MyMedR

Central serous retinopathy: a preliminary report of 33 cases

Eu-sen VO

Med J Malaya, 1969 Sep;24(1):18-20.

PMID: 4243836

Matched MeSH terms: Retina*

Advanced retinoblastoma in Malaysian children

Sinniah D, Narasimha G, Prathap K

Acta Ophthalmol, 1980 Oct;58(5):819-24.

PMID: 7211270

Twenty children with retinoblastoma are reviewed who were treated at the University Hospital, Kuala Lumpur over a 10-year-period. They constitute 6.6% of childhood malignancies and without exception all presented with advanced disease. Hereditary cases were notably absent in the the series probably because past cases have almost invariably succumbed without an opportunity to transmit the gene. With enucleation and radiotherapy six of the patients have survived from 2 to 12 years. The addition of vincristine and cyclophosphamide has not been associated with improved survival.

Matched MeSH terms: Retina/pathology

The retina in the diabetic

Kandiah R, Annuar Z, Sukumaran K

Family Physician, 1989;1:60-63.

Matched MeSH terms: Retina

Bilateral Norrie's disease in identical twins

Sukumaran K

Br J Ophthalmol, 1991 Mar;75(3):179-80.

PMID: 2012789

A case of Norrie's disease in an identical twins is reported. No positive family history was obtained. The couple had no other children. The older of the twins died at the age of 9 months of uncertain cause. To the best of my knowledge this is the first case of Norrie's disease reported in Malaysia. And its occurrence in an identical twins is very rare.

Matched MeSH terms: Retina/abnormalities*; Retina/pathology; Retinal Detachment/congenital; Retinal Detachment/pathology

Retinal findings in adult leukaemia: correlation with leukocytosis

Jackson N, Reddy SC, Hishamuddin M, Low HC

Clin Lab Haematol, 1996 Jun;18(2):105-9.

PMID: 8866143

The associations between retinal findings and haematological parameters in acute leukaemia are controversial. Sixty-three newly-diagnosed acute leukaemia patients, aged 12-77 years, were studied prospectively for the presence of intra-retinal haemorrhages (IRH), white-centred haemorrhages (WCH), cotton wool spots (CWS) and macular haemorrhages (MH), Thirty-three patients (52.4%) showed at least one retinal abnormality. The prevalence of individual findings was: IRH (30 cases), WCH (20 cases), CWS (5 cases), MH (11 cases). In contrast to previous studies, there was no association between any of these retinal findings and the haemoglobin level or the platelet count. There was a higher median WBC in patients with IRH (68 x 10(9)/l) than in those without IRH (15.4 x 10(9)/l), P = 0.037. When the acute myeloblastic leukaemia cases were considered separately, an association was also found between higher WBC and the presence of WCH and CWS. There was no association between retinal findings and FAB type in the AML cases. We conclude that a high WBC may be at least as important as anaemia and thrombocytopenia in the pathogenesis of the retinopathy of acute leukaemia.

Matched MeSH terms: Retina/pathology*; Retinal Hemorrhage/etiology*; Retinal Hemorrhage/pathology; Retinal Vessels/pathology*

Fundus magnification produced during direct ophthalmoscopy of the corrected eye

Chung KM

Optom Vis Sci, 1999 Feb;76(2):121-6.

PMID: 10082059

The clinical significance of fundus magnification produced during direct ophthalmoscopy of the corrected eye has not been fully established. Based on paraxial ray tracing, fundus magnification (M) can be defined by a simple equation, M = (K'/4) x (Fs/K), where K' is the dioptric axial power of the eye, Fs is the correcting thin lens power and K is the ocular ametropia. Refractive myopes produce greater fundus magnification than axial myopes, whereas refractive hyperopes produce lower fundus magnification than axial hyperopes. If we assume 15 x fundus magnification as our standard magnification for an emmetropic reduced eye, then wearing glasses or putting the focusing lens at or close to the anterior focus of the eye is able to achieve the standard magnification for axial myope and axial hyperope, whereas wearing contact lenses is able to achieve the standard magnification for refractive myope and refractive hyperope. Vertex distance has greater influence on fundus magnification produced during direct ophthalmoscopy than other funduscopic techniques. In conclusion, the newly defined formula has clinical applications during direct ophthalmoscopy.

Matched MeSH terms: Retina/pathology*

Late clinical and magnetic resonance imaging follow up of Nipah virus infection

Lim CC, Lee WL, Leo YS, Lee KE, Chan KP, Ling AE, et al.

J Neurol Neurosurg Psychiatry, 2003 Jan;74(1):131-3.

PMID: 12486285

The Nipah virus is a newly identified paramyxovirus responsible for an outbreak of fatal encephalitis in Malaysia and Singapore. This paper reports the follow up clinical and magnetic resonance imaging findings in 22 affected subjects. Of 13 patients with encephalitis, one died, one was lost to follow up, and seven recovered. Among the four remaining patients, one had residual sixth nerve palsy, another suffered from severe clinical depression, and a third patient had evidence of retinal artery occlusion. One patient with delayed onset Horner syndrome had a single lesion in the cervical spinal cord. The brain magnetic resonance findings were stable or improved in nine patients over 18 months of follow up. Among a second group of nine asymptomatic seropositive abattoir workers, magnetic resonance examination in seven subjects revealed discrete small lesions in the brain; similar to those detected in encephalitis patients. These findings suggest that in addition to encephalitis, the newly discovered Nipah virus affects the spinal cord and the retina. Late clinical and radiological findings can occur in Nipah virus infections as with other paramyxoviruses.

Matched MeSH terms: Retina/pathology

Retinopathy in acute leukaemia at initial diagnosis: correlation of fundus lesions and haematological parameters

Reddy SC, Jackson N

Acta Ophthalmol Scand, 2004 Feb;82(1):81-5.

PMID: 14738490

PURPOSE: To determine the prevalence of retinal changes in newly diagnosed acute leukaemia patients, and to establish the relationship between retinal lesions and haematological parameters in these patients.

METHODS: A total of 127 patients with acute leukaemia (myeloid and lymphoid), of both genders, aged between 13 and 77 years, were examined by an ophthalmologist for retinal changes using direct/indirect ophthalmoscopy within 2 days of diagnosis before starting chemotherapy.

RESULTS: Retinal lesions were seen in 62 cases (49%), with intraretinal haemorrhages being the most common lesion (42%). A high white blood cell count was significantly associated with intraretinal haemorrhages (p = 0.04) and white-centred haemorrhages (p = 0.001), while a low platelet count was significantly associated with intraretinal haemorrhages (p = 0.03) in acute myeloid leukaemia patients.

CONCLUSIONS: A high white blood cell count may be considered as important as a low platelet count in the pathogenesis of leukaemic retinopathy.

Matched MeSH terms: Retina/pathology*; Retinal Hemorrhage/diagnosis*; Retinal Neoplasms/blood; Retinal Neoplasms/diagnosis*; Retinal Neoplasms/drug therapy

Fulltext Sudden visual loss in acute leukaemia

Tengku Kamalden, T.A., Nurliza, K., Haris, A.R.

JUMMEC, 2008;11(1):30-32.

MyJurnal

The presenting signs of acute leukaemia occur as a result of bone marrow failure and organ infiltration. Increased bleeding tendencies are seen on the skin, gums and mucosal lining. Bleeding in the posterior segment of the eye, namely the retina and vitreous, may occur, but do not usually cause any visual disturbances. This case demonstrates visual loss as a result of premacular subhyaloid haemorrhage in acute leukaemia.

Matched MeSH terms: Retina; Retinal Hemorrhage

Combined large radial retinotomy and circumferential retinectomy in the management of advanced proliferative vitreoretinopathy

Lim AK, Alexander SM, Lim KS

Retina, 2009 Jan;29(1):112-6.

PMID: 18784619 DOI: 10.1097/IAE.0b013e318187f14a

Matched MeSH terms: Retina/surgery*; Retinal Detachment/surgery*

Fulltext Images in clinical medicine. Retinal detachment in malignant hypertension

Tajunisah I, Patel DK

N Engl J Med, 2009 Aug 27;361(9):899.

PMID: 19710488 DOI: 10.1056/NEJMicm0802683

Matched MeSH terms: Retina/pathology*; Retinal Detachment/etiology*; Retinal Detachment/pathology

Vascular intersection detection in retina fundus images using a new hybrid approach

Aibinu AM, Iqbal MI, Shafie AA, Salami MJ, Nilsson M

Comput Biol Med, 2010 Jan;40(1):81-9.

PMID: 20022595 DOI: 10.1016/j.compbiomed.2009.11.004

The use of vascular intersection aberration as one of the signs when monitoring and diagnosing diabetic retinopathy from retina fundus images (FIs) has been widely reported in the literature. In this paper, a new hybrid approach called the combined cross-point number (CCN) method able to detect the vascular bifurcation and intersection points in FIs is proposed. The CCN method makes use of two vascular intersection detection techniques, namely the modified cross-point number (MCN) method and the simple cross-point number (SCN) method. Our proposed approach was tested on images obtained from two different and publicly available fundus image databases. The results show a very high precision, accuracy, sensitivity and low false rate in detecting both bifurcation and crossover points compared with both the MCN and the SCN methods.

Matched MeSH terms: Retina/pathology*

Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network

Poznanski RR

J Integr Neurosci, 2010 Sep;9(3):299-335.

PMID: 21064220

Optical imaging of dendritic calcium signals provided evidence of starburst amacrine cells exhibiting calcium bias to somatofugal motion. In contrast, it has been impractical to use a dual-patch clamp technique to record membrane potentials from both proximal dendrites and distal varicosities of starburst amacrine cells in order to unequivocally prove that they are directionally sensitive to voltage, as was first suggested almost two decades ago. This paper aims to extend the passive cable model to an active cable model of a starburst amacrine cell that is intrinsically dependent on the electrical properties of starburst amacrine cells, whose various macroscopic currents are described quantitatively. The coupling between voltage and calcium just below the membrane results in a voltage-calcium system of coupled nonlinear Volterra integral equations whose solutions must be integrated into a prescribed model for example, for a synaptic couplet of starburst amacrine cells. Networks of starburst amacrine cells play a fundamental role in the retinal circuitry underlying directional selectivity. It is suggested that the dendritic plexus of starburst amacrine cells provides the substrate for the property of directional selectivity, while directional selectivity is a property of the exclusive layerings and confinement of their interconnections within the sublaminae of the inner plexiform layer involving cone bipolar cells and directionally selective ganglion cells.

Matched MeSH terms: Retina/cytology*

Analytical solution of reaction-diffusion equations for calcium wave propagation in a starburst amacrine cell

Poznanski RR

J Integr Neurosci, 2010 Sep;9(3):283-97.

PMID: 21064219

A reaction-diffusion model is presented to encapsulate calcium-induced calcium release (CICR) as a potential mechanism for somatofugal bias of dendritic calcium movement in starburst amacrine cells. Calcium dynamics involves a simple calcium extrusion (pump) and a buffering mechanism of calcium binding proteins homogeneously distributed over the plasma membrane of the endoplasmic reticulum within starburst amacrine cells. The system of reaction-diffusion equations in the excess buffer (or low calcium concentration) approximation are reformulated as a nonlinear Volterra integral equation which is solved analytically via a regular perturbation series expansion in response to calcium feedback from a continuously and uniformly distributed calcium sources. Calculation of luminal calcium diffusion in the absence of buffering enables a wave to travel at distances of 120 μm from the soma to distal tips of a starburst amacrine cell dendrite in 100 msec, yet in the presence of discretely distributed calcium-binding proteins it is unknown whether the propagating calcium wave-front in the somatofugal direction is further impeded by endogenous buffers. If so, this would indicate CICR to be an unlikely mechanism of retinal direction selectivity in starburst amacrine cells.

Matched MeSH terms: Retina/cytology*

Mass mortality of hatchery-produced larvae of Asian seabass, Lates calcarifer (Bloch), associated with viral nervous necrosis in Sabah, Malaysia

Ransangan J, Manin BO

Vet Microbiol, 2010 Sep 28;145(1-2):153-7.

PMID: 20427132 DOI: 10.1016/j.vetmic.2010.03.016

Culture of Asian seabass, Lates calcarifer (Bloch) is a popular aquaculture activity in Malaysia. This fish is in high demand and fetches a good price in the local market. The seed for this fish is commercially produced by induced spawning in hatcheries. However, the seed supply is affected by frequent mass mortality of larvae aged between 15 and 60 dph. The clinical signs shown by the affected larvae include lethargy, loss of appetite, uncoordinated swimming, unusual spiral movement pattern and dark coloration. Histological examination of brain and eye of the affected specimens revealed extensive cell vacuolation in larvae aged 15-25 dph. Partial nucleotide sequence of the nervous necrosis virus coat protein gene of the affected larvae showed 94.0-96.1% homology to the nucleotide sequences of coat protein gene from nervous necrosis virus isolated from other countries in the Southeast Asia and Australia. This study provides scientific evidence based on molecular technique that many episodes of mass mortality in seabass larvae in Sabah is associated with the viral nervous necrosis. Because no effective treatment has been reported for this infection, stringent biosecurity measures must be adopted for exclusion of the pathogen from the culture system.

Matched MeSH terms: Retina/pathology; Retina/virology

Fulltext Intracameral injection of ranibizumab caused regression of iris neovascularisation and clearance of hyphaema in a non-diabetic patient with ischaemic remnant retinal flap in a silicone filled eye

Bastion ML

BMJ Case Rep, 2010;2010.

PMID: 22242074 DOI: 10.1136/bcr.10.2009.2398

The use of 0.5 mg/0.05 ml of ranibizumab intracamerally, to induce regression of iris neovascularisation in a non-diabetic patient, is reported. A 55-year-old Malay man presented with left eye rubeosis and hyphaema secondary to ischaemic remnant retinal flap in his silicone filled pseudophakic eye. Regression of rubeosis and resolution of hyphaema was noted within 4 days of injection of intracameral ranibizumab, allowing repeat vitrectomy to be performed without much bleeding, thus facilitating removal of his intraocular lens and laser to remaining flap. One month postoperatively he remained comfortable with counting fingers vision similar to the pre-hyphaema period.

Matched MeSH terms: Retina

Fulltext Branch retinal vein occlusion associated with quetiapine fumarate

Yong KC, Kah TA, Ghee YT, Siang LC, Bastion ML

BMC Ophthalmol, 2011;11:24.

PMID: 21867521 DOI: 10.1186/1471-2415-11-24

To report a case of branch retinal vein occlusion in a young adult with bipolar mood disorder treated with quetiapine fumarate.

Matched MeSH terms: Retina/drug effects; Retina/pathology*; Retinal Vein Occlusion/chemically induced*; Retinal Vein Occlusion/diagnosis

Fulltext Surgical management of unilateral rhegmatogenous retinal detachment associated with ocular coloboma in a 7-year-old child with Noonan syndrome

Bastion ML, Qader AM

BMJ Case Rep, 2011;2011.

PMID: 22696753 DOI: 10.1136/bcr.02.2011.3889

The authors would like to present an unusual case of unilateral retinal detachment, phacodonesis, dense cataract and ocular coloboma in a 7-year-old Indian Muslim boy with Noonan syndrome. He underwent lensectomy, 23G pars planar vitrectomy, air fluid exchange, endolaser and silicone oil injection which successfully reattached the retina. His best corrected visual acuity was 6/24 6 months after the surgery and oil removal.

Matched MeSH terms: Retina/abnormalities*; Retina/surgery; Retinal Detachment/etiology; Retinal Detachment/surgery*

Kearns-Sayre syndrome: An unusual ophthalmic presentation

Ahmad SS, Ghani SA

Oman J Ophthalmol, 2012 May;5(2):115-7.

PMID: 22993469

Kearns-Sayre syndrome (KSS) belongs to the group of neuromuscular disorders known as mitochondrial encephalomyopathies. It has characteristic syndromal features, which include: chronic progressive external ophthalmoplegia, bilateral atypical pigmentary retinopathy, and cardiac conduction abnormalities. So far, only a single case has been reported where a patient with KSS had a normal retina. Herein, we report this extremely rare variant of KSS, which not only presented later than the normal age of presentation, but also had minimal pigmentary retinopathy.

Matched MeSH terms: Retina

Fulltext Brilliant crystallisation in the anterior chamber and subretinal space following adjunctive intravitreal ranibizumab for diabetic vitrectomy

Bastion ML, Mustapha M, Ho I

BMJ Case Rep, 2012;2012.

PMID: 23093508 DOI: 10.1136/bcr-2012-007260

To report a unique case of crystallisation in the anterior chamber and subretinal space in a Malay lady following inadvertent subretinal injection of ranibizumab prior to vitrectomy for proliferative diabetic retinopathy.

Matched MeSH terms: Retina

Displaying publications 1 - 20 of 94 in total