Displaying publications 1 - 20 of 365 in total

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  1. Lewthwaite R, Savoor SR
    Br J Exp Pathol, 1936;17:23-34.
    1. A strain of the urban form of tropical typhus has been established in guinea-pigs, and maintained in them for more than one hundred generations. The history and characteristics of the strain are given. The clinical criteria of infection are febrile and scrotal reactions.
    2. Methods of demonstration of Rickettsia in material from infected guinea-pigs and rabbits are described. In morphology, distribution and staining characteristics these Rickettsia do not appear to differ from R. prowazeki.
    3. The infection of rabbits by intra-ocular inoculation of virus has met with only partial success ; the strains rapidly lose virulence, and do not survive beyond the third generation. The results are closely similar to those reported by Nagayo et al., in corresponding infections of rabbits with the virus of typhus exanthematicus, and to those obtained by the authors in corresponding infections with a strain of Rocky Mountain spotted fever.
    4. Infection of white rats has been readily secured, and has been of the "inapparente" form.
    5. Two monkeys, inoculated intradermally with infected material, showed a mild general reaction only; no lesion developed at the site of inoculation.
    6. The results of the Weil-Felix reactions of sera from rabbits and monkeys convalescent from the infection are summarized. Agglutination is of the OX19 type of Proteus X strains, never of the OXK type.
    7. The experimental data obtained indicate that the guinea-pig is the laboratory animal of choice for the study of the urban form of tropical typhus.
    Matched MeSH terms: Rabbits
  2. Lewthwaite R, Savoor SR
    Br J Exp Pathol, 1936;17:448-60.
    1. Cross-immunity tests between strains of rural typhus and tsutsugamushi in the guinea-pig, rabbit and monkey were made. Complete cross-immunity between the strains was demonstrated.
    2. The problem of the absence of a primary ulcer in rural typhus and its presence in tsutsugamushi is discussed. Experimental findings are recorded; from consideration of these and certain clinical and epidemiological observations, the conclusion is drawn that one and the same virus may cause gradations of dermal lesion that vary greatly in extent and duration.
    3. Correlation of the results of cross-immunity tests and experimental infections with clinical, aetiological, epidemiological and serological findings indicates that the two diseases are identical. Rural typhus is not a disease sui generis, and the term should be discarded, the older designation, "tsutsugamushi disease ", being retained.
    Matched MeSH terms: Rabbits
  3. Lewthwaite R, Savoor SR
    Br J Exp Pathol, 1936;17:214-28.
    1. The results of the Weil-Felix reactions of sera from rabbits and monkeys inoculated with human virus or virus of laboratory strains of rural typhus, urban typhus or the tsutsugamushi disease are reported and discussed; as also are corresponding results in rabbits inoculated with the virus of two strains of tropical typhus recovered from wild rats.
    2. Instances are given of a change in type of antibody response; in particular, an experience is described in which the agglutinogenic properties of a virus of a tropical typhus strain underwent a temporary change, while the immunogenic properties remained unchanged.
    Matched MeSH terms: Rabbits
  4. Lewthwaite R, Savoor SR
    Br J Exp Pathol, 1936;17:461-72.
    Part VIII.
    1. Cross-immunity experiments in the guinea-pig, rabbit and monkey were carried out with the viruses of the tsutsugamushi disease (including rural typhus) and the urban typhus of Malaya; they showed that immunogenically the two viruses are distinct.
    2. The characteristics of setiology, epidemiology, serology and experimental infections are compared, and the conclusion drawn that the two diseases belong to entirely separate groups of rickettsial disease.
    Part IX.
    1. Cross-immunity experiments in the guinea-pig and rabbit were carried out with the viruses of Rocky Mountain spotted fever, tsutsugamushi (including rural typhus) and urban typhus. They showed that, immunologically, tsutsugamushi
    and spotted fever are entirely distinct; whereas urban typhus and spotted fever, though more distinct than alike immunologically, do possess a minor degree of reciprocal cross-immunity.
    2. Spotted-fever vaccine was found to have no protective value against the viruses of tsutsugamushi and urban typhus.
    Matched MeSH terms: Rabbits
  5. Lewthwaite R, Savoor S
    Br J Exp Pathol, 1940;21:117-25.
    1. Cross-protection tests between a strain of Sumatran mllite-fever and strains of the tsutsugamushi disease were done in the rabbit and monkev with the object of elucidating the inter-relation of these two diseases.
    2. It is concluded that Sumatran mite-fever is not a disease sui qeneris, but is identical with the tsutsugamushi disease.
    Matched MeSH terms: Rabbits
  6. Guest MF, Wong MM
    Med J Malaya, 1965 Dec;20(2):146-8.
    PMID: 4159506
    Matched MeSH terms: Rabbits
  7. Chan DP
    Med J Malaya, 1969 Jun;23(4):235-8.
    PMID: 4242165
    Matched MeSH terms: Rabbits
  8. Mukherjee AP
    Med J Malaya, 1969 Sep;24(1):21-3.
    PMID: 4243838
    Matched MeSH terms: Rabbits
  9. Yokogawa M
    Adv Parasitol, 1969;7:375-87.
    PMID: 4935271
    Matched MeSH terms: Rabbits
  10. Ghosh HK
    Med J Malaya, 1970 Jun;24(4):300-1.
    PMID: 4248352
    Matched MeSH terms: Rabbits
  11. Ghosh HK
    Med J Malaya, 1970 Sep;25(1):34-7.
    PMID: 4249491
    Matched MeSH terms: Rabbits
  12. Muul I
    Science, 1970 Dec 18;170(3964):1275-9.
    PMID: 5479006
    Insufficient use has been made of ecological data concerning potential hosts in studies to determine the life cycles of zoonotic parasites and pathogens. Factors such as the geographical distribution of hosts, the altitudes at which they live, their affinities for specific habitats, their vertical distribution within the habitat, and the periodicity of their activities have bearing on the hosts' predisposition to involvement in disease cycles. Diets and feeding habits may determine the likelihood of acquiring infection. Reproductive characteristics determine whether a species is suitable as a reservoir or as an amplifying host. Behavioral factors, such as selection of a particular kind of nest site, may also predispose the involvement of the host with parasites and pathogens. Behavior patterns may determine the maximum population densities of hosts. Estimates of population sizes, of relative abundances of species, and of the involvement of species in disease cycles may be strongly influenced by the collecting and sampling methods that are used and also by the behavioral response of the mammals toward collecting devices, such as traps.
    Matched MeSH terms: Rabbits
  13. Ping WW, Puvan IS
    Med J Malaysia, 1976 Mar;30(3):173-7.
    PMID: 822261
    Matched MeSH terms: Rabbits
  14. Kwan TK, Thambyrajah V
    Med J Malaysia, 1978 Mar;32(3):236-41.
    PMID: 683049
    Matched MeSH terms: Rabbits
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