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Reduced cannibalistic behavior of African catfish, Clarias gariepinus, larvae under dark and dim conditions

Mukai Y, Sanudin N, Firdaus RF, Saad S

Zoolog Sci, 2013 Jun;30(6):421-4.
PMID: 23721464 DOI: 10.2108/zsj.30.421

In general, African catfish shows higher survival rates in the dark conditions than in the light conditions. In this study, larval behavior of African catfish was observed under 0, 0.01, 0.1, 1, 10, and 100 lx using a CCD camera to investigate the reason why African catfish larvae show higher survival rates in dark conditions. The larvae showed significantly higher swimming activity under 0, 0.01, and 0.1 lx than that under 10 and 100 lx. The larvae also showed significantly increased aggressive behavior under 10 and 100 lx; the swimming larvae attacked resting individuals more frequently under 10 and 100 lx than under 0, 0.01, and 0.1 lx. The aggressive behavior and sharp teeth of the attacking larvae appeared to induce skin surface lesions on injured larvae. Chemical substances were then generated from the injured skin surface, and these chemical stimuli triggered cannibalistic behavior in other fish near the injured fish. The results of this study demonstrate that the higher survival rates of African catfish larvae under dark conditions are a result of inactivity and subsequent increase in chemical releasing stimuli concentrations around inactive individuals that triggers feeding behavior in nearby active catfish. Therefore, we recommend larval rearing of African catfish in dark or dim conditions, as it improves catfish survival rates.

Matched MeSH terms: Light
Photocatalytic magnetic separable beads for chromium (VI) reduction

Idris A, Hassan N, Mohd Ismail NS, Misran E, Yusof NM, Ngomsik AF, et al.

Water Res, 2010 Mar;44(6):1683-8.
PMID: 19963234 DOI: 10.1016/j.watres.2009.11.026

Magnetically separable photocatalyst beads containing nano-sized iron oxide in alginate polymer were prepared. This magnetic photocatalyst beads are used in slurry-type reactors. The magnetism of the catalyst arises from the nanostructured particles gamma-Fe(2)O(3), by which the catalyst can be easily recovered by the application of an external magnetic field. These synthesized beads are sunlight-driven photocatalyst. In the system without magnetic photocatalyst beads, no chromium reduction was observed under sunlight irradiation due to the stability of the chromium (VI). Upon the addition of magnetic photocatalyst beads, the photo-reduction of Cr(VI) was completed in just after only 50min under sunlight irradiation due to the photocatalytic activity of the beads. However when placed away from sunlight, the reduction rate of the chromium is just about 10%. These observations were explained in terms of absorption occurrence of chromium (VI) onto the catalyst surface which took place in this reaction. In addition, photo-reduction rate of chromium (VI) was more significant at lower pH. The results suggest that the use of magnetic separable photocatalyst beads is a feasible strategy for eliminating Cr(VI).

Matched MeSH terms: Light*
Asiatic acid stabilizes cytoskeletal proteins and prevents TNF-α-induced disorganization of cell-cell junctions in human aortic endothelial cells

Fong LY, Ng CT, Yong YK, Hakim MN, Ahmad Z

Vascul. Pharmacol., 2019 06;117:15-26.
PMID: 30114509 DOI: 10.1016/j.vph.2018.08.005

Endothelial hyperpermeability represents an initiating step in early atherosclerosis and it often occurs as a result of endothelial barrier dysfunction. Asiatic acid, a major triterpene isolated from Centella asiatica (L.) Urban, has previously been demonstrated to protect against tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. The present study aimed to investigate the mechanisms underlying the barrier protective effect of asiatic acid in human aortic endothelial cells (HAECs). The localization of F-actin, diphosphorylated myosin light chain (diphospho-MLC), adherens junctions (AJs) and tight junctions (TJs) was studied using immunocytochemistry techniques and confocal microscopy. Their total protein expressions were examined using western blot analysis. The endothelial permeability was assessed using In Vitro Vascular Permeability Assay kits. In addition, intracellular redistribution of the junctional proteins was evaluated using subcellular fractionation kits. We show that asiatic acid stabilized F-actin and diphospho-MLC at the cell periphery and prevented their rearrangement stimulated by TNF-α. However, asiatic acid failed to attenuate cytochalasin D-induced increased permeability. Besides, asiatic acid abrogated TNF-α-induced structural reorganization of vascular endothelial (VE)-cadherin and β-catenin by preserving their reticulum structures at cell-cell contact areas. In addition, asiatic acid also inhibited TNF-α-induced redistribution of occludin and zona occludens (ZO)-1 in different subcellular fractions. In conclusion, the barrier-stabilizing effect of asiatic acid might be associated with preservation of AJs and prevention of TJ redistribution caused by TNF-α. This study provides evidence to support the potential use of asiatic acid in the prevention of early atherosclerosis, which is initiated by endothelial barrier dysfunction.

Matched MeSH terms: Myosin Light Chains/metabolism
Fulltext Unilateral ischaemic retinopathy and bilateral subdural haemorrhage in an infant with non-accidental injury: An ophthalmological approach

Ee CL, Mohd Abdullah AA, Samsudin A, Khaliddin N

Ulus Travma Acil Cerrahi Derg, 2019 09;25(5):527-530.
PMID: 31475330 DOI: 10.5505/tjtes.2018.57059

Non-accidental injury (NAI) is not an uncommon problem worldwide, which leads to significant morbidity and mortality in infants. The presence of retinal or subdural haemorrhages, or encephalopathy with injuries inconsistent with the clinical history is highly suggestive of NAI. In this study, we report on a case of a a 3-month-old infant who presented to the casualty department with a very sudden onset of recurrent generalised tonic-clonic seizures. There was no history of trauma or visible external signs. She was found to have bilateral subdural haemorrhages and atypical unilateral ischaemic retinopathy. Retinal photocoagulation was performed with subsequent resolution of vitreous and retinal haemorrhages. However, visual recovery in that eye remained poor. The findings showed that a high index of suspicion of NAI is required in infants with intracranial haemorrhage and unilateral retinal haemorrhages.

Matched MeSH terms: Light Coagulation
Fulltext EFFECTS OF DIFFERENTEXPOSURE TIMES OF LED LIGHTS ON POSTHARVEST PERFORMANCES OF FRESH-CUT PINEAPPLE(Ananas comosusL. cv. Josapine)

LEONG JIA Q, WAN ZALIHA WAN SEMBOK

UMT Journal of Undergraduate Research, 2019;1(1):68-79.
MyJurnal

Pineapple is one of the most important commercial fruit crops served in fresh-cut form which is convenientfor the consumers. However, fresh-cut pineapple induces the activity of phenolic compounds which triggers the generation of brown or dark pigments. Browning incidence (BI) directly influences the fruit’s acceptability and marketability. Therefore, different exposure times (5mins, 10mins, 15mins and 20mins)and typesof LED lights (white, red and blue) were applied on fresh-cut pineapple stored at 5oC storage for twelve days to reduce BI. A significant interaction between the two factors was recorded in lightness coefficient, chroma, total phenolic and ascorbic acid (AA)contents. Regardless of exposure times, all types of LED lights, mainly the blue light, succeeded in delaying BI in fresh-cut pineapple. In conclusion, blue light had a tendency todelay BI andmaintaintheother postharvest quality attributes of fresh-cut pineapple.

Matched MeSH terms: Light
Fulltext Monitoring of water quality and microalgae species composition of Penaeus monodon ponds in Pulau Pinang, Malaysia

Asma Liyana Shaari, Misni Surif, Faazaz Abd. Latiff, Wan Maznah Wan Omar, Mohd Noor Ahmad

Trop Life Sci Res, 2011;22(1):-.
MyJurnal

Many reports have revealed that the abundance of microalgae in shrimp ponds vary with changes in environmental factors such as light, temperature, pH, salinity and nutrient level throughout a shrimp culture period. In this study, shrimp cultivation period was divided into three stages (initial = week 0–5, mid = week 6–10 and final = week 11–15). Physical and chemical parameters throughout the cultivation period were studied and species composition of microalgae was monitored. Physical parameters were found to
fluctuate widely with light intensity ranging between 182.23–1278 µmol photon m–2s–1, temperature between 29.56ºC –31.59ºC, dissolved oxygen (DO) between 4.56–8.21 mg/l, pH between 7.65–8.49 and salinity between 20‰–30‰. Ammonium (NH4+-N), nitrite (NO2– -N), nitrate (NO3– -N), and orthophosphate (PO43– -P) concentrations in the pond at all cultivation stages ranged from 0.017 to 0.38 mg/l, 0.24 to 2.12 mg/l, 0.06 to 0.98 mg/l and 0.16 to 1.93 mg/l respectively. Statistical test (ANOVA) showed that there were no significant difference (p

Matched MeSH terms: Light
Fulltext Preliminary study on the effectiveness of mosquito repelling lamp, E Da

Chen CD, Azahari AH, Saadiyah I, Lee HL

Trop Biomed, 2007 Dec;24(2):89-91.
PMID: 18209714 MyJurnal

Photon (light) technology has already been widely used in make-up, medical treatment etc, but repelling mosquitoes by photon technology is an innovation. The objective of this study was to determine the efficacy of a mosquito repelling lamp, E Da under indoor conditions. E Da lamp is a lamp coated with yellow luminous pigment on the inner part of the glass bulb of the lamp which is used to screen out the UV radiation, and when it is turned on, the yellow illuminating wavelength will drive the mosquitoes away. The tests were conducted inside 2 cabins measuring 8' X 8' X 20'. The mosquito population was estimated by using the Bare Leg Catch (BLC) techniques. For treated test, E Da lamp was placed indoor 2 - 3 meters away from a human bait. Another cabin without the lamp was used as untreated control. BLC was conducted in both sites simultaneously. The mosquitoes collected in this study were solely those of Culex quinquefasciatus and Aedes albopictus. There was an 91.34% reduction of Cx. quinquefasciatus population in the treated test compared with the untreated cabin during the 4 hours catches (p < 0.05). E Da mosquito repelling lamp used in this study exerted repellency effect against the mosquitoes especially Cx. quinquefasciatus.

Matched MeSH terms: Light*
Fulltext A comparative study of adult mosquito trapping using dry ice and yeast generated carbon dioxide

Oli K, Jeffery J, Vythilingam I

Trop Biomed, 2005 Dec;22(2):249-51.
PMID: 16883295 MyJurnal

Adult mosquito collections were conducted for 12 weeks in two residential areas in Kuala Lumpur. The CDC light traps were compared using dry ice and yeast as sources of carbon dioxide attractants for mosquitoes. The efficacy of the dry ice baited trap was significant over yeast generated CO2 trap. The predominant species obtained were Culex quinquefasciatus, Stegomyia albopicta and Armigeres subalbatus.

Matched MeSH terms: Light
Changes in photosynthesis and leaf characteristics with tree height in five dipterocarp species in a tropical rain forest

Kenzo T, Ichie T, Watanabe Y, Yoneda R, Ninomiya I, Koike T

Tree Physiol, 2006 Jul;26(7):865-73.
PMID: 16585032

Variations in leaf photosynthetic, morphological and biochemical properties with increasing plant height from seedlings to emergent trees were investigated in five dipterocarp species in a Malaysian tropical rain forest. Canopy openness increased significantly with tree height. Photosynthetic properties, such as photosynthetic capacity at light saturation, light compensation point, maximum rate of carboxylation and maximum rate of photosynthetic electron transport, all increased significantly with tree height. Leaf morphological and biochemical traits, such as leaf mass per area, palisade layer thickness, nitrogen concentration per unit area, chlorophyll concentration per unit dry mass and chlorophyll to nitrogen ratio, also changed significantly with tree height. Leaf properties had simple and significant relationships with tree height, with few intra- and interspecies differences. Our results therefore suggest that the photosynthetic capacity of dipterocarp trees depends on tree height, and that the trees adapt to the light environment by adjusting their leaf morphological and biochemical properties. These results should aid in developing models that can accurately estimate carbon dioxide flux and biomass production in tropical rain forests.

Matched MeSH terms: Light
High CO2 concentration increases relative leaf carbon gain under dynamic light in Dipterocarpus sublamellatus seedlings in a tropical rain forest, Malaysia

Tomimatsu H, Iio A, Adachi M, Saw LG, Fletcher C, Tang Y

Tree Physiol, 2014 Sep;34(9):944-54.
PMID: 25187569 DOI: 10.1093/treephys/tpu066

Understory plants in tropical forests often experience a low-light environment combined with high CO2 concentration. We hypothesized that the high CO2 concentration may compensate for leaf carbon loss caused by the low light, through increasing light-use efficiency of both steady-state and dynamic photosynthetic properties. To test the hypothesis, we examined CO2 gas exchange in response to an artificial lightfleck in Dipterocarpus sublamellatus Foxw. seedlings under contrasting CO2 conditions: 350 and 700 μmol CO2 mol(-1) air in a tropical rain forest, Pasoh, Malaysia. Total photosynthetic carbon gain from the lightfleck was about double when subjected to the high CO2 when compared with the low CO2 concentration. The increase of light-use efficiency in dynamic photosynthesis contributed 7% of the increased carbon gain, most of which was due to reduction of photosynthetic induction to light increase under the high CO2. The light compensation point of photosynthesis decreased by 58% and the apparent quantum yield increased by 26% at the high CO2 compared with those at the low CO2. The study suggests that high CO2 increases photosynthetic light-use efficiency under both steady-state and fluctuating light conditions, which should be considered in assessing the leaf carbon gain of understory plants in low-light environments.

Matched MeSH terms: Light*
Fulltext Artificial neural network modelling of photodegradation in suspension of manganese doped zinc oxide nanoparticles under visible-light irradiation

Abdollahi Y, Zakaria A, Sairi NA, Matori KA, Masoumi HR, Sadrolhosseini AR, et al.

ScientificWorldJournal, 2014;2014:726101.
PMID: 25538962 DOI: 10.1155/2014/726101

The artificial neural network (ANN) modeling of m-cresol photodegradation was carried out for determination of the optimum and importance values of the effective variables to achieve the maximum efficiency. The photodegradation was carried out in the suspension of synthesized manganese doped ZnO nanoparticles under visible-light irradiation. The input considered effective variables of the photodegradation were irradiation time, pH, photocatalyst amount, and concentration of m-cresol while the efficiency was the only response as output. The performed experiments were designed into three data sets such as training, testing, and validation that were randomly splitted by the software's option. To obtain the optimum topologies, ANN was trained by quick propagation (QP), Incremental Back Propagation (IBP), Batch Back Propagation (BBP), and Levenberg-Marquardt (LM) algorithms for testing data set. The topologies were determined by the indicator of minimized root mean squared error (RMSE) for each algorithm. According to the indicator, the QP-4-8-1, IBP-4-15-1, BBP-4-6-1, and LM-4-10-1 were selected as the optimized topologies. Among the topologies, QP-4-8-1 has presented the minimum RMSE and absolute average deviation as well as maximum R-squared. Therefore, QP-4-8-1 was selected as final model for validation test and navigation of the process. The model was used for determination of the optimum values of the effective variables by a few three-dimensional plots. The optimum points of the variables were confirmed by further validated experiments. Moreover, the model predicted the relative importance of the variables which showed none of them was neglectable in this work.

Matched MeSH terms: Light
Fulltext Optimization of culture conditions (sucrose, pH, and photoperiod) for in vitro regeneration and early detection of somaclonal variation in ginger lime (Citrus assamensis)

Yaacob JS, Mahmad N, Mat Taha R, Mohamed N, Mad Yussof AI, Saleh A

ScientificWorldJournal, 2014;2014:262710.
PMID: 24977187 DOI: 10.1155/2014/262710

Various explants (stem, leaf, and root) of Citrus assamensis were cultured on MS media supplemented with various combinations and concentrations (0.5-2.0 mg L(-1)) of NAA and BAP. Optimum shoot and root regeneration were obtained from stem cultures supplemented with 1.5 mg L(-1) NAA and 2.0 mg L(-1) BAP, respectively. Explant type affects the success of tissue culture of this species, whereby stem explants were observed to be the most responsive. Addition of 30 gL(-1) sucrose and pH of 5.8 was most optimum for in vitro regeneration of this species. Photoperiod of 16 hours of light and 8 hours of darkness was most optimum for shoot regeneration, but photoperiod of 24 hours of darkness was beneficial for production of callus. The morphology (macro and micro) and anatomy of in vivo and in vitro/ex vitro Citrus assamensis were also observed to elucidate any irregularities (or somaclonal variation) that may arise due to tissue culture protocols. Several minor micromorphological and anatomical differences were observed, possibly due to stress of tissue culture, but in vitro plantlets are expected to revert back to normal phenotype following full adaptation to the natural environment.

Matched MeSH terms: Light
Fulltext Photocatalysis and photoelectrochemical properties of tungsten trioxide nanostructured films

Lai CW

ScientificWorldJournal, 2014;2014:843587.
PMID: 24782669 DOI: 10.1155/2014/843587

Tungsten trioxide (WO₃) possesses a small band gap energy of 2.4-2.8 eV and is responsive to both ultraviolet and visible light irradiation including strong absorption of the solar spectrum and stable physicochemical properties. Thus, controlled growth of one-dimensional (1D) WO₃ nanotubular structures with desired length, diameter, and wall thickness has gained significant interest. In the present study, 1D WO₃ nanotubes were successfully synthesized via electrochemical anodization of tungsten (W) foil in an electrolyte composed of 1 M of sodium sulphate (Na₂SO₄) and ammonium fluoride (NH₄F). The influence of NH₄F content on the formation mechanism of anodic WO₃ nanotubular structure was investigated in detail. An optimization of fluoride ions played a critical role in controlling the chemical dissolution reaction in the interface of W/WO₃. Based on the results obtained, a minimum of 0.7 wt% of NH₄F content was required for completing transformation from W foil to WO₃ nanotubular structure with an average diameter of 85 nm and length of 250 nm within 15 min of anodization time. In this case, high aspect ratio of WO₃ nanotubular structure is preferred because larger active surface area will be provided for better photocatalytic and photoelectrochemical (PEC) reactions.

Matched MeSH terms: Light*
Fulltext Allocation of secondary metabolites, photosynthetic capacity, and antioxidant activity of Kacip Fatimah (Labisia pumila Benth) in response to CO2 and light intensity

Ibrahim MH, Jaafar HZ, Karimi E, Ghasemzadeh A

ScientificWorldJournal, 2014;2014:360290.
PMID: 24683336 DOI: 10.1155/2014/360290

A split plot 3 by 4 experiment was designed to investigate and distinguish the relationships among production of secondary metabolites, soluble sugar, phenylalanine ammonia lyase (PAL; EC 4.3.1.5) activity, leaf gas exchange, chlorophyll content, antioxidant activity (DPPH), and lipid peroxidation under three levels of CO2 (400, 800, and 1200 μ mol/mol) and four levels of light intensity (225, 500, 625, and 900 μ mol/m(2)/s) over 15 weeks in Labisia pumila. The production of plant secondary metabolites, sugar, chlorophyll content, antioxidant activity, and malondialdehyde content was influenced by the interactions between CO2 and irradiance. The highest accumulation of secondary metabolites, sugar, maliondialdehyde, and DPPH activity was observed under CO2 at 1200 μ mol/mol + light intensity at 225 μ mol/m(2)/s. Meanwhile, at 400 μ mol/mol CO2 + 900 μ mol/m(2)/s light intensity the production of chlorophyll and maliondialdehyde content was the highest. As CO2 levels increased from 400 to 1200 μ mol/mol the photosynthesis, stomatal conductance, f v /f m (maximum efficiency of photosystem II), and PAL activity were enhanced. The production of secondary metabolites displayed a significant negative relationship with maliondialdehyde indicating lowered oxidative stress under high CO2 and low irradiance improved the production of plant secondary metabolites that simultaneously enhanced the antioxidant activity (DPPH), thus improving the medicinal value of Labisia pumila under this condition.

Matched MeSH terms: Light
Fulltext Four-wave mixing crosstalk suppression based on the pairing combinations of differently linear-polarized optical signals

Abd H, Din NM, Al-Mansoori MH, Abdullah F, Fadhil HA

ScientificWorldJournal, 2014;2014:243795.
PMID: 24883364 DOI: 10.1155/2014/243795

A new approach to suppressing the four-wave mixing (FWM) crosstalk by using the pairing combinations of differently linear-polarized optical signals was investigated. The simulation was conducted using a four-channel system, and the total data rate was 40 Gb/s. A comparative study on the suppression of FWM for existing and suggested techniques was conducted by varying the input power from 2 dBm to 14 dBm. The robustness of the proposed technique was examined with two types of optical fiber, namely, single-mode fiber (SMF) and dispersion-shifted fiber (DSF). The FWM power drastically reduced to less than -68 and -25 dBm at an input power of 14 dBm, when the polarization technique was conducted for SMF and DSF, respectively. With the conventional method, the FWM powers were, respectively, -56 and -20 dBm. The system performance greatly improved with the proposed polarization approach, where the bit error rates (BERs) at the first channel were 2.57 × 10(-40) and 3.47 × 10(-29) at received powers of -4.90 and -13.84 dBm for SMF and DSF, respectively.

Matched MeSH terms: Light
Fulltext LiNbO3 coating on concrete surface: a new and environmentally friendly route for artificial photosynthesis

Nath RK, Zain MF, Kadhum AA

ScientificWorldJournal, 2013;2013:686497.
PMID: 24376384 DOI: 10.1155/2013/686497

The addition of a photocatalyst to ordinary building materials such as concrete creates environmentally friendly materials by which air pollution or pollution of the surface can be diminished. The use of LiNbO3 photocatalyst in concrete material would be more beneficial since it can produce artificial photosynthesis in concrete. In these research photoassisted solid-gas phases reduction of carbon dioxide (artificial photosynthesis) was performed using a photocatalyst, LiNbO3, coated on concrete surface under illumination of UV-visible or sunlight and showed that LiNbO3 achieved high conversion of CO2 into products despite the low levels of band-gap light available. The high reaction efficiency of LiNbO3 is explained by its strong remnant polarization (70 µC/cm(2)), allowing a longer lifetime of photoinduced carriers as well as an alternative reaction pathway. Due to the ease of usage and good photocatalytic efficiency, the research work done showed its potential application in pollution prevention.

Matched MeSH terms: Light
Facile synthesis of CaFe2O4 for visible light driven treatment of polluting palm oil mill effluent: Photokinetic and scavenging study

Charles A, Khan MR, Ng KH, Wu TY, Lim JW, Wongsakulphasatch S, et al.

Sci Total Environ, 2019 Apr 15;661:522-530.
PMID: 30682605 DOI: 10.1016/j.scitotenv.2019.01.195

In this paper, a facile synthesis method for CaFe2O4 is introduced that produces a catalyst capable of significant photocatalytic degradation of POME under visible light irradiation. The co-precipitation method was used to produce two catalysts at calcination temperatures of 550 °C and 700 °C dubbed CP550 and CP700. CP550 demonstrated the maximum COD removal of 69.0% at 0.75 g/L catalyst loading after 8 h of visible light irradiation which dropped to 61.0% after three consecutive cycles. SEM images indicated that the higher calcination temperature of CP700 led to annealing which reduced the pore volume (0.025 cm3/g) and pore diameter (10.3 nm) while simultaneously creating a smoother and more spherical surface with lower SBET (9.73 m2/g). In comparison, CP550 had a rough hair-like surface with higher SBET (27.28 m2/g) and pore volume (0.077 cm3/g) as evidenced by BET analysis. XRD data indicated the presence of CaFe5O7 in the CP550 composition which was not present in CP700. The presence of Wustite-like FeO structures in CaFe5O7 are likely the cause for lower photoluminescence intensity profile and hence better charge separation of CP550 as these structures in CaFe2O4 have been known to increase resistivity and electron localization. The COD removal of CP550 dropped from 69.0% to just 7.0% upon adding a small quantity of isopropanol into the reaction mixture indicating hydroxyl radicals as the primary reactive oxidative species.

Matched MeSH terms: Light
Fulltext Von Hippel angioma

Chong PK, Loo AV, Alagaratnam JV

Med J Malaysia, 2007 Oct;62(4):343-4.
PMID: 18551944 MyJurnal

We report a three year follow up of a 35-year-old Indian gentleman who presented with sudden, painless blurring of left (L) eye vision with initial visual acuity (VA) of 6/60. Fundoscopy revealed (L) vitreous haemorrhage and subsequently confirmed a (L) inferotemporal capillary haemangioma. The adjacent area of capillary haemangioma was treated with barricade argon laser photocoagulation to prevent progression of exudative retinal detachment inferiorly. Subsequent follow up showed mild regression of capillary haemangioma with maintenance of (L) eye vision at 6/9.

Matched MeSH terms: Light Coagulation/instrumentation
Outcomes of Subliminal Transscleral Cyclophotocoagulation treatment in glaucoma

Chow JY, Wan Norliza WM, Bastion MC

Med J Malaysia, 2021 03;76(2):236-240.
PMID: 33742635

BACKGROUND: Subliminal transscleral cyclophotocoagulation (SL-TSCPC) is a new alternative therapy to reduce intraocular pressure (IOP) safely and effectively. However, there are few studies regarding SL-TSCPC by Supra 810 laser machine and limited data regarding its effectiveness in moderate severity glaucoma that still has good preservation of vision. This study was conducted to evaluate the outcome of SL-TSPCPC in various types of glaucoma including patients with good vision.
METHODS: A retrospective, non-comparative, analytical case series of all patients who received SL-TSCPC treatment from October 2018 to April 2019 at Hospital Tengku Ampuan Afzan, Pahang, Malaysia. Data was collected during the second week, sixth week, third month and sixth month follow-up. The primary outcome measure gave success rate at six months post-treatment. Secondary measures were changes in visual acuity, mean IOP reduction, mean number of IOP lowering medications reduced and ocular side effects noted during follow-up.
RESULTS: The success rate was 43.8% (seven eyes out of sixteen eyes) at six months post-treatment. The mean IOP reduced from 43.0mmHg±14.8mmHg pre-treatment to 24.7mmHg±12.0mmHg at two weeks post treatment with 42.6% reduction. Subsequently, mean IOP at sixth week, third month and sixth month were 33.8mmHg±16.9mmHg, 35.2mmHg±14.9mmHg, and 29.0mmHg±16.2mmHg respectively. Vision maintained in 13 patients, two patients had improvement in vision however, five patients had deterioration in vision. No serious ocular side effects were noted.
CONCLUSION: Subliminal TSCPC is a safe and alternative method of lowering IOP in moderate to advanced glaucoma over 6 months duration of follow-up. As it has good safety profile and repeatability, it is a good treatment option for patients with uncontrolled glaucoma.

Matched MeSH terms: Light Coagulation
Fulltext Biochemical and molecular characteristics of Malaysian patients with lysinuric protein intolerance

Habib A, Azize NA, Yakob Y, Md Yunus Z, Wee TK

Malays J Pathol, 2016 Dec;38(3):305-310.
PMID: 28028301 MyJurnal

Lysinuric protein intolerance (LPI) is an inborn error of dibasic amino acid transport due to a defect in the dibasic amino acid transporter in the renal and intestine and has a heterogenous presentation. Three Malaysian patients with LPI were studied and their biochemical and molecular findings compared. There were differences and similarities in the biochemical and molecular findings. Molecular analysis of SLC7A7 gene revealed a novel mutation c.235G>A; p.(Gly79Arg) in exon three in Patient 1 and a mutation c.1417C>T; p.(Arg473*) in exon 10 in patient 2 and 3. The degree of concentration of dibasic amino acids may determine the type of disease of the cell membrane transport, however, a positive molecular confirmation will secure the diagnosis.

Matched MeSH terms: Antigens, CD98 Light Chains/genetics*

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