Displaying publications 1 - 20 of 69 in total

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  1. Mat Ariffin N, Islahudin F, Kumolosasi E, Makmor-Bakry M
    BMC Infect Dis, 2017 12 08;17(1):759.
    PMID: 29216842 DOI: 10.1186/s12879-017-2868-9
    BACKGROUND: Recurrence rates of Plasmodium vivax infections differ across various geographic regions. Interestingly, South-East Asia and the Asia-Pacific region are documented to exhibit the most frequent recurrence incidences. Identifying patients at a higher risk for recurrences gives valuable information in strengthening the efforts to control P. vivax infections. The aim of the study was to develop a tool to identify P. vivax- infected patients that are at a higher risk of recurrence in Malaysia.

    METHODS: Patient data was obtained retrospectively through the Ministry of Health, Malaysia, from 2011 to 2016. Patients with incomplete data were excluded. A total of 2044 clinical P. vivax malaria cases treated with primaquine were included. Data collected were patient, disease, and treatment characteristics. Two-thirds of the cases (n = 1362) were used to develop a clinical risk score, while the remaining third (n = 682) was used for validation.

    RESULTS: Using multivariate analysis, age (p = 0.03), gametocyte sexual count (p = 0.04), indigenous transmission (p = 0.04), type of treatment (p = 0.12), and incomplete primaquine treatment (p = 0.14) were found to be predictors of recurrence after controlling for other confounding factors; these predictors were then used in developing the final model. The beta-coefficient values were used to develop a clinical scoring tool to predict possible recurrence. The total scores ranged between 0 and 8. A higher score indicated a higher risk for recurrence (odds ratio [OR]: 1.971; 95% confidence interval [CI]: 1.562-2.487; p ≤ 0.001). The area under the receiver operating characteristic (ROC) curve of the developed (n = 1362) and validated model (n = 682) was of good accuracy (ROC: 0.728, 95% CI: 0.670-0.785, p value 

    Matched MeSH terms: Life Cycle Stages
  2. Ibrahim Ahmed Alhothily, Nazri Che Dom, Siti Aekbal Salleh, Anila Ali
    MyJurnal
    Introduction: Aedes albopictus is known for its aggressiveness towards human and recently expanded to more coun- tries outside the native regions. Thus, the demographic parameters of Aedes albopictus are important to determine the characteristics of this species mosquitoes in terms of the reproduction rates and dispersal distance. Materials and Methods: This study, was performed using a Shah Alam strain of Aedes albopictus originally collected in twenty district areas of the central zone of Shah Alam. This research applies field work-study with a cross-sectional design to investigate the demographic parameters of Aedes albopictus. The demographic evaluation of Aedes albopictus was conducted under the control environment in insectarium. Results: Investigation on the demographic parameters of Aedes albopictus clearly showed that there is a significance different observed in the total number of mosquito eggs produced in both high and low incidence rate IR areas (p=0.03). In contrast, other parameters showed insignificant value between high and low IR areas. Conclusion: The key to control the mosquito vectors population is by tracking the vector’s life cycle including its survival. Therefore, the outcome of this study may provide as a baseline to esti- mate the dengue outbreak in the current episystem.
    Matched MeSH terms: Life Cycle Stages
  3. MOHD OMAR
    Sains Malaysiana, 2012;41:493-497.
    Many researchers have developed various economic ordering quantity models by assuming an infinite time horizon and constant demand rate. However due to rapid technological advancement, shorter product life cycle and severe competition, those assumptions are no longer realistic. In this paper, we complement that shortcoming by considering an inventory model that satisfies a continuous time-varying demand rate for a finite time horizon when trade credit period and unit cash discount are allowed. The time horizon consists of n different cycles with equal or different cycles length. The trade credit period was assumed to be proportional to the cycle length. We developed mathematical models and presented a numerical example to support the effectiveness of these models.
    Matched MeSH terms: Life Cycle Stages
  4. Devadas VV, Khoo KS, Chia WY, Chew KW, Munawaroh HSH, Lam MK, et al.
    Bioresour Technol, 2021 Apr;325:124702.
    PMID: 33487515 DOI: 10.1016/j.biortech.2021.124702
    The accumulation of conventional petroleum-based polymers has increased exponentially over the years. Therefore, algae-based biopolymer has gained interest among researchers as one of the alternative approaches in achieving a sustainable circular economy around the world. The benefits of microalgae biopolymer over other feedstock is its autotrophic complex to reduce the greenhouse gases emission, rapid growing ability with flexibility in diverse environments and its ability to compost that gives greenhouse gas credits. In contrast, this review provides a comprehensive understanding of algae-based biopolymer in the evaluation of microalgae strains, bioplastic characterization and bioplastic blending technologies. The future prospects and challenges on the algae circular bioeconomy which includes the challenges faced in circular economy, issues regard to the scale-up and operating cost of microalgae cultivation and the life cycle assessment on algal-based biopolymer were highlighted. The aim of this review is to provide insights of algae-based biopolymer towards a sustainable circular bioeconomy.
    Matched MeSH terms: Life Cycle Stages
  5. Goh WHD, Lau HS, Yong WF
    Sci Total Environ, 2023 Sep 20;892:164582.
    PMID: 37277034 DOI: 10.1016/j.scitotenv.2023.164582
    Material synthesis requires an enormous amount of organic solvents which leads to huge environmental burdens. Being so, the necessity to utilize non-toxic chemicals is of growing interest in the global market. Harnessing a green fabrication strategy could be a sustainable remedy. Herein, life cycle assessment (LCA) and techno-economic assessment (TEA) using a cradle-to-gate approach to select the green synthesis route for the production of main components in mixed matrix membranes such as polymer and fillers were studied. Five representative synthesis routes of polymers of intrinsic microporosity (PIM-1) and fillers such as UiO-66-NH2 (UiO: University of Oslo) were conducted. Our findings revealed that the tetrachloroterephthalonitrile (TCTPN) synthesized PIM-1 using a novel approach (e.g., P5-Novel synthesis) and solvent-free synthesized UiO-66-NH2 (e.g., U5-Solvent-free) demonstrated the least environmental impact and are most economically feasible. The environmental burden and cost of PIM-1 synthesized by P5-Novel synthesis route decreased by 50 % and 15 %, respectively, while that of UiO-66-NH2 produced via U5-Solvent-free route reduced by 89 % and 52 %, respectively. Additionally, solvent reduction was found to have an apparent effect on cost-saving, whereby the production cost declined 13 % with a 30 % solvent reduction. Alleviation of environmental burdens could also be found through recovering solvents or substituting with a greener alternative (e.g., water). The fundamentals gained on the environmental impacts and economic feasibility of PIM-1 and UiO-66-NH2 production from this LCA-TEA study may provide a preliminary evaluation for the development of green and sustainable materials.
    Matched MeSH terms: Life Cycle Stages
  6. Lin Z, Ooi JK, Woon KS
    Sci Total Environ, 2022 Apr 10;816:151541.
    PMID: 34774629 DOI: 10.1016/j.scitotenv.2021.151541
    Food waste is a universal problem in many countries. In line with Sustainable Development Goals 7 and 12, it is crucial to identify a cost-effective food waste valorization management framework with the least human health and environmental impacts. However, studies on the synergistic effect of life cycle assessment and mathematical optimization interconnected with human health, environment, and economic are relatively few and far between; hence they cannot provide holistic recommendations to policymakers in developing environmental and economic feasibility of food waste management frameworks. Taking Malaysia as a case study, this study proposes a simple and deterministic model that integrates life cycle assessment and multi-objective mathematical optimization to unpack the health-environment-economic wellbeing nexus in food waste management sector. The model evaluates the life cycle human health, environmental, and economic impacts of five food waste disposal and valorization technologies: open landfill, sanitary landfill, aerated windrow composting, high-temperature drying sterilization, and anaerobic digestion, and identifies the optimal food waste valorization configuration solution in Malaysia. Based on the results modeled by SimaPro 9.0 and General Algebraic Modeling System with augmented ε-constraint, valorization of food waste into electricity via anaerobic digestion is the most favorable option, with 146% and 161% reduction of human health and ecosystems, respectively, as compared with open landfill. If cost is combined as an objective function with human health and ecosystems, high-temperature drying sterilization is the most attractive scenario due to the high livestock feed revenue. Among the 10 Pareto-optimal solutions, 9% sanitary landfill, 3% aerated windrow composting, 30% high-temperature drying sterilization, 30% anaerobic digestion to electricity, and 28% anaerobic digestion to cooking gas, is recommended as future food waste management configuration. The sensitivity results demonstrate that prices of electricity, cooking gas, and livestock feed affect the optimal configuration food waste management system.
    Matched MeSH terms: Life Cycle Stages
  7. Aziz NIHA, Hanafiah MM
    Environ Pollut, 2021 Jan 01;268(Pt B):115948.
    PMID: 33187839 DOI: 10.1016/j.envpol.2020.115948
    The sustainability performance of the desalination processes has received increasing attention in recent years. In this study, the current progress and future perspective of a life cycle assessment (LCA) of desalination technology in 62 previous studies have been reviewed for the period 2004-2019. It was found that the number of LCA studies related to seawater reverse osmosis has gained popularity compared to other types of desalination technologies. The review emphasized the application of LCA to desalination by means of research objective, scope of study, life stages, and impact assessment. Although previous LCA studies were conducted to assess the environmental performance of the desalination technology, little attention was given to evaluating the impact of other sustainability aspects (i.e., economic and social). The latter part of this study discusses the challenges, feasibility, and recommendations for future LCA studies on desalination technology. The integration of the LCA approach with other approaches allows a comprehensive assessment of the sustainability performance of desalination technology. Thus, the combined approaches should be explored in future studies to gain insight into the sensitivity and uncertainty of the data to make an assessment that can be useful in policy-making.
    Matched MeSH terms: Life Cycle Stages
  8. Balasbaneh AT, Yeoh D, Juki MI, Ibrahim MHW, Abidin ARZ
    PMID: 33712956 DOI: 10.1007/s11356-021-13190-4
    This research aims to assess the sustainability of the most common earth-retaining walls (Gravity Walls and Cantilever Walls) in terms of environmental impacts, economic issues, and their combination. Gravity walls observed in this study consist of Gabion Wall, Crib Wall, and Rubble Masonry Wall, while Cantilever Walls include Reinforced Concrete Wall. Six different criteria were taken into account, including global warming potential, fossil depletion potential, eutrophication potential, acidification potential, human toxicity potential, and cost. To achieve the aim of this study, life cycle assessments, life cycle costs, and multi-criteria decision-making methods were implemented. The results showed that the most environmental-friendly option among all alternatives was the Gabion Wall, followed by the Rubble Masonry Wall. However, in terms of economic aspects, the Cantilever Concrete Wall was the best option, costing about 17% less than the Gabion Wall. On the other hand, the results of multi-criteria decision-making showed that the Gabion Wall was the most sustainable choice. This study addressed the research gap by carrying out a sustainability assessment of different retaining walls while considering cost and environmental impacts at the same time.
    Matched MeSH terms: Life Cycle Stages
  9. Dzaki N, Azzam G
    PLoS One, 2018;13(3):e0194664.
    PMID: 29554153 DOI: 10.1371/journal.pone.0194664
    Members of the Aedes genus of mosquitoes are widely recognized as vectors of viral diseases. Ae.albopictus is its most invasive species, and are known to carry viruses such as Dengue, Chikugunya and Zika. Its emerging importance puts Ae.albopictus on the forefront of genetic interaction and evolution studies. However, a panel of suitable reference genes specific for this insect is as of now undescribed. Nine reference genes, namely ACT, eEF1-γ, eIF2α, PP2A, RPL32, RPS17, PGK1, ILK and STK were evaluated. Expression patterns of the candidate reference genes were observed in a total of seventeen sample types, separated by stage of development and age. Gene stability was inferred from obtained quantification data through three widely cited evaluation algorithms i.e. BestKeeper, geNorm, and NormFinder. No single gene showed a satisfactory degree of stability throughout all developmental stages. Therefore, we propose combinations of PGK and ILK for early embryos; RPL32 and RPS17 for late embryos, all four larval instars, and pupae samples; eEF1-γ with STK for adult males; eEF1-γ with RPS17 for non-blood fed females; and eEF1-γ with eIF2α for both blood-fed females and cell culture. The results from this study should be able to provide a more informed selection of normalizing genes during qPCR in Ae.albopictus.
    Matched MeSH terms: Life Cycle Stages/genetics*
  10. Saifur RG, Dieng H, Hassan AA, Salmah MR, Satho T, Miake F, et al.
    PLoS One, 2012;7(2):e30919.
    PMID: 22363516 DOI: 10.1371/journal.pone.0030919
    BACKGROUND: The domestic dengue vector Aedes aegypti mosquitoes breed in indoor containers. However, in northern peninsular Malaysia, they show equal preference for breeding in both indoor and outdoor habitats. To evaluate the epidemiological implications of this peridomestic adaptation, we examined whether Ae. aegypti exhibits decreased survival, gonotrophic activity, and fecundity due to lack of host availability and the changing breeding behavior.

    METHODOLOGY/PRINCIPAL FINDINGS: This yearlong field surveillance identified Ae. aegypti breeding in outdoor containers on an enormous scale. Through a sequence of experiments incorporating outdoors and indoors adapting as well as adapted populations, we observed that indoors provided better environment for the survival of Ae. aegypti and the observed death patterns could be explained on the basis of a difference in body size. The duration of gonotrophic period was much shorter in large-bodied females. Fecundity tended to be greater in indoor acclimated females. We also found increased tendency to multiple feeding in outdoors adapted females, which were smaller in size compared to their outdoors breeding counterparts.

    CONCLUSION/SIGNIFICANCE: The data presented here suggest that acclimatization of Ae. aegypti to the outdoor environment may not decrease its lifespan or gonotrophic activity but rather increase breeding opportunities (increased number of discarded containers outdoors), the rate of larval development, but small body sizes at emergence. Size is likely to be correlated with disease transmission. In general, small size in Aedes females will favor increased blood-feeding frequency resulting in higher population sizes and disease occurrence.

    Matched MeSH terms: Life Cycle Stages/physiology
  11. Selvi S, Edah MA, Nazni WA, Lee HL, Azahari AH
    Trop Biomed, 2007 Jun;24(1):63-75.
    PMID: 17568379 MyJurnal
    Larvae and adults of Culex quinquefasciatus were used for the test undertaken for malathion resistant strain (F61 - F65) and permethrin resistant strain (F54 - F58). The results showed that the LC50 for both malathion (F61 - F65) and permethrin (F54 - F58) resistant Cx. quinquefasciatus increased steadily throughout the subsequent five generations, indicating a marked development of resistance. The adult female malathion resistant strain have developed a high resistance level to malathion diagnostic dosage with a resistance ratio of 9.3 to 17.9 folds of resistance compared with the susceptible Cx. quinquefasciatus. Permethrin resistance ratio remained as 1.0 folds of resistance at every generation. It was obvious that malathion resistance developed at a higher rate in adult females compared to permethrin. Enzyme-based metabolic mechanisms of insecticide resistance were investigated based on the biochemical assay principle. From the results obtained obviously shows that there is a significant difference (p < 0.05) in esterase level in both malathion and permethrin selected strains. Female malathion selected strain has the higher level of esterase activity compared to the female permethrin selected strain at (0.8 to 1.04) alpha-Na micromol/min/mg protein versus (0.15 to 0.24) alpha-Na micromol/min/mg protein respectively. This indicated increased level of non-specific esterase is playing an important role in resistance mechanism in female malathion selected strain. Permethrin selected strain exhibited non-specific esterase activity at a very low level throughout the different life stages compared to malathion selected strain. This study suggests that life stages play a predominant role in conferring malathion and permethrin resistance in Cx. quinquefasciatus.
    Matched MeSH terms: Life Cycle Stages
  12. Sargsian S, Chen Z, Lee SC, Robertson A, Thur RS, Sproch J, et al.
    Cell Rep, 2022 Nov 29;41(9):111725.
    PMID: 36450245 DOI: 10.1016/j.celrep.2022.111725
    Soil-transmitted intestinal worms known as helminths colonize over 1.5 billion people worldwide. Although helminth colonization has been associated with altered composition of the gut microbiota, such as increases in Clostridia, individual species have not been isolated and characterized. Here, we isolate and sequence the genome of 13 Clostridia from the Orang Asli, an indigenous population in Malaysia with a high prevalence of helminth infections. Metagenomic analysis of 650 fecal samples from urban and rural Malaysians confirm the prevalence of species corresponding to these isolates and reveal a specific association between Peptostreptococcaceae family members and helminth colonization. Remarkably, Peptostreptococcaceae isolated from the Orang Asli display superior capacity to promote the life cycle of whipworm species, including hatching of eggs from Trichuris muris and Trichuris trichiura. These findings support a model in which helminths select for gut colonization of microbes that support their life cycle.
    Matched MeSH terms: Life Cycle Stages
  13. Rashid SS, Liu YQ
    Sci Total Environ, 2021 Feb 20;756:143849.
    PMID: 33248794 DOI: 10.1016/j.scitotenv.2020.143849
    The occurrence of various micropollutants such as pharmaceuticals personal care products, endocrine disrupting chemicals (PPCPs/EDCs) and metals in municipal wastewater, and their poor removal efficiencies can lead to toxicity impact on humans, and freshwater and terrestrial ecosystems. Life cycle assessment is an efficient and effective tool to evaluate the environmental impact of wastewater treatment plants, but guidelines for toxicity assessment are lacking due to the complexity. This study aims to evaluate both life cycle inventory by including metals and PEC, and life cycle toxicity assessment (LCIA) methods namely CML-IA, Recipe, USEtox, EDIP 2003 and IMPACT 2002+ in midpoint category with a large centralised wastewater treatment plant in Malaysia as a case study. The removal efficiencies of metals and PPCPs/EDCs in the wastewater ranged from 9% to 99% and no clear patterns were found about occurrence and removal efficiencies of metals and PPCPs/EDCs in developing and developed countries. The inclusion of metals and PPCPs/EDCs in effluent resulted in 76% increase in freshwater ecotoxicity potential (FEP) and 88% increase in terrestrial ecotoxicity potential (TEP) while only 4% increase in human toxicity potential (HTP). The results indicate the importance of including direct emissions such as metals and PPCPs/EDCs even in low-strength municipal wastewater for environmental toxicity assessment. The comparison of five LCIA methods suggests that HTP assessment is more challenging due to inconsistency between five LCIA methods while CML-IA, Recipe, and IMPACT 2002+ achieved consistent human toxicity and ecotoxicity assessment results in the WWTP. The results highlight the importance of sampling and inclusion of metals and PPCPs/EDCs data especially prioritised micropollutants for life cycle toxicity assessment and recommends LCIA methods for ecotoxicity assessment of WWTPs in the current scientific development situation on toxicity studies, which can provide guidance to researchers for life cycle toxicity assessment of wastewater treatment.
    Matched MeSH terms: Life Cycle Stages
  14. Ismail N, Ohtsuka S, Maran BA, Tasumi S, Zaleha K, Yamashita H
    Parasite, 2013;20:42.
    PMID: 24165196 DOI: 10.1051/parasite/2013041
    The complete life cycle of a pennellid copepod Peniculus minuticaudae Shiino, 1956 is proposed based on the discovery of all post-embryonic stages together with the post-metamorphic adult females infecting the fins of threadsail filefish Stephanolepis cirrhifer (Monacanthidae) cultured in a fish farm at Ehime Prefecture, Japan. The hatching stage was the infective copepodid. The life cycle of P. minuticaudae consists of six stages separated by moults: the copepodid, four chalimi and adult. In this study, the adult males were observed frequently in precopulatory amplexus with various stages of females however, copulation occurs only between adults. Fertilized pre-metamorphic adult females carrying spermatophores may detach from the host and settle again before undergoing massive differential growth into the post-metamorphic adult female. Comparison of the life cycle of P. minuticaudae has been made with three known pennellids: Lernaeocera branchialis (Linnaeus, 1767), Cardiodectes medusaeus (Wilson, 1908) and Lernaeenicus sprattae (Sowerby, 1806). Among the compared species, P. minuticaudae is the first ectoparasitic pennellid to be discovered to complete its life cycle on a single host without any change in infection site preferences between infective copepodid and fertilized pre-metamorphic female.
    Matched MeSH terms: Life Cycle Stages*
  15. K.D. Simon, A.G. Mazlan, Z.C. Cob
    Sains Malaysiana, 2013;42:1115-1119.
    Archerfishes Toxotes chatareus (Hamilton 1822) and Toxotes jaculatrix (Pallas 1767) inhabits mangrove estuaries, which are a critically important habitat as a spawning and nursery ground as well as the full life cycle of many fish species. In order to manage and conserve resilience fish species like the archerfish, we need to know some basic parameters about their biology and life history. Our research has focused on understanding the annual condition factors of these two species of archerfishes, as a complimentary to other several biological aspects of this two species that have been published. Our results indicated that, both species are in good conditions as the mean values of condition factors (Fulton condition factor K and Relative condition factor Kn) are greater than values of unity (K, Kn >1). The average K and Kn values of T. chatareus and T. jaculatrix were lowest in November and highest in September, indicates the spawning and recovery condition of the fishes. Condition factors measure overall fish population health that can be used by fisheries biologists and resource managers in proper management of fish resources in Malaysia waters.
    Matched MeSH terms: Life Cycle Stages
  16. Borkhanuddin MH, Cech G, Molnár K, Németh S, Székely C
    Syst Parasitol, 2014 Jul;88(3):245-59.
    PMID: 24935127 DOI: 10.1007/s11230-014-9496-1
    Molecular and morphometric investigations were conducted on the actinosporean morphotypes of myxosporeans surveyed in oligochaetes of Lake Balaton and Kis-Balaton Water reservoir. Oligochaetes belonging to the species Isochaetides michaelseni Lastočkin and Branchiura sowerbyi Beddard as well as to the genera Nais Dujardin, Dero Müller and Aeolosoma Ehrenberg were studied during an 18-month period. Actinosporeans were obtained exclusively from I. michaelseni (7,818 specimens) with very low prevalence (0.01-0.06%). Four new actinosporean morphotypes of the collective groups raabeia (2 types), synactinomyxon (1 type) and neoactinomyxum (1 type) were found and described, including the first synactinomyxon collective group from Hungarian biotopes and a new raabeia morphotype. Except for Synactinomyxon type 1, the 18S rDNA analysis revealed that the spores did not match any myxospore entity found in the GenBank.
    Matched MeSH terms: Life Cycle Stages
  17. Suárez-Morales E
    PLoS One, 2011;6(8):e22915.
    PMID: 21853055 DOI: 10.1371/journal.pone.0022915
    Monstrilloid copepods are protelean parasites of different groups of marine benthic invertebrates. Only their first naupliar, preadult, and adult phases are planktonic. Monstrilloids are currently represented by more than 115 nominal species contained in four genera. Its taxonomic knowledge has been hampered by nomenclatural and descriptive problems derived from their peculiar ontogeny and poor definitions of taxa. One of the most important difficulties is that of matching males to females. The only reliable methods to link the sexes of a species are the confirmation of particular apomorphies shared by both sexes, finding both sexes in the same host or as a pre-copulatory male-female pair in the plankton, or by the use of molecular markers. A general overview of the morphology of the group and its life cycle is provided herein. Recently, upgraded descriptive standards have been established and the relevance of redescribing taxa based on type and museum specimens has been demonstrated. The rate of species description per decade has had several peaks between 1840 and 2010: (1971-1980, 1991-2000, 2001-2010), each related to the activity of a few researchers. An analysis of the world distribution of published records of the Monstrilloida revealed that the Northeast Atlantic is the best studied region (45% of all records), followed by the Northwestern Atlantic (17%); the least surveyed areas include regions of the southern hemisphere (less than 3%). The Northeast Atlantic region harbors the highest number of known species (32 nominal species), followed by the Caribbean Sea/Gulf of Mexico (24), the Mediterranean/Black Sea (19), Indonesia-Malaysia-Philippines region (17), Japanese waters (17), and the Brazil-Argentina area (16). Other than these generalized patterns, little can be concluded concerning the biogeography of the group. Many species records are doubtful or improbable, and purportedly cosmopolitan nominal species are being revealed as species complexes yet to be studied.
    Matched MeSH terms: Life Cycle Stages
  18. He Y, Kiehbadroudinezhad M, Hosseinzadeh-Bandbafha H, Gupta VK, Peng W, Lam SS, et al.
    Environ Pollut, 2024 Feb 01;342:123081.
    PMID: 38072018 DOI: 10.1016/j.envpol.2023.123081
    E-waste, encompassing discarded materials from outdated electronic equipment, often ends up intermixed with municipal solid waste, leading to improper disposal through burial and incineration. This improper handling releases hazardous substances into water, soil, and air, posing significant risks to ecosystems and human health, ultimately entering the food chain and water supply. Formal e-waste recycling, guided by circular economy models and zero-discharge principles, offers potential solutions to this critical challenge. However, implementing a circular economy for e-waste management due to chemical and energy consumption may cause environmental impacts. Consequently, advanced sustainability assessment tools, such as Life Cycle Assessment (LCA), have been applied to investigate e-waste management strategies. While LCA is a standardized methodology, researchers have employed various routes for environmental assessment of different e-waste management methods. However, to the authors' knowledge, there lacks a comprehensive study focusing on LCA studies to discern the opportunities and limitations of this method in formal e-waste management strategies. Hence, this review aims to survey the existing literature on the LCA of e-waste management under a circular economy, shedding light on the current state of research, identifying research gaps, and proposing future research directions. It first explains various methods of managing e-waste in the circular economy. This review then evaluates and scrutinizes the LCA approach in implementing the circular bioeconomy for e-waste management. Finally, it proposes frameworks and procedures to enhance the applicability of the LCA method to future e-waste management research. The literature on the LCA of e-waste management reveals a wide variation in implementing LCA in formal e-waste management, resulting in diverse results and findings in this field. This paper underscores that LCA can pinpoint the environmental hotspots for various pathways of formal e-waste recycling, particularly focusing on metals. It can help address these concerns and achieve greater sustainability in e-waste recycling, especially in pyrometallurgical and hydrometallurgical pathways. The recovery of high-value metals is more environmentally justified compared to other metals. However, biometallurgical pathways remain limited in terms of environmental studies. Despite the potential for recycling e-waste into plastic or glass, there is a dearth of robust background in LCA studies within this sector. This review concludes that LCA can offer valuable insights for decision-making and policy processes on e-waste management, promoting environmentally sound e-waste recycling practices. However, the accuracy of LCA results in e-waste recycling, owing to data requirements, subjectivity, impact category weighting, and other factors, remains debatable, emphasizing the need for more uncertainty analysis in this field.
    Matched MeSH terms: Life Cycle Stages
  19. Mohd Abd Razak MR, Afzan A, Ali R, Amir Jalaluddin NF, Wasiman MI, Shiekh Zahari SH, et al.
    PMID: 25510573 DOI: 10.1186/1472-6882-14-492
    The development of resistant to current antimalarial drugs is a major challenge in achieving malaria elimination status in many countries. Therefore there is a need for new antimalarial drugs. Medicinal plants have always been the major source for the search of new antimalarial drugs. The aim of this study was to screen selected Malaysian medicinal plants for their antiplasmodial properties.
    Matched MeSH terms: Life Cycle Stages
  20. How YF, Lee CY
    J Med Entomol, 2010 May;47(3):305-12.
    PMID: 20496576
    This study examined the effects of different life stages (first, second, third, fourth, and five instars; adult females and adult males) and feeding regimes (starved and blood fed) on the active movement activity of the tropical bed bug, Cimex hemipterus (F.), under mixed-stage conditions. We used an extended arena made from Tygon tube coils and observed the movement frequency and movement distance at selected time intervals up to 120 h. The fifth instars and adult males and females showed significantly (P < 0.01) greater movement frequency compared with the other stages. The first and second instars showed limited movement (< 8 m) over the experimental period. Starved bed bugs showed greater movement frequency compared with blood-fed bed bugs, with the exception of adult females. Blood-fed adult females exhibited significantly (P < 0.01) greater movement frequency and distance compared with starved females. Blood-fed females moved up to 42.3 m over 120 h. Regression analysis between movement distance of the fifth instars and adults and the time intervals revealed a positive relationship (r2 = 0.6583; P < 0.01), suggesting that delays in bed bug control efforts will increase the risk of the greater infestation. During bed bug inspection, the presence of only late instars and adults in premises would indicate a new infestation, whereas an established infestation likely would consist of mixed stages.
    Matched MeSH terms: Life Cycle Stages/physiology
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