Displaying publications 1 - 20 of 77 in total

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  1. [A perfect pair for the brilliant masterpiece, History of Chinese Medicine-in commemoration of the 130(th) and 140(th) anniversary of the birthday of distinguished modern medical historians, K. Chimin Wong and Wu Lien-teh respectively]
    Zhen Y, Cai JF
    Zhonghua Yi Shi Za Zhi, 2019 Nov 28;49(6):323-329.
    PMID: 32564524 DOI: 10.3760/cma.j.issn.0255-7053.2019.06.001
    It happens that 2019 is the commemoration date for the 130(th) and 140(th) birthday of K. Chimin Wong and Wu Lien-teh respectively, both famous modern Chinese medical historians, the authors of the book History of Chinese Medicine. Originally, they were inhabitants separated thousand miles away, the former in Eastern China, and the other in Penang, Malaysia. Both were busying in their own business works, Wong was specialized in establishing Museum of Medical History, then the first of its kind in China and the world, with splendid results. Whereas, Wu was fighting at the frontier of the overwhelming pneumonic plague in Manchuria, having successfully terminated this virulent infectious disease in a short period of about a quarter, achieving a global reputation in medical world and thus presided the International Plague Conference held in Mukden, China, attended by invited experts from 11 countries. The latter was also active in the creation of hospitals and medical schools, plague prevention and quarantine services in China. Incidentally, when one of them read the book History of Medicine written by the famous American medical historian Fielding Hudson Garrison, to find that this 700+ -page work only includes the contents for Chinese medicine next to nothing and even with wrong descriptions, both were very frustrated and wrote a letter to its author for clarification. They were even more irritated to receive a reply, complaining that the mistakes were not his own, but simply due to shortage of sources, and even that bit of content was from western sources! To wipe up these wrong "foreign descriptions" , they made up their mind to write a similar book of its own in English language, so as to fill up the gaps in this field, hence, the completion of History of Chinese Medicine in a long course of almost 16 years, formally published in 1932, and an enlarged and revised 2nd edition in 1936. This work is divided into 2 books. Book One is devoted to traditional Chines medicine written by K. Chimin Wong; the other Book Two, written by Wu Lien-teh, is devoted to modern and contemporary Chinese medical history, dealing with western medicine to China from its introduction and after experiencing tortuous course and eventually constituting an integral system on biomedicine in China. At the end of the work, there are appendices, including chronological table, geographical names, person names and subject indices. Evaluation of History of Chinese Medicine after 1949 experienced a huge difference. During the first decades, people deemed it to contain lots of mistakes and to have been influenced by national nihilism and western missionary medicine. As a result, the whole work has been roughly translated into a Chinese version, marked by "for criticism" on its cover. After the country carries out a reform and opening to outside world policy, improper appraisal for this work has been changed and is crowned with "brilliant masterpiece" which virtually fills the gaps of the lack of Chinese medical history in western language. It is known that a Chinese version for this work is ongoing and will be officially published soon.
    Matched MeSH terms: Medicine, Chinese Traditional/history*
  2. Fulltext What future for traditional Chinese medicine outside China?
    Ooi GL
    World Health Forum, 1993;14(1):79-85.
    PMID: 8439383
    In certain countries of east and south-east Asia, traditional Chinese medicine continues to be used by many people. However, the pattern of use favours the advance of the drug-retailing side of this sector rather than medical care, and there is consequently some concern about the professional status of practitioners in the long term.
    Matched MeSH terms: Medicine, Chinese Traditional*
  3. Fulltext Structural analysis of raw and commercial farm edible bird nests
    Kew PE, Wong SF, Lim PK, Mak JW
    Trop Biomed, 2014 Mar;31(1):63-76.
    PMID: 24862046 MyJurnal
    Edible bird nests (EBNs) are consumed worldwide for various health benefits. EBNs are nests built from the saliva of swiftlets of Aerodramus species. The global market for EBNs is on the rise, especially from Hong Kong and mainland China. In the past, EBNs were harvested mainly from natural caves; however in the recent years, there has been a rapid growth of swiftlet farming. Little is known about the actual composition of EBNs except for protein, carbohydrate, ash and lipid contents, amino acids, vitamins and macro/ micronutrients. Besides the biochemical components of EBNs, are there any other structures that are associated with EBNs? This paper reports on the structural analysis of raw unprocessed farm and processed commercial EBNs. The raw EBNs were purchased from swiftlet farms in five locations in Peninsula Malaysia: Kuala Sanglang (Perlis; 6° 16' 0"N, 100° 12' 0"E), Pantai Remis (Perak; 4º 27' 0" N, 100º 38' 0" E), Kluang (Johor; 02º 012 303N 103º 192 583E), Kajang (Selangor; 2º 59' 0"N, 101º 47' 0"E) and Kota Bharu (Kelantan; 6º 8' 0"N, 102º 15' 0"E). The commercial nests were purchased from five different Chinese traditional medicinal shops (Companies A-E). A portion of each EBN was randomly broken into small fragments, attached to carbon tape and coated with gold and palladium particles for examination and photography under a scanning electron microscope. Structural analysis revealed the presence of mites, fungi, bacteria and feather strands on both the raw and commercial nests. Mite eggshells and faecal pellets, and body parts of other arthropods were seen only in the raw nests. The commercial nests had a variety of unidentified structures and substances coated on the nests' surfaces that were not found on the raw nests. The presence of these contaminants may jeopardise the quality of EBNs and pose health risks to consumers. Further identification of the mites and their allergens, fungi and bacteria are on-going and will be reported separately.
    Matched MeSH terms: Medicine, Chinese Traditional*
  4. Effects of EBN on embryo implantation, plasma concentrations of reproductive hormones, and uterine expressions of genes of PCNA, steroids, growth factors and their receptors in rats
    Albishtue AA, Yimer N, Zakaria MZA, Haron AW, Babji AS, Abubakar AA, et al.
    Theriogenology, 2019 Mar 01;126:310-319.
    PMID: 30605790 DOI: 10.1016/j.theriogenology.2018.12.026
    This study was conducted to determine the effect of edible bird's nest (EBN) supplement on uterine function and embryo-implantation rate. A total of 24 adult female rats, divided equally into four groups, were treated with different doses of EBN for 8 weeks. In the last week of treatment, intact fertile male rats were introduced into each group (three per group) for overnight for mating. On day 7 post-mating (post-implantation), blood samples were collected from the hearts of anaesthetised rats that were later sacrificed. The uteri were removed for assessment of embryo implantation rate, histological and electron microscopic examination, and immunohistochemical analyses. Results showed that as the concentration of EBN supplemented increased, the pregnancy and embryo implantation rates were also increased in the treated groups; significantly at G3 and G4. Although histological evaluation did not show much difference among the groups, scanning electron microscopic examination showed enhanced development of elongated microvilli and pinopods in G4. Results also revealed up-regulated expressions of epidermal growth factor (EGF), EGF receptor (EGFR), vascular endothelial growth factor (VEGF), proliferating cell nulear antigen (PCNA), and progesterone and estrogen receptors (P4R, E2R) in the uteri of treated groups. Moreover, plasma E2, P4, growth hormone (GH) and prolactin (P) levels were higher (p 
    Matched MeSH terms: Medicine, Chinese Traditional*
  5. Fulltext Nasal scarring by joss stick burns
    Krishnan G, Khanijow VJ
    Med J Malaysia, 1994 Mar;49(1):90-2.
    PMID: 8057998
    Vasomotor rhinitis is a common condition in Malaysia. Patients' dissatisfaction with medical treatment of this recurring condition leads them to seek other forms of traditional cures. This paper highlights the complications in such patients who seek traditional cures for their chronic condition.
    Matched MeSH terms: Medicine, Chinese Traditional*
  6. Traditional beliefs and practices affecting medical care in Malaysian Chinese communities
    Dunn FL
    Med J Malaysia, 1974 Sep;29(1):7-10.
    PMID: 4282636
    Matched MeSH terms: Medicine, Chinese Traditional*
  7. Some characteristics and services of Chinese medical practitioners in Malaysia
    Meade MS
    Med J Malaysia, 1976 Sep;31(1):14-6.
    PMID: 1023006
    Matched MeSH terms: Medicine, Chinese Traditional*
  8. Fulltext Recent Updates in Neuroprotective and Neuroregenerative Potential of Centella asiatica
    Lokanathan Y, Omar N, Ahmad Puzi NN, Saim A, Hj Idrus R
    Malays J Med Sci, 2016 Jan;23(1):4-14.
    PMID: 27540320 MyJurnal
    Centella asiatica, locally well known in Malaysia as pegaga, is a traditional herb that has been used widely in Ayurvedic medicine, traditional Chinese medicine, and in the traditional medicine of other Southeast Asian countries including Malaysia. Although consumption of the plant is indicated for various illnesses, its potential neuroprotective properties have been well studied and documented. In addition to past studies, recent studies also discovered and/or reconfirmed that C. asiatica acts as an antioxidant, reducing the effect of oxidative stress in vitro and in vivo. At the in vitro level, C. asiatica promotes dendrite arborisation and elongation, and also protects the neurons from apoptosis. In vivo studies have shown that the whole extract and also individual compounds of C. asiatica have a protective effect against various neurological diseases. Most of the in vivo studies on neuroprotective effects have focused on Alzheimer's disease, Parkinson's disease, learning and memory enhancement, neurotoxicity and other mental illnesses such as depression and anxiety, and epilepsy. Recent studies have embarked on finding the molecular mechanism of neuroprotection by C. asiatica extract. However, the capability of C. asiatica in enhancing neuroregeneration has not been studied much and is limited to the regeneration of crushed sciatic nerves and protection from neuronal injury in hypoxia conditions. More studies are still needed to identify the compounds and the mechanism of action of C. asiatica that are particularly involved in neuroprotection and neuroregeneration. Furthermore, the extraction method, biochemical profile and dosage information of the C. asiatica extract need to be standardised to enhance the economic value of this traditional herb and to accelerate the entry of C. asiatica extracts into modern medicine.
    Matched MeSH terms: Medicine, Chinese Traditional
  9. Potential transmission of hymenolepiasis by a practice of Malaysian Chinese folk medicine
    Sullivan JT, Palmieri JP, Chu GS
    J Parasitol, 1977 Feb;63(1):172.
    PMID: 845735
    Matched MeSH terms: Medicine, Chinese Traditional*
  10. Synergistic antifungal indolecarbazoles from Streptomyces sp. CNS-42 associated with traditional Chinese medicine Alisma orientale
    Liu M, Huang P, Wang Q, Ren B, Oyeleye A, Liu M, et al.
    J Antibiot (Tokyo), 2017 05;70(5):715-717.
    PMID: 28074054 DOI: 10.1038/ja.2016.160
    Matched MeSH terms: Medicine, Chinese Traditional/methods
  11. Chinese medicine in Malaysia and Singapore: the business of healing
    Ooi GL
    Am J Chin Med, 1993;21(3-4):197-212.
    PMID: 8135163 DOI: 10.1142/S0192415X93000236
    Traditional Chinese medicine as it persists in several East and Southeast Asian countries, has undergone major changes. Such changes have reinforced the trading aspects of traditional Chinese medical practice with relatively little advantage for the medical care component. This paper examines the nature of changes in contemporary ethnic Chinese medical practice in Malaysia and Singapore with the aim of understanding their implications for the persistence of this medical tradition.
    Matched MeSH terms: Medicine, Chinese Traditional*
  12. Differential identification of mushrooms sclerotia by IR macro-fingerprint method
    Choong YK, Lan J, Lee HL, Chen XD, Wang XG, Yang YP
    Spectrochim Acta A Mol Biomol Spectrosc, 2016 Jan 5;152:34-42.
    PMID: 26186395 DOI: 10.1016/j.saa.2015.07.054
    Many macrofungus sclerotia are well-known medicinal herbs, health food and nutritional supplements. However, the prevalent adulterant commercial products are major hindrances to their incorporation into mainstream medical use in many countries. The mushroom sclerotia of Lignosus rhinocerotis, Poria cocos, Polyporus umbellatus, Pleurotus tuber-regium and Omphalia lapidescens are commonly used in traditional Chinese medicine. In this study, IR macro-fingerprint method was used in the identification of these sclerotia. The results showed that the spectrum of L. rhinocerotis (LR) was comparable with P. cocos with 94.4% correlation, except that the peak at 1543cm(-1) of LR appeared in lower intensity. The spectrum of P. umbellatus and P. tuber-regium was also correlated (91.5%), as both spectra could be clearly discriminated in that P. umbellatus spectrum has small base peaks located at the range of 1680-1500cm(-1). O. lapidescens was not comparable with all the other sclerotia as its spectrum was totally different. Its base peak was broad and derivated equally along the range. The first IR has revealed the dissimilarity among five mushrooms sclerotia. The second derivative and 2DIR further enhanced the identification in detail.
    Matched MeSH terms: Medicine, Chinese Traditional
  13. Traditional and modern medicine in Malaysia
    Chen PCY
    Soc Sci Med Med Psychol Med Sociol, 1981 Mar;15A(2):127-36.
    PMID: 7244696 DOI: 10.1016/0271-7123(81)90032-8
    Malaysia has a large variety of traditional medical systems that are a direct reflection of the wide ethnic diversity of its population. These can be grouped into four basic varieties, namely, traditional “native”. traditional Chinese. traditional Indian, and modem medicine, examples of which are described. In spite of the great inroads made by modem medicine, the traditional systems are firmly established. Patients move from one system to another or use several systems simultaneously. The integration of the traditional Malay birth attendant into the health team is described. The forces influencing the development, acceptance, and integration of the medical systems are discussed.
    Matched MeSH terms: Medicine, Chinese Traditional
  14. Black magic and illness in a Malaysian Chinese community
    Mo B
    Soc Sci Med, 1984;18(2):147-57.
    PMID: 6701559
    Ah Yuk Je is a successful Hakka Chinese spirit medium practicing in a small Chinese community in Malaysia. Her clientele consists largely of young children suffering from a culturally specific condition called haak geng or 'soul loss' and women concerned about infertility, prenatal problems and errant spouses. While in a trance state, assisted by her tutelary spirits, she diagnoses, prescribes and treats illnesses. Her treatment includes naturalistic and magico-religious elements such as 'cooling' herbal teas, tonics to strengthen the body, rituals and amulets. Because Ah Yuk Je is a wife and mother, women find her sympathetic and astute at solving family problems. When faced with an illness herself, which she suspects to be the result of kong tao (black magic) instigated by someone in her own village, she seeks assistance from a healer outside her own ethnic group as well as outside her community. Four important factors influence Ah Yuk Je's decision to seek out this healer. The first two, recommendation from a trusted friend and a positive previous experience, are obvious, and require no further discussion. The remaining factors are the special nature of the illness, which requires treatment from a specialist, and her practice as a spirit medium. Successful spirit mediums are perceived to have a certain immunity to and control over supernatural forces. Thus the need for secrecy when a spirit medium becomes the victim of evil forces. She is able to preserve her professional reputation by consulting someone outside her ethnic group of potential clients as well as outside her physical community.
    Matched MeSH terms: Medicine, Chinese Traditional*
  15. Medical systems in Malaysia: cultural bases and differential use
    Chen PCY
    Soc Sci Med, 1975 Mar;9(3):171-80.
    PMID: 1129610 DOI: 10.1016/0037-7856(75)90054-2
    A variety of traditional medical systems thrive with vigour in Malaysia among the Malay, Orang Asli, Iban, Kadazan and Chinese peoples. The bases of these systems reflect the cultural concept of the “universe” of each ethnic group. It is noted that traditional medicine accomodates a larger proportion of illness thought to be due to supernatural causes than does modern medicine. Traditional medicine is supportive, personal and holistic in its approach in contrast with modern scientific medicine which tends to be mechanistic, impersonal, organ-oriented and individualistic. Modern and traditional medical systems are viewed as potentially complementary rather than contradictory. The traditional medicine-man can be viewed as a ritual specialist and a focus of social and emotional support for the patient, such a role being complementary to the role of the modern physician.
    Matched MeSH terms: Medicine, Chinese Traditional*
  16. Fulltext Influence of Chinese cultural health beliefs among Malaysian Chinese in a suburban population: a survey
    Chew KS, Tan TW, Ooi YT
    Singapore Med J, 2011 Apr;52(4):252-6.
    PMID: 21552785
    In a multiethnic nation, it is not uncommon for doctors to encounter patients of different cultural backgrounds. Often, patients' cultural beliefs influence their perception of health and illnesses, and their treatment option. Many Chinese cultural beliefs are influenced by the Taoist concept of yin-yang balance.
    Matched MeSH terms: Medicine, Chinese Traditional
  17. Fulltext The incidence of upper gastro-intestinal disease in a Malaysian community
    Ross IN, Nair S, Jayakumar CR
    Singapore Med J, 1985 Jun;26(3):271-8.
    PMID: 4048988
    The results of 2449 investigations of the upper gastrointestinal tract were analysed to determine the incidence of disease. Abnormalities were detected in 53% of patients who had endoscopy, but were found in only 24% of patients who had barium studies (p <= 0.001). Altogether 916 patients had abnormal findings. Duodenal ulcer accounted for 42% of cases, gastric ulcer 16% and gastric cancer 9%. The prevalence of perforated ulcer was 13%. The annual incidence/1000 in males and females (>14 years) were respectively, for duodenal ulcer 1.66 and 0.42, for gastric ulcer 0.57 and 0.25, for perforated ulcer 0.36 and 0.05, and for gastric cancer 0.29 and 0.14. Most types of gastro-duodenal disease were less common in Malays than expected (p = <0.001). However oesophageal cancer and varices were more common in Indians compared to Malays and Chinese (p = <0.001). This study showed that the pallern of perforating ulcers was not the same as that of non-peforating ulcers, suggesting a differing pathogenesis. Identification of the factors causing a different prevalence of disease between the three ethnic groups would help in the understanding of the causes of upper gastrointestinal disease.
    Matched MeSH terms: Medicine, Chinese Traditional
  18. Exploring the Traditional Chinese Medicine (TCM) database chemical space to target I7L protease from monkeypox virus using molecular screening and simulation approaches
    Khan A, Shahab M, Nasir F, Waheed Y, Alshammari A, Mohammad A, et al.
    SAR QSAR Environ Res, 2023;34(9):689-708.
    PMID: 37675795 DOI: 10.1080/1062936X.2023.2250723
    In the current study, we used molecular screening and simulation approaches to target I7L protease from monkeypox virus (mpox) from the Traditional Chinese Medicines (TCM) database. Using molecular screening, only four hits TCM27763, TCM33057, TCM34450 and TCM31564 demonstrated better pharmacological potential than TTP6171 (control). Binding of these molecules targeted Trp168, Asn171, Arg196, Cys237, Ser240, Trp242, Glu325, Ser326, and Cys328 residues and may affect the function of I7L protease in in vitro assay. Moreover, molecular simulation revealed stable dynamics, tighter structural packing and less flexible behaviour for all the complexes. We further reported that the average hydrogen bonds in TCM27763, TCM33057, TCM34450 and TCM31564I7L complexes remained higher than the control drug. Finally, the BF energy results revealed -62.60 ± 0.65 for the controlI7L complex, for the TCM27763I7L complex -71.92 ± 0.70 kcal/mol, for the TCM33057I7L complex the BF energy was -70.94 ± 0.70 kcal/mol, for the TCM34450I7L the BF energy was -69.94 ± 0.85 kcal/mol while for the TCM31564I7L complex the BF energy was calculated to be -69.16 ± 0.80 kcal/mol. Although, we used stateoftheart computational methods, these are theoretical insights that need further experimental validation.
    Matched MeSH terms: Medicine, Chinese Traditional*
  19. Fulltext Cannabis sativa subsp. sativa's pharmacological properties and health effects: A scoping review of current evidence
    Lim XY, Tan TYC, Muhd Rosli SH, Sa'at MNF, Sirdar Ali S, Syed Mohamed AF
    PLoS One, 2021;16(1):e0245471.
    PMID: 33465140 DOI: 10.1371/journal.pone.0245471
    INTRODUCTION: Hemp (Cannabis sativa subsp. sativa), commonly used for industrial purposes, is now being consumed by the public for various health promoting effects. As popularity of hemp research and claims of beneficial effects rises, a systematic collection of current scientific evidence on hemp's health effects and pharmacological properties is needed to guide future research, clinical, and policy decision making.

    OBJECTIVE: To provide an overview and identify the present landscape of hemp research topics, trends, and gaps.

    METHODS: A systematic search and analysis strategy according to the preferred reporting items for systematic review and meta-analysis-ScR (PRISMA-ScR) checklist on electronic databases including MEDLINE, OVID (OVFT, APC Journal Club, EBM Reviews), Cochrane Library Central and Clinicaltrials.gov was conducted to include and analyse hemp research articles from 2009 to 2019.

    RESULTS: 65 primary articles (18 clinical, 47 pre-clinical) were reviewed. Several randomised controlled trials showed hempseed pills (in Traditional Chinese Medicine formulation MaZiRenWan) improving spontaneous bowel movement in functional constipation. There was also evidence suggesting benefits in cannabis dependence, epilepsy, and anxiety disorders. Pre-clinically, hemp derivatives showed potential anti-oxidative, anti-hypertensive, anti-inflammatory, anti-diabetic, anti-neuroinflammatory, anti-arthritic, anti-acne, and anti-microbial activities. Renal protective effects and estrogenic properties were also exhibited in vitro.

    CONCLUSION: Current evidence on hemp-specific interventions are still preliminary, with limited high quality clinical evidence for any specific therapeutic indication. This is mainly due to the wide variation in test item formulation, as the multiple variants of this plant differ in their phytochemical and bioactive compounds. Future empirical research should focus on standardising the hemp plant for pharmaceutical use, and uniformity in experimental designs to strengthen the premise of using hemp in medicine.

    Matched MeSH terms: Medicine, Chinese Traditional
  20. Fulltext Lab-on-a-Chip-Based PCR-RFLP Assay for the Detection of Malayan Box Turtle (Cuora amboinensis) in the Food Chain and Traditional Chinese Medicines
    Asing, Ali ME, Abd Hamid SB, Hossain MA, Mustafa S, Kader MA, et al.
    PLoS One, 2016;11(10):e0163436.
    PMID: 27716792 DOI: 10.1371/journal.pone.0163436
    The Malayan box turtle (Cuora amboinensis) (MBT) is a vulnerable and protected turtle species, but it is a lucrative item in the illegal wildlife trade because of its great appeal as an exotic food item and in traditional medicine. Although several polymerase chain reaction (PCR) assays to identify MBT by various routes have been documented, their applicability for forensic authentication remains inconclusive due to the long length of the amplicon targets, which are easily broken down by natural decomposition, environmental stresses or physiochemical treatments during food processing. To address this research gap, we developed, for the first time, a species-specific PCR-restriction fragment length polymorphism (RFLP) assay with a very short target length (120 bp) to detect MBT in the food chain; this authentication ensured better security and reliability through molecular fingerprints. The PCR-amplified product was digested with Bfa1 endonuclease, and distinctive restriction fingerprints (72, 43 and 5 bp) for MBT were found upon separation in a microfluidic chip-based automated electrophoresis system, which enhances the resolution of short oligos. The chances of any false negative identifications were eliminated through the use of a universal endogenous control for eukaryotes, and the limit of detection was 0.0001 ng DNA or 0.01% of the meat under admixed states. Finally, the optimized PCR-RFLP assay was validated for the screening of raw and processed commercial meatballs, burgers and frankfurters, which are very popular in most countries. The optimized PCR-RFLP assay was further used to screen MBT materials in 153 traditional Chinese medicines of 17 different brands and 62 of them were found MBT positive; wherein the ingredients were not declared in product labels. Overall, the novel assay demonstrated sufficient merit for use in any forensic and/or archaeological authentication of MBT, even under a state of decomposition.
    Matched MeSH terms: Medicine, Chinese Traditional/methods
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