Displaying publications 1 - 20 of 2084 in total

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  1. WALTERS JP, HARRISON JL
    Med J Malaya, 1959 Dec;14:99-105.
    PMID: 13842715
    Matched MeSH terms: Mice
  2. Gordon Smith CE, Turner LH, Armitage P
    Bull World Health Organ, 1962;27:717-27.
    PMID: 13993152
    Because of the risk of introduction of yellow fever to South-East Asia, comparative studies were made of yellow fever vaccination in Malayans who had a high prevalence of antibody to related viruses and in volunteers without related antibody. The proportions of positive neutralizing antibody responses to subcutaneous vaccination with 17D vaccine were not significantly different between volunteers with and without heterologous antibody but the degree of antibody response was greater in those without. The ID(50) of 17D in both groups was about 5 mouse intracerebral LD(50). Multiple puncture vaccination with 17D gave a much lower response rate than subcutaneous vaccination in volunteers with heterologous antibody. In both groups subcutaneous doses of about 50 mouse intracerebral LD(50) gave larger antibody responses than higher doses. The neutralizing indices and analysis of results were calculated by a method based on the survival time of the mice. This method, which has advantages over that of Reed & Muench, is fully described in an annex to this paper.
    Matched MeSH terms: Mice
  3. Wharton RH, Eyles DE, Warren M, Moorhouse DE, Sandosham AA
    Bull World Health Organ, 1963;29:357-74.
    PMID: 14058228
    Although mosquitos of the Anopheles umbrosus group have long been recognized as important vectors of human malaria in Malaya, there have been doubts about the origin of some of the malaria infections found, especially in A. umbrosus and A. letifer. Investigations have accordingly been carried out in the Malayan swamp-forest, in conjunction with laboratory studies, into the nature of malaria infections in wild-caught mosquitos, the biting behaviour of anophelines and the presence of malaria infection in man and animals. The authors conclude from the results reported in this paper that A. umbrosus is a vector of mouse deer malaria and rarely, if ever, transmits primate malaria; that A. letifer transmits both human and mouse deer malaria; and that A. baezai and A. roperi are probably vectors of mouse deer malaria.
    Matched MeSH terms: Mice
  4. Gordon Smith CE, McMahon DA, Turner LH
    Bull World Health Organ, 1963;29:75-80.
    PMID: 14043754
    In view of the risk of introduction of yellow fever into South-East Asia, comparative studies have been made of yellow fever vaccination in Malayan volunteers with a high prevalence of antibody to related viruses and in volunteers without related antibody. In a previous paper the neutralizing antibody responses of these volunteers were reported. The present paper describes the haemagglutinin-inhibiting (HI) antibody responses of the same groups of volunteers and discusses the relationship of these responses to the neutralizing antibody responses.The HI responses to yellow fever following vaccination closely paralleled the neutralizing antibody responses whether vaccination was subcutaneous or by multiple puncture. Volunteers with a high level of YF HI antibody due to infection with other group B viruses were found to be less likely to show a significant YF HI response than those without antibody. 90% of HI responses could be detected by the 21st day after vaccination.As with neutralizing antibody responses, volunteers given vaccine doses of 50-500 mouse intracerebral LD(50) subcutaneously gave greater responses than those given higher doses.
    Matched MeSH terms: Mice
  5. ELLISON DW, BAKER HJ
    Med J Malaysia, 1964 Sep;19:65-6.
    PMID: 14244224
    Matched MeSH terms: Mice
  6. Nakanishi K, Sasaki S, Kiang AK, Goh J, Kakisawa H, Ohashi M, et al.
    Chem Pharm Bull (Tokyo), 1965 Jul;13(7):882-90.
    PMID: 5867816
    Matched MeSH terms: Mice
  7. Singh RB
    Med J Malaya, 1966 Dec;21(2):177-98.
    PMID: 4227390
    Matched MeSH terms: Mice
  8. Macdonald WW, Smith CE, Dawson PS, Ganapathipillai A, Mahadevan S
    J Med Entomol, 1967 May;4(2):146-57.
    PMID: 4383192
    Matched MeSH terms: Mice*
  9. Tan DS, Smith CE, McMahon DA, Bowen ET
    Nature, 1967 Jun 10;214(5093):1154-5.
    PMID: 4964058
    Matched MeSH terms: Mice
  10. Kruatrachue M, Chesdapan C
    Med J Malaya, 1968 Mar;22(3):231-2.
    PMID: 4234367
    Matched MeSH terms: Mice
  11. Ravina A
    Presse Med, 1968 Dec 7;76(48):2271-3.
    PMID: 5720934
    Matched MeSH terms: Mice
  12. Okuno T, Okada T, Kondo A, Suzuki M, Kobayashi M, Oya A
    Bull World Health Organ, 1968;38(4):547-63.
    PMID: 5302450
    The immunological characteristics of 26 strains of Japanese encephalitis virus (JEV) isolated in Japan and Malaya between 1935 and 1966 have been investigated mainly by the antibody-absorption variant of the haemagglutination-inhibition test, and to a certain extent also by conventional haemagglutination-inhibition and complement-fixation tests. The antibody-absorption technique shows promise as a routine method for the immunotyping of JEV.At present, two immunotypes can be distinguished. One comprises 2 strains, Nakayama-NIH and I-58, and is designated as the I-58 immunotype. The other immunotype, JaGAr 01, comprises 17 strains which share the characteristics of the JaGAr 01 strain, including one subline of the Nakayama strain, Nakayama-Yakken. The Nakayama-RFVL strain was found to have the characteristics of both immunotypes. The I-58 immunotype differs more markedly from related arboviruses, such as the Murray Valley encephalitis virus and the West Nile Eg101 strain, than does the JaGAr 01 immunotype.Evidence is presented which suggests that a given JEV strain can change immunotype on repeated passage through mice.
    Matched MeSH terms: Mice
  13. Pearson JMH, Pettit JHS, Rees RJ
    PMID: 4877115
    Proof that a patient is suffering from sulfone-resistant leprosy depends on demonstrating that his bacilli can multiply in the mouse foot pad even when the mice are fed sulfone in the diet. Hitherto the maximal dose of DDS tolerated by the mouse has been used in such tests. This paper concerns a patient whose bacilli multiplied in mice fed lower doses of DDS, but were inhibited when the maximal dose was used . His clinical features are distinctive and probably characteristic of this type of "partial" resistance. It is likely that more cases of this type will be found . Recommendations are made concerning the investigation of possible DDS-resistant leprosy patients and their treatment.
    Matched MeSH terms: Mice
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