Displaying publications 1 - 20 of 52 in total

Abstract:
Sort:
  1. Azira NM, Zeehaida M
    Asian Pac J Trop Biomed, 2011 Apr;1(2):164-5.
    PMID: 23569750 DOI: 10.1016/S2221-1691(11)60018-X
    Ocular toxocariasis is prevalent among children. The symptoms and signs may mimic other ocular pathologies such as malignancies and other infectious diseases (such as toxoplasmosis and syphilis). We presented a case of progressive blurring of vision in a single eye of a 9-year-old boy. The presence of anti-toxocara antibody in serum samples helps to confirmation the diagnosis in our patient. Despite of treatment, the boy had lost his vision on the affected eye.
    Matched MeSH terms: Eye Infections, Parasitic/immunology; Eye Infections, Parasitic/parasitology*
  2. Chong PP, Tung CH, Rahman NA, Yajima M, Chin FW, Yeng CL, et al.
    Acta Ophthalmol, 2014 Nov;92(7):e569-79.
    PMID: 25043991 DOI: 10.1111/aos.12427
    The aim of the study was to determine the prevalence of human papillomavirus (HPV) in primary and recurrent pterygia samples collected from different ethnic groups in the equatorial Malay Peninsula.
    Matched MeSH terms: Eye Infections, Viral/ethnology; Eye Infections, Viral/virology*
  3. Rahman ZA, Harun A, Hasan H, Mohamed Z, Noor SS, Deris ZZ, et al.
    Eye Contact Lens, 2013 Sep;39(5):355-60.
    PMID: 23982472 DOI: 10.1097/ICL.0b013e3182a3026b
    Ocular surface infections that include infections of conjunctiva, adnexa, and cornea have the potential risk of causing blindness within a given population. Empirical antibiotic therapy is usually initiated based on epidemiological data of common causative agents. Thus, the aims of this study were to determine the bacterial agents and their susceptibility patterns of isolates from ocular surface specimens in our hospital.
    Matched MeSH terms: Eye Infections, Bacterial/drug therapy; Eye Infections, Bacterial/microbiology*
  4. Höllhumer R, Zairani Mz A, Watson S
    Cornea, 2016 Sep;35(9):1255-6.
    PMID: 27227396 DOI: 10.1097/ICO.0000000000000889
    PURPOSE: Syphilitic interstitial keratitis is a stromal inflammatory disease with characteristic secondary vascularization. This case illustrates a late complication of hemorrhagic Descemet membrane detachment.

    METHODS: Case report.

    RESULTS: The patient presented with painless sudden visual loss and progressive shallowing of the anterior chamber caused by hemorrhagic Descemet membrane detachment. She had corneal neovascularization and a positive syphilis serology. Owing to the risk of pupil block glaucoma, the patient had surgical drainage of the blood via an ab externo approach.

    CONCLUSIONS: This case illustrates a previously unreported complication of syphilitic interstitial keratitis. The patient recovered good visual acuity and had residual pigment deposits in the pre-Descemet interface.

    Matched MeSH terms: Eye Infections, Bacterial/diagnosis; Eye Infections, Bacterial/microbiology*; Eye Infections, Bacterial/therapy
  5. Norina TJ, Raihan S, Bakiah S, Ezanee M, Liza-Sharmini AT, Wan Hazzabah WH
    Singapore Med J, 2008 Jan;49(1):67-71.
    PMID: 18204773
    Corneal ulceration remains one of the major causes of blindness in developing countries, including Malaysia. Our objective is to determine the epidemiological characteristics, clinical features, risk factors and the aetiology of microbial keratitis in patients admitted to Hospital Universiti Sains Malaysia (HUSM).
    Matched MeSH terms: Eye Infections, Bacterial/diagnosis*; Eye Infections, Fungal/diagnosis*
  6. Chew FL, Soong TK, Shin HC, Samsudin A, Visvaraja S
    J Ocul Pharmacol Ther, 2010 Apr;26(2):219-22.
    PMID: 20415627 DOI: 10.1089/jop.2009.0077
    To report the treatment of therapy-resistant Pseudomonas aeruginosa keratitis with topical piperacillin/tazobactam.
    Matched MeSH terms: Eye Infections, Bacterial/drug therapy*; Eye Infections, Bacterial/physiopathology
  7. Jeevanan J, Gendeh BS, Faridah HA, Vikneswaran T
    Med J Malaysia, 2006 Mar;61(1):106-8.
    PMID: 16708746 MyJurnal
    A case of rhino-orbito-cerebral mucormycosis is presented showing its aggressive nature and progression of disease. The typical clinical features, neuroimaging and histological findings are highlighted in this report. Amphotericin B and surgical debridement remain the mainstay of treatment. However, associated co-morbidities need to be addressed.
    Matched MeSH terms: Eye Infections, Fungal/diagnosis*; Eye Infections, Fungal/microbiology; Eye Infections, Fungal/surgery*
  8. Chen KJ, Chou HD, Teh WM
    Ophthalmol Retina, 2019 10;3(10):887.
    PMID: 31585711 DOI: 10.1016/j.oret.2019.05.023
    Matched MeSH terms: Eye Infections, Fungal/diagnosis*; Eye Infections, Fungal/microbiology
  9. Reddy SC, Tajunisah I
    Ann Ophthalmol (Skokie), 2008;40(1):39-44.
    PMID: 18556981
    Fifty-six contact lens-related corneal ulcers (central in 32; hypopyon in 24 and stromal abscess in 6) were studied. Culture was positive in 78.9%. Corneal ulcers healed with intense antibiotic therapy in nearly all patients. Increased awareness of lens care/disinfection and frequent replacement of storage cases and solution, and early detection of pathogens and intensive appropriate antibiotic therapy are key points in management.
    Matched MeSH terms: Eye Infections, Bacterial/drug therapy; Eye Infections, Bacterial/microbiology*
  10. Teh SW, Mok PL, Abd Rashid M, Bastion MC, Ibrahim N, Higuchi A, et al.
    Int J Mol Sci, 2018 Feb 13;19(2).
    PMID: 29438279 DOI: 10.3390/ijms19020558
    Ocular microbial infection has emerged as a major public health crisis during the past two decades. A variety of causative agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may result in loss of visual function in patients if early and effective treatments are not received. The conventional therapeutic approaches to treat vision impairment and blindness resulting from microbial infections involve antimicrobial therapy to eliminate the offending pathogens or in severe cases; by surgical methods and retinal prosthesis replacing of the infected area. In cases where there is concurrent inflammation, once infection is controlled, anti-inflammatory agents are indicated to reduce ocular damage from inflammation which ensues. Despite advances in medical research; progress in the control of ocular microbial infections remains slow. The varying level of ocular tissue recovery in individuals and the incomplete visual functional restoration indicate the chief limitations of current strategies. The development of a more extensive therapy is needed to help in healing to regain vision in patients. Stem cells are multipotent stromal cells that can give rise to a vast variety of cell types following proper differentiation protocol. Stem cell therapy shows promise in reducing inflammation and repairing tissue damage on the eye caused by microbial infections by its ability to modulate immune response and promote tissue regeneration. This article reviews a selected list of common infectious agents affecting the eye; which include fungi; viruses; parasites and bacteria with the aim of discussing the current antimicrobial treatments and the associated therapeutic challenges. We also provide recent updates of the advances in stem cells studies on sepsis therapy as a suggestion of optimum treatment regime for ocular microbial infections.
    Matched MeSH terms: Eye Infections/drug therapy; Eye Infections/therapy*
  11. Muslim A, Fong MY, Mahmud R, Sivanandam S
    Trop Biomed, 2013 Dec;30(4):727-30.
    PMID: 24522144 MyJurnal
    A case of human eye infection caused by Brugia pahangi was reported in 2010 in a semi rural village in Selangor, peninsular Malaysia. Our report here reveals results of investigation on the vector and animal host for the transmission of the infection. We conducted entomological survey and cat blood examination in the vicinity of the patient's home. The mosquito species Armigeres subalbatus was incriminated as the vector, whereas cat served as the reservoir host.
    Matched MeSH terms: Eye Infections, Parasitic/diagnosis*; Eye Infections, Parasitic/parasitology
  12. Khan NA, Anwar A, Siddiqui R
    Curr Med Chem, 2018 May 10.
    PMID: 29745319 DOI: 10.2174/0929867325666180510125633
    BACKGROUND: First discovered in the early 1970s, Acanthamoeba keratitis has remained a major eye infection and presents a significant threat to the public health, especially in developing countries. The aim is to present a timely review of our current understanding of the advances made in this field in a comprehensible manner and includes novel concepts and provides clear directions for immediate research priorities.

    METHOD: We undertook a search of bibliographic databases for peer-reviewed research literature and also summarized our published results in this field.

    RESULTS: The present review focuses on novel diagnostic and therapeutic strategies in details which can provide access to management and treatment of Acanthamoeba keratitis. This coupled with the recently available genome sequence information together with high throughput genomics technology and innovative approaches should stimulate interest in the rational design of preventative and therapeutic measures. Current treatment of Acanthamoeba keratitis is problematic and often leads to infection recurrence. Better understanding of diagnosis, pathogenesis, pathophysiology and therapeutic regimens, would lead to novel strategies in treatment and prophylaxis.

    Matched MeSH terms: Eye Infections
  13. Ho HC, Liew OH, Teh SS, Hanizasurana H, Ibrahim M, Shatriah I
    Clin Ophthalmol, 2015;9:553-6.
    PMID: 25848206 DOI: 10.2147/OPTH.S82204
    Rhino-orbital-cerebral mucormycosis (ROCM) is an uncommon but fatal fungal infection. We report a rare case of unilateral ROCM with ipsilateral central retinal artery occlusion and contralateral choroiditis, which later progressed to endogenous fungal endophthalmitis. The patient was successfully treated with sinuses debridement, systemic liposomal amphotericin B, and intravitreal amphotericin B. The endophthalmitis completely resolved with good vision, but the ROCM eye remained blind due to central retinal artery occlusion.
    Matched MeSH terms: Eye Infections, Fungal
  14. Shankar Ganesh, K.
    Jurnal Veterinar Malaysia, 2017;29(2):25-26.
    MyJurnal
    The livestock industry has been relying merely on chemically synthesized antibiotic for eye infections as sprays and ointment. A natural remedy from Curcuma spp. has been tested for efficacy in curing keratoconjunctivitis and uveitis. A severe case of uveitis has been cured within 7 days, with impaired vision restored. These results are observations of a preliminary study conducted in a goat with uveitis.
    Matched MeSH terms: Eye Infections
  15. Tajunisah I, Reddy SC
    Ann Ophthalmol (Skokie), 2007;39(1):57-62.
    PMID: 17914207
    We report a case of unilateral acute retinal necrosis (ARN) with marked vitritis and retinal necrosis leading to retinal breaks following chicken pox successfully treated with intravenous acyclovir followed by oral acyclovir, orbital floor triamcinolone injections to contain the inflammation, and barrier laser therapy to secure the retinal breaks with good visual outcome. This case is unusual in its severity and the novel use orbital floor triamcinolone therapy to contain ARN inflammation.
    Matched MeSH terms: Eye Infections, Viral/diagnosis; Eye Infections, Viral/etiology; Eye Infections, Viral/virology
  16. Tajunisah I, Reddy SC
    Compr Ther, 2007;33(1):25-31.
    PMID: 17984490
    Acute retinal necrosis (ARN) is known to occur in conjunction with primary varicella or chickenpox infection. The majority of ARN cases reported in the literature were of milder form with mild to moderate vitritis, limited retinitis, and rare occurrence of retinal breaks or detachment that responded well to intravenous acyclovir, with or without oral prednisolone. We report a case of unilateral ARN with marked vitritis and retinal necrosis leading to retinal breaks following chickenpox in a 32-year-old healthy lady. This patient was successfully treated with intravenous acyclovir followed by oral acyclovir and orbital floor triamcinolone injections to contain the inflammation with barrier laser therapy to secure the retinal breaks with good visual outcome. This case is unusual in its severity, and to our knowledge, orbital floor triamcinolone therapy was not used earlier to contain ARN inflammation.
    Matched MeSH terms: Eye Infections, Viral/drug therapy; Eye Infections, Viral/etiology*
  17. Embong Z, Wan Hitam WH, Yean CY, Rashid NH, Kamarudin B, Abidin SK, et al.
    BMC Ophthalmol, 2008;8:7.
    PMID: 18445283 DOI: 10.1186/1471-2415-8-7
    The sensitivity and specificity of 18S rRNA polymerase chain reaction (PCR) in the detection of fungal aetiology of microbial keratitis was determined in thirty patients with clinical diagnosis of microbial keratitis.
    Matched MeSH terms: Eye Infections, Fungal/diagnosis*
  18. Adam Zafdri Md Zali, Rashidah Iberahim
    MyJurnal
    Pseudomonas aeruginosa and Staphylococcus aureus are types of bacteria known to cause bacterial keratitis. Pseudomonas aeruginosa causes bacterial keratitis by adhering to the surface of the contact lenses, when the P. aeruginosa are in contact with the eye, resulting in infectious keratitis. As for Staphylococcus aureus, when there is a predisposing factor such as wearing expired or extended use of contact lenses (contact lenses that can be used continually for up to one week even while sleeping) weaken the individual defences and leads to the development of bacterial keratitis. Both bacteria are capable to infect eye cornea and lead to bacterial keratitis through contact lenses wearer. The findings of this study provide information on the importance of routine practices in handling contact lenses to help reduce the incidence of bacterial keratitis caused by wear contact lenses in an individual. The side effect of wearing contact lenses such as redness of the eye and keratitis due to the infection by pathogenic bacteria which comes from the behavior and low hygiene level management of individual had led the study to create awareness to contact lenses wearer. In this study, 25 soft and hard contact lenses with purposed for colored or toric contact lenses were obtained among UiTM Negeri Sembilan students. The users required to answer the questionnaire form regarding the type, behavior, and routine practices of their contact lenses. Pathogenic bacteria were isolated using the cotton swab technique and cultured on nutrient broth. The streak technique was used to cultured bacteria from broth to nutrient agar, blood agar, and MacConkey agar. Later, the identification of bacteria was carried out using biochemical tests and microscopic observation. From the laboratory results, 84% of the tested contact lenses contained pathogenic bacteria on their surface. These findings concluded that the presences of pathogenic microorganisms on the contact lenses used closely related to the behavior in handling and hygenic practices level by the contact lenses users.
    Matched MeSH terms: Eye Infections, Bacterial
  19. Kah TA, Yong KC, Rahman RA
    BMC Ophthalmol, 2011;11:30.
    PMID: 22044440 DOI: 10.1186/1471-2415-11-30
    To report a case of disseminated fusariosis with endogenous endophthalmitis in a patient with acute lymphoblastic leukemia. Transfusion-associated immune modulation secondary to platelet transfusion could play an important role in the pathophysiology of this case.
    Matched MeSH terms: Eye Infections, Fungal/etiology*
  20. Kusrini E, Sabira K, Hashim F, Abdullah NA, Usman A, Putra N, et al.
    Acta Ophthalmol, 2021 Mar;99(2):e178-e188.
    PMID: 32701190 DOI: 10.1111/aos.14541
    PURPOSE: Contact lenses have direct contact with the corneal surface and can induce sight-threatening infection of the cornea known as Acanthamoeba keratitis. The objective of this study was to evaluate the dysprosium-based nanoparticles (Dy-based NPs), namely Fe3 O4 -PEG-Dy2 O3 nanocomposites and Dy(OH)3 nanorods, as an active component against Acanthamoeba sp., as well as the possibility of their loading onto contact lenses as the drug administering vehicle to treat Acanthamoeba keratitis (AK).

    METHODS: The Dy-based NPs were synthesized, and they were loaded onto commercial contact lenses. The loading content of the NPs and their release kinetics was determined based on the absorbance of their colloidal solution before and after soaking the contact lenses. The cytotoxicity of the NPs was evaluated, and the IC50 values of their antiamoebic activity against Acanthamoeba sp. were determined by MTT colorimetric assay, followed by observation on the morphological changes by using light microscopy. The mechanism of action of the Dy-based NPs against Acanthamoeba sp. was evaluated by DNA laddering assays.

    RESULTS: The loading efficiencies of the Dy-based NPs onto the contact lens were in the range of 30.6-36.1% with respect to their initial concentration (0.5 mg ml-1 ). The Dy NPs were released with the flux approximately 5.5-11 μg cm-2  hr-1 , and the release was completed within 10 hr. The emission of the NPs consistently showed a peak at 575 nm due to Dy3+ ion, offering the possible monitoring and tracking of the NPs. The SEM images indicated the NPs are aggregated on the surface of the contact lenses. The DNA ladder assay suggested that the cells underwent DNA fragmentation, and the cell death was due most probably to necrosis, rather than apoptosis. The cytotoxicity assay of Acanthamoeba sp. suggested that Fe3 O4 -PEG, Fe3 O4 -PEG-Dy2 O3 , Dy(NO3 )3 .6H2 O and Dy(OH)3 NPs have an antiamoebic activity with the IC50 value being 4.5, 5.0, 9.5 and 22.5 μg ml-1 , respectively.

    CONCLUSIONS: Overall findings in this study suggested that the Dy-based NPs can be considered as active antiamoebic agents and possess the potential as drugs against Acanthamoeba sp. The NPs could be loaded onto the contact lenses; thus, they can be potentially utilized to treat Acanthamoeba keratitis (AK).

    Matched MeSH terms: Eye Infections, Bacterial/microbiology; Eye Infections, Bacterial/pathology; Eye Infections, Bacterial/prevention & control*
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links