858 MyJurnal
    The onset of carcinoma of the larynx, especially of the glottis, is heralded mainly by a change of voice. It has a male preponderance and is almost exclusively common to smokers and patients with heavy alcohol consumption. We report a case of glottic carcinoma in a non-smoker female patient. The only possible risk factor for her is a history of laryngopharyngeal reflux.
    Matched MeSH terms: Alcohol Drinking
  4. Zaini Hamzah, Siti Afiqah Abdul Rahman, Ahmad Saat, Siti Shahrina Agos, Zaharudin Ahmad
    MyJurnal
    The presence of 226 Ra in water is a great concern in human life since it can cause health risk to a certain extent. In the state of Kelantan, being known of its granitic area, there is a lack measurement of 226 Ra content in river water, since water is the major source of water supply. According to the INTERIM National Water Quality Standards for Malaysia (INWQS), 226 Ra activity concentration in water cannot exceed 0.1 Bq/L. For this reasons, this research was planned to carry out a systematic measurement of water along Sungai Kelantan. Liquid Scintillation Counting was used for measurement of 226 Ra in water samples from Sungai Kelantan mainly in district of Kuala Krai. In this paper, the results obtained is about 26 water samples, filtered and unfiltered, collected along Sungai Lebir, Sungai Sok and Bukit Sabah. Thus, the assessment activity concentration of 226 Ra in river water was obtained as well as annual effective dose for consumption of drinking water.
    Matched MeSH terms: Drinking Water
  5. Zaini Hamzah, Ahmad Saat, Mohammed Kassim
    MyJurnal
    Many studies were carried out throughout the world on radon measurement in water especially drinking water for it can cause problem to human health. This study is an attempt to measure the level of radon present in water collect from rivers and lakes. Data gathered from this study provides important information about radiation levels in water at selected sites, because radon gas is the largest contributor to natural radioactive radiation exposure to humans. Exposure to radon gas can cause lung cancer. Liquid scintillation counting (LSC) has been applied to determine the activity concentration of radon ( 222 Rn) in water. Water samples were collected from, ex-mining lake in Perak, Sok River in Kelantan, Tembeling River in Pahang. Water samples were prepared in polyethylene bottles mixed with liquid scintillator and stored for 3 weeks to allow 222 Rn and its progeny to reach the equilibrium, and the activity concentrations ranged from 0.24-1.27 Bq/L, and 0.029 – 0.155 Bq/L for radon and radium respectively.
    Matched MeSH terms: Drinking Water
  6. Zaini Hamzah, Wan Noorhayani Wan Rosdi, Abdul Khalik Wood
    MyJurnal
    Well water is a renewable natural resources and one of the drinking water sources. The well water may constituted of dissolved essential chemicals such as K+, Ca''+ and Na+ ; and natural radionuclides such as radioisotopes from uranium-thorium decay series. The geology and mineral composition of the soil will determined the kinds and levels of chemical contents in the groundwater resources. The water flows through the geological formation and dissolved the chemicals before reaching the aquifers. To evaluate how much chemicals and natural radioactive in the water resources, a study has been carried out. Well water samples in this study were taken from 3 districts in Kelantan, which is Bachok, Machang and Kuala Krai. Similarly, in situ water quality parameters were measured using YSI portable water quality parameter include pH, salinity, dissolve oxygen(DO), conductivity, turbidity and total dissolved solids(TDS). The concentrations of K', Ca" and Na' were determined using Energy Dispersive X-ray Fluorescence (EDXRF). Five ml of filtered sample was pipette into the sample cup and, irradiated and measured for 100 seconds counting times. The type of filter used for measuring If+ and Cat{ was Al-thin and default for Nat The ranged of concentration of Kt Ce and Na+ is 23.04-251.89, 3.12-.45.41, and 3.71-125.75 ppm, respectively.
    Matched MeSH terms: Drinking Water
  7. Zain RB
    Oral Oncol, 2001 Apr;37(3):205-10.
    PMID: 11287272
    This is an update on cultural and dietary risk factors for oral precancer and cancer. It is an overview on ethnic differences (where possible) and socio-cultural risk factors (tobacco/areca nut/betel quid, alcohol use and dietary factors) in relation to oral precancer and cancer. While studies were from Western countries, India and China, this update also attempts to include and highlight some studies conducted in the Asia-Pacific region.
    Matched MeSH terms: Alcohol Drinking/adverse effects
  8. Zain NM, Low WY, Othman S
    PMID: 26521527
    Pregnancy among unmarried women may have negative social and health implications in Malaysia. The number of pregnancies among unmarried women has increased in Malaysia, but the socio-demographic profile of these women is unclear. This study aims to evaluate the characteristics of unmarried pregnant women and the factors associated with unmarried pregnancies among young women in Malaysia. We conducted a cross sectional study at six hospitals and six women's shelters in Peninsular Malaysia during 2011-2012. Unmarried pregnant women were compared with married pregnant women. Participants were interviewed using a structured questionnaire asking for socio-demographic data, family background, risky sexual behavior, social support and pregnancy details. A total of 484 women (239 unmarried and 245 married) were included in the study. Most unmarried subjects were adolescents, from urban areas, from a low socioeconomic group, and lived with parents prior to pregnancy. Age (OR=0.67; 95% CI: 0.61-0.74), studying status (OR=17.33; 95% CI: 2.65-113.19), alcohol use (OR=40.46; 95% CI: 2.51-652.38) exposure to pornographic material (OR=13.48; 95% CI: 3.24-56.01), contraceptive use (OR=0.20; 95% CI: 0.08-0.51), and social support (OR=0.90; 95% CI: 0.86-0.94) were all associated with unmarried pregnancy. These factors need to be considered when.designing an intervention program.
    Matched MeSH terms: Alcohol Drinking/epidemiology*
  9. Zailina H, Najibah H, Aiezzati AN, Praveena SM, Patimah I
    Biomed Res Int, 2014;2014:797603.
    PMID: 25530970 DOI: 10.1155/2014/797603
    A cross-sectional study was carried out to determine the arsenic (As) and cadmium (Cd) concentrations in blood, urine, and drinking water as well as the health implications on 100 residents in an urban and a rural community. Results showed the blood As, urinary Cd, DNA damage, and water As and Cs were significantly (P < 0.001) higher in the rural community. Findings showed significant (P < 0.005) correlations between blood As and DNA damage with household income, years of residence, and total glasses of daily water consumption among the rural residents. The urinary NAG concentrations, years of residence, milk powder intake (glass/week), and seafood intake (per week) were significantly correlated (P < 0.005) with urinary Cd concentrations among respondents. In addition, urinary Cd level significantly influenced the urinary NAG concentrations (P < 0.001). The rural respondents experienced significantly higher lymphocyte DNA damage and blood As influenced by their years of residence and water consumption. The Cd in drinking water also resulted in the rural respondents having significantly higher urinary NAG which had a significant relationship with urinary Cd.
    Matched MeSH terms: Drinking Water/chemistry*
  10. Yusoff F, Sahril N, Rasidi NM, Zaki NA, Muhamad N, Ahmad N
    Asia Pac J Public Health, 2014 Sep;26(5 Suppl):100S-7S.
    PMID: 25038195 DOI: 10.1177/1010539514542425
    Illicit drug use among adolescents has become a public health issue in Malaysia. This study was from the Global School-Based Student Health Survey (GSHS) and aimed to determine the prevalence of and factors associated with illicit drug use among school-going adolescents in Malaysia. A 2-stage stratified cluster sampling method was used and data were collected via a self-administered questionnaire. A total of 25 507 students participated in the study. The prevalence of adolescents who ever used illicit drugs was 1.7%. Adolescents who ever used illicit drugs were associated with current smoking (adjusted odds ratio [aOR] = 6.99; 95% CI = 5.19, 9.40), current alcohol use (aOR = 4.63; 95% CI = 3.43, 6.26), ever having sex (aOR = 4.76; 95% CI = 3.54, 6.41), truancy (aOR = 1.43; 95% CI = 1.07, 1.90), lack of peer support (aOR = 1.47; 95% CI = 1.07, 2.03), and lack of parental monitoring (aOR = 1.71; 95% CI = 1.22, 2.39). Public health intervention should be addressed to prevent illicit drug used among adolescents.
    Study name: Global School-Based Student Health Survey (GSHS)
    Matched MeSH terms: Alcohol Drinking/epidemiology
  11. Yong, Kang Cheah
    MyJurnal
    In light of the increases in alcohol-induced diseases and social problems, the present study sets out to examine the factors affecting alcohol consumption among adults in Penang (Malaysia) using a cross-sectional survey sample consisting of 398 respondents. The results of the logistic regression analysis show that age, gender, ethnicity, marital status and smoking are significantly associated with alcohol consumption. In particular, males (OR: 3.720; 95% CI: 1.939, 7.136), Chinese (OR: 3.628; 95% CI: 1.808, 7.279) and smokers (OR: 5.083; 95% CI: 1.876, 13.774) are more likely to consume alcohol than others, whereas, old individuals (OR: 0.971; 95% CI: 0.941, 1.002), Malays (OR: 0.059; 95% CI: 0.021, 0.165) and married individuals (OR: 0.419; 95% CI: 0.211, 0.833) are less likely to consume alcohol than others. Based on the findings of the present study, several intervention strategies toward reducing alcohol consumption are proposed. Specifically, these strategies should be targeted at young individuals, males, Chinese, unmarried individuals and smokers.
    Matched MeSH terms: Alcohol Drinking
  12. Yong PL, Chan KG
    ScientificWorldJournal, 2014;2014:874764.
    PMID: 25177734 DOI: 10.1155/2014/874764
    We isolated a bacterial isolate (F7) from potable water. The strain was identified as Mesorhizobium sp. by 16S rDNA gene phylogenetic analysis and screened for N-acyl homoserine lactone (AHL) production by an AHL biosensor. The AHL profile of the isolate was further analyzed using high resolution triple quadrupole liquid chromatography mass spectrometry (LC/MS) which confirmed the production of multiple AHLs, namely, N-3-oxo-octanoyl-L-homoserine lactone (3-oxo-C8-HSL) and N-3-oxo-decanoyl-L-homoserine lactone (3-oxo-C10-HSL). These findings will open the perspective to study the function of these AHLs in plant-microbe interactions.
    Matched MeSH terms: Drinking Water/microbiology*
  13. Yong HY, Mohd Shariff Z, Mohd Yusof BN, Rejali Z, Tee YYS, Bindels J, et al.
    Nutrients, 2021 Jun 27;13(7).
    PMID: 34199062 DOI: 10.3390/nu13072208
    The contribution and impact of beverage intake to total nutrient and energy intake may be substantial. Given the link between lifestyle, diet, and the risk of pregnancy complications, this study investigated the association between the quantity and types of beverages with gestational diabetes mellitus (GDM) risk. The study included 452 women from the Seremban Cohort Study (SECOST). The mean energy by beverage intake was 273 ± 23.83 kcal/day (pre-pregnancy), 349 ± 69.46 kcal/day (first trimester) and 361 ± 64.24 kcal/day (second trimester). Women significantly increased intake of maternal milks and malted drinks, but significantly reduced the intake of carbonated drinks and other drinks from before until the second trimester of pregnancy. For chocolate drinks, carbonated drinks, and soy milk, women increased intake from pre-conception to the first trimester, but reduced their intake from the first to the second trimester. While higher intake of cultured-milk drinks was associated with an increased risk of GDM, higher fruit juice intake was associated with a lower risk of GDM. However, these associations were only observed for intake prior to pregnancy and during the first trimester. Further research is needed to corroborate these findings and investigate the contributions of different beverages to overall diet quality as well as adverse health outcomes during pregnancy.
    Matched MeSH terms: Drinking
  14. Yong HY, Mohd Shariff Z, Rejali Z, Mohd Yusof BN, Yasmin F, Palaniveloo L
    BMJ Open, 2018 01 21;8(1):e018321.
    PMID: 29358431 DOI: 10.1136/bmjopen-2017-018321
    INTRODUCTION: Both gestational diabetes mellitus (GDM) and hyperglycaemia less severe than GDM are associated with risk of adverse pregnancy outcomes. We describe the study design of a prospective cohort of pregnant women recruited in early pregnancy with follow-ups of mothers and infants up to 2 years after birth. The primary aim of the study was to identify the determinants and outcomes of maternal glycaemia.
    METHODS AND ANALYSIS: Seremban Cohort Study (SECOST) is an ongoing prospective cohort study in which eligible pregnant women in first trimester (<10 weeks of gestation) are recruited from Maternal and Child Health clinics in Seremban District, Negeri Sembilan with seven follow-ups during pregnancy through 2 years postnatally. Infants are followed up every 6 months after birth until 2 years old. A standard 75 g oral glucose tolerance test is performed between 24 and 32 of weeks of gestation and as close to 28 weeks of gestation. Pregnancy and birth information are obtained from medical records. Sociodemographic, anthropometric, biochemical, dietary, physical activity, smoking, depression, child feeding and other data of mothers and infants are obtained at follow-ups.
    ETHICS AND DISSEMINATION: This study is approved by the Medical Research Ethics Committee (MREC), Universiti Putra Malaysia (UPM/FPSK/100-9/2-MJKEtika) and MREC, Ministry of Health Malaysia (KKM/NIHSEC/08/0804/P12- 613). Permission to conduct this study is also obtained from the Head of Seremban District Health Office. All participants are required to provide written informed consent prior to data collection. The research findings will be disseminated at journals and conference presentations.
    Study name: Seremban Cohort Study (SECOST)
    Matched MeSH terms: Alcohol Drinking
  15. Yi S, Ngin C, Peltzer K, Pengpid S
    Subst Abuse Treat Prev Policy, 2017 06 26;12(1):32.
    PMID: 28651601 DOI: 10.1186/s13011-017-0117-2
    BACKGROUND: Heavy drinking among university students has been globally recognized as a major public health burden. In the Association of Southeast Asian Nations (ASEAN) region, studies on this issue have been scant, country-specific and in different time frames. The aim of this study was to identify social and behavioral factors associated with binge drinking among university students in nine ASEAN countries.

    METHODS: This cross-sectional study was conducted in 2015 among 8809 undergraduate university students from 13 universities in Cambodia, Indonesia, Laos, Malaysia, Myanmar, the Philippines, Singapore, Thailand and Vietnam using self-administered questionnaire. Multivariate logistic regression analyses were conducted to explore the associated factors.

    RESULTS: More than half (62.3%) of the study sample were female with a mean age of 20.5 (SD = 2.0) years. Of total, 12.8% were infrequent (

    Matched MeSH terms: Alcohol Drinking in College/psychology*; Binge Drinking/epidemiology*; Binge Drinking/psychology*
  16. Yang C, Guadamuz TE, Lim SH, Koe S, Wei C
    LGBT Health, 2016 Apr;3(2):168-74.
    PMID: 26789393 DOI: 10.1089/lgbt.2014.0041
    We explored factors associated with alcohol use before or during sex among a sample of 10,861 men who have sex with men (MSM) in Asia who were recruited online for the study. Multinomial logistic regression analysis indicated that having sex under the influence of alcohol was associated with having multiple male partners, seeking partners primarily through gay bar/gym/dance party/friends, selling sex and using multiple drugs during the past 6 months, and unprotected anal sex. More efforts are needed to better assess alcohol use and misuse among MSM in Asia and understand contextual influences on alcohol use and HIV-related behaviors in order to implement culturally-specific interventions.
    Matched MeSH terms: Alcohol Drinking
  17. Yajima I
    Nihon Eiseigaku Zasshi, 2017;72(1):49-54.
    PMID: 28154361 DOI: 10.1265/jjh.72.49
    Several experimental studies on hygiene have recently been performed and fieldwork studies are also important and essential tools. However, the implementation of experimental studies is insufficient compared with that of fieldwork studies on hygiene. Here, we show our well-balanced implementation of both fieldwork and experimental studies of toxic-element-mediated diseases including skin cancer and hearing loss. Since the pollution of drinking well water by toxic elements induces various diseases including skin cancer, we performed both fieldwork and experimental studies to determine the levels of toxic elements and the mechanisms behind the development of toxic-element-related diseases and to develop a novel remediation system. Our fieldwork studies in several countries including Bangladesh, Vietnam and Malaysia demonstrated that drinking well water was polluted with high concentrations of several toxic elements including arsenic, barium, iron and manganese. Our experimental studies using the data from our fieldwork studies demonstrated that these toxic elements caused skin cancer and hearing loss. Further experimental studies resulted in the development of a novel remediation system that adsorbs toxic elements from polluted drinking water. A well-balanced implementation of both fieldwork and experimental studies is important for the prediction, prevention and therapy of toxic-element-mediated diseases.
    Matched MeSH terms: Drinking Water/adverse effects*; Drinking Water/analysis*
  18. Yadav KK, Kumar S, Pham QB, Gupta N, Rezania S, Kamyab H, et al.
    Ecotoxicol Environ Saf, 2019 Oct 30;182:109362.
    PMID: 31254856 DOI: 10.1016/j.ecoenv.2019.06.045
    In low concentration, fluoride is considered a necessary compound for human health. Exposure to high concentrations of fluoride is the reason for a serious disease called fluorosis. Fluorosis is categorized as Skeletal and Dental fluorosis. Several Asian countries, such as India, face contamination of water resources with fluoride. In this study, a comprehensive overview on fluoride contamination in Asian water resources has been presented. Since water contamination with fluoride in India is higher than other Asian countries, a separate section was dedicated to review published articles on fluoride contamination in this country. The status of health effects in Asian countries was another topic that was reviewed in this study. The effects of fluoride on human organs/systems such as urinary, renal, endocrine, gastrointestinal, cardiovascular, brain, and reproductive systems were another topic that was reviewed in this study. Different methods to remove fluoride from water such as reverse osmosis, electrocoagulation, nanofiltration, adsorption, ion-exchange and precipitation/coagulation were introduced in this study. Although several studies have been carried out on contamination of water resources with fluoride, the situation of water contamination with fluoride and newly developed technology to remove fluoride from water in Asian countries has not been reviewed. Therefore, this review is focused on these issues: 1) The status of fluoride contamination in Asian countries, 2) health effects of fluoride contamination in drinking water in Asia, and 3) the existing current technologies for defluoridation in Asia.
    Matched MeSH terms: Drinking Water
  19. Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, et al.
    Int J Cancer, 2015 Oct 15;137(8):1953-66.
    PMID: 25866035 DOI: 10.1002/ijc.29559
    Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment versus the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), 0.91 (0.63-1.30), respectively, (ptrend  = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
    Matched MeSH terms: Alcohol Drinking/epidemiology*
  20. Wong YL
    JUMMEC, 2002;7:59-61.
    The majority of migrant workers studied in this survey were males Muslims from Bangladesh. The mean age was 30 and the majority were aged between 21-30 years. Although almost all of them had 7-13 years of schooling, the majority were working in the service industry. More than two thrids of the migrant workers were provided with various forms of housing by their employers. Majority of them stated that they had better amenities, such as piped drinking water and sanitary toilets, in Malaysia compared to those in their home countries. From their reports, it appears that the majority did not engage in risk behaviours such as, smoking, alcohol and drug abuse.
    Matched MeSH terms: Drinking
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