Displaying publications 1 - 20 of 429 in total

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  1. Kyaw Oo M, Mandal UK, Chatterjee B
    Pharm Dev Technol, 2017 Feb;22(1):2-12.
    PMID: 26616399 DOI: 10.3109/10837450.2015.1116568
    High melting point polymeric carrier without plasticizer is unacceptable for solid dispersion (SD) by melting method. Combined polymer-plasticizer carrier significantly affects drug solubility and tableting property of SD.
    Matched MeSH terms: Solubility
  2. Ougi K, Okada K, Leong KH, Hayashi Y, Kumada S, Onuki Y
    Eur J Pharm Sci, 2020 Nov 01;154:105502.
    PMID: 32750421 DOI: 10.1016/j.ejps.2020.105502
    The purpose of this study was to investigate the effect of molecular mobility of water adsorbed by disintegrants on the hydrolytic degradation of active pharmaceutical ingredients (APIs). Fourteen different disintegrants were tested. First, powdered disintegrants were stored at conditions of 40 °C/75% relative humidity ("humid conditions") and their T2 relaxation times were measured by time-domain nuclear magnetic resonance for examination of the molecular mobility of water adsorbed by the disintegrant. From the observed T2 values, the water molecular mobility was fully characterized. In particular, the molecular mobility of water adsorbed by crospovidones was much higher than the molecular mobility of water adsorbed by the other test disintegrants because of longer T2 values. The next study examined the hydrolytic degradation of acetylsalicylic acid (ASA), a model moisture-sensitive API, stored under humid conditions. Physical mixtures of ASA and disintegrants or their model tablets were used as test samples, and they were stored for 7 d. The disintegrants contained in the samples clearly affected the ASA degradation: the most significant ASA degradation was observed for the crospovidone-containing samples. Finally, we analyzed the effect of the molecular mobility of water adsorbed by disintegrants on the ASA degradation by the least absolute shrinkage and selection operator (Lasso) regression techniques. As in the T2 experiment, various properties of disintegrants (i.e., water content, pH, and water activity) were used in this experiment as the explanatory variables. From the Lasso analysis, we successfully showed that the higher molecular mobility of water adsorbed by disintegrants significantly enhanced ASA degradation. These findings provide profound insights into the chemical stability of moisture-sensitive APIs in tablets.
    Matched MeSH terms: Solubility
  3. Venkateskumar K, Parasuraman S, Gunasunderi R, Sureshkumar K, Nayak MM, Shah SA, et al.
    Int J Pharm Investig, 2016 Oct-Dec;6(4):194-200.
    PMID: 28123988 DOI: 10.4103/2230-973X.195925
    The objective of this study is to provide a mechanistic insight into solubility enhancement and dissolution of acyclovir (ACY) by polyethylene glycol20000 (PEG20000).
    Matched MeSH terms: Solubility
  4. Chan SY, Toh SM, Khan NH, Chung YY, Cheah XZ
    Drug Dev Ind Pharm, 2016 Nov;42(11):1800-1812.
    PMID: 27049232
    Solution-mediated transformation has been cited as one of the main problems that deteriorate dissolution performances of solid dispersion (SD). This is mainly attributed by the recrystallization tendency of poorly soluble drug. Eventually, it will lead to extensive agglomeration which is a key process in reducing the dissolution performance of SD and offsets the true benefit of SD system. Here, a post-processing treatment is suggested in order to reduce the recrystallization tendency and hence bring forth the dissolution advantage of SD system.
    Matched MeSH terms: Solubility
  5. Abdellah A, Noordin MI, Wan Ismail WA
    Saudi Pharm J, 2015 Jan;23(1):9-13.
    PMID: 25685037 DOI: 10.1016/j.jsps.2013.06.003
    Pharmaceutical excipients are no longer inert materials but it is effective and able to improve the characteristics of the products' quality, stability, functionality, safety, solubility and acceptance of patients. It can interact with the active ingredients and alter the medicament characteristics. The globalization of medicines' supply enhances the importance of globalized good manufacturing practice (GMP) requirements for pharmaceutical excipients. This review was intended to assess the globalization status of good manufacturing practice (GMP) requirements for pharmaceutical excipients. The review outcomes demonstrate that there is a lack of accurately defined methods to evaluate and measure excipients' safety. Furthermore good manufacturing practice requirements for excipients are not effectively globalized.
    Matched MeSH terms: Solubility
  6. Mohd Faiz Nasruddin, Theocharospoulos, Antonios, Ray, Noel, Burke, Francis M.
    MyJurnal
    Fitting accuracy of dental prostheses is essential for clinical success. An ideal marginal and internal fit will minimize plaque accumulation, gingival irritation, cement dissolution and micro leakage as well as enhancing the mechanical behaviour of a fixed partial denture (FPD) (1). Unfortunately, there is disagreement about acceptable marginal and internal fit discrepancies of FPD’s (2) from 75-200μm. There are two main manufacturing routes of CAD/CAM FPD’s: the subtractive and the additive route. The subtractive route is a top-down approach which involves milling the desired article out of a block of the material of choice using a series of burs. This route is currently the most common CAD/CAM technique for the fabrication of metal alloy FPD’s. The additive route is a bottom-up approach where the desired article is fabricated layer by layer out of the material of choice. Examples include selective laser sintering and selective laser melting for metal alloy FPD’s.
    Matched MeSH terms: Solubility
  7. Lim CH, Rasti B, Sulistyo J, Hamid MA
    Heliyon, 2021 Feb;7(2):e06305.
    PMID: 33665455 DOI: 10.1016/j.heliyon.2021.e06305
    Transglycosylation is the in-vivo or in-vitro process of transferring glycosyl groups from a donor to an acceptor, which is usually performed by enzymatic reactions because of their simplicity, low steric hindrance, high region-specificity, low production cost, and mild processing conditions. One of the enzymes commonly used in the transglycosylation reaction is cyclodextrin glucanotransferase (CGTase). The transglycosylated products, catalyzed by CGTase, are widely used in food additives, supplements, and personal care and cosmetic products. This is due to improvements in the solubility, stability, bioactivity and length of the synthesized products. This paper's focus is on the importance of enzymes used in the transglycosylation reaction, their characteristics and mechanism of action, sources and production yield, and donor and acceptor specificities. Moreover, the influence of intrinsic and extrinsic factors on the enzymatic reaction, catalysis of glycosidic linkages, and advantages of CGTase transglycosylation reactions are discussed in detail.
    Matched MeSH terms: Solubility
  8. Hardwick J, Taylor J, Mehta M, Satija S, Paudel KR, Hansbro PM, et al.
    Curr Pharm Des, 2021;27(1):2-14.
    PMID: 32723255 DOI: 10.2174/1381612826666200728151610
    Curcumin is a major curcuminoid present in turmeric. The compound is attributed to various therapeutic properties, which include anti-oxidant, anti-inflammatory, anti-bacterial, anti-malarial, and neuroprotection. Due to its therapeutic potential, curcumin has been employed for centuries in treating different ailments. Curcumin has been investigated lately as a novel therapeutic agent in the treatment of cancer. However, the mechanisms by which curcumin exerts its cytotoxic effects on malignant cells are still not fully understood. One of the main limiting factors in the clinical use of curcumin is its poor bioavailability and rapid elimination. Advancements in drug delivery systems such as nanoparticle-based vesicular drug delivery platforms have improved several parameters, namely, drug bioavailability, solubility, stability, and controlled release properties. The use of curcumin-encapsulated niosomes to improve the physical and pharmacokinetic properties of curcumin is one such approach. This review provides an up-to-date summary of nanoparticle-based vesicular drug carriers and their therapeutic applications. Specifically, we focus on niosomes as novel drug delivery formulations and their potential in improving the delivery of challenging small molecules, including curcumin. Overall, the applications of such carriers will provide a new direction for novel pharmaceutical drug delivery, as well as for biotechnology, nutraceutical, and functional food industries.
    Matched MeSH terms: Solubility
  9. Mohamad Mazlan M, Talib RA, Chin NL, Shukri R, Taip FS, Mohd Nor MZ, et al.
    Foods, 2020 Jul 31;9(8).
    PMID: 32751949 DOI: 10.3390/foods9081023
    Single-screw extrusion of a fibrous-structured meat analog from soy proteins added with low-grade oyster mushroom was successful. Satisfactory extrudates were obtained at a barrel temperature of 140 °C, screw speed range of 100-160 rpm, and oyster mushroom addition at 0%, 7.5%, and 15% via factorial experiments. Single-screw extrusion equipped with a slit die successfully produced expanded oyster mushroom-soy protein extrudates. However, the increase in the oyster mushroom content significantly decreased (p ≤ 0.05) the expansion ratio of the extrudate from 1.26 to 0.98. This result indicated that adding more oyster mushroom restrained the expansion ratio. The extrudates had a medium density range (max of 1393.70 ± 6.30 kg/m3). By adding oyster mushroom, the extrudates attained a higher moisture content (range = 34.77% to 37.93%) compared with the extrudates containing the protein mixture only (range = 26.99% to 32.33%). The increase in screw speed and oyster mushroom significantly increased (p ≤ 0.05) the water absorption index. The increase in the texturization index was significantly influenced (p ≤ 0.05) by oyster mushroom addition rather than the screw speed. A defined fibrous structure supported the high texturization index and small shape of air cells observed in the extrudates.
    Matched MeSH terms: Solubility
  10. Danov KD, Stanimirova RD, Kralchevsky PA, Slavova TG, Yavrukova VI, Ung YW, et al.
    J Colloid Interface Sci, 2021 Nov;601:474-485.
    PMID: 34090025 DOI: 10.1016/j.jcis.2021.05.147
    HYPOTHESIS: Many ionic surfactants with wide applications in personal-care and house-hold detergency show limited water solubility at lower temperatures (Krafft point). This drawback can be overcome by using mixed solutions, where the ionic surfactant is incorporated in mixed micelles with another surfactant, which is soluble at lower temperatures.

    EXPERIMENTS: The solubility and electrolytic conductivity for a binary surfactant mixture of anionic methyl ester sulfonates (MES) with nonionic alkyl polyglucoside and alkyl polyoxyethylene ether at 5 °C during long-term storage were measured. Phase diagrams were established; a general theoretical model for their explanation was developed and checked experimentally.

    FINDINGS: The binary and ternary phase diagrams for studied surfactant mixtures include phase domains: mixed micelles; micelles + crystallites; crystallites, and molecular solution. The proposed general methodology, which utilizes the equations of molecular thermodynamics at minimum number of experimental measurements, is convenient for construction of such phase diagrams. The results could increase the range of applicability of MES-surfactants with relatively high Krafft temperature, but with various useful properties such as excellent biodegradability and skin compatibility; stability in hard water; good wetting and cleaning performance.

    Matched MeSH terms: Solubility
  11. Saleem MA, Yasir Siddique M, Nazar MF, Khan SU, Ahmad A, Khan R, et al.
    Langmuir, 2020 07 14;36(27):7908-7915.
    PMID: 32551692 DOI: 10.1021/acs.langmuir.0c01016
    Nanostructures play an important role in targeting sparingly water-soluble drugs to specific sites. Because of the structural flexibility and stability, the use of template microemulsions (μEs) can produce functional nanopharmaceuticals of different sizes, shapes, and chemical properties. In this article, we report a new volatile oil-in-water (o/w) μE formulation comprising ethyl acetate/ethanol/brij-35/water to obtain the highly water-dispersible nanoparticles of an antihyperlipidemic agent, ezetimibe (EZM-NPs), to enhance its dissolution profile. A pseudoternary phase diagram was delineated in a specified brij-35/ethanol ratio (1:1) to describe the transparent, optically isotropic domain of the as-formulated μE. The water-dilutable μE formulation, comprising an optimum composition of ethyl acetate (18.0%), ethanol (25.0%), brij-35 (25.0%), and water (32.0%), showed a good dissolvability of EZM around 4.8 wt % at pH 5.2. Electron micrographs showed a fine monomodal collection of EZM-loaded μE droplets (∼45 nm) that did not coalesce even after lyophilization, forming small spherical EZM-NPs (∼60 nm). However, the maturity of nanodrug droplets observed through dynamic light scattering suggests the affinity of EZM to the nonpolar microenvironment, which was further supported through peak-to-peak correlation of infrared analysis and fluorescence measurements. Moreover, the release profile of the as-obtained EZM-nanopowder increased significantly >98% in 30 min, which indicates that a reduced drug concentration will be needed for capsules or tablets in the future and can be simply incorporated into the multidosage formulation of EZM.
    Matched MeSH terms: Solubility
  12. Brishti FH, Chay SY, Muhammad K, Ismail-Fitry MR, Zarei M, Karthikeyan S, et al.
    Food Res Int, 2020 12;138(Pt B):109783.
    PMID: 33288169 DOI: 10.1016/j.foodres.2020.109783
    Mung bean is an inexpensive yet sustainable protein source. Current work compared the effects of freeze (FD), spray (SD) and oven drying (OD), on mung bean protein isolate (MBPI) produced on pilot scale. All samples showed no dissociation of protein subunits and were thermally stable (Td = 157.90-158.07 °C). According to morphological studies, FD formed a porous protein while SD and OD formed wrinkled and compact crystals, respectively. FD and SD formed elastic gels with better gelling capacity than OD (aggregated gel). FD showed exceptional protein solubility, water and oil absorption capacity (4.23 g/g and 8.38 g/g, respectively). SD demonstrated the smallest particle size, excellent emulsion activity index (29.21 m2/g) and stability (351.90 min) and the highest β-sheet amount (37.61%). FTIR spectra for all samples showed characteristic peaks which corresponded well to the secondary structure of legume proteins. Rheological analysis revealed that gelation temperature for all MBPI lied around 90 °C. Current work described the different final properties achieved for MBPI produced under different drying techniques that allowed tailoring for different food systems, whereby FD is ideal for meat extender, SD is suitable for meat emulsion while OD is suitable in general protein-based application.
    Matched MeSH terms: Solubility
  13. Yeoh, Cheow Keat, Srimala Sreekantan, Sabar Derita Hutagalung, Zainal Arifin Ahmad
    MyJurnal
    CaCu3Ti4O12 was synthesized starting from a solution of TiO2 to which Ca and Cu nitrates were added. Due to the differences in the solubilities of the Ca, Cu and Ti, initial variations from ideal stoichiometry and a high solution pH was necessary to obtain stoichiometric CaCu3Ti4O12 precipitates. As precipitated samples were amorphous with CuO phases observed after drying of the precipitates at 300 oC. CaCu3Ti4O12 phases were observed after heat treatment at 1000 oC. XRD studies show the presence of CuO and TiO2 in addition to the CaCu3Ti4O12 for non stoichiometric samples. Observations under the SEM show the presence of Cu rich and Ti rich phases in addition to the CaCu3Ti4O12.
    Matched MeSH terms: Solubility
  14. Chik MW, Hussain Z, Zulkefeli M, Tripathy M, Kumar S, Majeed ABA, et al.
    Drug Deliv Transl Res, 2019 04;9(2):578-594.
    PMID: 29594914 DOI: 10.1007/s13346-018-0505-9
    Carbon nanotubes (CNTs) possess outstanding properties that could be useful in several technological, drug delivery, and diagnostic applications. However, their unique physical and chemical properties are hindered due to their poor solubility. This article review's the different ways and means of solubility enhancement of single-wall carbon nanotubes (SWNTs). The advantages of SWNTs over the multi-walled carbon nanotubes (MWNTs) and the method of non-covalent modification for solubility enhancement has been the key interest in this review. The review also highlights a few examples of dispersant design. The review includes some interesting utility of SWNTs being wrapped with polymer especially in biological media that could mediate proper drug delivery to target cells. Further, the use of wrapped SWNTs with phospholipids, nucleic acid, and amphiphillic polymers as biosensors is of research interest. The review aims at summarizing the developments relating to wrapped SWNTs to generate further research prospects in healthcare.
    Matched MeSH terms: Solubility
  15. Ling I, Kumari H, Mirzamani M, Sobolev AN, Garvey CJ, Atwood JL, et al.
    Chem Commun (Camb), 2018 Sep 25;54(77):10824-10827.
    PMID: 30140821 DOI: 10.1039/c8cc05650a
    We report on the assembly of three-fold axially compressed icosahedral arrays of the bowl shaped p-sulfonatocalix[4]arene molecules in the solid-state, intricately bound to dipicolinate and yttrium(iii) ions, with the compression reflected in Hirshfeld surface analyses. Solution studies show dissolution of the icosahedra intact, but with a geometrical rearrangement to regular icosahedra.
    Matched MeSH terms: Solubility
  16. Tounsia Abbas-Aksil, Salem Benamara
    Sains Malaysiana, 2015;44:301-308.
    Lyophilized powder (LP) from Algerian arbutus wild berries (Arbutus unedo L.) was obtained. This present paper reports about the dissolution (releasing) properties of LP-based tablets, evaluated through the electric conductivity (EC) of distilled water which is employed as surrounding medium, at three different temperatures (291, 298 and 309 K). In addition to this, secondary physicochemical characteristics such as elementary analysis, color and compressibility were evaluated. Regarding the modeling of ionic transfer, among the three tested models, namely Peleg, Singh et al. and Singh and Kulshestha, the latter seems to be the most appropriate (R2 = 0.99), particularly in the case of compacted tablets under 2000 Pa. The temperature dependence of the dissolution process was also studied applying Arrhenius equation (R2>0.8) which allowed to deduce the activation energy, ranging from 18.7 to 21.4 kJ.mol-1 according to the model and compression force employed.
    Matched MeSH terms: Solubility
  17. Ab'lah N, Yusuf CYL, Rojsitthisak P, Wong TW
    Int J Biol Macromol, 2023 Jun 30;241:124506.
    PMID: 37085071 DOI: 10.1016/j.ijbiomac.2023.124506
    Starch is a polysaccharide with varying amylose-to-amylopectin ratios as a function of its biological sources. It is characterized by low shear stress resistance, poor aqueous/organic solubility and gastrointestinal digestibility which limit its ease of processing and functionality display as an oral drug delivery vehicle. Modulation of starch composition through genetic engineering primarily alters amylose-to-amylopectin ratio. Greater molecular properties changes require chemical and enzymatic modifications of starch. Acetylation reduces water solubility and enzymatic digestibility of starch. Carboxymethylation turns starch acid-insoluble and aggregative at low pHs. The summative effects are sustaining drug release in the upper gut. Acid-insoluble carboxymethylated starch can be aminated to provide an ionic character essential for hydrogel formation which further reduces its drug release. Ionic starch can coacervate with oppositely charged starch, non-starch polyelectrolyte or drug into insoluble, controlled-release complexes. Enzymatically debranched and resistant starch has a small molecular size which confers chain aggregation into a helical hydrogel network that traps the drug molecules, protecting them from biodegradation. The modified starch has been used to modulate the intestinal/colon-specific or controlled systemic delivery of oral small molecule drugs and macromolecular therapeutics. This review highlights synthesis aspects of starch and starch derivatives, and their outcomes and challenges of applications in oral drug delivery.
    Matched MeSH terms: Solubility
  18. Putra NR, Rizkiyah DN, Aziz AHA, Mamat H, Jusoh WMSW, Idham Z, et al.
    Sci Rep, 2023 Jul 05;13(1):10871.
    PMID: 37407592 DOI: 10.1038/s41598-023-32181-8
    The purpose of this work was to establish the best particle size for recovering high yields of total phenolic compounds (TPC), total anthocyanin compounds(TAC) and total flavonoid compounds (TFC) from roselle (Hibiscus sabdariffa) by applying supercritical carbon dioxide (ScCO2). The extraction rate, diffusivity and solubility of yield in ScCO2 were also studied and calculated utilizing models. Pressure (10 and 30 MPa), temperature (40 and 60 °C), and particle size (250 µm 
    Matched MeSH terms: Solubility
  19. Zhou Y, Sun Y, Pan D, Xia Q, Zhou C
    J Sci Food Agric, 2023 Aug 30;103(11):5412-5421.
    PMID: 37038882 DOI: 10.1002/jsfa.12616
    BACKGROUND: Goose meat is rough and embedded with dense connective tissue, impairing protein solubility. Therefore, to improve the functional properties of goose myofibrillar protein (GMP), ultrasound was used to assist the phosphorylation of GMP.

    RESULTS: The fact that GMP attached covalently with the phosphate group of sodium tripolyphosphate (GMP-STP) was disclosed directly by Fourier transform infrared spectroscopy. Furthermore, ultrasound significantly improved the hydrophobicity and solubility of GMP-STP, which could be attributed to the conversion of α-helix to β-sheet, β-turns, and random coils by sonication. The spatial stabilization of the protein phosphorylation process was boosted by ultrasound, making the droplets more dispersed, and thus an improvement in the functional properties of GMP-STP was observed. Water-holding capacity, oil-binding capacity, and emulsifying and foaming properties were best at an ultrasound power of 400 W.

    CONCLUSION: Ultrasound-assisted phosphorylation has great potential to modulate the structure-function relationship of proteins. © 2023 Society of Chemical Industry.

    Matched MeSH terms: Solubility
  20. Alshati F, Alahmed TAA, Sami F, Ali MS, Majeed S, Murtuja S, et al.
    Curr Pharm Des, 2023;29(36):2853-2866.
    PMID: 37946351 DOI: 10.2174/0113816128266398231027100119
    Many methods, including solid dispersion, micellization, and inclusion complexes, have been employed to increase the solubility of potent drugs. Beta-cyclodextrin (βCD) is a cyclic oligosaccharide consisting of seven glucopyranoside molecules, and is a widely used polymer for formulating soluble inclusion complexes of hydrophobic drugs. The enzymatic activity of Glycosyltransferase or α-amylase converts starch or its derivatives into a mixture of cyclodextrins. The βCD units are characterized by α -(1-4) glucopyranose bonds. Cyclodextrins possess certain properties that make them very distinctive because of their toroidal or truncated cage-like supramolecular configurations with multiple hydroxyl groups at each end. This allowed them to encapsulate hydrophobic compounds by forming inclusion complexes without losing their solubility in water. Chemical modifications and newer derivatives, such as methylated βCD, more soluble hydroxyl propyl methyl βCD, and sodium salts of sulfobutylether-βCD, known as dexolve® or captisol®, have envisaged the use of CDs in various pharmaceutical, medical, and cosmetic industries. The successful inclusion of drug complexes has demonstrated improved solubility, bioavailability, drug resistance reduction, targeting, and penetration across skin and brain tissues. This review encompasses the current applications of β-CDs in improving the disease outcomes of antimicrobials and antifungals as well as anticancer and anti-tubercular drugs.
    Matched MeSH terms: Solubility
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