MyMedR

Stomal recurrence after total laryngectomy: a 10-year review in Universiti Kebangsaan Malaysia Medical Center

bte Abdul Rashid NH, Yunus MR, bte Baki MM, bte Ami M, Athar PP

J Pak Med Assoc, 2012 May;62(5):466-9.

To determine the frequency of stomal recurrence in patients following total laryngectomy in our center and to compare the frequency of previously reported risk factors such as preoperative tracheostomy, subglottic invasion and the level of lymph node metastases, with the rest of the world.

Matched MeSH terms: Laryngeal Neoplasms/pathology*; Laryngeal Neoplasms/surgery*

Fulltext Glottic cancer in a non-smoking patient with laryngopharyngeal reflux

Zainuddin N, Mohd Kornain NK

Malays Fam Physician, 2016;11(2-3):35-37.

PMID: 28461858 MyJurnal

The onset of carcinoma of the larynx, especially of the glottis, is heralded mainly by a change of voice. It has a male preponderance and is almost exclusively common to smokers and patients with heavy alcohol consumption. We report a case of glottic carcinoma in a non-smoker female patient. The only possible risk factor for her is a history of laryngopharyngeal reflux.

Matched MeSH terms: Laryngeal Neoplasms

Fulltext Pseudomonas laryngeal perichondritis: unexpected diagnosis

Zainal Abidin SS, Kew TY, Azman M, Mat Baki M

BMJ Case Rep, 2020 Dec 22;13(12).

PMID: 33370978 DOI: 10.1136/bcr-2020-237129

A 57-year-old male chronic smoker with underlying diabetes mellitus presented with dysphonia associated with cough, dysphagia and reduced effort tolerance of 3 months' duration. Videoendoscope finding revealed bilateral polypoidal and erythematous true and false vocal fold with small glottic airway. The patient was initially treated as having tuberculous laryngitis and started on antituberculous drug. However, no improvement was observed. CT of the neck showed erosion of thyroid cartilage, which points to laryngeal carcinoma as a differential diagnosis. However, the erosion was more diffuse and appeared systemic in origin. The diagnosis of laryngeal perichondritis was made when the histopathological examination revealed features of inflammation, and the tracheal aspirate isolated Pseudomonas aeruginosa The patient made a good recovery following treatment with oral ciprofloxacin.

Matched MeSH terms: Laryngeal Neoplasms/diagnosis

Fulltext Lipoma of vallecula-a case report

Tan KS, Jalaluddin WMS

BJR Case Rep, 2016;2(3):20150460.

PMID: 30459991 DOI: 10.1259/bjrcr.20150460

Lipomas of the larynx, oropharynx and hypopharynx are rare, accounting for approximately 1% of benign laryngeal neoplasms. We present a rare case of a simple lipoma arising from the right vallecula. A 55-year-old male presented with worsening dysphagia for 1 week. CT scan revealed a lesion of fat attenuation in the right vallecula. The patient underwent surgical excision and recovered uneventfully. To our knowledge, there are only two cases of vallecular lipoma that have been reported and they are both of spindle cell subtype and located on the left side. This is the first reported case of a simple lipoma arising from the right vallecula and causing obstructive symptoms. CT scan or MRI is essential in confirming the diagnosis and assessing the extent, thus allowing prompt excision, especially when the patient is symptomatic.

Matched MeSH terms: Laryngeal Neoplasms

Fulltext Microbiome of tracheoesophageal prosthesis: who are they?

Syatirah Abdullah, Janet Quinn, Mohamed EL-Badawey, Nicholas Jakubovics

Malaysian Journal of Medicine and Health Sciences, 2019;15(108):44-44.

MyJurnal

Introduction: Laryngectomy patients undergo voice rehabilitation that requires implantation of trachea-oesophagal speech valves (TESV). Usually, laryngeal cancer patients require insertion of these devices post-operatively to im-prove their quality of life. Implantation of TESV dates back to 1979 by pioneering work of Blom and Singer. There are cases of aspiration of TESV wearer reported, and obstruction of the TESV causes leakage through the valve and is suggested as a main reason for replacement of the device. The dysfunctional failure may be caused by microbial colonization on the valve or physical malfunction and requires immediate replacement is desirable. The aim of this study is to identify the microbial community members of selected TESVs using both culture-independent techniques (Next-generation sequencing) to analyse the microbiota, including unculturable species, and routine microbiology techniques (culture-dependent method) and to obtain representative isolates that can form the basis for experiments to enable increased understanding of the community. Methods: Biofilms were harvested from 16 explanted speech valves from patients visiting the ENT clinic in Freeman Hospital, Newcastle, UK. Routine microbiology techniques (culture-dependent method) including ChromeID® plates and Matrix-Assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) Mass Spectrometry were used for identification of TESV microbiome. Sequencing of the samples was performed at MR DNA (www.mrdnalab.com, USA) on a MiSeq following the manufacturer’s guidelines in order to determine the bacteria and candida composition in the biofilm community. Results: The most frequently isolated fungal species was C. albicans, which was cultured from 11 out of 16 TESVs (79%), followed by five TESVs with C. tropicalis (36%), three TESVs had C. glabrata (21%) and only one TESV contained S. cerevisiae (7%). Interestingly no biofilm communities contained more than two fungal species and 2 TESVs (12%) possessed only bacterial species. There were only 16 species of bacteria cultured and identified by MALDI-TOF MS. This was far lower than the 91 species that were detected by NGS. Species from the genus Lactobacillus were found in 10 of 16 TESVs (63%), the highest frequency of any bacterial genus isolated from TESVs followed by S. aureus found in eight TESVs of 16. S. epidermidis was identified in two TESVs (13%), Streptococcus spp., K. oxytoca and O. anthropi were both identified in five different TESVs, while the gut bacterium E. faecium was found in four TESVs. Only one TESV contained E. coli. Conclusion: TESV biofilm composition was dominated by Candida spp. and occasionally contained other types of eukaryote such as Saccharomycetes. It was not uncommon for more than one Candida species to be present. The biofilms also harboured a mixture of bacteria, with lactic acid producers (Lactobacillus sp. and Streptococcus sp.) normally accompanying Candida sp. in the biofilm.

Matched MeSH terms: Laryngeal Neoplasms

Fulltext Detection of human papillomavirus, p53 and c-erbb-2 protein expression in juvenile laryngeal papillomatosis: a report of 2 cases

Siti Aishah Md Ali, Ilina Isahak, Dahlan Sabi, Fatimah Sahlan, Lokman Saim, Abdullah Sani Mohamed

Medicine & Health, 2006;1(1):67-74.

MyJurnal

The association of human papillomavirus (HPV) with juvenile laryngeal papillomatosis has been well documented. We report two cases of juvenile laryngeal papillomatosis and correlated these cases with presence of HPV, p53 and c-erbB-2 proteins. The first case was a one-year-old male patient and the second a six-year-old female patient. Formalin-fixed paraffin-embedded biopsy specimens were tested for the presence of HPV genome by the technique of in situ hybridisation using wide spectrum and type specific biotinylated probes while the immunohistochemical expression of p53 (D07, 1:50) and c-erbB-2 (DAKO A0485, 1:300) proteins were evaluated with commercially available antibodies. Histologically the tumours in both cases showed papillary configuration of squamous papilloma. The first case detected HPV type 6, HPV type 11 and p53 protein expression while the second case showed only HPV type 6. Both cases of HPV showed positive signals confined to the nuclei in the superficial squamous epithelium. The first case showed p53 positivity seen from the basal region up to one third of the epithelium of laryngeal papillomas and the subsequent recent repeat biopsy showed the positivity of p53 had extended throughout the upper layers of the epithelium. Expression of c-erbB-2 protein was not detected in both cases. These findings were similar as in other studies where follow-up of the cases was recommended since they tend to recur.

Matched MeSH terms: Laryngeal Neoplasms

Construction and analysis of protein-protein interaction network to identify the molecular mechanism in laryngeal cancer

Sarahani Harun, Nurulisa Zulkifle

Sains Malaysiana, 2018;47:2933-2940.

Laryngeal cancer is the most common head and neck cancer in the world and its incidence is on the rise. However, the
molecular mechanism underlying laryngeal cancer pathogenesis is poorly understood. The goal of this study was to
develop a protein-protein interaction (PPI) network for laryngeal cancer to predict the biological pathways that underlie
the molecular complexes in the network. Genes involved in laryngeal cancer were extracted from the OMIM database
and their interaction partners were identified via text and data mining using Agilent Literature Search, STRING and
GeneMANIA. PPI network was then integrated and visualised using Cytoscape ver3.6.0. Molecular complexes in the
network were predicted by MCODE plugin and functional enrichment analyses of the molecular complexes were performed
using BiNGO. 28 laryngeal cancer-related genes were present in the OMIM database. The PPI network associated with
laryngeal cancer contained 161 nodes, 661 edges and five molecular complexes. Some of the complexes were related to
the biological behaviour of cancer, providing the foundation for further understanding of the mechanism of laryngeal
cancer development and progression.

Matched MeSH terms: Laryngeal Neoplasms

Fulltext Carcinoma of the larynx in Malaysia

Sani A, Said H, Lokman S

Med J Malaysia, 1992 Dec;47(4):297-302.

PMID: 1303483

A retrospective study of cases with carcinoma of the larynx seen in the Universiti Kebangsaan Malaysia (UKM) and General Hospital Kuala Lumpur (GHKL) between 1981 to 1988 was performed. The aim was to document the distribution and the pattern of behaviour of this tumour amongst our patients. There were 137 cases, the majority of whom were Chinese (54%). The peak incidence was in the seventh decade and the male to female ratio was 7.6:1. The most common symptom at presentation was hoarseness (90%). The most common histological type was squamous cell carcinoma (87%) whilst by site, transglottic involvement was commonest (55%). The overall 3 year survival rate was 68%. Supraglottic carcinoma behaved differently in that a significantly large number presented with dysphagia (33.3%) and neck nodes (42%). Compared to tumours of other sites of the larynx, they had the poorest 3 year survival rate of 50%. Amongst the T2 and T3 tumours, the results of surgery appeared better than primary radiotherapy. Considering that 26% of patients presented with stridor, 20% with neck nodes and 55% with multiple site involvement, it can be concluded that our patients present themselves late.

Matched MeSH terms: Laryngeal Neoplasms/ethnology; Laryngeal Neoplasms/mortality; Laryngeal Neoplasms/epidemiology*

Laryngeal metastasis from a rectal carcinoma

Ramanathan Y, Rajagopalan R, Rahman NA

Ear Nose Throat J, 2007 Nov;86(11):685-6.

PMID: 18225631

Metastases to the larynx from distant primaries are rare. We report a case of a laryngeal metastasis from a rectal carcinoma.

Matched MeSH terms: Laryngeal Neoplasms/radiography; Laryngeal Neoplasms/secondary*

The floppy vocal polyp

Rahmat O, Prepageran N

Ear Nose Throat J, 2008 Dec;87(12):668-9.

PMID: 19105136

Matched MeSH terms: Laryngeal Neoplasms/complications; Laryngeal Neoplasms/pathology*; Laryngeal Neoplasms/surgery

Fulltext Delayed complication of radiotherapy: laryngeal fibrosis and bilateral vocal cord immobility

Prepageran N, Raman R

Med J Malaysia, 2005 Aug;60(3):377-8.

PMID: 16379198

Radiotherapy is the accepted treatment for early laryngeal carcinomas with the advantage of voice preservation. It is however, not without complications. We report a case of bilateral vocal cord immobility 15 years after radiotherapy. This appears to be due to ankylosis of cricoarytenoid joint and fibrosis of the larynx.

Matched MeSH terms: Laryngeal Neoplasms/radiotherapy*

Fulltext Vocal cord hemangioma

Prasad SC, Prasad KC, Bhat J

Med J Malaysia, 2008 Dec;63(5):419-20.

PMID: 19803307

Laryngeal hemangiomas are relatively rare. Laryngeal hemangiomas occur in two main forms--infantile and adult laryngeal hemangiomas. While infantile hemangiomas are usually found to occur in the subglottis, adult hemangiomas occur commonly in the supraglottic regions of the larynx. Laryngeal hemangioma with cavernous features isolated to the free edge of the vocal fold is a very rare clinical finding. We present a case of hemangioma of the right vocal cord in an adult, which was managed successfully in our center.

Matched MeSH terms: Laryngeal Neoplasms/diagnosis*; Laryngeal Neoplasms/surgery

Fulltext Cutaneous metastases from head and neck squamous cell carcinoma

Poovaneswaran S, Paleri V, Charlton F, Dobrowsky W, Kelly C

Med J Malaysia, 2012 Aug;67(4):430-2.

PMID: 23082459 MyJurnal

The presence of cutaneous metastases in squamous cell carcinomas of the head and neck (SCCHN) is rare and associated with a dismal prognosis. It is vital to distinguish these lesions from direct invasion of the skin by SCCHN or primary cutaneous malignancies as the prognosis is vastly different and so is the management. In this case report, we present four cases of cutaneous metastases and also briefly review the literature pertaining to this phenomenon.

Matched MeSH terms: Laryngeal Neoplasms/pathology*; Laryngeal Neoplasms/therapy

Neurogenous tumour of the larynx (a case report)

Phang WK, Raman R, Jayalaksmi E

J Laryngol Otol, 1987 Nov;101(11):1209-10.

PMID: 3694036

Matched MeSH terms: Laryngeal Neoplasms/diagnosis*; Laryngeal Neoplasms/pathology

Fulltext Laryngeal Leiomyosarcoma: A Rare Case

Ng BHK, Tang IP, Suhashini G, Chai CK

Indian J Otolaryngol Head Neck Surg, 2019 Oct;71(Suppl 1):795-797.

PMID: 31742066 DOI: 10.1007/s12070-018-1553-7

Laryngeal leiomyosarcoma is a rare smooth muscle malignancy of the head and neck region. Diagnosis is based on immunohistochemistry. Here we present a case of laryngeal leiomyosarcoma that was diagnosed and treated in our center, focusing on the clinical features, histological diagnosis and management of this rare disease.

Matched MeSH terms: Laryngeal Neoplasms

Malignant Transformation of Juvenile Recurrent Respiratory Papillomatosis

Muhammad Fauzi HG, Mohan Singh AS, Abdul Rahim S, Chooi LL, Ramasamy V, Mohamad Pakarul Razy NH, et al.

Gulf J Oncolog, 2021 May;1(36):79-81.

PMID: 35017141

Malignant transformation of recurrent respiratory papillomatosis (RRP) is a rare entity occurring in only less than 5% of patients with RRP. The risk of transformation can arise even in the absence of risk factors such as smoking and radiation. We describe a patient with juvenile RRP diagnosed since childhood, who suffered malignant transformation into a squamous cell carcinoma after 29 years. Keywords: Recurrent respiratory papillomatosis; laryngeal neoplasms; squamous cell carcinoma; human papilloma-virus.

Matched MeSH terms: Laryngeal Neoplasms*

Feasibility of Salvage Selective Neck Dissection after Primary Irradiation of Pharyngeal and Laryngeal Carcinoma

Mat Lazim N, Abdullah K, Karakullukcu B, Tan IB

ORL J Otorhinolaryngol Relat Spec, 2018;80(1):10-18.

PMID: 29428959 DOI: 10.1159/000486371

INTRODUCTION: The concept of neck dissection (ND) in the management armamentarium of head and neck squamous cell carcinoma has evolved throughout the years. Nowadays, ND becomes more functional.

METHODOLOGY: A retrospective study of 865 patients was performed at Netherlands Cancer Institute-Antoni Van Leeuwenhoek Hospital to investigate the feasibility of selective ND (SND). All patients with squamous cell carcinoma of the pharynx and larynx who received primary radiation and underwent salvage ND were included in the study.

RESULT: A total of 29 NDs were analyzed. In 17 neck sides, viable metastases were found (58%), whereas in the other 12 specimens there were no viable metastases. In 16 of the 17 necks (94%), the metastases were located either in level II, III, or IV or in a combination of these 3 levels. Level V was involved in only 1 case (6%).

CONCLUSION: It is well justified to perform a salvage SND (levels II, III, and IV) for pharyngeal and laryngeal carcinoma after primary radiation. In carefully selected cases of supraglottic and oropharyngeal carcinoma, a superselective ND also appears as an efficient option.

Matched MeSH terms: Laryngeal Neoplasms/radiotherapy; Laryngeal Neoplasms/surgery*

Prevention of aspiration following recurrent dislodgement of voice prosthesis: a patient's innovation

Masaany M, Marina MB, Asma A, Sani A

J Laryngol Otol, 2009 Jun;123(6):680-2.

PMID: 18544175 DOI: 10.1017/S0022215108002958

To demonstrate a simple, practical, cheap method of preventing potentially fatal aspiration of a dislodged voice prosthesis; this method was developed by a laryngectomised patient.

Matched MeSH terms: Laryngeal Neoplasms/radiotherapy; Laryngeal Neoplasms/surgery

Fulltext A rare case of primary extranodal laryngeal non hodgkin lymphoma

Mark P., Najihah Hanim A., Eshamsol Kamar O., Suhaila A., Irfan M.

International Medical Journal Malaysia, 2018;17(3):85-88.

MyJurnal

Lymphoma is generally a nodal disease and arises from lymphoid tissues or organs. Extranodal lymphoma accounts for almost a third of malignant lymphomas. Squamous cell carcinoma accounts for 90 % of laryngeal carcinoma, while extranodal Non Hodgkin Lymphoma (NHL) attributes only less than 1% of laryngeal neoplasms. Less than 100 of such cases been reported in literature since 1952. As to our best knowledge, no such case was ever reported in our country. We report a case of a 58-year-old gentleman who presented the typical history of laryngeal malignancy however the pathology turned out to be as NHLof Diffuse Large B-cell subtype.

Matched MeSH terms: Laryngeal Neoplasms

Fulltext Triple primary cancers of the larynx, lung and thyroid presenting in one patient

Iqbal FR, Sani A, Gendeh BS, Aireen I

Med J Malaysia, 2008 Dec;63(5):417-8.

PMID: 19803306 MyJurnal

Patients with multiple malignant primary tumours are often described, based on their chronology of presentation, as simultaneous, synchronous or metachronous tumours. Lung malignancies presenting in association with head and neck tumours are well documented while there have been small series of thyroid synchronous cancers presenting with laryngeal lesions in literature. No cases, to our knowledge, have been reported in literature of a single patient with all three laryngeal, lung and thyroid malignancies. We report one such case of a 71-year-old Chinese man who had undergone a total laryngectomy for a recurrent cancer of the larynx only to be found to have tumours of the lung and thyroid in the post-operative period and he eventually died of post-operative complications. We also discuss screening for lung and thyroid malignancies in patients with head and neck squamous cell carcinoma (SCC).

Matched MeSH terms: Laryngeal Neoplasms/diagnosis*; Laryngeal Neoplasms/surgery

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