Displaying all 13 publications

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  1. Mohamad MA, Jarmin R, Md Pauzi SH
    Malays J Pathol, 2020 Dec;42(3):455-459.
    PMID: 33361729
    Schwannomas are mesenchymal tumors that are characteristically benign and slow growing, which originate from any nerve with Schwann cell sheath. Gastrointestinal schwannomas are rare with distinct morphologic features as compared to schwannomas of soft tissue or central nervous system. A 77-year-old male patient was diagnosed with gastrointestinal stromal tumor based on radiological findings and clinical impression when he presented with worsening abdominal discomfort and pain. He underwent distal gastrectomy however histopathological examination of the tumour revealed schwannoma. This case report presents a rare case of a symptomatic gastric schwannoma, whose definitive diagnosis was established by histopathological and immunohistochemical findings postoperatively.
    Matched MeSH terms: Neurilemmoma/pathology*
  2. Shi R, Chew MH, Leow WQ
    Malays J Pathol, 2017 Dec;39(3):293-296.
    PMID: 29279593
    Gastrointestinal stromal tumour (GIST) is a common mesenchymal tumour arising in the gastrointestinal tract, but not frequently encountered in the rectum. Herein, we describe a case of a rectal GIST which mimicked histomorphological features of a schwannoma; thus, making intraoperative frozen section evaluation challenging. Although subsequent immunohistochemistry and molecular findings readily confirmed the diagnosis of a GIST, we wish to draw attention to three clues that will help the pathologist steer clear of this potential diagnostic pitfall. One, GISTs are relatively more common than schwannomas in the rectum. Two, schwannomas usually have very little mitoses. Three, rectal GISTs commonly exhibit nuclear palisades. We also discuss the diagnostic, prognostic and therapeutic functions of immunohistochemical and molecular investigations. As the surgical intent for rectal GISTs is for en-bloc excision with wide margins, we surmise that the intraoperative consult should include GIST as a possible differential diagnosis for rectal mesenchymal tumours. In view of the potential for neoadjuvant treatment with imatinib before surgical excision to preserve sphincter function, a multidisciplinary approach is recommended for establishing most effective treatment strategy in these rare complex cases.
    Matched MeSH terms: Neurilemmoma/pathology
  3. Goh ASC, Kim YD, Woo KI, Lee JI
    Ophthalmology, 2013 Mar;120(3):635-641.
    PMID: 23149128 DOI: 10.1016/j.ophtha.2012.08.015
    OBJECTIVE: The orbital apex is an important anatomic landmark that hosts numerous critical neurovascular structures. Tumor resection performed at this complex region poses a therapeutic challenge to orbital surgeons and often is associated with significant visual morbidity. This article reports the efficacy and safety of multisession gamma knife radiosurgery (GKRS) in benign, well-circumscribed tumors located at the orbital apex.

    DESIGN: Retrospective interventional case series.

    PARTICIPANTS: Five patients with visual disturbances resulting from a benign, well-circumscribed orbital apex tumor (3 cases of cavernous hemangioma and 2 cases of schwannoma).

    METHODS: Each patient treated with GKRS with a total radiation dose of 20 Gy in 4 sessions (5 Gy in each session with an isodose line of 50%) delivered to the tumor margin.

    MAIN OUTCOME MEASURES: Best-corrected visual acuity, visual field changes, orbital imaging, tumor growth control, and side effects of radiation.

    RESULTS: All patients demonstrated improvement in visual acuity, pupillary responses, color vision, and visual field. Tumor shrinkage was observed in all patients and remained stable until the last follow-up. No adverse events were noted during or after the radiosurgery. None of the patients experienced any radiation-related ocular morbidity.

    CONCLUSIONS: From this experience, multisession GKRS seems to be an effective management strategy to treat solitary, benign, well-circumscribed orbital apex tumors.

    Matched MeSH terms: Neurilemmoma/pathology
  4. Azurah AG, Grover S, McGregor D
    J Reprod Med, 2013 Jul-Aug;58(7-8):365-8.
    PMID: 23947092
    Schwannoma (neurilemoma) is a benign, slow-growing tumor of the nerve sheath. These tumors are rarely found in the female genitalia and to date only 1 case of clitoral schwannoma has been reported in a young girl. We report here the second case of schwannoma of the clitoris.
    Matched MeSH terms: Neurilemmoma/pathology
  5. Qi Qi C, Ajit Singh V
    BMJ Case Rep, 2012;2012.
    PMID: 22892228 DOI: 10.1136/bcr.01.2012.5518
    The authors present an interesting case under our follow-up who has had five different forms of tumours with different pathologies throughout his lifetime. He started off with hepatoma, followed by pleomorphic sarcoma of the thigh, adenocarcinoma of the prostate, meningioma and finally schwanoma. He is still alive to this date.
    Matched MeSH terms: Neurilemmoma/pathology*
  6. Husain S, Husain S, Yunus MR, Yunus MR, Ramli R, Ramli R, et al.
    J Pak Med Assoc, 2011 May;61(5):500-1.
    PMID: 22204190
    The case of a 10-year-old girl is presented who had a slow-growing, painless swelling on the left side of the tongue since six months. This was associated with disturbances in mastication and phonation. Examination revealed a 5 cm x 4 cm. globular smooth, mobile mass on left side of the tongue. There was no neurological deficit and no neck nodes palpable. She underwent excision of the mass under general anaesthesia. Complete enucleation with primary closure was carried out. The patient had an uneventful postoperative recovery and histological evaluation was consistent with schwannoma. The patient was recurrence free after one year.
    Matched MeSH terms: Neurilemmoma/pathology
  7. Saiful Azli MN, Abd Rahman IG, Md Salzihan MS
    Med J Malaysia, 2007 Aug;62(3):256-8.
    PMID: 18246922 MyJurnal
    Cystic spinal or ancient schwannoma is a rare form of intradural tumour especially in the conus medullaris region. Due to its indolent behavior and benign course, the diagnosis of schwannoma is always a challenge and the imaging findings can be misleading. Our patient presented with chronic mild sciatica pain without any other neurological symptom. MRI of the spine showed intradural tumour located at the conus medullaris region with nerves compression and was reported as ependymoma. L3-L5 laminectomy and total excision of tumour was performed without any neurological complication. We concluded that ancient schwannoma of the conus medullaris is a rare benign tumour that can present with minimal non-specific neurological symptom that lead to misdiagnosis. Radical tumour excision is safe with an excellent outcome.
    Matched MeSH terms: Neurilemmoma/pathology
  8. Philip R, Chong AW, Rosalind S, Gurdeep S, Kalyani S
    Med J Malaysia, 2007 Jun;62(2):175-6.
    PMID: 18705460 MyJurnal
    Schwannomas are benign tumors. A series of three unusual cases involving the head and neck region at the Department of ENT, Hospital Ipoh from July 2004 to June 2005 is presented. The first case was a pedunculated schwannoma of the tongue base. The second was a schwannoma of the cervical sympathetic chain who developed a transient Horner's Syndrome upon fine needle aspiration cytology. The third case was a bilobed cervical vagal schwannoma which developed immediate vocal cord palsy postoperatively which was evident at six months follow-up. All tumors were removed surgically.
    Matched MeSH terms: Neurilemmoma/pathology*
  9. Ghani AR, Ariff AR, Romzi AR, Sayuthi S, Hasnan J, Kaur G, et al.
    Clin Neurol Neurosurg, 2005 Jun;107(4):318-24.
    PMID: 15885392
    Giant nerve sheath tumour is a rare tumour originating from the nerve sheath. It differs from the conventional nerve sheath tumour only by the size these tumours can reach. There are two main type of tumours that occur in the nerve sheath which include neurofibroma and schwannoma. The current views are that schwannomas arise from the progenitor of the schwann cell. Whereas the neurofibroma series probably arise from a mesenchymal origin closer to a fibroblast. We report on six cases of nerve sheath tumour that occur in the spinal and paraspinal region that presented to us over a 5 year period.
    Matched MeSH terms: Neurilemmoma/pathology*
  10. Hazarika P, Dipak RN, Parul P, Kailesh P
    Med J Malaysia, 2004 Aug;59(3):323-9.
    PMID: 15727377
    A few series of parapharyngeal space tumours have been reported earlier but recently not many series have been published in English literature. It is rare for any medical center, let alone an individual surgeon, to develop sufficient experience in evaluating these tumours. We present our experience in the treatment of 41 cases of parapharyngeal tumours from January 1992 to December 2001. FNAC, ultrasound and CT scan of the presenting mass was done in most of the patients as the main pre-operative work-up. The strategic location and extension of the tumour may occasionally alter the surgical approach for tumour excision.
    Matched MeSH terms: Neurilemmoma/pathology
  11. Siar CH, Ng KH, Chia TY, Kulkarni MG
    Singapore Med J, 1988 Feb;29(1):83-5.
    PMID: 3406779
    The aetiology, clinical and histological features of neurilemmomas of the oral and paraoral regions are briefly outlined. Two cases of atypical neurilemmomas of the tongue are described with an intent to document the partial encapsulation and multilobular distribution of the neurogenic tissue noted in these two lesions.
    Matched MeSH terms: Neurilemmoma/pathology
  12. Phang WK, Raman R, Jayalaksmi E
    J Laryngol Otol, 1987 Nov;101(11):1209-10.
    PMID: 3694036
    Matched MeSH terms: Neurilemmoma/pathology
  13. Jaais F, Sivanesan S
    Med J Malaysia, 1986 Dec;41(4):356-60.
    PMID: 3670161
    A case of metastatic malignant schwannoma of the right orbit is presented here. Although the patient had disseminated disease, it was the eye problems which were striking and most symptomatic.
    The orbital lesion was at first thought to be the primary tumour until a history of an excised right wrist mass was probed into and the histology traced.
    This report is written as malignant schwannoma is an uncommon tumour. The difficulty in diagnosing malignant schwannoma is mentioned. The importance of diagnosis of an orbital metastatic lesion is also pointed out as this is often misdiagnosed.
    Matched MeSH terms: Neurilemmoma/pathology
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