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Fulltext Synthesis and Anti-Pancreatic Cancer Activity Studies of Novel 3-Amino-2-hydroxybenzofused 2-Phospha-γ-lactones

Balam SK, Soora Harinath J, Krishnammagari SK, Gajjala RR, Polireddy K, Baki VB, et al.

ACS Omega, 2021 May 04;6(17):11375-11388.
PMID: 34056293 DOI: 10.1021/acsomega.1c00360

A series of 3-amino-2-hydroxybenzofused 2-phosphalactones (4a-l) has been synthesized from the Kabachnik-Fields reaction via a facile route from a one-pot three-component reaction of diphenylphosphite with various 2-hydroxybenzaldehyes and heterocyclic amines in a new way of expansion. The in vitro anti-cell proliferation studies by MTT assay have revealed them as potential Panc-1, Miapaca-2, and BxPC-3 pancreatic cell growth inhibitors, and the same is supported by molecular docking, QSAR, and ADMET studies. The MTT assay of their SAHA derivatives against the same cell lines evidenced them as potential HDAC inhibitors and identified 4a, 4b, and 4k substituted with 1,3-thiazol, 1,3,4-thiadiazol, and 5-sulfanyl-1,3,4-thiadiazol moieties on phenyl and diethylamino phenyl rings as potential ones. Additionally, the flow cytometric analyses of 4a, 4b, and 4k against BxPC-3 cells revealed compound 4k as a lead compound that arrests the S phase cell cycle growth at low micromolar concentrations. The ADMET properties have ascertained their inherent pharmacokinetic potentiality, and the wholesome results prompted us to report it as the first study on anti-pancreatic cancer activity of cyclic α-aminophosphonates. Ultimately, this study serves as a good contribution to update the existing knowledge on the anticancer organophosphorus heterocyclic compounds and elevates the scope for generation of new anticancer drugs. Further, the studies like QSAR, drug properties, toxicity risks, and bioactivity scores predicted for them have ascertained the synthesized compounds as newer and potential drug candidates. Hence, this study had augmented the array of α-aminophosphonates by adding a new collection of 3-amino-2-hydroxybenzofused 2-phosphalactones, a class of cyclic α-aminophosphonates, to it, which proved them as potential anti-pancreatic cancer agents.

Matched MeSH terms: Family Characteristics
Influences of women empowerment indices on demand for childcare services: Evidence from the Nigeria Demographic and Health Surveys

Dejun Z, Remi RA, Mouchun Y, Romanus O, Mihajlo J

Afr J Reprod Health, 2023 Oct 31;27(10):65-80.
PMID: 37915165 DOI: 10.29063/ajrh2023/v27i10.6

This study examined the effect of various dimensions of women's empowerment on childcare use in Nigeria, utilizing information from five rounds of the National Demographic and Health Surveys. The analysis made use of both binary and multinomial logistic regression. The findings show that women who share household choices with their spouses were more likely to undertake postnatal care for their babies in either private or public hospitals compared to self-medication/others/traditional. Also, women who owned houses and those who participate in economic activities are significantly more inclined to use postnatal services for babies in health facilities. By implication, women empowerment is a significant factor to consider in improving childcare services in Nigeria. This suggests that in order to improve the health of children, women's inputs in household decision-making should be accommodated, while efforts should be made to enhance household socioeconomic position, and support mothers to have formal education. The findings also suggest that promoting women's empowerment can play a crucial role in increasing the demand for formal childcare services.

Matched MeSH terms: Family Characteristics
The survival of influenza A(H1N1)pdm09 virus on 4 household surfaces

Oxford J, Berezin EN, Courvalin P, Dwyer DE, Exner M, Jana LA, et al.

Am J Infect Control, 2014 Apr;42(4):423-5.
PMID: 24679569 DOI: 10.1016/j.ajic.2013.10.016

We investigated the survival of a pandemic strain of influenza A H1N1 on a variety of common household surfaces where multiple samples were taken from 4 types of common household fomite at 7 time points. Results showed that influenza A H1N1sw virus particles remained infectious for 48 hours on a wooden surface, for 24 hours on stainless steel and plastic surfaces, and for 8 hours on a cloth surface, although virus recovery from the cloth may have been suboptimal. Our results suggest that pandemic influenza A H1N1 can survive on common household fomites for extended periods of time, and that good hand hygiene and regular disinfection of commonly touched surfaces should be practiced during the influenza season to help reduce transmission.

Matched MeSH terms: Family Characteristics*
Fulltext Childhood Cryptosporidium infection among aboriginal communities in Peninsular Malaysia

Al-Mekhlafi HM, Mahdy MA, 'Azlin MY, Fatmah MS, Norhayati M

Ann Trop Med Parasitol, 2011 Mar;105(2):135-43.
PMID: 21396250 DOI: 10.1179/136485911X12899838683368

Cryptosporidium is a coccidian parasite that is prevalent worldwide, some species of which cause morbidity in both immunocompromised and immunocompetent individuals. The prevalence and predictors of Cryptosporidium infection, and its effect on nutritional status, have recently been explored among 276 children (141 boys and 135 girls, aged 2-15 years) in aboriginal (Orang Asli) villages in the Malaysian state of Selangor. Faecal smears were examined by the modified Ziehl-Neelsen staining technique while socio-economic data were collected using a standardized questionnaire. Nutritional status was assessed by anthropometric measurements. Cryptosporidium infection, which was detected in 7.2% of the aboriginal children, was found to be significantly associated with low birthweight (≤2.5 kg), being part of a large household (with more than seven members) and prolonged breast feeding (>2 years). The output of a binary logistic regression confirmed that large household size was a significant predictor of Cryptosporidium infection (giving an odds ratio of 2.15, with a 95% confidence interval of 1.25-5.02). Cryptosporidium infection is clearly a public-health problem among the aboriginal children of Selangor, with person-to-person the most likely mode of transmission.

Matched MeSH terms: Family Characteristics
Design considerations in the estimation of intraclass correlation

Donner A, Koval JJ

Ann. Hum. Genet., 1982 07;46(3):271-7.
PMID: 7125598 DOI: 10.1111/j.1469-1809.1982.tb00718.x

The design of family studies to estimate the value of an intraclass correlation coefficient p is considered when ni individuals are to be selected from each of k families, i = 1, 2, ..., k. In particular, the accuracy of a balance design (ni = n, i = 1, 2, ..., k) for estimating p is compared with the accuracy of an unbalanced "natural" design, in which the ni are sampled at random from family size distributions that tend to occur in practice. It is found for two different estimators of p that the balanced design is usually preferable, but only to a small degree if the number of families sampled is greater than 50.

Matched MeSH terms: Family Characteristics*
Ability to Pay for Future National Health Financing Scheme among Malaysian Households

Aizuddin AN, Aljunid SM

Ann Glob Health, 2017 11 21;83(3-4):654-660.
PMID: 29221542 DOI: 10.1016/j.aogh.2017.10.002

BACKGROUND: Malaysia is no exception to the challenging health care financing phenomenon of globalization.
OBJECTIVES: The objective of the present study was to assess the ability to pay among Malaysian households as preparation for a future national health financing scheme.
METHODS: This was a cross-sectional study involving representative samples of 774 households in Peninsular Malaysia.
FINDINGS: A majority of households were found to have the ability to pay for their health care. Household expenditure on health care per month was between MYR1 and MYR2000 with a mean (standard deviation [SD]) of 73.54 (142.66), or in a percentage of per-month income between 0.05% and 50% with mean (SD) 2.74 (5.20). The final analysis indicated that ability to pay was significantly higher among younger and higher-income households.
CONCLUSIONS: Sociodemographic and socioeconomic statuses are important eligibility factors to be considered in planning the proposed national health care financing scheme to shield the needed group from catastrophic health expenditures.

Matched MeSH terms: Family Characteristics*
Fulltext Ethanol Induces Microglial Cell Death via the NOX/ROS/PARP/TRPM2 Signalling Pathway

Sha'fie MSA, Rathakrishnan S, Hazanol IN, Dali MHI, Khayat ME, Ahmad S, et al.

Antioxidants (Basel), 2020 Dec 09;9(12).
PMID: 33317056 DOI: 10.3390/antiox9121253

Microglial cells are the primary immune cell resident in the brain. Growing evidence indicates that microglial cells play a prominent role in alcohol-induced brain pathologies. However, alcohol-induced effects on microglial cells and the underlying mechanisms are not fully understood, and evidence exists to support generation of oxidative stress due to NADPH oxidases (NOX_-mediated production of reactive oxygen species (ROS). Here, we investigated the role of the oxidative stress-sensitive Ca2+-permeable transient receptor potential melastatin-related 2 (TRPM2) channel in ethanol (EtOH)-induced microglial cell death using BV2 microglial cells. Like H2O2, exposure to EtOH induced concentration-dependent cell death, assessed using a propidium iodide assay. H2O2/EtOH-induced cell death was inhibited by treatment with TRPM2 channel inhibitors and also treatment with poly(ADP-ribose) polymerase (PARP) inhibitors, demonstrating the critical role of PARP and the TRPM2 channel in EtOH-induced cell death. Exposure to EtOH, as expected, led to an increase in ROS production, shown using imaging of 2',7'-dichlorofluorescein fluorescence. Consistently, EtOH-induced microglial cell death was suppressed by inhibition of NADPH oxidase (NOX) as well as inhibition of protein kinase C. Taken together, our results suggest that exposure to high doses of ethanol can induce microglial cell death via the NOX/ROS/PARP/TRPM2 signaling pathway, providing novel and potentially important insights into alcohol-induced brain pathologies.

Matched MeSH terms: Family Characteristics
Nutritional assessment of rural villages and estates in peninsular Malaysia: Total blood cholesterol values in children, adolescents and adults

Wai TN, Lin KG, Siong TE, Hashim N

Asia Pac J Clin Nutr, 2000 Jun;9(2):115-21.
PMID: 24394397

The present study is unique in the Malaysian context on two counts; first, it employs for the first time a functional group approach (groups based on occupational or economic activity) in the assessment of community nutritional status. Second, the study provides on a nationwide-sampling basis, information on total blood cholesterol (TC) levels in rural children (7.0-12.9 years; n = 1921) and adolescents (13.0-17.9 years; n = 753) which were hitherto unavailable. Total blood cholesterol measurements were performed on 7184 subjects ranging from 7 to 75-years-old (males = 3151; females = 4033) from households in 69 rural villages and seven estates in peninsular Malaysia, which were based on selected multistage random sampling according to the household's involvement in the following economic activities: rice farming, rubber smallholding, coconut smallholding, fishing and employment in estates. In all functional groups, TC values increased with age and there was a distinct gender effect, namely females had higher TC values than males throughout the age spectrum analyzed. Mean TC levels for children and adolescents were in the range 3.85-4.37 mmol/L, rising markedly during adulthood to an overall mean of 4.91 ± 1.13 mmol/L for men and 5.17 ± 1.11 mmol/L for women. In adults (>= 18.0 years), there was marked disparity in mean TC values among the functional groups; males and females from rice households had the lowest mean TC values (4.58 and 4.99 mmol/L, respectively). Individuals at 'high risk' (TC > 6.20 mmol/L) averaged 16.0% in women and 11.6% in men, with women from the fishing, rubber and coconut households particularly affected (17.1-21.1%). When compared to earlier rural TC data reported for closely similar rural communities in the peninsula, the present findings suggest a 'hypercholesterolemic shift' approximating 0.39 mmol/L (15 mg/dL) in the adult population; however, this was not apparent in the children and adolescents from these rural communities.

Matched MeSH terms: Family Characteristics
Fulltext Prevalence of overweight among Malaysian adults from rural communities

Khor GL, Yusof AM, Tee ES, Kandiah M, Lee Huang MS

Asia Pac J Clin Nutr, 1999 Dec;8(4):272-9.
PMID: 24394228

Assessment of the nutritional status of 4054 households from rural communities in Peninsular Malaysia was undertaken from 1992 to 1995. Body mass index (BMI) and waist-to-hip ratio (WHR) were obtained from a self-selected sample of 1854 men and 2741 women aged >= 18 years. The BMI and WHR results are presented according to gender, age groups and type of community as defined by the main occupation, namely, fishing, rice farming, estate work, rubber and coconut small-holding. The mean BMI for men and women of all age groups are 22.5 kg/m2 and 23.8 kg/m2, respectively. The mean BMI for both genders increases with age between 18.0 and 49.9 years, after which the value declines. The prevalence of pre-obese (BMI >= 25.0-29.9 kg/m2) is 19.8% for men and 28.0% for women. The prevalence of obese men and women (>= 30.0 kg/m2) is 4.2% and 11.1%, respectively. The highest prevalence of pre-obese and obese men is found in the age groups of 30.0-49.9 years, while that for women is in the 40.0-49.9 years age group. The prevalence of pre-obesity and obesity is higher in women than in men for every age group. A similar result was indicated by WHR whereby a higher proportion of women (22.5%) than men (5%) for all ages was found to show central obesity. The prevalence of overweight adults is higher when compared with previous studies on subjects from almost similar rural communities. This study indicated that overweight is on the increase in rural communities, especially among female subjects.

Matched MeSH terms: Family Characteristics
Socio-economic determinants of nutritional status of children in rural peninsular Malaysia

Marjan ZM, Taib MN, Lin KG, Siong TE

Asia Pac J Clin Nutr, 1998 Dec;7(3/4):307-10.
PMID: 24393689

The data presented is part of the findings from a four-year collaborative research project between Universiti Putra Malaysia, the Institute for Medical Research and the Ministry of Health Malaysia. The project assessed the nutritional status of the major functional groups in Peninsular Malaysia. Mukim Sayong and Pulau Kemiri in the District of Kuala Kangsar, Perak were two of the subdistricts selected to represent small rubber holdings in Peninsular Malaysia. This paper attempts to analyse the socio-economic profile of the households and the nutritional status of children below 9 years of age. A total of 307 households were studied. Approximately 63% of the households were involved in rubber activities and the majority of them were hired tappers. The average monthly income of the households was RM467 and the income ranged between RM30 to RM2120. Based on the per capita poverty line income of RM84.38, it was found that 14.1% of the households earned less than RM42.19, which can be considered as hard-core poor, while 32.7% were poor (monthly per capita income between RM42.19 and RM84.38). Slightly more than half (52.7%) earned income above the poverty line. The average family size was 4.5, ranging from 1 through to 16. The majority of the heads of households (56.6%) had between 3 and 6 years of education, and 14.5% did not receive any formal education. The prevalence of stunting among children 0-5 years of age was 26%, while 31.5% were underweight and 3.8% wasted. Among children aged between 5 and 9 years, almost the same pattern of nutritional status was noted. The overall percentages of stunting, underweight and wasting among these children were 29.2%, 26.1% and 0.62%, respectively. Analysis on nutritional status according to income level showed a noticeable difference in the prevalence of malnutrition in children above and below the poverty line income. The Student's t-test indicated significant differences in weight-for-age and weight-for-height between the two poverty line income for children below 5 years of age. Pearson's correlation coefficient showed a significant correlation between height-for-age with household size (r = -0.26, p<0.05), and monthly per capita income with weight-for-height (r = 0.25, p<0.05). There was a highly significant correlation between acreage of land cultivated and weight-for-height (r = 0.42, p<0.01), and weight-for-age (r = 0.25, p<0.05). The findings indicated the influence of socio-economic factors on the nutritional status of children.

Matched MeSH terms: Family Characteristics
Fulltext Food variety score is associated with dual burden of malnutrition in Orang Asli (Malaysian indigenous peoples) households: implications for health promotion

Saibul N, Shariff ZM, Lin KG, Kandiah M, Ghani NA, Rahman HA

Asia Pac J Clin Nutr, 2009;18(3):412-22.
PMID: 19786390

This paper reports on the presence of dual burden households in Orang Asli (OA, indigenous people) communities and its associated factors. A total of 182 OA households in two districts in Selangor with the required criteria (182 non-pregnant women of child bearing age and 284 children aged 2-9 years old) participated in the study. Height and weight of both women and children were measured. Energy intake and food variety score (FVS) were determined using three 24-hour diet recalls. While 58% were underweight and 64% of the children were stunted, the prevalence of overweight and obesity in women were 31% and 20% respectively. The percentage of dual burden households (overweight mother/underweight child) was 25.8% while 14.8% households had normal weight mother/normal weight child. The mean food variety score (FVS) was similar for women (7.0+/-2.1) and children (6.9+/-1.9). Dual burden households were associated with women's employment status (OR: 3.18, 95% CI: 2.65-5.66), FVS of children (OR: 0.71, 95% CI: 0.51-0.95) and FVS of women (OR: 1.39, 95% CI: 1.02- 1.89). The FVS of children (OR: 0.49, 95% CI: 0.25-0.89) and women (OR: 1.92, 95% CI: 1.64-2.77) remained significant even when dual burden households were compared to only households with normal weight mother/normal weight child. In these OA communities, food variety may predict a healthier diet in children, but may increase the risk of overweight and obesity in adults. Efforts to address households with dual burden malnutrition should consider promotion of healthy diets and lifestyle for all members.

Matched MeSH terms: Family Characteristics/ethnology
Fulltext Dual forms of malnutrition in the same households in Malaysia--a case study among Malay rural households

Khor GL, Sharif ZM

Asia Pac J Clin Nutr, 2003;12(4):427-37.
PMID: 14672867

This report is a part of a multi-centre study in Asia on the problem of dual forms of malnutrition in the same households. In Malaysia, the prevalence of underweight and stunting persist among young children from poor rural areas. Overweight in adults, especially women from poor rural areas has been reported in recent years. Thus, this study was undertaken in order to assess the presence of the dual burden of underweight child-overweight mother pairs in a poor rural community. Out of 140 Malay households identified to have at least one child aged 1-6 years and mother aged above 20 years, 52.1% of the mothers were overweight, 15.7% of the children were underweight, 27.1% stunted and 5% wasted. Socio-economic background and food intake frequency data were collected from 54 underweight child/overweight mother pairs (UW/OW) and 41 normal weight child/normal weight mother pairs (NW/NW). Compared with the overweight mothers, a higher percentage of the normal weight mothers had received secondary education, were employed and with a higher household monthly income, although these differences were not significant. Patterns of food intake of the mothers and children appeared to have more similarities than differences between the UW/OW and NW/NW groups. Quantitative dietary intakes for 2 days using 24-hr recall and physical activity energy expenditure over the same period were assessed in a sub-group of UW/OW and NW/NW mothers and children. The NW/NW children showed significantly higher intake of total calories, fat and riboflavin than the UW/OW counterparts. Mean energy and nutrient intake of mothers from both groups were not significantly different, although the NW/NW mothers showed higher intake adequacy for total calories and most nutrients. While most of the mothers from both groups reported having no chronic illnesses, about half of the children in both groups had infections, especially gastrointestinal infections, over a 2-week period. Energy expenditure from physical activity for both UW/OW and NW/NW mothers and children did not differ significantly. This study confirmed inadequate intake of total energy and nutrients as the major factor for underweight in Malay children from rural areas. However, assessing intake and physical activity by interview methods were not sensitive enough to overcome perceived problems of under-reporting of energy intake and over-estimation of energy expenditure, especially by overweight subjects. Further investigations on a larger sample are necessary to understand the family dynamics leading to the double burden of malnutrition within the same household.

Matched MeSH terms: Family Characteristics*
Fulltext A profile of injuries in four villages in the Jasin District of Malacca, Malaysia

Htay Moe

Asia Pac J Public Health, 2002;14(2):118-22.
PMID: 12862417

Injuries are a major public health problem in Malaysia. A cross-sectional study on the profile of injuries was conducted in four villages in the Jasin District of Malacca using a prepared questionnaire among the residents. A sample of 199 households was selected from the total of 385 by using the simple random method and personal interviews were carried out. Injuries were common (56%) among the family members within the period of one year prior to the survey. Home and residential injuries were the most common type (60.2%) followed by road traffic injuries and injuries at work place. Among the home injuries (68 cases), falls were the most common type of injuries encountered with most occurring in the evenings within the house compounds. For all types of injuries (113 cases), the majority (46.9%) preferred to seek treatment at government clinics and hospitals. Among the road injuries (29 cases), most occurred in the evenings and at nights. They were more severe in nature and some required admission to the hospital. The extremities were the most severe injuries among the home and road ones. Preventive strategies should be targeted towards the home and road injuries by environmental and behavioural changes together with community participation on injury prevention and control at district level.

Matched MeSH terms: Family Characteristics
Milk tolerance among malnourished school children in Malaysia

Chen ST, Domala Z

Asia Pac J Public Health, 1989;3(4):274-7.
PMID: 2638907 DOI: 10.1177/101053958900300405

1,256 malnourished children, aged seven to ten years, were selected for study, 575 from Kuala Langat, 416 from Wilayah Persekutuan and 265 from Ulu Selangor. Ninety-three percent of the children were from low socioeconomic groups with large family size, and most of their parents had only primary or no formal education. During the study period, children in Kuala Langat received daily milk supplementation for five days per week, those in Wilayah Persekutuan for two days per week, while those in Ulu Selangor did not receive any milk supplementation. The study shows that a majority of the malnourished primary school children liked to drink milk and that milk intolerance was not a problem among them.

Matched MeSH terms: Family Characteristics
A knowledge, attitude and practices (KAP) study on dengue among selected rural communities in the Kuala Kangsar district

Hairi F, Ong CH, Suhaimi A, Tsung TW, bin Anis Ahmad MA, Sundaraj C, et al.

Asia Pac J Public Health, 2003;15(1):37-43.
PMID: 14620496

A cross-sectional survey was conducted to assess the level of knowledge, attitude and practices concerning dengue and its vector Aedes mosquito among selected rural communities in the Kuala Kangsar district from 16-25th June, 2002. It was found that the knowledge of the community was good. Out of the 200 respondents, 82.0% cited that their main source of information on dengue was from television/radio. The respondents' attitude was found to be good and most of them were supportive of Aedes control measures. There is a significant association found between knowledge of dengue and attitude towards Aedes control (p = 0.047). It was also found that good knowledge does not necessarily lead to good practice. This is most likely due to certain practices like water storage for domestic use, which is deeply ingrained in the community. Mass media is an important means of conveying health messages to the public even among the rural population, thus research and development of educational strategies designed to improve behaviour and practice of effective control measures among the villagers are recommended.

Matched MeSH terms: Family Characteristics
Social support and burden among caregivers of patients with dementia in Malaysia

Choo WY, Low WY, Karina R, Poi PJ, Ebenezer E, Prince MJ

Asia Pac J Public Health, 2003;15(1):23-9.
PMID: 14620494 DOI: 10.1177/101053950301500105

This study aims to examine selected factors of dementia patients and their caregivers that were associated with the burden of family caregivers. This cross sectional study involves face-to-face interview with family caregivers of patients with dementia. Participants were recruited through convenient sampling from geriatric and psychiatry outpatient clinics from three government hospitals, one university hospital, one rural health centre and Alzheimer Disease caregivers' support groups. 70 caregivers took part in the study. Measures included patient and caregiver demographic variables and caregiver burden using the Zarit Burden Interview (ZBI). Caregiver burden was found to be significantly associated with both ethnicity and informal support. Chinese caregivers were found to have a higher level of burden compared to Indians and Malays. Informal support, in particular assistance from family members, was significantly associated with a lower burden perceived by the caregivers. However, the study shows that formal support such as assistance from maids and private nurses did not alleviate the burden of caregivers. Results highlighted the importance of improving the coping skills in burdened caregivers particularly among family members with dementia relatives. Interventions should be designed for specific needs of caregivers of different ethnicities.

Matched MeSH terms: Family Characteristics/ethnology
Fulltext Sex preference for children in Thailand and some other South-East Asian countries

Wongboonsin K, Ruffolo VP

Asia Pac Popul J, 1995 Sep;10(3):43-62.
PMID: 12290694
Matched MeSH terms: Family Characteristics
Fulltext Ime course detachment of biofilms in pipes by hydrochlorination

Shanzay, A., Siddra, T. A., Warda, F., Sheeza, A., Maryam, A., Aina, S. Z., et al.

Asian Journal of Medicine and Biomedicine, 2018;1(1):28-31.
MyJurnal

Bacterial biofilms are a complex community of microbes in which the cells are embedded in a polysaccharide matrix.
This slime is a mean of protection in hostile environments. Biofilms in hospital settings are perilous as they not only
make treatment difficult, cause blockage of pipes but are also cause of serious nosocomial infections thus making their
dispersal an even more important phenomenon. Any foaming method is not applicable at all places for the cleaning of
biofilms hence biofilm dispersal by household sweep containing hydrochloric acid was checked using the microliter
plate assay as dispersal strategy. Bacteria from hospital waste disposal pipes were isolated, its ability to form biofilm
was noted under different time intervals and then finally biofilm degradation was done using different concentrations
of household sweep. It was noted that household sweep can be successfully employed at many places especially waste
disposal pipes and acid resistant tubes. Our results indicated that 20% sweep (HCl conc. 1%) if used for only one
minute can reduce the biofilms to 50%. Similarly increasing contact time can reduce the biofilms further.

Matched MeSH terms: Family Characteristics
Tobacco Use Prevention for the Young (TUPY-S): Development, Validity and Reliability of an Interactive Multimedia Strategy from the Adolescents’ Perspective in Malaysia

Mohd Zin F, Hillaluddin AH, Mustaffa J

Asian Pac J Cancer Prev, 2017 05 01;18(5):1435-1443.
PMID: 28612599

Objective: This study aims to develop, validate and determine the reliability of an interactive multimedia strategy
to prevent tobacco use among the young (TUPY-S) from an adolescents’ perspective. Methods: A descriptive study
design was utilized. A modular instruction guideline by Russel (1974) was followed in the entire process, comprising
a feasibility study, a review of existing modules, specification of the objectives, identification of the construct criterion
items, learner analysis and entry behavior specification, establishment of the sequence instruction and media selection,
a tryout with students and a field test. Result: Feasibility was agreed among the researchers and the school authorities.
Culturally suitable rigorously developed tobacco use preventive strategies delivered using information technology (IT)
are lacking in the literature. The objective of TUPY-S is to prevent tobacco use among adolescents living in Malaysia.
Identified construct criterion items include knowledge, attitude, intention to use, self-efficacy, and refusal skill. The target
population was early adolescents belonging to generation-Z. Content was developed from the adolescents’ perspective
and delivered using IT in Malay language. Content validity, assessed by six experts in the field and module development,
was good at 86%. The students’ tryout showed satisfactory face validity subjectively and objectively (85.5%) and
high alpha Cronbach reliability (0.91). Conclusion: TUPY-S was confirmed to suit early adolescents of the current
generation living in Malaysia. It demonstrated good content validity among the experts, satisfactory face validity and
reliability among the target population. TUPY-S is ready to be evaluated for its effectiveness among early adolescents.

Matched MeSH terms: Family Characteristics
Fulltext Individual aspiration or family survival: rural-urban female migration in Malaysia

Kusago T

Asian Pac Migr J, 1998;7(4):483-523.
PMID: 12295220 DOI: 10.1177/011719689800700404

"This paper analyzes the determinants of female migration to export processing zones (EPZs) in Malaysia. A comparison of the individual and household migration models reveals interesting and important contrasting results. First, the role played by the expected net income gains is opposite in the two models: negative in the individual model, positive in the household model. Second, family migration experience is significant in the individual model but not in the household model. Third, attitudes matter to the household decision on a daughter's migration but not in the individual model. These contrasting results suggest that explaining the daughter's migration decision may require more than separation of the individual motives and familial needs."

Matched MeSH terms: Family Characteristics*

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