Displaying publications 1 - 20 of 1134 in total

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  1. Yang P, Chen Y, Huang Z, Xia H, Cheng L, Wu H, et al.
    Elife, 2022 Oct 06;11.
    PMID: 36200862 DOI: 10.7554/eLife.80127
    Despite the importance of innate immunity in invertebrates, the diversity and function of innate immune cells in invertebrates are largely unknown. Using single-cell RNA-seq, we identified prohemocytes, monocytic hemocytes, and granulocytes as the three major cell-types in the white shrimp hemolymph. Our results identified a novel macrophage-like subset called monocytic hemocytes 2 (MH2) defined by the expression of certain marker genes, including Nlrp3 and Casp1. This subtype of shrimp hemocytes is phagocytic and expresses markers that indicate some conservation with mammalian macrophages. Combined, our work resolves the heterogenicity of hemocytes in a very economically important aquatic species and identifies a novel innate immune cell subset that is likely a critical player in the immune responses of shrimp to threatening infectious diseases affecting this industry.
    Matched MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
  2. A'qilah Ahmad Dahalan, Azali Saudi, Jumat Sulaiman
    MyJurnal
    Mobile robots often have to discover a path of collision-free towards a specific goal point in their environment. We are trying to resolve the mobile robot problem iteratively by means of numerical technique. It is built on a method of potential field that count on the use of Laplace’s equation in the mobile robot’s configuration space to constrain/which reduces the generation of a potential function over regions. This paper proposed an iterative approach in solving robot path finding problem known as Accelerated Over-Relaxation (AOR). The experiment shows that these suggested approach can establish a smooth path between the starting and goal points by engaging with a finite-difference technique. The simulation results also show that a more rapidly solution with smoother path than the previous work is achieved via this numerical approach.
    Matched MeSH terms: Family Characteristics
  3. Pan Y, Ong EC
    Xenobiotica, 2017 Oct;47(10):923-932.
    PMID: 27690753 DOI: 10.1080/00498254.2016.1244370
    1. This article aims to evaluate the potentials of using cytochrome P450 2W1 (CYP2W1) as a biomarker and a drug target of cancer because of its characteristic cancer-specific expression. 2. Discrepant findings comparing the expression levels of CYP2W1 in cancer and non-cancer samples were reported. In general, the expression followed a developmental pattern. The demethylation status of CpG island and the expression levels of CYP2W1 genes was positively correlated. 3. CYP2W1 was able to activate several procarcinogens, anticancer pro-drugs and to metabolise many endogenous substances including fatty acids and lysophospholipids. 4. CYP2W1 expression level was suggested to serve as an independent prognostic biomarker in colorectal cancer and hepatocellular carcinoma. The correlation of genetic polymorphisms of CYP2W1 and cancer risk was uncertain. 5. Further characterisation of CYP2W1 structure is suggested to link to its functions. More studies are warranted to reveal the true status and the regulation of CYP2W1 expression across normal and cancer tissues. Catalytic activity of CYP2W1 should be tested on a wider spectrum of endogenous and exogenous substances before its use as the drug target. Larger size of clinical samples can be included to verify the potential of CYP2W1 as the prognostic or cancer risk biomarker.
    Matched MeSH terms: Cytochrome P450 Family 2/metabolism*
  4. Hasniah AL, Jamalludin AR, Norrashidah AW, Norzila MZ, Asiah K, Anida AR, et al.
    World J Pediatr, 2012 Feb;8(1):38-42.
    PMID: 22105571 DOI: 10.1007/s12519-011-0279-3
    Sleep-disordered breathing (SDB) is common but often underdiagnosed in children. The Pediatric Sleep Questionnaire developed by University of Michigan, USA (English UM PSQ) has high sensitivity and specificity in identifying children with sleep-disordered breathing. This study aimed to translate and adapt the English UM PSQ into Malay language as a screening tool to assess SDB among the Malay speaking population. The second objective was to determine the psychometric measurements of the translated UM PSQ (Malay UM PSQ).
    Matched MeSH terms: Family
  5. Maizatul-Suriza M, Dickinson M, Idris AS
    World J Microbiol Biotechnol, 2019 Feb 27;35(3):44.
    PMID: 30810828 DOI: 10.1007/s11274-019-2618-9
    Bud rot disease is a damaging disease of oil palm in Colombia. The pathogen responsible for this disease is a species of oomyctes, Phytophthora palmivora which is also the causal pathogen of several tropical crop diseases such as fruit rot and stem canker of cocoa, rubber, durian and jackfruit. No outbreaks of bud rot have been reported in oil palm in Malaysia or other Southeast Asian countries, despite this particular species being present in the region. Analysis of the genomic sequences of several genetic markers; the internal transcribe spacer regions (ITS) of the ribosomal RNA gene cluster, beta-tubulin gene, translation elongation factor 1 alpha gene (EF-1α), cytochrome c oxidase subunit I & II (COXI and COXII) gene cluster along with amplified fragment length polymorphism (AFLP) analyses have been carried out to investigate the genetic diversity and variation of P. palmivora isolates from around the world and from different hosts in comparison to Colombian oil palm isolates, as one of the steps in understanding why this species of oomycetes causes devastating damage to oil palm in Latin America but not in other regions. Phylogenetic analyses of these regions showed that the Colombian oil palm isolates were not separated from Malaysian isolates. AFLP analysis and a new marker PPHPAV, targeting an unclassified hypothetical protein, was found to be able to differentiate Malaysian and Colombian isolates and showed a clear clade separations. Despite this, pathogenicity studies did not show any significant differences in the level of aggressiveness of different isolates against oil palm in glasshouse tests.
    Matched MeSH terms: Multigene Family
  6. Subramanian AP, Jaganathan SK, Mandal M, Supriyanto E, Muhamad II
    World J Gastroenterol, 2016 Apr 21;22(15):3952-61.
    PMID: 27099438 DOI: 10.3748/wjg.v22.i15.3952
    AIM: To investigate the inhibitory action of diet-derived phenolic compound gallic acid (GA) against HCT-15 colon cancer cells.
    METHODS: The antiproliferative effect of GA against colon cancer cells was determined by performing thiazolyl blue tetrazolium bromide (MTT) assay. The colony forming ability of GA treated colon cancer cells was evaluated using the colony forming assay. The cell cycle changes induced by GA in HCT-15 cells were analyzed by propidium iodide staining. Levels of reactive oxygen species (ROS) and mitochondrial membrane potential of HCT-15 exposed to GA was assessed using 2',7'-dichlorfluorescein-diacetate and rhodamine-123 respectively, with the help of flow cytometry. Morphological changes caused by GA treatment in the colon cancer cells were identified by scanning electron microscope and photomicrograph examination. Apoptosis was confirmed using flow cytometric analysis of GA treated HCT-15 cells after staining with Yo-Pro-1.
    RESULTS: MTT assay results illustrated that GA has an inhibitory effect on HCT-15 cells with IC50 value of 740 μmol/L. A time-dependent inhibition of colony formation was evident with GA treatment. Cell cycle arrest was evident from the accumulation of GA treated HCT-15 cells at sub-G1 phase (0.98 ± 1.03 vs 58.01 ± 2.05) with increasing exposure time. Flow cytometric analysis of GA treated HCT-15 cells depicted early events associated with apoptosis like lipid layer breakage and fall in mitochondrial membrane potential apart from an increase in the generation of ROS which were in a time dependent manner. SEM and photomicrograph images of the GA-treated cells displayed membrane blebbing and cell shrinking characteristics of apoptosis. Further apoptosis confirmation by Yo-Pro-1 staining also showed the time-dependent increase of apoptotic cells after treatment.
    CONCLUSION: These results show that GA induced ROS dependent apoptosis and inhibited the growth of colon cancer cells.
    KEYWORDS: Apoptosis; Cell cycle; Colon cancer; Gallic acid; Lipid layer break; Reactive oxygen species
    Matched MeSH terms: Family Characteristics
  7. Karim R
    World Health Forum, 1998;19(4):365-8.
    PMID: 10050161
    The author reflects on 24 years of involvement in WHO activities, and their effect on her own life and on the maternal and child health services in Malaysia.
    Matched MeSH terms: Family Planning Services/trends
  8. World Dev Forum, 1987 Nov 30;5(21):1-2.
    PMID: 12269045
    Throughout India and China, South Korea and Taiwan, Pakistan and Malaysia, the same sentiment recurs: "The birth of girl is an occasion for gloom, not cheer, for bitterness, not pleasure." In all these countries "patriarchal traditions and social stigmas" make females the unwanted sex, reports Asiaweek. The tragic result: prenatal gender tests are flourishing. And for many women, if the test indicates a female, they abort. In India, sex tests and abortions are legal, cheap and readily available. Some 1500 sex-tested girls are aborted annually in Bombay alone. In China, abortions are legal, but gender tests strictly forbidden. Says one official: We cannot afford to let people know what sex the fetus is because all the girls would be aborted." Yet the numbers of baby girls in China have been reduced--and illicit gender tests and female infanticide are considered partly to blame. In South Korea, gender tests have been banned and most abortions are illegal, but "clandestine tests" are available, and according to the government some 30,000 pregnancies are terminated annually. The number of aborted females is not known, but birth ratios have shown "an alarming swing towards males" in recent years. Can laws and education change the social attitudes against girls in these Asian countries? Indian activist Vibhuti Patel, a lobbyist for stronger controls over sex-testing, hopes so. She urges a "continuous campaign" to fight the "centuries-old values" that encourages gender tests. Says Patel: Nothing less than the very survival of women is at stake."
    Matched MeSH terms: Family Planning Services
  9. World AIDS Day Newsl, 1994;?(2):3.
    PMID: 12287964
    PIP: Five positive and negative experiences of families dealing with AIDS are recounted. Imrat in Malaysia is an HIV-infected son who was not rejected by his family. Prudence of Botswana is an infected widow with five children who had a less positive experience with her in-laws, while Eric of Sweden considers his friends to constitute his family. His relationships with friends have only strengthened since his HIV-positive status became known. Mary of Zimbabwe, however, was infected with HIV by her husband. She was formerly angry at him for having brought home the virus, but they have since stop quarreling and are focusing upon building a stronger relationship. Finally, the brief story of Juan in Colombia is told. Thirty-two years old, married, and with a 17-month old daughter, Juan did not tell his wife that he was actively bisexual. Once infected with HIV, Juan's wife threw him out, more because he had sex with men than because of his HIV serostatus.
    Matched MeSH terms: Family Characteristics*; Family Relations*
  10. Javaid MU, Bano S, Mirza MZ, Isha ASN, Nadeem S, Jawaid A, et al.
    Work, 2019;64(3):551-561.
    PMID: 31658088 DOI: 10.3233/WOR-193016
    BACKGROUND: Psychological conditions are experiences of the conscious and unconscious elements of the work context, which revolve around workers' perceptions of feeling either engaged or disengaged with the assigned tasks. In the psychosocial work environment of hazardous industries like petrochemicals where production lasts twenty-four hours a day and continues seven-days-a-week, a psychologically available worker is extremely important. Psychological availability refers to when workers who are physically, emotionally and psychologically engaged at the moment of performing tasks.

    OBJECTIVE: The broad objective of this study was to investigate the direct and indirect effects of behavioral factors on the psychological and physiological health of workers.

    METHODS: The latest, second generation technique, which is structural equation modeling, is used to identify the relationships between behavioral antecedents and health outcomes. A total of 277 technical workers participated, aged between 20 and 49 and were healthy in all aspects.

    RESULTS: The study results showed quantitative demands, emotional demands, work-family conflict, and job insecurity were significantly associated with both psychological (stress) and physiological (Body Mass Index) factors. The social support of colleagues produced mixed findings with direct and indirect paths. Stress also significantly mediates the psychosocial factors and burnout of the workers.

    CONCLUSION: The study concluded that workers were physically available, but they experienced distractions as members of social systems, affecting their physiological and psychological health.

    Matched MeSH terms: Family Conflict
  11. Karim Ghani WA, Rusli IF, Biak DR, Idris A
    Waste Manag, 2013 May;33(5):1276-81.
    PMID: 23415709 DOI: 10.1016/j.wasman.2012.09.019
    Tremendous increases in biodegradable (food waste) generation significantly impact the local authorities, who are responsible to manage, treat and dispose of this waste. The process of separation of food waste at its generation source is identified as effective means in reducing the amount food waste sent to landfill and can be reused as feedstock to downstream treatment processes namely composting or anaerobic digestion. However, these efforts will only succeed with positive attitudes and highly participations rate by the public towards the scheme. Thus, the social survey (using questionnaires) to analyse public's view and influencing factors towards participation in source separation of food waste in households based on the theory of planned behaviour technique (TPB) was performed in June and July 2011 among selected staff in Universiti Putra Malaysia, Serdang, Selangor. The survey demonstrates that the public has positive intention in participating provided the opportunities, facilities and knowledge on waste separation at source are adequately prepared by the respective local authorities. Furthermore, good moral values and situational factors such as storage convenience and collection times are also encouraged public's involvement and consequently, the participations rate. The findings from this study may provide useful indicator to the waste management authorities in Malaysia in identifying mechanisms for future development and implementation of food waste source separation activities in household programmes and communication campaign which advocate the use of these programmes.
    Matched MeSH terms: Family Characteristics
  12. Ogiri IA, Sidique SF, Talib MA, Abdul-Rahim AS, Radam A
    Waste Manag Res, 2019 Jul;37(7):755-762.
    PMID: 30967098 DOI: 10.1177/0734242X19842328
    To encourage recycling in Malaysian households, a waste separation at source programme was implemented that made it mandatory for households to sort their waste into different categories before leaving it out for collection. Penalties designed to act as a deterrent are imposed on households that fail to sort their waste appropriately. But does this deterrence motivate compliance with the programme directives? This study employs the deterrence theory to investigate if deterrence alone is sufficient to motivate households to actively participate in recycling. A total of 866 questionnaires were administered in person in households in Putrajaya and Melaka. Data were analysed using structural equation modelling. The results of the structural model reveal that just 25% of the variance in compliance is explained by the severity of the sanction, and the perceived certainty of penalty imposed. Perceived severity of sanction (β = 0.149, p = 0.012) and perceived certainty of sanction (β = 0.383, p = 0.000) were found to contribute significantly to compliance behaviour to the programme directives. However, deterrence alone cannot motivate household participation in waste separation at source because it only explains 25% of compliance behaviour. The present study provides information that could allow policymakers to understand recycling habits better and implement more effective compliance strategies.
    Matched MeSH terms: Family Characteristics*
  13. PMID: 6677001
    Matched MeSH terms: Family Planning Services
  14. Jaganathan S, Toung OP, Yee PL, Yew TD, Yoon CP, Keong LB
    Virol J, 2011;8:437.
    PMID: 21914166 DOI: 10.1186/1743-422X-8-437
    Porcine circovirus type 2 is the primary etiological agent associated with a group of complex multi-factorial diseases classified as Porcine Circovirus Associated Diseases (PCVAD). Sporadic cases reported in Malaysia in 2007 caused major economic losses to the 2.2 billion Malaysian ringgit (MYR) (approximately 0.7 billion US dollar) swine industry. The objective of the present study was to determine the association between the presence of PCV2 and occurrences of PCVAD.
    Matched MeSH terms: Multigene Family
  15. Ozawa S, Wonodi C, Babalola O, Ismail T, Bridges J
    Vaccine, 2017 11 07;35(47):6429-6437.
    PMID: 29037575 DOI: 10.1016/j.vaccine.2017.09.079
    BACKGROUND: Understanding and ranking the reasons for low vaccination uptake among parents in northern Nigeria is critical to implement effective policies to save lives and prevent illnesses. This study applies best-worst scaling (BWS) to rank various factors affecting parents' demand for routine childhood immunization.

    METHODS: We conducted a household survey in Nahuche, Zamfara State in northern Nigeria. Nearly two hundred parents with children under age five were asked about their views on 16 factors using a BWS technique. These factors focused on known attributes that influence the demand for childhood immunization, which were identified from a literature review and reviewed by a local advisory board. The survey systematically presented parents with subsets of six factors and asked them to choose which they think are the most and least important in decisions to vaccinate children. We used a sequential best-worst analysis with conditional logistic regression to rank factors.

    RESULTS: The perception that vaccinating a child makes one a good parent was the most important motivation for parents in northern Nigeria to vaccinate children. Statements related to trust and social norms were ranked higher in importance compared to those that highlighted perceived benefits and risks, healthcare service, vaccine information, or opportunity costs. Fathers ranked trust in the media and views of their leaders to be of greatest importance, whereas mothers placed greater importance on social perceptions and norms. Parents of children without routine immunization ranked their trust in local leaders about vaccines higher in considerations, and the media's views lower, compared to parents with children who received routine immunization.

    CONCLUSIONS: Framing immunization messages in the context of good parenting and hearing these messages from trusted information sources may motivate parental uptake of childhood vaccines. These results are useful to policymakers to prioritize resources in order to increase awareness and demand for childhood immunization.

    Matched MeSH terms: Family Characteristics
  16. Tumin M, Mohd Satar NH, Zakaria RH, Raja Ariffin RN, Soo-Kun L, Kok-Peng N, et al.
    Urol J, 2015 Sep 04;12(4):2245-50.
    PMID: 26341766
    PURPOSE: This study explores the factors affecting the willingness of dialysis patients' family members to become involved in living and deceased organ donation.

    MATERIALS AND METHODS: We utilize cross sectional data on 350 family members of dialysis patients collected through self-administered survey from June to October 2013. The factors affecting willingness to become deceased and living organ donors among respondents were identified by running logistic regressions.

    RESULTS: The findings reveal that ethnicity, education and role in family are significant factors explaining will­ingness for living donation, while ethnicity, knowledge of organ donation and donor age drive willingness for deceased donation. We also find that the reasons of respondents being unwilling to donate center on the lack of information and family objections for deceased donation, while being medically unfit, scared of surgery and family objections are the reasons for unwillingness to donate living organs.

    CONCLUSION: In light of our findings, educational efforts are suggested to decrease the reluctance to become in­volved in living and deceased donation.

    Matched MeSH terms: Family/psychology*
  17. NURUL NADHILAH FEIZAL, SHAHNAZ ISMAIL, WAN ZURIATI WAN ZAKARI, NADIA MOHD NAWI
    MyJurnal
    The advancement of technology in digital revolution such as Internet of Things has gained attention in all over the world. This myriad of technology innovations affects all aspects of the human lives today. The generation who has grown up during this era, knownastheiGens,mostlyreliesonthetechnologyineveryaspectoftheirlives,including education. Thus, technology also gives profound impact in educational transformation nowadays to convey innovative education. However, lack of innovation in education becomes a challenge to meet this demand. Therefore, this study was carried out with the aim to discover factors which may affect academic performance of the iGen students in the university. A total of 250 self-administered questionnaires were distributed to the accountingstudentsatUMTwitharesponserateof93.6%(234).Usingmultipleregression analysis, the findings showed that parental involvement and student’s attitude contribute more towards academic performance of iGen students rather than the technology itself. This finding showed that human factor such as support fromtheir parents and individual factor are vital towards their academic performance regardless of from technology savvy generation or not.
    Matched MeSH terms: Family Characteristics
  18. LEONG JIA Q, WAN ZALIHA WAN SEMBOK
    MyJurnal
    Pineapple is one of the most important commercial fruit crops served in fresh-cut form which is convenientfor the consumers. However, fresh-cut pineapple induces the activity of phenolic compounds which triggers the generation of brown or dark pigments. Browning incidence (BI) directly influences the fruit’s acceptability and marketability. Therefore, different exposure times (5mins, 10mins, 15mins and 20mins)and typesof LED lights (white, red and blue) were applied on fresh-cut pineapple stored at 5oC storage for twelve days to reduce BI. A significant interaction between the two factors was recorded in lightness coefficient, chroma, total phenolic and ascorbic acid (AA)contents. Regardless of exposure times, all types of LED lights, mainly the blue light, succeeded in delaying BI in fresh-cut pineapple. In conclusion, blue light had a tendency todelay BI andmaintaintheother postharvest quality attributes of fresh-cut pineapple.
    Matched MeSH terms: Family Characteristics
  19. NUR SYUHADA IBRAHIM, ZIKRI MUHAMMAD, JUMADIL SAPUTRA
    MyJurnal
    Industrial development plays the most important role inthe degradationof the global environment. In line with this issue, most universities in the world have introduced environmentalmanagement to increase awarenessamong young generation towards the environment. Therefore, this study is employed to examine the influences of hygiene practices, awareness and involvement levels towards environmentalhygiene among UMT students. The design of this study is quantitative using cross-sectionaldata collectedfrom students at residential colleges in Universiti Malaysia Terengganu. A total of 120 respondents participatedbut only data from 100 students could be used for further analysis after the datascreening process. The result of this study showed that the level of awareness of UMT students on environmental issues could be categorized as moderate. Besides that, this study found that the level of awareness had significant positive influences on environmentalhygiene. Meanwhile, hygiene practices and the level of involvement did not have significant influences on environmentalhygiene. In addition, using the findings of this study, we suggest that the stakeholders of UMT increase the hygiene practice and involvement among young generation to increase the level of awareness regarding environmental hygiene.
    Matched MeSH terms: Family Characteristics
  20. Jahanfar S, Jaffar SH
    Twin Res Hum Genet, 2013 Feb;16(1):246-7.
    PMID: 23110917 DOI: 10.1017/thg.2012.80
    The National Malaysian Twin Registry was established in Royal College of Medicine, Perak, University Kuala Lumpur (UniKL) in June 2008 through a grant provided by UniKL. The general objective is to facilitate scientific research involving participation of twins and their family members in order to answer questions of health and wellbeing relevant to Malaysians. Recruitment is done via mass media, poster, and pamphlets. We now have 266 adult and 204 children twins registered. Several research projects including reproductive health study of twins and the role of co-bedding on growth and development of children are carried out. Registry holds annual activities for twins and seeks to provide health-related information for twins. We seek international collaboration.
    Matched MeSH terms: Family
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