Displaying publications 1 - 20 of 69 in total

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  1. Fulltext A Review of Indoor Air Quality and Respiratory System among Schoolchildren in Malaysia
    Foo, Ming Hui
    Borneo Journal of Medical Sciences, 2018;12(101):51-0.
    MyJurnal
    In this era, most of us are suffering some level of respiratory problem. Respiratory system of our children is even more sensitive compare to adults. As our children spending an average of 8 hours in school, indoor air quality of the classroom become an important element. Many studies have shown that indoor air quality not only affecting the respiratory system of schoolchildren but their performance in academy as well.
    Matched MeSH terms: Respiratory System
  2. Fulltext A description of health complaints and treatment among patients visiting medical relief camps at Aceh and Balakot two months post disastery
    Adlina, S., Narimah, A.H.H., Mazlin, M.M., Nuraliza, A.S., Hakimi, Z.A., Soe, S.A., et al.
    Malaysian Journal of Public Health Medicine, 2006;6(1):51-57.
    MyJurnal
    This study was conducted to determine the patterns of disease and treatment at two disaster sites. Studies prior to this have shown that all natural disasters are unique in that each affected region of the world have different social, economic and health backgrounds. However, similarities exist among the health effects of different disasters which if recognized can ensure that health and emergency medical relief and limited resources are well managed. This study found that although Aceh and Balakot were two totally different areas with reference to locality and climate it was noticed that the patterns of disease two months post disaster are similar the commonest being respiratory conditions followed by musculoskeletal conditions and gastrointestinal conditions. For the treatment patterns it was observed that the two areas prescribed almost similar, types of medicine mainly for gastrointestinal and respiratory systems. However in Aceh, there were more skin treatment and in Balakot there was more usage of musculoskeletal drugs.
    Matched MeSH terms: Respiratory System
  3. A pitfall in diagnosis: endobronchial tuberculosis as a cause of acute on chronic stridor
    Norlijah, O., Abu, M.N., Mohd Nor, A., Yip, C.W.
    Malaysian Journal of Paediatrics and Child Health, 2007;15(1):33-36.
    MyJurnal
    Endobronchial tuberculosis is an uncommon manifestation involving the tracheobronchial tree. The clinical presentation is typically non-specific. We report this unusual complication of pulmonary tuberculosis initially diagnosed as foreign body in a 16-month-old child.
    Matched MeSH terms: Respiratory System
  4. Fulltext A rare case of a sharp foreign body on the vocal cord
    Nor Hisyam CI, Misron K, Mohamad I
    Malays Fam Physician, 2017;12(2):23-25.
    PMID: 29423126 MyJurnal
    A foreign body (FB) in the upper aerodigestive tract is a common clinical problem that presents as as acute emergency. Sharp FB, such as fish bone or chicken bone, commonly lodges in the tonsil, base of tongue, vallecula or pyriform fossa. Dislodgement of a FB into the laryngopharynx is very rare and specifically onto the vocal cord is extremely uncommon. This case report illustrates a rare case of a sharp FB that was dislodged into the airway and stuck on to the right vocal cord, which was removed under local anaesthesia.
    Matched MeSH terms: Respiratory System
  5. Fulltext A review on development of blood substitute
    Mislia Othman, Muhammad Azrul Zabidi
    Jurnal Sains Kesihatan Malaysia, 2020;18(2):59-71.
    MyJurnal
    This review paper aims to present an overview of the development of blood substitute particularly red blood cell substitute or artificial oxygen carrier. Knowledge on human blood inspired from the understanding of human blood circulation system. Ibn Nafis was first to describe that blood flow through respiratory system before entering the heart. This finding denied the claim that tiny pores present within the septum of the heart. Then, William Harvey further described human cardiovascular system in detail and contributed to better understanding on the roles of blood in body. Several blood transfusions were attempted using blood collected from human, animal and other blood substitutes such as milk before the practice was banned for almost 150 years in Europe. Major discoveries on blood group and antibody reaction have made blood transfusion safer. However, several issues and challenges have re-triggered the exploration to develop red cell substitutes. Two approaches have been taken to develop the red blood cell substitute which are classified into biological and chemical based oxygen carriers. The earliest efforts have been on haemoglobin based oxygen carrier (HBOC) and perfluorocarbon (PFC) while the recent developement are on polymer-based oxygen carrier and in-vitro stem cell derived red blood cell.
    Matched MeSH terms: Respiratory System
  6. A scanning electron microscopic study of in vivo tissue engineered respiratory epithelium in sheep
    Heikal MY, Aminuddin BS, Jeevanan J, Chen HC, Sharifah S, Ruszymah BH
    Med J Malaysia, 2008 Jul;63 Suppl A:34.
    PMID: 19024970
    Normal tracheal mucociliary clearance is the key to maintaining the health and defense of respiratory airway. Therefore the present of cilia and mucous blanket are important for tracheal epithelium to function effectively. In the present study, we prepared a tissue engineered respiratory epithelium construct (TEREC) made of autologous respiratory epithelium cells, fibroblast and fibrin from sheep owns blood which replaced a created tracheal mucosal defect. Scanning electron microscopy (SEM) showed encouraging result where immature cilia were present on the surface of TEREC. This result indicates that engineered respiratory epithelium was able to function as normal tissue.
    Matched MeSH terms: Respiratory System/cytology*
  7. Airborne particles in the city center of Kuala Lumpur: Origin, potential driving factors, and deposition flux in human respiratory airways
    Khan MF, Hamid AH, Bari MA, Tajudin ABA, Latif MT, Nadzir MSM, et al.
    Sci Total Environ, 2019 Feb 10;650(Pt 1):1195-1206.
    PMID: 30308807 DOI: 10.1016/j.scitotenv.2018.09.072
    Equatorial warming conditions in urban areas can influence the particle number concentrations (PNCs), but studies assessing such factors are limited. The aim of this study was to evaluate the level of size-resolved PNCs, their potential deposition rate in the human respiratory system, and probable local and transboundary inputs of PNCs in Kuala Lumpur. Particle size distributions of a 0.34 to 9.02 μm optical-equivalent size range were monitored at a frequency of 60 s between December 2016 and January 2017 using an optical-based compact scanning mobility particle sizer (SMPS). Diurnal and correlation analysis showed that traffic emissions and meteorological confounding factors were potential driving factors for changes in the PNCs (Dp ≤1 μm) at the modeling site. Trajectory modeling showed that a PNC <100/cm3 was influenced mainly by Indo-China region air masses. On the other hand, a PNC >100/cm3 was influenced by air masses originating from the Indian Ocean and Indochina regions. Receptor models extracted five potential sources of PNCs: industrial emissions, transportation, aged traffic emissions, miscellaneous sources, and a source of secondary origin coupled with meteorological factors. A respiratory deposition model for male and female receptors predicted that the deposition flux of PM1 (particle mass ≤1 μm) into the alveolar (AL) region was higher (0.30 and 0.25 μg/h, respectively) than the upper airway (UA) (0.29 and 0.24 μg/h, respectively) and tracheobronchial (TB) regions (0.02 μg/h for each). However, the PM2.5 deposition flux was higher in the UA (2.02 and 1.68 μg/h, respectively) than in the TB (0.18 and 0.15 μg/h, respectively) and the AL regions (1.09 and 0.91 μg/h, respectively); a similar pattern was also observed for PM10.
    Matched MeSH terms: Respiratory System
  8. Fulltext Airway models in a pandemic: Suitability of models in modeling SARS-CoV-2
    Teo A, Chua CLL, Chan LLY
    PLoS Pathog, 2022 Mar;18(3):e1010432.
    PMID: 35349597 DOI: 10.1371/journal.ppat.1010432
    Matched MeSH terms: Respiratory System
  9. Fulltext An Influenza A Vaccine Based on the Extracellular Domain of Matrix 2 Protein Protects BALB/C Mice Against H1N1 and H3N2
    Ong HK, Yong CY, Tan WS, Yeap SK, Omar AR, Razak MA, et al.
    Vaccines (Basel), 2019 08 19;7(3).
    PMID: 31430965 DOI: 10.3390/vaccines7030091
    Current seasonal influenza A virus (IAV) vaccines are strain-specific and require annual reconstitution to accommodate the viral mutations. Mismatches between the vaccines and circulating strains often lead to high morbidity. Hence, development of a universal influenza A vaccine targeting all IAV strains is urgently needed. In the present study, the protective efficacy and immune responses induced by the extracellular domain of Matrix 2 protein (M2e) displayed on the virus-like particles of Macrobrachium rosenbergii nodavirus (NvC-M2ex3) were investigated in BALB/c mice. NvC-M2ex3 was demonstrated to be highly immunogenic even in the absence of adjuvants. Higher anti-M2e antibody titers corresponded well with increased survival, reduced immunopathology, and morbidity of the infected BALB/c mice. The mice immunized with NvC-M2ex3 exhibited lower H1N1 and H3N2 virus replication in the respiratory tract and the vaccine activated the production of different antiviral cytokines when they were challenged with H1N1 and H3N2. Collectively, these results suggest that NvC-M2ex3 could be a potential universal influenza A vaccine.
    Matched MeSH terms: Respiratory System
  10. Antimicrobial susceptibility pattern of clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital
    Raja NS, Singh NN
    J Microbiol Immunol Infect, 2007 Feb;40(1):45-9.
    PMID: 17332906
    BACKGROUND AND PURPOSE: Pseudomonas aeruginosa is an important cause of morbidity and mortality in hospitalized, critically ill patients and patients with underlying medical conditions such as cystic fibrosis, neutropenia, and iatrogenic immunosuppression. The prevalence of multiresistant P. aeruginosa isolates has been increasing. The aim of this study was to determine the antimicrobial susceptibility patterns in P. aeruginosa strains isolated at a university teaching hospital in Kuala Lumpur, Malaysia.
    METHODS: The Laboratory Information System of the microbiology department was retrospectively reviewed to determine the susceptibility patterns of P. aeruginosa isolates to anti-pseudomonal antibiotics, from January to June 2005. Disk diffusion methods were employed and results were interpreted according to National Committee for Clinical Laboratory Standards guidelines.
    RESULTS: 505 clinical isolates of P. aeruginosa were tested. Major sources of these isolates included respiratory tract, wound, urine and blood. The rates of antimicrobial resistance of isolates were 6.73% to amikacin, 12.9% to gentamicin, 10.1% to netilmicin, 10.9% to ceftazidime, 11.3% to ciprofloxacin, 9.9% to imipenem, 10.8% to piperacillin, 9.4% to piperacillin-tazobactam and 0% to polymyxin B. Of the 505 isolates, 29 (5.74%) were found to be multidrug-resistant; these were most commonly isolated from respiratory tract specimens of patients in surgical units, followed by respiratory tract specimens in patients in medical units.
    CONCLUSIONS: The data in this study showed low rates of antibiotic resistance among P. aeruginosa isolates. Combinations of aminoglycosides plus beta-lactams or quinolones should be the appropriate choice for empirical therapy in P. aeruginosa infections. Active antibiotic susceptibility testing and surveillance should be continued in order to curtail the problem of antibiotic resistance.
    Matched MeSH terms: Respiratory System/microbiology
  11. Fulltext Bilateral Jensen disease in a healthy young lady
    Ghani Siti-Ilyana, Koh, Yi-Ni, Embong Zunaina
    Journal of Biomedical and Clinical Sciences, 2018;3(1):19-24.
    MyJurnal
    Toxoplasmic optic neuropathy is rare and usually occurs monoocularly. This case report demonstrates a rare presentation of bilateral
    juxtapapillary retinochoroiditis (Jensen disease) due to toxoplasma infection in
    a young healthy patient. A 20-year-old lady presented with bilateral painless
    blurring of central vision for 5 days duration. It was preceded by fever, upper
    respiratory tract symptoms and headache. There was no history of contact or
    being scratched by a cat. Visual acuity was counting fingers for the right eye
    and 6/45 for the left eye. There was presence of relative afferent pupillary
    defect in the right eye. Optic nerve functions were impaired bilaterally which
    was severe in the right eye. Both eyes showed the presence of mild anterior
    segment inflammation and vitritis. Fundus examination revealed juxtapapillary
    retinochoroiditis bilaterally with swollen optic disc. Optical coherence
    tomography (OCT) showed presence of intra-retinal and sub-retinal fluid at
    macular area bilaterally. Serology for anti-toxoplasma Immunoglobulin G (IgG)
    was positive with titre of 1450 IU/ml. Computed tomography scan (CT scan) of
    brain and orbit was normal. A diagnosis of bilateral juxtapapillary
    retinochoroiditis or Jensen disease was made. Oral azithromycin 500 mg daily
    and guttae prednisolone 4 hourly for 6 weeks was commenced. Oral
    prednisolone 50 mg daily (1 mg/kg/day) was added after completion of 1 week
    of antibiotic and was tapered down within 5 weeks. There was improvement of
    vision as early as 3 weeks post initiation of the treatment. Upon 6 weeks
    completing the treatment, her vision has improved to 6/7.5 on both eyes with
    resolution of optic disc swelling and sub-retinal fluid. Early recognition and
    initiation of treatment in toxoplasma infection associated with juxtapapillary
    retinochoroiditis usually result in good visual prognosis.
    Matched MeSH terms: Respiratory System
  12. Fulltext Biomarker as a research tool in linking exposure to air particles and respiratory health
    Suhaimi NF, Jalaludin J
    Biomed Res Int, 2015;2015:962853.
    PMID: 25984536 DOI: 10.1155/2015/962853
    Some of the environmental toxicants from air pollution include particulate matter (PM10), fine particulate matter (PM2.5), and ultrafine particles (UFP). Both short- and long-term exposure could result in various degrees of respiratory health outcomes among exposed persons, which rely on the individuals' health status.

    METHODS: In this paper, we highlight a review of the studies that have used biomarkers to understand the association between air particles exposure and the development of respiratory problems resulting from the damage in the respiratory system. Data from previous epidemiological studies relevant to the application of biomarkers in respiratory system damage reported from exposure to air particles are also summarized.

    RESULTS: Based on these analyses, the findings agree with the hypothesis that biomarkers are relevant in linking harmful air particles concentrations to increased respiratory health effects. Biomarkers are used in epidemiological studies to provide an understanding of the mechanisms that follow airborne particles exposure in the airway. However, application of biomarkers in epidemiological studies of health effects caused by air particles in both environmental and occupational health is inchoate.

    CONCLUSION: Biomarkers unravel the complexity of the connection between exposure to air particles and respiratory health.

    Matched MeSH terms: Respiratory System Abnormalities/blood*; Respiratory System Abnormalities/chemically induced; Respiratory System Abnormalities/physiopathology
  13. Fulltext BrdU pulse labelling in vivo to characterise cell proliferation during regeneration and repair following injury to the airway wall in sheep
    Yahaya B, McLachlan G, Collie DD
    ScientificWorldJournal, 2013;2013:871932.
    PMID: 23533365 DOI: 10.1155/2013/871932
    The response of S-phase cells labelled with bromodeoxyuridine (BrdU) in sheep airways undergoing repair in response to endobronchial brush biopsy was investigated in this study. Separate sites within the airway tree of anaesthetised sheep were biopsied at intervals prior to pulse labelling with BrdU, which was administered one hour prior to euthanasia. Both brushed and spatially disparate unbrushed (control) sites were carefully mapped, dissected, and processed to facilitate histological analysis of BrdU labelling. Our study indicated that the number and location of BrdU-labelled cells varied according to the age of the repairing injury. There was little evidence of cell proliferation in either control airway tissues or airway tissues examined six hours after injury. However, by days 1 and 3, BrdU-labelled cells were increased in number in the airway wall, both at the damaged site and in the regions flanking either side of the injury. Thereafter, cell proliferative activity largely declined by day 7 after injury, when consistent evidence of remodelling in the airway wall could be appreciated. This study successfully demonstrated the effectiveness of in vivo pulse labelling in tracking cell proliferation during repair which has a potential value in exploring the therapeutic utility of stem cell approaches in relevant lung disease models.
    Matched MeSH terms: Respiratory System/cytology; Respiratory System/injuries*; Respiratory System/metabolism
  14. Cancer of the lung, trachea and larynx in singapore
    Muir CS
    Br. J. Cancer, 1960;14:1-7.
    DOI: 10.1038/bjc.1960.1
    The main morbid anatomical features of the 176 lung, the 2 tracheal, and the 13 laryngeal cancers seen in the 22,997 post-mortems performed by the University and Government Departments of Pathology, Singapore, from 1948-58 inclusive, are described, and are seen to be as elsewhere. About one-tenth of all cancers admitted to hospital, and of all cancers registered by the Registrar-General (Singapore) from 1954-58 inclusive were in the lung. In 15 per cent of all post-mortems on persons with malignant disease, the primary tumour was of pulmonary origin. The crude death rate for cancer of the lung in Singapore for 1954-58 inclusive was 0-065 per 1000 living per annum. More cases of lung cancer are seen before the age of 40 than in the West. The consumption of tobacco in Singapore is noted to be 3-7 lb. (1.7 kg) per person per annum. A portion of the literature on cancer of the lung in South-East Asia and in China is discussed. I wish to thank Professor R. Kirk for kind help and encouragement, my colleagues of the Government and University Departments of Pathology for access to their post-mortem notes and records, Mr. E. J. Phillips and Mr. S. C. Chua of the Department of Statistics, Singapore, and Mr. Lee of the Customs Department, Singapore, for various data, Mr. Ti Teow See for Fig. 1, and Mr. P. A. Samuel who typed the script. This communication forms part of a thesis for the degree of Ph.D. (Malaya). © 1960, The British Empire Cancer Campaign for Research. All rights reserved.
    Matched MeSH terms: Respiratory System
  15. Causes of chronic oxygen dependency in new borns in a tertiary level neonatal unit
    Jacqueline, H.O.
    Malaysian Journal of Child Health, 1992;4(1):20-22.
    MyJurnal
    A retrospective survey was carried out in a neonatal unit to identify babies who required oxygen for more than the first 28 days of life and to determine the cause of their oxygen dependency. A total of 9173 neonates were admitted over a three year period. Approximately 750 were ventilated. Fifteen required oxygen for more than the first 28 days. Ten (67%) of these were due to bronchopulmonary dysplasia. 2 had upper airway complications of mechanical ventilation, one had recurrent apnoea, one had recurrent pneumonia, and one who did not require ventilation had chronic oxygen dependency of unknown cause. Bronchopulmonary dysplasia was the commonest cause of chronic oxygen dependency. The incidence was 1.5% of ventilated babies.
    Matched MeSH terms: Respiratory System
  16. Cellular and humoral responses in the respiratory tract of goats following intranasal stimulation using formalin-killed Pasteurella haemolytica A2
    Zamri-Saad M, Effendy AW, Israf DA, Azmi ML
    Vet Microbiol, 1999 Mar 12;65(3):233-40.
    PMID: 10189198
    A study to determine the immunoglobulin and cellular responses in the respiratory tract of goats following intranasal exposures to formalin-killed Pasteurella haemolytica A2 was carried out. Forty-two goats were divided into two groups. Goats in Group 1 were subjected to double intranasal exposures to formalin-killed P. haemolytica A2 while goats in Group 2 were the unexposed control. Prior to and at weekly intervals post-exposure, three goats from each group were killed, serum samples were collected while the lungs were flushed with 50 ml normal saline before the right apical lobes were fixed in 10% buffered formalin. Both serum and lung lavage fluid were subjected to enzyme-linked immunosorbent assay (ELISA) to determine the levels of IgA, IgM and IgG while the formalin-fixed tissues were examined histologically. IgA levels in the lung lavage fluid increased rapidly to reach a significantly (p < 0.05) high level as early as Week 2 post-exposure and remained significantly (p < 0.05) high throughout the study period. The IgM levels increased at an intermediate rate to reach a significantly (p < 0.05) high level at Week 3 post-exposure before they decreased to an insignificant (p > 0.05) level the following week and the weeks thereafter. IgG levels increased gradually and only reached a significantly (p < 0.01) high level at Weeks 5 and 6 of the study. The size of the bronchus-associated lymphoid tissue (BALT) and the number of lymphocytes in BALT increased significantly from Week 2 and remained high thereafter. However, differences in the numbers of BALT were insignificant (p > 0.05) initially before becoming significantly (p < 0.05) high at Weeks 5 and 6. The BALT responses were parallel to those of imunoglobulins in the lung lavage fluid.
    Matched MeSH terms: Respiratory System/immunology*; Respiratory System/microbiology
  17. Challenges and future direction of molecular research in air pollution-related lung cancers
    Shahadin MS, Ab Mutalib NS, Latif MT, Greene CM, Hassan T
    Lung Cancer, 2018 04;118:69-75.
    PMID: 29572006 DOI: 10.1016/j.lungcan.2018.01.016
    Hazardous air pollutants or chemical release into the environment by a variety of natural and/or anthropogenic activities may give adverse effects to human health. Air pollutants such as sulphur dioxide (SO2), nitrogen oxides (NOx), carbon monoxide (CO), heavy metals and particulate matter (PM) affect number of different human organs, especially the respiratory system. The International Agency for Research on Cancer (IARC) reported that ambient air pollution is a cause of lung cancer. Recently, the agency has classified outdoor air pollution as well as PM air pollution as Group 1 carcinogens. In addition, several epidemiological studies have shown a positive association between air pollutants to lung cancer risks and mortality. However, there are only a few studies examining the molecular effects of air pollution exposure specifically in lung cancer due to multiple challenges to mimic air pollution exposure in basic experimentation. Another major issue is the lack of adequate adjustments for exposure misclassification as air pollution may differ temporo-spatially and socioeconomically. Thus, the purpose of this paper is to review the current molecular understanding of air pollution-related lung cancer and potential future direction in this challenging yet important research field.
    Matched MeSH terms: Respiratory System/pathology*
  18. Fulltext Characteristics of photo-luminescent (PL) powder applied with polyester resin as glow-in-the-dark emergency signage
    Siti Khadijah Che Osm, Munikanan, Vikneswaran, Hapsa Husen, Zuliziana Suif, Maidiana Othman, Nordila Ahmad, et al.
    ZULFAQAR International Journal of Defence Science, Engineering & Technology, 2020;3(1):32-38.
    MyJurnal
    During a disaster, the rescuer must reach the disaster area within the fastest time with the help of navigation tools. However, there might be some obstacles during the night time that make the evacuation of the victims difficult especially due to the bad weather. Hence, an attempt to produce glow-in-the-dark emergency signage to ease the evacuation process and to enhance visibility during night time is necessary. In this present study, particular emphasis is given to investigate the characteristic of photo-luminescent (PL)powder applied with polyester resin as glow-in-the-dark emergency signage. Five samples of signage were fabricated with different percentage of PL powder, i.e. 20%, 40%. 60%, 80% and 100% and mixed with 150g polyester resin. Three types of luminance test were performed to check the workability of the samples. The tests are physical appearance, one-hours illuminance test and afterglow duration tests. The result showed that the maximum lux meter reading was recorded in Sample 5 with 6 lux luminosity and provided the longest glow duration of the sample before completely off after 12-hours. Results proved that the highest percentage of the PL powder content, the longer the afterglow duration will be achieved. It also noted that the polyester resin could be a good binder of PL powder for producing the glow-in-the-dark emergency signage.
    Matched MeSH terms: Respiratory System Abnormalities
  19. Clinical features and management of COVID-19: A systematic review
    Daha SK, Koirala B, Chapagain D, Lohani P, Acharya S, Sharma P
    Trop Biomed, 2020 Jun 01;37(2):409-420.
    PMID: 33612810
    Novel coronavirus disease, the latest world pandemic is one of the most contagious viral infections to date. There has been a lack of uniformity on recognizing this condition clinically because of poorly understood pathophysiology and clinical nature. Also due to ongoing clinical trials, its management is also varied. This is a systematic review from evidence-based studies until March 1st, 2020, covering an update on its clinical features and management. This study shows the multisystem involvement of COVID-19 with dominant respiratory features followed by the musculoskeletal, gastrointestinal system and others. The clinical features varied from asymptomatic to severe forms. Major causes of fatality were acute respiratory distress syndrome, shock, acute cardiac injury, acute kidney injury, rhabdomyolysis, and arrhythmia. Major modalities of management included supportive, antiviral and antibiotic therapy. There was no direct relationship between the specific treatment and the outcome.
    Matched MeSH terms: Respiratory System/physiopathology; Respiratory System/virology
  20. Comparative analysis of realistic CT-scan and simplified human airway models in airflow simulation
    Johari NH, Osman K, Helmi NH, Abdul Kadir MA
    Comput Methods Biomech Biomed Engin, 2015;18(1):48-56.
    PMID: 23521065 DOI: 10.1080/10255842.2013.776548
    Efforts to model the human upper respiratory system have undergone many phases. Geometrical proximity to the realistic shape has been the subject of many research projects. In this study, three different geometries of the trachea and main bronchus were modelled, which were reconstructed from computed tomography (CT) scan images. The geometrical variations were named realistic, simplified and oversimplified. Realistic refers to the lifelike image taken from digital imaging and communications in medicine format CT scan images, simplified refers to the reconstructed image based on natural images without realistic details pertaining to the rough surfaces, and oversimplified describes the straight wall geometry of the airway. The characteristics of steady state flows with different flow rates were investigated, simulating three varied physical activities and passing through each model. The results agree with previous studies where simplified models are sufficient for providing comparable results for airflow in human airways. This work further suggests that, under most exercise conditions, the idealised oversimplified model is not favourable for simulating either airflow regimes or airflow with particle depositions. However, in terms of immediate analysis for the prediction of abnormalities of various dimensions of human airways, the oversimplified techniques may be used.
    Matched MeSH terms: Respiratory System/radiography*
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