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Pharmacokinetics of propofol infusion in Asian patients undergoing coronary artery bypass grafting

Lee HS, Khoo YM, Chua BC, Ng AS, Tan SS, Chew SL

Ther Drug Monit, 1995 Aug;17(4):336-41.
PMID: 7482686

The pharmacokinetics of propofol was studied in 11 Asian patients with fentanyl-isoflurane anaesthesia during cardiopulmonary bypass (CPB) and undergoing elective coronary artery bypass grafting (CABG). Instead of the usual increments of morphine and a benzodiazepine, propofol (4 mg/kg/h) was initiated at the start of CPB and ceased at CPB separation. Whole blood propofol concentrations were determined during and postinfusion using high-performance liquid chromatography with fluorescence detection. Data from four patients seemed to fit a two-compartment model, whereas those from seven patients were significantly (F test, p < 0.05) better fitted to a three-compartment model. The pharmacokinetic parameters were as follows: The mean (SD) of the initial distribution phase t1/2 pi, intermediate distribution phase t1/2 alpha, and elimination phase t1/2 beta were 2.22 (1.04) min, 42.9 (16.4) min, and 370 (138) min, respectively. The mean clearance of 1.31 (0.50) L/min was lower than those reported from other studies, whereas the mean blood concentration of 2.2 (1.0) mg/L at the 1-h infusion period was higher. The mean calculated apparent Css was 3.9 (1.5) mg/L. The low clearance is likely to be due to hemodynamic changes during CPB and CABG, thereby affecting drug distribution and blood flow to the liver.

Matched MeSH terms: Indonesia/ethnology
Cytogenetic abnormalities in de novo acute myeloid leukemia in adults: relation to morphology, age, sex and ethnicity - a single center study from Singapore

Enjeti AK, Tien SL, Sivaswaren CR

Hematol. J., 2004;5(5):419-25.
PMID: 15448668

Cytogenetic analysis performed at diagnosis is considered to be the most valuable prognostic factor in acute myeloid leukemia (AML). Large systematic studies of cytogenetic abnormalities in AML patients from Southeast Asia are not available. The karyotypic patterns in AML patients from a single center in Singapore were studied and compared with reports from other regions of the world to identify possible geographic heterogeneity.

Matched MeSH terms: Indonesia/ethnology
Social and behavioral aspects of filariasis transmission in Kumpeh, Jambi, Indonesia

Sudomo M, Kasnodiharjo, Oemijati S

Southeast Asian J. Trop. Med. Public Health, 1993;24 Suppl 2:26-30.
PMID: 7973942

Studies on the social and behavioral aspects of filariasis transmission were conducted in the transmigration area of Kumpeh, in the province of Jambi, Sumatra, Indonesia. Three methods were used in the study namely, interview, participation observation and focus group discussion. A total of 266 respondents (136 males and 130 females) were interviewed. The results of the study showed the most of the transmigrants were not familiar with the word "filariasis". They were more used to the name of "penyakit kaki gajah" or "elephant's leg" disease or "untut". The word "untut" is similar to what people of Selangor, Malaysia call this disease. The community attitude towards control efforts against filariasis was positive, as evidenced by their readiness in being bled and their readiness to help change the environment which serves as mosquito breeding places. Usually the transmigrants live in the "ladang" or dry farming area for 3-4 months to protect their crops from damages by pests. This habit was rather negative, because in their "ladangs" they exposed themselves to high risk of mosquito bites and thus to filariasis infection.

Matched MeSH terms: Indonesia/ethnology
Suicidal Thoughts, Attempts and Motives Among University Students in 12 Muslim-Majority Countries

Eskin M, AlBuhairan F, Rezaeian M, Abdel-Khalek AM, Harlak H, El-Nayal M, et al.

Psychiatr Q, 2019 03;90(1):229-248.
PMID: 30498939 DOI: 10.1007/s11126-018-9613-4

There is a scarcity of research on suicidal phenomena in the Muslim world. Therefore, this study aimed at investigating the self-reported prevalence of suicidal thoughts, attempts and motives in 12 Muslim countries. A total of 8417 (54.4% women) university students were surveyed by means of a self-report questionnaire. Overall, 22% of the participants reported suicidal ideation and 8.6% reported attempting suicide. The odds of suicidal thoughts were elevated in Azerbaijan, Indonesia and Saudi Arabia, while reduced ORs were recorded in Egypt, Jordan, Lebanon and Malaysia. While odds of suicide attempts were high in Azerbaijan, Palestine and Saudi Arabia reduced odds ratios (OR) were detected in Indonesia, Iran, Jordan, Lebanon, Malaysia and Tunisia. Taking drugs and using a sharp instrument were the two most frequently used methods to attempt suicide. Only 32.7% of attempts required medical attention. Escape motives were endorsed more than social motives by participants who attempted suicide. Suicidal behaviors were more frequent in women than in men. Compered to men, fewer attempts by women required medical attention. Moreover, our results show that making suicide illegal does not reduce the frequency of suicidal behavior. Results from this comparative study show that suicidal thoughts and attempts are frequent events in young adults in countries where religious scripture explicitly prohibit suicide and the frequencies of nonfatal suicidal behavior show large variation in nations adhering to the same religion.

Matched MeSH terms: Indonesia/ethnology
Fulltext Pre-employment medical examination of Indonesian domestic helpers in a private clinic in Johor Bahru--an eight year review

Leong CC

Med J Malaysia, 2006 Dec;61(5):592-8.
PMID: 17623961

On review of 3117 patients' records (all were female Indonesian foreign workers over the span of eight years (1997 to 2004 in a private clinic in Johor Bahru, 223 cases (7.2%) were found to have various medical problems. These 3117 foreigners were to be employed as domestic helpers in Malaysia. They were examined upon arrival in Johor Bahru even though our government did not require this pre-requisite (before 1st August 2005) as they were examined and certified fit in their country of origin before embarking to Malaysia. The proportion of female Indonesian foreign workers who were afflicted with category 1 conditions was 55.6% (which rendered them unfit for employment) and category 2 conditions was 44.4%. The medical problem detected most frequently was hypertension. Sixty-one (80.3%) out of 76 workers had stage 2 hypertension (JNC 7 report). Pulmonary tuberculosis ranked second in this review and is a category 1 condition. This paper supports the recent move by the Malaysian Ministry of Health to implement mandatory medical examinations for all foreign workers arriving in Malaysia within one month of arrival regardless of whether or not they are certified fit in their countries of origin.

Matched MeSH terms: Indonesia/ethnology
A survey of geriatric cases in the psychiatric wards--University Hospital admitted in July 1967 to December 1969

Essa M

Med J Malaysia, 1974 Jun;28(4):221-5.
PMID: 4278973
Matched MeSH terms: Indonesia/ethnology
Risk factors for sebaceous gland diseases and their relationship to gastrointestinal dysfunction in Han adolescents

Zhang H, Liao W, Chao W, Chen Q, Zeng H, Wu C, et al.

J Dermatol, 2008 Sep;35(9):555-61.
PMID: 18837699 DOI: 10.1111/j.1346-8138.2008.00523.x

Sebaceous gland diseases are a group of common dermatological diseases with multiple causes. To date, a systematic report of the risk factors for sebaceous gland diseases in adolescents has not been published. The aim of this study was to assess the prevalence and risk factors for certain sebaceous gland diseases (seborrhea, seborrheic dermatitis, acne, androgenetic alopecia and rosacea) and their relationship to gastrointestinal dysfunction in adolescents. From August-October, 2002-2005, a questionnaire survey was carried out to obtain epidemiological data about sebaceous gland diseases. Using random cluster sampling, 13 215 Han adolescents aged 12-20 years were recruited from four countries or districts (Macau; Guangzhou, China; Malaysia; and Indonesia). The statistical software SPSS ver. 13.0 was used to analyze the data. The prevalence of seborrhea, seborrheic dermatitis, acne, androgenetic alopecia and rosacea was 28.27%, 10.17%, 51.03%, 1.65% and 0.97%, respectively. Based on multivariate logistic regression analysis, the risk factors for sebaceous gland diseases included: age; duration of local residency; halitosis; gastric reflux; abdominal bloating; constipation; sweet food; spicy food; family history of acne; late night sleeping on a daily basis; excessive axillary, body and facial hair; excessive periareolar hair; and anxiety. There was a statistically significant difference in the prevalence of gastrointestinal symptoms (halitosis; gastric reflux; abdominal bloating; constipation) between patients with and without sebaceous gland diseases (chi(2) = 150.743; P = 0.000). Gastrointestinal dysfunction is an important risk factor for diseases of the sebaceous glands and is correlated with their occurrence and development.

Matched MeSH terms: Indonesia/ethnology
Oculogyric spasm in Asian psychiatric in-patients on maintenance medication

Tan CH, Chiang PC, Ng LL, Chee KT

Br J Psychiatry, 1994 Sep;165(3):381-3.
PMID: 7994510

BACKGROUND: The objective was to investigate the occurrence and characteristics of oculogyric spasm (OGS) in an Asian country.
METHOD: All 2035 Asian (88% Chinese, 7% Malays and 5% Indonesians) psychiatric in-patients in the state psychiatric hospital in Singapore were surveyed for occurrence of oculogyric spasm (OGS) over a two-month period.
RESULTS: Thirty-four patients (1.7%) developed OGS (53% male and 47% female). All the 34 patients had been on maintenance antipsychotic drugs for more than five months. Eighteen patients had recurrent attacks. The mean chlorpromazine equivalent daily dose for those patients with recurrent OGS was 511 mg. This was significantly higher (P < 0.05) than the 277 mg daily dose received by those without recurrent OGS. Most (68%) of the attacks occurred between 1400-2000 h suggesting that OGS may have a diurnal variation.
CONCLUSIONS: OGS presenting as tardive dystonia may be due to a relative increase in cholinergic activity.

Matched MeSH terms: Indonesia/ethnology
Adaptation problems of asian migrants

Hastings J

Aust N Z J Psychiatry, 1977 Dec;11(4):219-21.
PMID: 272878
Matched MeSH terms: Indonesia/ethnology
Fulltext Falciparum Malaria Outbreak in Sabah Linked to an Immigrant Rubber Tapper

Jeffree SM, Ahmed K, Safian N, Hassan R, Mihat O, Lukman KA, et al.

Am J Trop Med Hyg, 2018 Jan;98(1):45-50.
PMID: 29141714 DOI: 10.4269/ajtmh.17-0081

Sabah is a Malaysian state situated in the northern part of Borneo, and it is endemic for malaria. The incidence of malaria is the lowest (0.05/1,000 population) in Penampang districts of Sabah. In June 26, 2012, two Plasmodium falciparum malaria cases were notified to public health department from a village in Penampang. Immediate investigation was initiated to identify the risk factors and to institute control measures. We performed active case finding by asking household members of all houses in the village regarding malaria symptoms and by examining blood smears. Environmental investigation was performed by collecting samples to detect mosquito breeding sites and to identify malaria transmitting vector mosquitoes. A case-control study with a ratio of 1:4 (11 cases and 44 controls) was conducted using self-administered questionnaire. The microscopic examination of blood smear for malarial parasite and entomology sampling was carried out. The malarial attack rate was 2.3%, 6/11 smears have gametocyte, and the case fatality rate was 9.1%. One case was a migrant rubber tapper from Indonesia which happened to be the first case with gametocyte positive. Overall, the incidence of malaria was higher (6/11) among rubber tappers. The odds of cases for those living nearby stagnant water were 7.3 [95% confidence interval: 1.2-43.5] times higher. In conclusion, an outbreak of P. falciparum malaria was introduced into a malaria-free village by a migrant rubber tapper, by whom the imported parasite was introduced to the community via vector Anopheles balabacensis. Living near stagnant water bodies was the risk factor in this outbreak.

Matched MeSH terms: Indonesia/ethnology
Solidarity by demand? Exit and voice in international medical travel - the case of Indonesia

Ormond M

Soc Sci Med, 2015 Jan;124:305-12.
PMID: 24947552 DOI: 10.1016/j.socscimed.2014.06.007

Globally, more patients are intentionally travelling abroad as consumers for medical care. However, while scholars have begun to examine international medical travel's (IMT) impacts on the people and places that receive medical travellers, study of its impacts on medical travellers' home contexts has been negligible and largely speculative. While proponents praise IMT's potential to make home health systems more responsive to the needs of market-savvy healthcare consumers, critics identify it as a way to further de-politicise the satisfaction of healthcare needs. This article draws from work on political consumerism, health advocacy and social movements to argue for a reframing of IMT not as a 'one-off' statement about or an event external to struggles over access, rights and recognition within medical travellers' home health systems but rather as one of a range of critical forms of on-going engagement embedded within these struggles. To do this, the limited extant empirical work addressing domestic impacts of IMT is reviewed and a case study of Indonesian medical travel to Malaysia is presented. The case study material draws from 85 interviews undertaken in 2007-08 and 2012 with Indonesian and Malaysian respondents involved in IMT as care recipients, formal and informal care-providers, intermediaries, promoters and policy-makers. Evidence from the review and case study suggests that IMT may effect political and social change within medical travellers' home contexts at micro and macro levels by altering the perspectives, habits, expectations and accountability of, and complicity among, medical travellers, their families, communities, formal and informal intermediaries, and medical providers both within and beyond the container of the nation-state. Impacts are conditioned by the ideological foundations underpinning home political and social systems, the status of a medical traveller's ailment or therapy, and the existence of organised support for recognition and management of these in the home context.

Matched MeSH terms: Indonesia/ethnology
Factors associated with obesity in Chinese-American children

Chen JL, Kennedy C

Pediatr Nurs, 2005 Mar-Jun;31(2):110-5.
PMID: 15934563

OBJECTIVE:A cross-sectional study design was utilized to examine factors associated with obesity in Chinese-American children.
SUBJECTS:Chinese-American children (8 to 10 years old) and their mothers (N = 68) in California participated in the study.
MEASUREMENTS:Mothers completed demographic information, the Family Assessment Device, Attitudes Toward Child Rearing Scale, and Suinn-Lew Asian Self-identity Acculturation Scale. Children's body mass index was measured, and children completed a self-administered physical activity checklist, Food Frequency Questionnaire, and the Schoolagers' Coping Strategies Inventory.
RESULTS:Results indicated three variables that predicted children's body mass index: older age, a more democratic parenting style, and poor communication (R2=.263, F=8.727, p = .0001). Children whose mothers had a low level of acculturation were also more likely to be overweight than were children whose mothers were highly acculturated.
CONCLUSION:This study revealed that children's ages, a democratic parenting style, and poor family communication contribute to increased body mass index in Chinese-American children. Other factors related to children's BMI and dietary intake include acculturation level of the mother and family affective responses. Future studies should examine the change in BMI over time and in different age groups and why parenting and family communication impact children's body weight.

Matched MeSH terms: Indonesia/ethnology
Fulltext Genome of a middle Holocene hunter-gatherer from Wallacea

Carlhoff S, Duli A, Nägele K, Nur M, Skov L, Sumantri I, et al.

Nature, 2021 Aug;596(7873):543-547.
PMID: 34433944 DOI: 10.1038/s41586-021-03823-6

Much remains unknown about the population history of early modern humans in southeast Asia, where the archaeological record is sparse and the tropical climate is inimical to the preservation of ancient human DNA1. So far, only two low-coverage pre-Neolithic human genomes have been sequenced from this region. Both are from mainland Hòabìnhian hunter-gatherer sites: Pha Faen in Laos, dated to 7939-7751 calibrated years before present (yr cal BP; present taken as AD 1950), and Gua Cha in Malaysia (4.4-4.2 kyr cal BP)1. Here we report, to our knowledge, the first ancient human genome from Wallacea, the oceanic island zone between the Sunda Shelf (comprising mainland southeast Asia and the continental islands of western Indonesia) and Pleistocene Sahul (Australia-New Guinea). We extracted DNA from the petrous bone of a young female hunter-gatherer buried 7.3-7.2 kyr cal BP at the limestone cave of Leang Panninge2 in South Sulawesi, Indonesia. Genetic analyses show that this pre-Neolithic forager, who is associated with the 'Toalean' technocomplex3,4, shares most genetic drift and morphological similarities with present-day Papuan and Indigenous Australian groups, yet represents a previously unknown divergent human lineage that branched off around the time of the split between these populations approximately 37,000 years ago5. We also describe Denisovan and deep Asian-related ancestries in the Leang Panninge genome, and infer their large-scale displacement from the region today.

Matched MeSH terms: Indonesia/ethnology
Legislating separation and solidarity in plural societies: the Chinese in Indonesia and Malaysia

Hwang JC, Sadiq K

Nationalism Ethn Polit, 2010;16(2):192-215.
PMID: 20648997 DOI: 10.1080/13537113.2010.490757

The Chinese minority plays a dominant role in the economies of Indonesia and Malaysia, a fact that evokes indigenous resentment. However, Indonesia and Malaysia dealt differently with the issue. Malaysia legislated the Malays into the economy and protected Chinese citizenship, making them an integral part of a multicultural state. By contrast, New Order Indonesia adopted policies of economic manipulation, forced assimilation, and unequal citizenship. Only when the New Order regime fell did Chinese integration begin. The policy trajectories of Indonesia and Malaysia offer important lessons for plural states.

Matched MeSH terms: Indonesia/ethnology
Potential forensic implications of kerokan therapy - a traditional Indonesian therapy associated with neck bruising

Samberkar PN, Samberkar SP, Byard RW

Med Sci Law, 2020 Oct;60(4):315-318.
PMID: 32501165 DOI: 10.1177/0025802420926867

Kerokan is a traditional Indonesian treatment involving abrading the skin over various parts of the body with a blunt object such as a coin or a piece of ginger which may create suspicious injuries. Here, the case of a 30-year-old woman who had undergone kerokan therapy is reported. She was complaining of retro-sternal pain and epigastric discomfort and subsequently became markedly short of breath and died. The observation of injuries predominantly located around the neck initiated a police investigation and forensic autopsy. Scattered abrasions, blisters and bruises were present on the forehead, the bridge of the nose extending to the ala, the upper and anterior aspect of the chin and the sternal notch, with discrete fresh and scabbed abrasions around the neck, over the sternum and on the backs of both hands. There were, however, no facial or conjunctival petechiae and no bruising of the underlying strap muscles, or fractures of the hyoid bone or thyroid cartilage. Histology revealed that myocarditis was the cause of death. Traditional practices may cause unusual bruises, abrasions, blisters and burns that may raise suspicion of inflicted injury from an assault. Knowledge of the manifestations of socio-ethnic practices such as kerokan is important in the evaluation of trauma in specific cultural groups.

Matched MeSH terms: Indonesia/ethnology
Fulltext Malagasy dialects and the peopling of Madagascar

Serva M, Petroni F, Volchenkov D, Wichmann S

J R Soc Interface, 2012 Jan 07;9(66):54-67.
PMID: 21632612 DOI: 10.1098/rsif.2011.0228

The origin of Malagasy DNA is half African and half Indonesian, nevertheless the Malagasy language, spoken by the entire population, belongs to the Austronesian family. The language most closely related to Malagasy is Maanyan (Greater Barito East group of the Austronesian family), but related languages are also in Sulawesi, Malaysia and Sumatra. For this reason, and because Maanyan is spoken by a population which lives along the Barito river in Kalimantan and which does not possess the necessary skill for long maritime navigation, the ethnic composition of the Indonesian colonizers is still unclear. There is a general consensus that Indonesian sailors reached Madagascar by a maritime trek, but the time, the path and the landing area of the first colonization are all disputed. In this research, we try to answer these problems together with other ones, such as the historical configuration of Malagasy dialects, by types of analysis related to lexicostatistics and glottochronology that draw upon the automated method recently proposed by the authors. The data were collected by the first author at the beginning of 2010 with the invaluable help of Joselinà Soafara Néré and consist of Swadesh lists of 200 items for 23 dialects covering all areas of the island.

Matched MeSH terms: Indonesia/ethnology
The "other" side of labor reform: accounts of incarceration and resistance in the Straits Settlements penal system, 1825-1873

Pieris A

J Soc Hist, 2011;45(2):453-79.
PMID: 22299197

The rhetoric surrounding the transportation of prisoners to the Straits Settlements and the reformative capacity of the penal labor regime assumed a uniform subject, an impoverished criminal, who could be disciplined and accordingly civilized through labor. Stamford Raffles, as lieutenant governor of Benkulen, believed that upon realizing the advantages of the new colony, criminals would willingly become settlers. These two colonial prerogatives of labor and population categorized transportees into laboring classes where their exploitation supposedly brought mutual benefit. The colonized was collectively homogenized as a class of laborers and evidence to the contrary, of politically challenging and resistant individuals was suppressed. This paper focuses on two prisoners who were incriminated during the anti-colonial rebellions of the mid-nineteenth century and were transported to the Straits Settlements. Nihal Singh, a political prisoner from Lahore, was incarcerated in isolation to prevent his martyrdom and denied the supposed benefits of labor reform. Conversely, Tikiri Banda Dunuwille, a lawyer from Ceylon was sent to labor in Melaka as a form of humiliation. Tikiri’s many schemes to evade labor damned him in the eyes of the authorities. The personal histories of these two individuals expose how colonial penal policy recognized and manipulated individual differences during a time of rising anti-colonial sentiment. The experiences of these prisoners, the response of their communities and the voices of their descendents offer us a very different entry point into colonial penal history.

Matched MeSH terms: Indonesia/ethnology
Allele frequencies for the PowerPlex 16 STR loci in Javanese population in Malaysia

Othman MI, Seah LH, Panneerchelvam S, Nor NM

J Forensic Sci, 2004 Jan;49(1):190-1.
PMID: 14979376
Matched MeSH terms: Indonesia/ethnology
Succinic Semialdehyde Dehydrogenase Deficiency in a Chinese Boy: A Novel ALDH5A1 Mutation With Severe Phenotype

Tay CG, Ariffin H, Yap S, Rahmat K, Sthaneshwar P, Ong LC

J Child Neurol, 2015 Jun;30(7):927-31.
PMID: 25122112 DOI: 10.1177/0883073814540523

Succinic semialdehyde dehydrogenase deficiency is a rare autosomal recessive disorder affecting catabolism of the neurotransmitter gamma-aminobutyric acid (GABA), with a wide range of clinical phenotype. We report a Malaysian Chinese boy with a severe early onset phenotype due to a previously unreported mutation. Urine organic acid chromatogram revealed elevated 4-hydroxybutyric acid. Magnetic resonance imaging (MRI) of the brain demonstrated cerebral atrophy with atypical putaminal involvement. Molecular genetic analysis showed a novel homozygous 3-bp deletion at the ALDH5A1 gene c.1501_1503del (p.Glu501del). Both parents were confirmed to be heterozygotes for the p.Glu501del mutation. The clinical course was complicated by the development of subdural hemorrhage probably as a result of rocking the child to sleep for erratic sleep-wake cycles. This case illustrates the need to recognize that trivial or unintentional shaking of such children, especially in the presence of cerebral atrophy, can lead to subdural hemorrhage.

Matched MeSH terms: Indonesia/ethnology
Opium and empire: some evidence from colonial-era Asian stock and commodity markets

Bailey W, Truong L

J Southeast Asian Stud, 2001;32(2):173-93.
PMID: 19192502
Matched MeSH terms: Indonesia/ethnology

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