Displaying publications 1 - 20 of 77 in total

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  1. Shafiu Kamba A, Zakaria ZA
    Biomed Res Int, 2014;2014:215097.
    PMID: 24734228 DOI: 10.1155/2014/215097
    Calcium carbonate (CaCO3) nanocrystals derived from cockle shells emerge to present a good concert in bone tissue engineering because of their potential to mimic the composition, structure, and properties of native bone. The aim of this study was to evaluate the biological response of CaCO3 nanocrystals on hFOB 1.19 and MC3T3 E-1 osteoblast cells in vitro. Cell viability and proliferation were assessed by MTT and BrdU assays, and LDH was measured to determine the effect of CaCO3 nanocrystals on cell membrane integrity. Cellular morphology was examined by SEM and fluorescence microscopy. The results showed that CaCO3 nanocrystals had no toxic effects to some extent. Cell proliferation, alkaline phosphatase activity, and protein synthesis were enhanced by the nanocrystals when compared to the control. Cellular interactions were improved, as indicated by SEM and fluorescent microscopy. The production of VEGF and TGF-1 was also affected by the CaCO3 nanocrystals. Therefore, bio-based CaCO3 nanocrystals were shown to stimulate osteoblast differentiation and improve the osteointegration process.
    Matched MeSH terms: Nanotechnology/methods*
  2. Hussein MZ, Jaafar AM, Yahaya AH, Masarudin MJ, Zainal Z
    Int J Mol Sci, 2014;15(11):20254-65.
    PMID: 25380526 DOI: 10.3390/ijms151120254
    Multi-walled carbon nanotubes (MWCNTs) were prepared via chemical vapor deposition (CVD) using a series of different catalysts, derived from FeCoNiAl, CoNiAl and FeNiAl layered double hydroxides (LDHs). Catalyst-active particles were obtained by calcination of LDHs at 800 °C for 5 h. Nitrogen and hexane were used as the carrier gas and carbon source respectively, for preparation of MWCNTs using CVD methods at 800 °C. MWCNTs were allowed to grow for 30 min on the catalyst spread on an alumina boat in a quartz tube. The materials were subsequently characterized through X-ray diffraction, Fourier transform infrared spectroscopy, surface area analysis, field emission scanning electron microscopy and transmission electron microscopy. It was determined that size and yield of MWCNTs varied depending on the type of LDH catalyst precursor that is used during synthesis. MWCNTs obtained using CoNiAl-LDH as the catalyst precursor showed smaller diameter and higher yield compared to FeCoNiAl and FeNiAl LDHs.
    Matched MeSH terms: Nanotechnology/methods*
  3. Ebrahimiasl S, Yunus WM, Kassim A, Zainal Z
    Sensors (Basel), 2011;11(10):9207-16.
    PMID: 22163690 DOI: 10.3390/s111009207
    Nanocrystalline SnO(x) (x = 1-2) thin films were prepared on glass substrates by a simple chemical bath deposition method. Triethanolamine was used as complexing agent to decrease time and temperature of deposition and shift the pH of the solution to the noncorrosive region. The films were characterized for composition, surface morphology, structure and optical properties. X-ray diffraction analysis confirms that SnO(x) thin films consist of a polycrystalline structure with an average grain size of 36 nm. Atomic force microscopy studies show a uniform grain distribution without pinholes. The elemental composition was evaluated by energy dispersive X-ray spectroscopy. The average O/Sn atomic percentage ratio is 1.72. Band gap energy and optical transition were determined from optical absorbance data. The film was found to exhibit direct and indirect transitions in the visible spectrum with band gap values of about 3.9 and 3.7 eV, respectively. The optical transmittance in the visible region is 82%. The SnO(x) nanocrystals exhibit an ultraviolet emission band centered at 392 nm in the vicinity of the band edge, which is attributed to the well-known exciton transition in SnO(x). Photosensitivity was detected in the positive region under illumination with white light.
    Matched MeSH terms: Nanotechnology/methods*
  4. Dutse SW, Yusof NA
    Sensors (Basel), 2011;11(6):5754-68.
    PMID: 22163925 DOI: 10.3390/s110605754
    Microfluidics-based lab-on-chip (LOC) systems are an active research area that is revolutionising high-throughput sequencing for the fast, sensitive and accurate detection of a variety of pathogens. LOCs also serve as portable diagnostic tools. The devices provide optimum control of nanolitre volumes of fluids and integrate various bioassay operations that allow the devices to rapidly sense pathogenic threat agents for environmental monitoring. LOC systems, such as microfluidic biochips, offer advantages compared to conventional identification procedures that are tedious, expensive and time consuming. This paper aims to provide a broad overview of the need for devices that are easy to operate, sensitive, fast, portable and sufficiently reliable to be used as complementary tools for the control of pathogenic agents that damage the environment.
    Matched MeSH terms: Nanotechnology/methods
  5. Aziz MS, Jukgoljan B, Daud S, Tan TS, Ali J, Yupapin PP
    Artif Cells Nanomed Biotechnol, 2013 Jun;41(3):178-83.
    PMID: 22991944 DOI: 10.3109/10731199.2012.715087
    This paper presents the use of a modified add/drop optical filter incorporating with microring resonators known as a PANDA microring resonator system which can fabricate on small chip. By using an optical tweezer, the required molecules can be trapped and moved to the required destinations at the add/drop ports. The novelty is that the stored molecules in the designed chip can transport via the optical waveguide and can also be used to form molecular filter, which is an important technique for drug delivery, drug targeting, and molecular electronics. Results have shown that the multivariable filter can be obtained by tunable trapping control.
    Matched MeSH terms: Nanotechnology/methods
  6. Bahadoran M, Noorden AF, Chaudhary K, Mohajer FS, Aziz MS, Hashim S, et al.
    Sensors (Basel), 2014;14(7):12885-99.
    PMID: 25046015 DOI: 10.3390/s140712885
    A new photonics biosensor configuration comprising a Double-side Ring Add-drop Filter microring resonator (DR-ADF) made from SiO2-TiO2 material is proposed for the detection of Salmonella bacteria (SB) in blood. The scattering matrix method using inductive calculation is used to determine the output signal's intensities in the blood with and without presence of Salmonella. The change in refractive index due to the reaction of Salmonella bacteria with its applied antibody on the flagellin layer loaded on the sensing and detecting microresonator causes the increase in through and dropper port's intensities of the output signal which leads to the detection of SB in blood. A shift in the output signal wavelength is observed with resolution of 0.01 nm. The change in intensity and shift in wavelength is analyzed with respect to the change in the refractive index which contributes toward achieving an ultra-high sensitivity of 95,500 nm/RIU which is almost two orders higher than that of reported from single ring sensors and the limit of detection is in the order of 1 × 10(-8) RIU. In applications, such a system can be employed for a high sensitive and fast detection of bacteria.
    Matched MeSH terms: Nanotechnology/methods
  7. Hussein MZ, Nasir NM, Yahaya AH
    J Nanosci Nanotechnol, 2008 Nov;8(11):5921-8.
    PMID: 19198327
    Metanilate-layered double hydroxide nanohybrid compound was synthesized for controlled release purposes through co-precipitation method of the metal cations and organic anion. The effect of various divalent metal cations (M2+), namely Zn2+, Mg2+ and Ca2+ on the formation of metanilate-LDH nanohybrids, in which metanilate anion was intercalated into three different layered double hydroxide (LDH) systems; Zn-Al, Mg-Al and Ca-Al were investigated. The syntheses were carried out with M2+ to Al3+ initial molar ratio, R of 4. The pH of the mother liquor was maintained at pH 7.5 and 10 during the synthesis, and the resulting mixture was aged at around 70 degrees C for about 18 h. The intercalation of metanilate anion into the host was found to be strongly influenced by the M2+ that formed the inorganic metal hydroxide layers. Under our experimental condition, the formation of the nanohybrid materials was found to be more feasible for the Zn-Al than for the other two systems, in which the former showed well-ordered layered organic-inorganic nanohybrid structure with good crystallinity. Intercalation is confirmed by the expansion of the interlayer spacing to about 15-17 A when metanilate was introduced into the interlamellae of Zn-Al LDHs. In addition, CHNS and FTIR analyses also support that metanilate anion has been successfully intercalated into the interlamellae of the inorganic LDH. Apart from M2+, this study also shows that the initial pH of the mother liquor plays an important role in determining the physicochemical properties of the resulting nanohybrids, especially the mole fraction of the Zn2+ substituted by the Al3+ ion in the LDH inorganic sheets which in turn controlled the loading percentage of the organic anion, surface properties and the true density. Preliminary study shows that LDH can be used to host beneficial guests, active agent with controlled release capability of the guests. Generally the overall process is governed by pseudo second order kinetic but for the first 180 min, the release process can be slightly better described by parabolic diffusion than the other models.
    Matched MeSH terms: Nanotechnology/methods*
  8. Hussein MZ, Mohd Amin JB, Zainal Z, Yahaya AH
    J Nanosci Nanotechnol, 2002 Apr;2(2):143-6.
    PMID: 12908300
    Hydrotalcite-like inorganic layers of Zn-Al, a host containing an organic moiety, 2,4-dichlorophenoxy-acetate, as a guest, was prepared by the spontaneous self-assembly method from an aqueous solution for the formation of a new layered organic-inorganic hybrid nanocomposite material. In this synthesis, the host- and guest-forming species were simultaneously included in the mother liquor, aged, and separated. Various Zn/Al ratios (R = 2, 3, and 4), concentrations of 2,4-dichlorophenoxyacetic acid (0.03-0.1 M), and pH (7 and 10) were studied to optimize the formation of the layered nancomposite. It was found that the optimum conditions for the formation of the nanocomposite were R = 4, pH 7, and concentration of 2,4-dichlorophenoxyacetic acid = 0.08 M. X-ray diffraction shows that this sample affords a nanolayered structure with a basal spacing of 24.6 A.
    Matched MeSH terms: Nanotechnology/methods*
  9. Noroozi M, Zakaria A, Moksin MM, Wahab ZA
    Int J Mol Sci, 2012;13(8):10350-8.
    PMID: 22949865 DOI: 10.3390/ijms130810350
    The thermal effusivity of Al(2)O(3) and CuO nanofluids in different base fluids, i.e., deionized water, ethylene glycol and olive oil were investigated. The nanofluids, nanoparticles dispersed in base fluids; were prepared by mixing Al(2)O(3), CuO nanopowder and the base fluids using sonication with high-powered pulses to ensure a good uniform dispersion of nanoparticles in the base fluids. The morphology of the particles in the base fluids was investigated by transmission electron microscopy (TEM). In this study, a phase frequency scan of the front pyroelectric configuration technique, with a thermally thick PVDF pyroelectric sensor and sample, was used to measure the thermal effusivity of the prepared nanofluids. The experimental results of the thermal effusivity of the studied solvents (deionized water, ethylene glycol and olive oil) showed good agreement with literature values, and were reduced in the presence of nanoparticles. The thermal effusivity of the nanofluid was found to be particularly sensitive to its base fluid and the type of nanoparticles.
    Matched MeSH terms: Nanotechnology/methods*
  10. Low PL, Yong BE, Ong BH, Matsumoto M, Tou TY
    J Nanosci Nanotechnol, 2011 Mar;11(3):2640-3.
    PMID: 21449444
    The substrate effects on surface morphologies, crystal structures, and magnetic properties of the sputter-deposited FePt thin films on Corning 1737, normal glass, and Si wafer substrates, respectively, were investigated. High in-plane coercivities of 10 kOe were obtained for the air-annealed films on Corning 1737 and Si wafer, where both films similarly have granular-like morphologies. Besides, increasing grain size and surface roughness of all the FePt films with the post-anneal temperature were observed. Moreover, partially separated grains were seen in the film on Si wafer, where the formation of Fe silicides during post-anneal is suspected, in which has enhanced the magnetic ordering.
    Matched MeSH terms: Nanotechnology/methods
  11. Nasir N, Yahya N, Kashif M, Daud H, Akhtar MN, Zaid HM, et al.
    J Nanosci Nanotechnol, 2011 Mar;11(3):2551-4.
    PMID: 21449424
    This is our initial response towards preparation of nano-inductors garnet for high operating frequencies strontium iron garnet (Sr3Fe5O12) denoted as SrIG and yttrium iron garnet (Y3Fe5O12) denoted as YIG. The garnet nano crystals were prepared by novel sol-gel technique. The phase and crystal structure of the prepared samples were identified by using X-ray diffraction analysis. SEM images were done to reveal the surface morphology of the samples. Raman spectra was taken for yttrium iron garnet (Y3Fe5O12). The magnetic properties of the samples namely initial permeability (micro), relative loss factor (RLF) and quality factor (Q-Factor) were done by using LCR meter. From the XRD profile, both of the Y3Fe5O12 and Sr3Fe5O12 samples showed single phase garnet and crystallization had completely occurred at 900 degrees C for the SrIG and 950 degrees C for the YIG samples. The YIG sample showed extremely low RLF value (0.0082) and high density 4.623 g/cm3. Interesting however is the high Q factor (20-60) shown by the Sr3Fe5O12 sample from 20-100 MHz. This high performance magnetic property is attributed to the homogenous and cubical-like microstructure. The YIG particles were used as magnetic feeder for EM transmitter. It was observed that YIG magnetic feeder with the EM transmitter gave 39% higher magnetic field than without YIG magnetic feeder.
    Matched MeSH terms: Nanotechnology/methods
  12. bin Hussein MZ, Zainal Z, Hin TY, Tat OW
    PMID: 15040529
    Nanocomposites of Zn/Al-layered double hydroxide(anthraquinone-2,6-disulfonate) were synthesized by spontaneous direct assembly of inorganic and organic phases from aqueous solution. Powder X-ray diffraction patterns showed that a pure, single nanocomposite phase of good crystallinity was obtained using 1.0 M antraquinone-2,6-disulfonate ion (AQ26) and aging at 80 degrees C using conventional heating for 7 days or 0.5 h under microwave radiation, and these samples are denoted as ZAAN26C or ZAAN26MH, respectively. Zn/Al-nitrate-layered double hydroxide synthesized by a conventional method (ZANLC) showed a basal spacing of 8.3 A while both the nanocomposites showed 18.8 A as a result of AQ26 intercalation. FTIR study showed that the resulting nanocomposites are free from nitrate, the co-anion present in the mother liquor, indicating that only AQ26 is preferred during intercalation for the formation of the nanocomposite. The Brunauer, Emmet and Teller (BET) and micropore surface areas for ZAAN26C decreased relative to the ZANLC from 16.2 to 4.7 and 1.6 to 1.3 m2/g, respectively. These results indicate that AQ26 can be rapidly interdcalated in layered double hydroxide using microwave-aging resulting in a nanocomposite.
    Matched MeSH terms: Nanotechnology/methods*
  13. Sivakumar M, Tang SY, Tan KW
    Ultrason Sonochem, 2014 Nov;21(6):2069-83.
    PMID: 24755340 DOI: 10.1016/j.ultsonch.2014.03.025
    Novel nanoemulsion-based drug delivery systems (DDS) have been proposed as alternative and effective approach for the delivery of various types of poorly water-soluble drugs in the last decade. This nanoformulation strategy significantly improves the cell uptake and bioavailability of numerous hydrophobic drugs by increasing their solubility and dissolution rate, maintaining drug concentration within the therapeutic range by controlling the drug release rate, and reducing systemic side effects by targeting to specific disease site, thus offering a better patient compliance. To date, cavitation technology has emerged to be an energy-efficient and promising technique to generate such nanoscale emulsions encapsulating a variety of highly potent pharmaceutical agents that are water-insoluble. The micro-turbulent implosions of cavitation bubbles tear-off primary giant oily emulsion droplets to nano-scale, spontaneously leading to the formation of highly uniform drug contained nanodroplets. A substantial body of recent literatures in the field of nanoemulsions suggests that cavitation is a facile, cost-reducing yet safer generation tool, remarkably highlighting its industrial commercial viability in the development of designing novel nanocarriers or enhancing the properties of existing pharmaceutical products. In this review, the fundamentals of nanoemulsion and the principles involved in their formation are presented. The underlying mechanisms in the generation of pharmaceutical nanoemulsion under acoustic field as well as the advantages of using cavitation compared to the conventional techniques are also highlighted. This review focuses on recent nanoemulsion-based DDS development and how cavitation through ultrasound and hydrodynamic means is useful to generate the pharmaceutical grade nanoemulsions including the complex double or submicron multiple emulsions.
    Matched MeSH terms: Nanotechnology/methods*
  14. Anarjan N, Jafarizadeh-Malmiri H, Nehdi IA, Sbihi HM, Al-Resayes SI, Tan CP
    Int J Nanomedicine, 2015;10:1109-18.
    PMID: 25709435 DOI: 10.2147/IJN.S72835
    Nanodispersion systems allow incorporation of lipophilic bioactives, such as astaxanthin (a fat soluble carotenoid) into aqueous systems, which can improve their solubility, bioavailability, and stability, and widen their uses in water-based pharmaceutical and food products. In this study, response surface methodology was used to investigate the influences of homogenization time (0.5-20 minutes) and speed (1,000-9,000 rpm) in the formation of astaxanthin nanodispersions via the solvent-diffusion process. The product was characterized for particle size and astaxanthin concentration using laser diffraction particle size analysis and high performance liquid chromatography, respectively. Relatively high determination coefficients (ranging from 0.896 to 0.969) were obtained for all suggested polynomial regression models. The overall optimal homogenization conditions were determined by multiple response optimization analysis to be 6,000 rpm for 7 minutes. In vitro cellular uptake of astaxanthin from the suggested individual and multiple optimized astaxanthin nanodispersions was also evaluated. The cellular uptake of astaxanthin was found to be considerably increased (by more than five times) as it became incorporated into optimum nanodispersion systems. The lack of a significant difference between predicted and experimental values confirms the suitability of the regression equations connecting the response variables studied to the independent parameters.
    Matched MeSH terms: Nanotechnology/methods*
  15. Kian LK, Saba N, Jawaid M, Sultan MTH
    Int J Biol Macromol, 2019 Jan;121:1314-1328.
    PMID: 30208300 DOI: 10.1016/j.ijbiomac.2018.09.040
    The utilization of nanocellulose has increasingly gained attentions from various research fields, especially the field of polymer nanocomposites owing to the growing environmental hazardous of petroleum based fiber products. Meanwhile, the searching of alternative cellulose sources from different plants has become the interests for producing nanocellulose with varying characterizations that expectedly suit in specific field of applications. In this content the long and strong bast fibers from plant species was gradually getting its remarkable position in the field of nanocellulose extraction and nanocomposites fabrications. This review article intended to present an overview of the chemical structure of cellulose, different types of nanocellulose, bast fibers compositions, structure, polylactic acid (PLA) and the most probable processing techniques on the developments of nanocellulose from different bast fibers especially jute, kenaf, hemp, flax, ramie and roselle and its nanocomposites. This article however more focused on the fabrication of PLA based nanocomposites due to its high firmness, biodegradability and sustainability properties in developed products towards the environment. Along with this it also explored a couple of issues to improve the processing techniques of bast fibers nanocellulose and its reinforcement in the PLA biopolymer as final products.
    Matched MeSH terms: Nanotechnology/methods*
  16. Tang SY, Shridharan P, Sivakumar M
    Ultrason Sonochem, 2013 Jan;20(1):485-97.
    PMID: 22633626 DOI: 10.1016/j.ultsonch.2012.04.005
    In the present investigation, the operating efficiency of a bench-top air-driven microfluidizer has been compared to that of a bench-top high power ultrasound horn in the production of pharmaceutical grade nanoemulsions using aspirin as a model drug. The influence of important process variables as well as the pre-homogenization and drug loading on the resultant mean droplet diameter and size distribution of emulsion droplets was studied in an oil-in-water nanoemulsion incorporated with a model drug aspirin. Results obtained show that both the emulsification methods were capable of producing very fine nanoemulsions containing aspirin with the minimum droplet size ranging from 150 to 170 nm. In case of using the microfluidizer, it has been observed that the size of the emulsion droplets obtained was almost independent of the applied microfluidization pressure (200-600 bar) and the number of passes (up to 10 passes) while the pre-homogenization and drug loading had a marginal effect in increasing the droplet size. Whereas, in the case of ultrasound emulsification, the droplet size was generally decreased with an increase in sonication amplitude (50-70%) and period of sonication but the resultant emulsion was found to be dependent on the pre-homogenization and drug loading. The STEM microscopic observations illustrated that the optimized formulations obtained using ultrasound cavitation technique are comparable to microfluidized emulsions. These comparative results demonstrated that ultrasound cavitation is a relatively energy-efficient yet promising method of pharmaceutical nanoemulsions as compared to microfluidizer although the means used to generate the nanoemulsions are different.
    Matched MeSH terms: Nanotechnology/methods*
  17. Vyas T, Rapalli VK, Chellappan DK, Dua K, Dubey SK, Singhvi G
    Life Sci, 2021 Dec 15;287:120148.
    PMID: 34785190 DOI: 10.1016/j.lfs.2021.120148
    BACKGROUND: Biofilms are microcolonies of microbes that form communities with a variety of microbes, exhibit the same gene composition but differ in gene expression. Biofilm-associated infections have been in existence for a long, however, biofilm-associated skin disorders have not been investigated much.

    OBJECTIVES: Biofilms, which are made mostly of the matrix can be thought of as communities of microbes that are more virulent and more difficult to eradicate as compared to their planktonic counterparts. Currently, several formulations are available in the market which have the potential to treat biofilm-assisted skin disorders. However, the existing pharmacotherapies are not competent enough to cure them effectively and entirely, in several cases.

    KEY FINDINGS: Especially with the rising resistance towards antibiotics, it has become particularly challenging to ameliorate these disorders completely. The new approaches are being used to combat biofilm-associated skin disorders, some of them being photodynamic therapy, nanotherapies, and the use of novel drug delivery systems. The focus of attention, however, is nanotherapy. Micelles, solid lipid nanoparticles, quatsomes, and many others are being considered to find a better solution for the biofilm-associated skin disorders.

    SIGNIFICANCE: This review is an attempt to give a perspective on these new approaches for treating bacterial biofilms associated with skin disorders.

    Matched MeSH terms: Nanotechnology/methods*
  18. Nanda A, Pandey P, Rajinikanth PS, Singh N
    Int J Biol Macromol, 2024 Mar;260(Pt 1):129416.
    PMID: 38224810 DOI: 10.1016/j.ijbiomac.2024.129416
    Zein, a protein-based biopolymer derived from corn, has garnered attention as a promising and eco-friendly choice for packaging food due to its favorable physical attributes. The introduction of electrospinning technology has significantly advanced the production of zein-based nanomaterials. This cutting-edge technique enables the creation of nanofibers with customizable structures, offering high surface area and adjustable mechanical and thermal attributes. Moreover, the electrospinning process allows for integrating various additives, such as antioxidants, antimicrobial agents, and flavoring compounds, into the zein nanofibers, enhancing their functionalities for food preservation. In this comprehensive review, the various electrospinning techniques employed for crafting zein-based nanofibers, and we delve into their enhanced properties. Furthermore, the review illuminates the potential applications of zein nanofibers in active and intelligent packaging materials by incorporating diverse constituents. Altogether, this review highlights the considerable prospects of zein-based nanocomposites in the realm of food packaging, offering sustainable and innovative solutions for food industry.
    Matched MeSH terms: Nanotechnology/methods
  19. Senthilpari C, Diwakar K, Singh AK
    Recent Pat Nanotechnol, 2009;3(1):61-72.
    PMID: 19149756
    The paper discuss the design of 1-bit full adder circuit using Shannon theorem. This proposed full adder circuit is used as one of the circuit component for implementation of Non- Restoring and Restoring divider circuits. The proposed adder and divider schematics are designed by using DSCH2 CAD tool and their layouts are generated by Microwind 3 VLSI CAD tool. The divider circuits are designed by using standard CMOS 0.35 microm feature size and corresponding power supply 3.5 V. The parameters analyses are carried out by BSIM 4 analysis. We have compared the simulated results of the Shannon based divider circuit with CPL and CMOS adder cell based divider circuits. We have further compared the results with published results and observed that the proposed adder cell based divider circuit dissipates lower power, gives faster response, lower latency, low EPI and high throughput.
    Matched MeSH terms: Nanotechnology/methods
  20. Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, et al.
    J Nanobiotechnology, 2018 Sep 19;16(1):71.
    PMID: 30231877 DOI: 10.1186/s12951-018-0392-8
    Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.
    Matched MeSH terms: Nanotechnology/methods
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