Displaying publications 1 - 20 of 450 in total

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  1. A Hamid MS, Mohamed Ali MR, Yusof A, George J
    PMID: 22866670 DOI: 10.1186/1471-2474-13-138
    Muscle injuries are one of the commonest injuries affecting athletes. It often leads to significant pain and disability causing loss of training and competition time. With current treatment, the duration to return-to-play ranges form six weeks to never, depending on injury severity. Recent researches have suggested that autologous platelet-rich plasma (PRP) injection into the injured site may hasten soft tissues healing. To-date, there has been no randomised clinical trials to evaluate the effects of PRP on muscle healing. The aim of this study is to examine the effects of autologous PRP on duration to return-to-play after muscle injury.
    Matched MeSH terms: Research Design*
  2. A'qilah Ahmad Dahalan, Azali Saudi, Jumat Sulaiman
    MyJurnal
    Mobile robots often have to discover a path of collision-free towards a specific goal point in their environment. We are trying to resolve the mobile robot problem iteratively by means of numerical technique. It is built on a method of potential field that count on the use of Laplace’s equation in the mobile robot’s configuration space to constrain/which reduces the generation of a potential function over regions. This paper proposed an iterative approach in solving robot path finding problem known as Accelerated Over-Relaxation (AOR). The experiment shows that these suggested approach can establish a smooth path between the starting and goal points by engaging with a finite-difference technique. The simulation results also show that a more rapidly solution with smoother path than the previous work is achieved via this numerical approach.
    Matched MeSH terms: Research Design
  3. Ab Rahman N, Lim MT, Lee FY, Wo WK, Yeoh HS, Peariasamy KM, et al.
    Sci Rep, 2023 Nov 22;13(1):20471.
    PMID: 37993548 DOI: 10.1038/s41598-023-47486-x
    This study assessed the association between COVID-19 vaccines, SARS-CoV-2 infection and the risk of thrombocytopenia and venous thromboembolism (VTE). This self-controlled case series study used hospital records between 1st February 2021 and 28th February 2022 linked to the national immunisation registry and COVID-19 surveillance data in Malaysia. Conditional Poisson regression was used to estimate incidence rate ratios (IRR) of events in the risk period (day 1-21 post-exposure) relative to control period with the corresponding 95% confidence interval (CI) adjusted for calendar period. We found no significant increased risk of thrombocytopenia in 1-21 days following BNT162b2, CoronaVac and ChAdOx1 vaccines while the risk was increased following SARS-CoV-2 infection (IRR 15.52, 95% CI 13.38-18.00). Similarly, vaccination with BNT162b2, CoronaVac, or ChAdOx1 was not associated with an increased risk of VTE during the 1-21 days risk period. SARS-CoV-2 infection was associated with increased risk of VTE (IRR 39.84, 95% CI 27.45-32.44). Our findings showed low event rates of thrombocytopenia and VTE following booster vaccination with comparable safety profiles between those who received homologous and heterologous booster combinations. Our findings showed the risk of thrombocytopenia and VTE was not increased after COVID-19 vaccination while the risks were substantially higher after SARS-CoV-2 infection.
    Matched MeSH terms: Research Design
  4. Abdollahi Y, Sairi NA, Said SB, Abouzari-lotf E, Zakaria A, Sabri MF, et al.
    PMID: 26119355 DOI: 10.1016/j.saa.2015.06.036
    It is believe that 80% industrial of carbon dioxide can be controlled by separation and storage technologies which use the blended ionic liquids absorber. Among the blended absorbers, the mixture of water, N-methyldiethanolamine (MDEA) and guanidinium trifluoromethane sulfonate (gua) has presented the superior stripping qualities. However, the blended solution has illustrated high viscosity that affects the cost of separation process. In this work, the blended fabrication was scheduled with is the process arranging, controlling and optimizing. Therefore, the blend's components and operating temperature were modeled and optimized as input effective variables to minimize its viscosity as the final output by using back-propagation artificial neural network (ANN). The modeling was carried out by four mathematical algorithms with individual experimental design to obtain the optimum topology using root mean squared error (RMSE), R-squared (R(2)) and absolute average deviation (AAD). As a result, the final model (QP-4-8-1) with minimum RMSE and AAD as well as the highest R(2) was selected to navigate the fabrication of the blended solution. Therefore, the model was applied to obtain the optimum initial level of the input variables which were included temperature 303-323 K, x[gua], 0-0.033, x[MDAE], 0.3-0.4, and x[H2O], 0.7-1.0. Moreover, the model has obtained the relative importance ordered of the variables which included x[gua]>temperature>x[MDEA]>x[H2O]. Therefore, none of the variables was negligible in the fabrication. Furthermore, the model predicted the optimum points of the variables to minimize the viscosity which was validated by further experiments. The validated results confirmed the model schedulability. Accordingly, ANN succeeds to model the initial components of the blended solutions as absorber of CO2 capture in separation technologies that is able to industries scale up.
    Matched MeSH terms: Research Design
  5. Abduh MY, Norazmi-Lokman NH, Syahnon M, Roslan GAG, Ismail NH, Abol-Munafi AB
    Data Brief, 2020 Dec;33:106557.
    PMID: 33304955 DOI: 10.1016/j.dib.2020.106557
    Despite having high economical value and declining wild population, the aquaculture of the Malaysian mahseer (Tor tambroides) is still way behind. Crucial information such as on its sexual dimorphism is scarce thus making its broodstock management in captivity challenging. The first step in studying fish sexual dimorphism is by observing and identifying the morphological differences between each sex. Thus, this article collected and described morphometric measurements data of broodstock reared in captive conditions. The broodstock were reared and raised in captivity for five years since they were bought from a local commercial supplier while they were five-inch fingerlings. Seven conventional and 21 Truss network morphometric measurements were taken from 27 male (TL: 53.88 ± 2.86 cm; W: 1.82 ± 0.23 kg) and 27 female (TL: 53.97 ± 3.62 cm; W: 1.86 ± 0.35 kg) T. tambroides broodstocks using digital image analysis. Photograph of the fish broodstocks were captured and the morphometric measurements were conducted using imageJ freeware. Statistical analysis was later conducted on the morphometric data to identify the morphological differences between the broodstocks. This dataset will not only aid the sex identification of this species but also in stock population studies thus accelerating the development of T. tambroides aquaculture while improving its conservation efforts.
    Matched MeSH terms: Research Design
  6. Abdul Aziz Jemain, Al-Omari A, Kamarulzaman Ibrahim
    McIntyre was the first to suggest ranked set sampling (RSS) method for estimating the population mean. In this paper, we modify RSS to come up with new sampling method, namely, two stage ranked set sampling (TSRSS) for samples of size m=3k (k=1,2,..). The TSRSS is suggested for estimating the population median in order to increase the efficiency of the estimators. The TSRSS was compared to the simple random sampling (SRS), ranked set sampling (RSS), extreme ranked set sampling (ERSS), median ranked set sampling (MRSS) and balance groups ranked set sampling (BGRSS) methods. It is found that, TSRSS gives an unbiased estimator of the population median of symmetric distributions and it is more efficient than SRS. Also, it is more efficient than RSS, ERSS, MRSS and BGRSS based on the same number of measured units. For asymmetric distributions considered in this study, TSRSS has a small bias and smaller variance than SRS, RSS, ERSS, MRSS and BGRSS methods.
    Matched MeSH terms: Research Design
  7. Abdul Kader H
    Malays J Reprod Health, 1983 Dec;1(2):139-52.
    PMID: 12313335
    Matched MeSH terms: Research Design
  8. Abdul Khalil K, Mustafa S, Mohammad R, Bin Ariff A, Shaari Y, Abdul Manap Y, et al.
    Biomed Res Int, 2014;2014:787989.
    PMID: 24527457 DOI: 10.1155/2014/787989
    This study was undertaken to optimize skim milk and yeast extract concentration as a cultivation medium for optimal Bifidobacteria pseudocatenulatum G4 (G4) biomass and β -galactosidase production as well as lactose and free amino nitrogen (FAN) balance after cultivation period. Optimization process in this study involved four steps: screening for significant factors using 2(3) full factorial design, steepest ascent, optimization using FCCD-RSM, and verification. From screening steps, skim milk and yeast extract showed significant influence on the biomass production and, based on the steepest ascent step, middle points of skim milk (6% wt/vol) and yeast extract (1.89% wt/vol) were obtained. A polynomial regression model in FCCD-RSM revealed that both factors were found significant and the strongest influence was given by skim milk concentration. Optimum concentrations of skim milk and yeast extract for maximum biomass G4 and β -galactosidase production meanwhile low in lactose and FAN balance after cultivation period were 5.89% (wt/vol) and 2.31% (wt/vol), respectively. The validation experiments showed that the predicted and experimental values are not significantly different, indicating that the FCCD-RSM model developed is sufficient to describe the cultivation process of G4 using skim-milk-based medium with the addition of yeast extract.
    Matched MeSH terms: Research Design*
  9. Abdul Manaf SA, Mohamad Fuzi SFZ, Low KO, Hegde G, Abdul Manas NH, Md Illias R, et al.
    Appl Microbiol Biotechnol, 2021 Nov;105(21-22):8531-8544.
    PMID: 34611725 DOI: 10.1007/s00253-021-11616-0
    Carbon nanomaterials, due to their catalytic activity and high surface area, have potential as cell immobilization supports to increase the production of xylanase. Recombinant Kluyveromyces lactis used for xylanase production was integrated into a polymeric gel network with carbon nanomaterials. Carbon nanomaterials were pretreated before cell immobilization with hydrochloric acid (HCl) treatment and glutaraldehyde (GA) crosslinking, which contributes to cell immobilization performance. Carbon nanotubes (CNTs) and graphene oxide (GO) were further screened using a Plackett-Burman experimental design. Cell loading and agar concentration were the most important factors in xylanase production with low cell leakage. Under optimized conditions, xylanase production was increased by more than 400% compared to free cells. Immobilized cell material containing such high cell densities may exhibit new and unexplored beneficial properties because the cells comprise a large fraction of the component. The use of carbon nanomaterials as a cell immobilization support along with the entrapment method successfully enhances the production of xylanase, providing a new route to improved bioprocessing, particularly for the production of enzymes. KEY POINTS: • Carbon nanomaterials (CNTs, GO) have potential as cell immobilization supports. • Entrapment in a polymeric gel network provides space for xylanase production. • Plackett-Burman design screen for the most important factor for cell immobilization.
    Matched MeSH terms: Research Design
  10. Abdulelah H, Negash BM, Yekeen N, Al-Hajri S, Padmanabhan E, Al-Yaseri A
    ACS Omega, 2020 Aug 18;5(32):20107-20121.
    PMID: 32832765 DOI: 10.1021/acsomega.0c01738
    The influence of an anionic surfactant, a cationic surfactant, and salinity on adsorbed methane (CH4) in shale was assessed and modeled in a series of systematically designed experiments. Two cases were investigated. In case 1, the crushed Marcellus shale samples were allowed to react with anionic sodium dodecyl sulfate (SDS) and brine. In case 2, another set of crushed Marcellus shale samples were treated with cetyltrimethylammonium bromide (CTAB) and brine. The surfactant concentration and salinity of brine were varied following the Box-Behnken experimental design. CH4 adsorption was then assessed volumetrically in the treated shale at varying pressures (1-50 bar) and a constant temperature of 30 °C using a pressure equilibrium cell. Mathematical analysis of the experimental data yielded two separate models, which expressed the amount of adsorbed CH4 as a function of SDS/CTAB concentration, salinity, and pressure. In case 1, the highest amount of adsorbed CH4 was about 1 mmol/g. Such an amount was achieved at 50 bar, provided that the SDS concentration is kept close to its critical micelle concentration (CMC), which is 0.2 wt %, and salinity is in the range of 0.1-20 ppt. However, in case 2, the maximum amount of adsorbed CH4 was just 0.3 mmol/g. This value was obtained at 50 bar and high salinity (∼75 ppt) when the CTAB concentration was above the CMC (>0.029 wt %). The findings provide researchers with insights that can help in optimizing the ratio of salinity and surfactant concentration used in shale gas fracturing fluid.
    Matched MeSH terms: Research Design
  11. Abdulra'uf LB, Tan GH
    Food Chem, 2013 Dec 15;141(4):4344-8.
    PMID: 23993624 DOI: 10.1016/j.foodchem.2013.07.022
    Solid-phase microextraction (SPME) is a solvent-less sample preparation method which combines sample preparation, isolation, concentration and enrichment into one step. In this study, multivariate strategy was used to determine the significance of the factors affecting the solid phase microextraction of pesticide residues (fenobucarb, diazinon, chlorothalonil and chlorpyrifos) using a randomised factorial design. The interactions and effects of temperature, time and salt addition on the efficiency of the extraction of the pesticide residues were evaluated using 2(3) factorial designs. The analytes were extracted with 100 μm PDMS fibres according to the factorial design matrix and desorbed into a gas chromatography-mass spectrometry detector. The developed method was applied for the analysis of apple samples and the limits of detection were between 0.01 and 0.2 μg kg(-)(1), which were lower than the MRLs for apples. The relative standard deviations (RSD) were between 0.1% and 13.37% with average recovery of 80-105%. The linearity ranges from 0.5-50 μg kg(-)(1) with correlation coefficient greater than 0.99.
    Matched MeSH terms: Research Design
  12. Abrams S
    PMID: 12294443
    Matched MeSH terms: Research Design
  13. Abu Hassan Z, Hanafi NS, Teng CL
    Malays Fam Physician, 2006;1(1):29-31.
    PMID: 26998208
    Matched MeSH terms: Research Design*
  14. Abu ML, Nooh HM, Oslan SN, Salleh AB
    BMC Biotechnol, 2017 Nov 10;17(1):78.
    PMID: 29126403 DOI: 10.1186/s12896-017-0397-7
    BACKGROUND: Pichia guilliermondii was found capable of expressing the recombinant thermostable lipase without methanol under the control of methanol dependent alcohol oxidase 1 promoter (AOXp 1). In this study, statistical approaches were employed for the screening and optimisation of physical conditions for T1 lipase production in P. guilliermondii.

    RESULT: The screening of six physical conditions by Plackett-Burman Design has identified pH, inoculum size and incubation time as exerting significant effects on lipase production. These three conditions were further optimised using, Box-Behnken Design of Response Surface Methodology, which predicted an optimum medium comprising pH 6, 24 h incubation time and 2% inoculum size. T1 lipase activity of 2.0 U/mL was produced with a biomass of OD600 23.0.

    CONCLUSION: The process of using RSM for optimisation yielded a 3-fold increase of T1 lipase over medium before optimisation. Therefore, this result has proven that T1 lipase can be produced at a higher yield in P. guilliermondii.

    Matched MeSH terms: Research Design
  15. Abu Maloh HIA, Soh KL, Chong SC, Ismail SIF, Soh KG, Abu Maloh DI, et al.
    Clin Nurs Res, 2023 Feb;32(2):288-297.
    PMID: 35915917 DOI: 10.1177/10547738221112759
    Benson's relaxation affects many symptoms among hemodialysis patients. A cluster-randomized active control clinical trial with three repeated measures; pre, 1-week, and 1-month post-intervention sought to evaluate the effectiveness of Benson's Relaxation on pain and perceived stress (P&PS) among hemodialysis patients. Two governmental hospitals were randomly assigned to intervention and control. Thirty-six participants were randomly selected; 18 were intervention, and 18 were controlled. The intervention group performed Benson's Relaxation twice a day for 10 minutes for 8 weeks after a training session. The control group received an educational session about Progressive Relaxation. Findings revealed a statistically significant reduction in the PSS-10 and PRI scores between pre-intervention and 1 month after-intervention (p  .05). Benson's Relaxation significantly relieved P&PS among hemodialysis patients but not after only 1 week of practicing.
    Matched MeSH terms: Research Design
  16. Abusafia AH, Khraisat AMS, Tableb OK, Al-Mugheed K, Alabdullah AA, Abdelaliem SMF
    BMC Palliat Care, 2024 Jan 22;23(1):21.
    PMID: 38246991 DOI: 10.1186/s12904-024-01356-z
    PURPOSE: This study aimed to assess the impact of the Nursing Spiritual Care Module on the competence of nurses in providing spiritual care in the context of Malaysia.

    METHOD: This study employed an experimental design and involved a total of 122 nurses, with 59 in the experimental group and 63 in the control group. Participants were selected from palliative care wards associated with Hospital Universiti Sains Malaysia. Nurses in the experimental group underwent a two-week educational module on nursing spiritual care, while nurses in the control group attended a single lecture on spiritual care provided by the hospital.

    RESULTS: The results indicated no significant differences in sociodemographic characteristics between the two groups. A significant difference in spiritual care competence within the intervention group and the control group over time (p-value = 0.001), between the two groups (p-value = 0.038), and in the interaction between time and group (p-value = 0.001).

    CONCLUSION: The Nursing Spiritual Care Module is crucial in aiding nurses and healthcare professionals in cultivating the appropriate and wholesome attitudes and practices necessary to address the spiritual needs of patients.

    Matched MeSH terms: Research Design*
  17. Adeloye D, Agarwal D, Barnes PJ, Bonay M, van Boven JF, Bryant J, et al.
    J Glob Health, 2021;11:15003.
    PMID: 34737870 DOI: 10.7189/jogh.11.15003
    Background: The global prevalence of chronic obstructive pulmonary disease (COPD) has increased markedly in recent decades. Given the scarcity of resources available to address global health challenges and respiratory medicine being relatively under-invested in, it is important to define research priorities for COPD globally. In this paper, we aim to identify a ranked set of COPD research priorities that need to be addressed in the next 10 years to substantially reduce the global impact of COPD.

    Methods: We adapted the Child Health and Nutrition Research Initiative (CHNRI) methodology to identify global COPD research priorities.

    Results: 62 experts contributed 230 research ideas, which were scored by 34 researchers according to six pre-defined criteria: answerability, effectiveness, feasibility, deliverability, burden reduction, and equity. The top-ranked research priority was the need for new effective strategies to support smoking cessation. Of the top 20 overall research priorities, six were focused on feasible and cost-effective pulmonary rehabilitation delivery and access, particularly in primary/community care and low-resource settings. Three of the top 10 overall priorities called for research on improved screening and accurate diagnostic methods for COPD in low-resource primary care settings. Further ideas that drew support involved a better understanding of risk factors for COPD, development of effective training programmes for health workers and physicians in low resource settings, and evaluation of novel interventions to encourage physical activity.

    Conclusions: The experts agreed that the most pressing feasible research questions to address in the next decade for COPD reduction were on prevention, diagnosis and rehabilitation of COPD, especially in low resource settings. The largest gains should be expected in low- and middle-income countries (LMIC) settings, as the large majority of COPD deaths occur in those settings. Research priorities identified by this systematic international process should inform and motivate policymakers, funders, and researchers to support and conduct research to reduce the global burden of COPD.

    Matched MeSH terms: Research Design
  18. Ahmad Fuad Abdul Rahim, Muhamad Saiful Bahri Yusoff
    ASEAN Journal of Psychiatry, 2010;11(1):56-63.
    MyJurnal
    Objective: Medical training has always been regarded as a highly stressful environment to students. This article described a preliminary data on impact of a stress-management programme on medical students’ stress level. Methods: This is a quasi-experimental before after comparison study design. The programme was run over half-day and convenient sampling method was applied. Sample size as calculated for this preliminary study was 38. The 12 items General Health Questionnaire (GHQ-12) was administered prior to the
    programme and four months later. Data was analysed using SPSS version 12. Results: 34 participants were involved in this study. This study found that there was a significant difference in participants’ GHQ-12 scores before and after the programme (p
    Matched MeSH terms: Research Design
  19. Ahmad Hazmi AS, Abd Maurad Z, Mohd Noor MA, Nek Mat Din NSM, Idris Z
    J Sep Sci, 2021 Apr;44(7):1471-1481.
    PMID: 33522105 DOI: 10.1002/jssc.202000929
    Ethylene glycol is a super commodity chemical and it has vital roles in various applications. Its co-production with other chemicals, such as ethylene carbonate and glycerol carbonate, has promised cheaper production cost. Its quantification presents a challenge as its contaminants, such as ethylene carbonate, produce a signal-reducing effect in flame ionized detector. The aim of this study is to evaluate external standard to quantify the composition of glycol mixture. Measurement system analysis was employed on the external standard method. Reliability of the external standard is statistically significant with low p-values, excellent capability indices, and high F-values. The external standard is found to have remarkable precision and trueness as both capability indices are mirroring each other. Furthermore, the capability analysis has a strong correlation with quality measurement. Based on capability indices, the limit of detection is recommended at S/N = 25 and the limit of quantification is recommended at S/N = 100 for a reliable measurement. A high degree of reliability is achieved coherently as almost all uncertainties of coefficients of variations are less than 5%. The established method was validated and successfully applied to glycol mixture at azeotropic distillation pilot plant.
    Matched MeSH terms: Research Design
  20. Ahmad Khairuddin Mohd G, Haikal Anuar A, Daniella M, Najwa Afiqa R, Nazuha S
    Jurnal Psikologi Malaysia, 2018;32:165-175.
    Family functioning and achievement motivation are two aspects that have been frequently discussed by psychologists. Findings from previous research found that both aspects are related to each other. The objective of this research was to identify the levels of family functioning and motivation achievements among civil servants from the Ministry of Human Resources. Besides that, this research intended to observe the influence of family functioning towards motivation achievement of the same sample. This research involved 945 respondents comprised of employees with different grades and position within the Ministry of Human Resource in which they were chosen via simple random sampling. The Family Functioning Style Scale (FFSS) was used to measure family functioning while the Cassidy and Lynn Achievement Scale (CLAM) was used to measure achievement motivation. Analysis was carried out using Statistical Package for Social Science (SPSS) version 22 on the data collected. Results showed that majority of the respondents were found to have high levels of family functioning, however, majority of the respondents reported average level of achievement motivation. Results also found that family functioning was influential to motivation achievement.
    Matched MeSH terms: Research Design
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