Displaying publications 1 - 20 of 28 in total

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  1. Our recent experiences with sarin poisoning cases in Japan and pesticide users with references to some selected chemicals
    Yokoyama K
    Neurotoxicology, 2007 Mar;28(2):364-73.
    PMID: 16730798
    Attention has been paid to neurobehavioral effects of occupational and environmental exposures to chemicals such as pesticides, heavy metals and organic solvents. The area of research that includes neurobehavioral methods and effects in occupational and environmental health has been called "Occupational and Environmental Neurology and Behavioral Medicine." The methods, by which early changes in neurological, cognitive and behavioral function can be assessed, include neurobehavioral test battery, neurophysiological methods, questionnaires and structured interview, biochemical markers and imaging techniques. The author presents his observations of neurobehavioral and neurophysiological effects in Tokyo subway sarin poisoning cases as well as in pesticide users (tobacco farmers) in Malaysia in relation to Green Tobacco Sickness (GTS). In sarin cases, a variety effects were observed 6-8 months after exposure, suggesting delayed neurological effects. Studies on pesticide users revealed that organophosphorus and dithiocarbamate affected peripheral nerve conduction and postural balance; subjective symptoms related to GTS were also observed, indicating the effects of nicotine absorbed from wet tobacco leaves. In addition, non-neurological effects of pesticides and other chemicals are presented, in relation to genetic polymorphism and oxidative stress.
    Matched MeSH terms: Thiocarbamates/adverse effects
  2. Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework
    Sun RW, Zhang M, Li D, Zhang ZF, Cai H, Li M, et al.
    Chemistry, 2015 Dec 14;21(51):18534-8.
    PMID: 26459298 DOI: 10.1002/chem.201503656
    A dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin-resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug-release testing, in this study, a set of transwell assay-based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn-MOF towards A2780cis.
    Matched MeSH terms: Thiocarbamates/chemistry*
  3. Fulltext Satisfaction with amplification in daily life (SADL) in different types and degrees of hearing loss
    Nursakinah Abd Ghani, Wan Ahmad Wan Aslynn
    International Journal of Allied Health Sciences, 2019;3(4):933-938.
    MyJurnal
    Introduction: The aim of this study is to determine the satisfaction level of hearing aid users in different types and degrees of hearing loss using the satisfaction with amplification in daily life (SADL) questionnaire. Methods: 35 hearing aid users with different types of hearing loss who sought help from the International Islamic University, Malaysia (IIUM) Hearing and Speech Clinic at Jalan Hospital Campus, Kuantan, IIUM Medical Specialist Centre and private hearing aid centres were involved in this study. The data was collected from the participants who filled in the Malay SADL questionnaires. Results: Among the thirty-five (35) participants, there was no significant difference reported between the types of hearing loss and their satisfaction level in the SADL global score and each of the subscales. It was found that satisfaction level with the hearing aids may depend on several factors such as cosmetic preference, cost of hearing aid and audiologist competence. Meanwhile, in terms of degrees of hearing loss, 80% of the users were relatively satisfied with their hearing aids. Yet, there was no correlation between hearing aid users’ satisfaction level and their degrees of hearing loss for all subscales and SADL global score. Conclusions: This study indicates that although hearing aid users reported to be satisfied with their hearing aids; there are some who are not satisfied in terms of feedback, telephone use, cosmetic appearance and costs of hearing aid. The findings of this study can benefit the audiologists, as they would be able to use the information to help future patients understand and adapt to the use of the hearing aids better.
    Matched MeSH terms: Thiocarbamates
  4. Taste thresholds for phenylthiocarbamide of some population groups. I The thresholds of some civilized ethnic groups living in Malaya
    LUGG JW, WHYTE JM
    Ann. Hum. Genet., 1955 Jun;19(4):290-311.
    PMID: 14388535
    Matched MeSH terms: Thiocarbamates*
  5. Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N((i)Pr)CH2CH2OH] for R = Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways
    Jamaludin NS, Goh ZJ, Cheah YK, Ang KP, Sim JH, Khoo CH, et al.
    Eur J Med Chem, 2013 Sep;67:127-41.
    PMID: 23856069 DOI: 10.1016/j.ejmech.2013.06.038
    The synthesis and characterisation of R3PAu[S2CN((i)Pr)CH2CH2OH], for R = Ph (1), Cy (2) and Et (3)4, is reported. Compounds 1-3 are cytotoxic against the doxorubicin-resistant breast cancer cell line, MCF-7R, with 1 exhibiting greater potency and cytotoxicity than either of doxorubicin and cisplatin. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis by 1, and necrosis by 2 and 3, are demonstrated, by both extrinsic and intrinsic pathways. Compound 1 activates the p53 gene, 2 activates only the p73 gene, whereas 3 activates both the p53 and p73 genes. Compounds 1 and 3 activate NF-κB, and each inhibits topoisomerase I.
    Matched MeSH terms: Thiocarbamates/chemistry*
  6. Fulltext Penggunaan aplikasi GIS dalam penyakit tuberkulosis di Cheras, Kuala Lumpur, Malaysia
    Shamsul Azhar Shah, Md. Idris Mohd. Nor, Abdul Hadi Harman Shah, Tahir Aris
    Malaysian Journal of Public Health Medicine, 2002;2(2):15-26.
    MyJurnal
    Tuberkulosis merupakan penyakit yang masih meigadi masalah kesihatan di seluruh dunia amnya dan di Malaysia khasnya. Kajian telah dilakukan ali Cheras, Kuala Lumpur menggunakan aplikasi GIS untuk mengenalpasti taburan geografi dan tren tuberkulosis daripada tahun 1996 sehingga tahun 2000. Kajian ini juga dilakukan untuk melihat kebolehan GIS sebagai alat surveilan penyakit beyangkit. Hasil kajian dengan menggunakan aplikasi GIS mendapati tren peningkatan tuberkulosis di kawasan·kawasan yang tertentu di Cheras. Penumpuan kes-kes tuberkulosis dapat dilihat di kawasan taburan penduduk yang kepadatan tinggi dan sederhana tinggi terutama di kawasan Kampung Pandan, kawasan penempatan Jalan Cheras dan Bandar Tun Razak. Kes—kes tersebut juga kebanyakannya adalah dalam lingkungan 100 meter ke 200 meter di antara satu sama lain. Kesimpulannya secara am, aplikasi GIS memberikan dimensi baru dalam kawalan penyakit dan ia pasti dapat digunakan dalam membantu aktiviti surveilan penyakit tuberkulosis.
    Matched MeSH terms: Thiocarbamates
  7. Copper complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin induced apoptosis in breast cancer cell
    Foo JB, Low ML, Lim JH, Lor YZ, Zainol Abidin R, Eh Dam V, et al.
    Biometals, 2018 08;31(4):505-515.
    PMID: 29623473 DOI: 10.1007/s10534-018-0096-4
    Copper complexes have been widely studied for the anti-tumour application as cancer cells are reported to take up greater amounts of copper than normal cells. Preliminary study revealed that the newly synthesised copper complex [Cu(SBCM)2] displayed marked anti-proliferative towards triple-negative MDA-MB-231 breast cancer cells. Therefore, Cu(SBCM)2 has great potential to be developed as an agent for the management of breast cancer. The present study was carried out to investigate the mode of cell death induced by Cu(SBCM)2 towards MDA-MB-231 breast cancer cells. The inhibitory and morphological changes of MDA-MB-231 cells treated with Cu(SBCM)2 was determined by using MTT assay and inverted light microscope, respectively. The safety profile of Cu(SBCM)2 was also evaluated towards human dermal fibroblast (HDF) normal cells. Confirmation of apoptosis and cell cycle arrest were determined by flow cytometry analysis. The expression of p53, Bax, Bcl-2 and MMP2 protein were detected with western blot analysis. Cu(SBCM)2 significantly inhibited the growth of MDA-MB-231 cells in a dose-dependent manner with GI50 18.7 ± 3.06 µM. Indeed, Cu(SBCM)2 was less toxic towards HDF normal cells with GI50 31.8 ± 4.0 µM. Morphological study revealed that Cu(SBCM)2-treated MDA-MB-231 cells experienced cellular shrinkage, membrane blebbing, chromatin condensation and formation of apoptotic bodies, suggesting that Cu(SBCM)2 induced apoptosis in the cells, which was confirmed by Annexin-V/PI flow cytometry analysis. It was also found that Cu(SBCM)2 induced G2/M phase cell cycle arrest towards MDA-MB-231 cells. The induction of apoptosis and cell cycle arrest in the present study is possibly due to the down-regulation of the mutant p53 and MMP2 protein. In conclusion, Cu(SBCM)2 can be developed as a targeted therapy for the treatment of triple-negative breast cancer.
    Matched MeSH terms: Thiocarbamates/pharmacology; Thiocarbamates/chemistry
  8. Cytotoxicity of triphenyltin(IV) methyl- and ethylisopropyldithiocarbamate compounds in chronic myelogenus leukemia cell line (K-562)
    Awang N, Kamaludin NF, Hamid A, Mokhtar NW, Rajab NF
    Pak J Biol Sci, 2012 Sep 01;15(17):833-8.
    PMID: 24163967
    Studies on the discovery of new cancer treatment by using metal-based compounds such as tin (Sn) has now greatly being synthesized and evaluated to identify their effectiveness and suitability to be developed as a new anticancer drug.

    APPROACH: This study was carried out to evaluate the cytotoxicity of triphenyltin(lV) methylisopropyldithiocarbamate (compound 1) and triphenyltin(IV) ethylisopropyldithiocarbamate (compound (2) on chronic myelogenus leukemia cells. The determination of their cytotoxicity (IC50) at different time of exposure and concentration was carried out through the employment of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay.

    RESULTS: The IC50 values obtained for compound 1 and 2 following treatment at 24, 48 and 72 h were 0.660, 0.223, 0.370 microM and 0.677, 0.306, 0.360 microM, respectively. Cell morphological changes such as apoptotic and necrotic features were also been observed.

    CONCLUSION: The compounds tested were found to give cytotoxic effect against chronic myelogenus leukemia (K-562) cell at a micromolar dose. Thus, further study on their specific mechanism of actions in the human cells should be carried out to elucidate their potential as an anticancer agent.

    Matched MeSH terms: Thiocarbamates/pharmacology*
  9. Pengenalpastian dan profil pengekspresan gen biosintesis asid amino yis psikrofil, glaciozyma antarctica
    Izwan Bharudin, Radziah Zolkefli, Shazilah Kamaruddin, Farah Diba Abu Bakar, Abdul Munir Abdul Murad, Mohd Faizal Abu Bakar, et al.
    Sains Malaysiana, 2018;47:1675-1684.
    Mekanisme pengambilan dan penghasilan asid amino bagi mikroorganisma psikrofil yang bermandiri dan berpoliferasi
    pada persekitaran sejuk melampau masih belum difahami sepenuhnya. Objektif kajian ini ialah untuk mengenal pasti
    gen yang terlibat dalam penjanaan asid amino bagi yis psikrofil, Glaciozyma antarctica serta menentukan pengekspresan
    gen tersebut semasa kehadiran dan kekurangan asid amino dalam medium pertumbuhan. Pengenalpastian gen telah
    dilakukan melalui penjanaan penanda jujukan terekspres (ESTs) daripada dua perpustakaan cDNA yang dibina daripada
    sel yang dikultur dalam medium pertumbuhan kompleks dan medium pertumbuhan minimum tanpa asid amino. Sebanyak
    3552 klon cDNA daripada setiap perpustakaan dipilih secara rawak untuk dijujuk menghasilkan 1492 transkrip unik
    (medium kompleks) dan 1928 transkrip unik (medium minimum). Analisis pemadanan telah mengenl pasti gen mengekod
    protein yang terlibat di dalam pengambilan asid amino bebas, biosintesis asid amino serta gen yang terlibat dengan
    kitar semula asid amino berdasarkan tapak jalan yang digunakan oleh yis model, Saccharomyces cerevisiae. Analisis
    pengekspresan gen menggunakan kaedah RT-qPCR menunjukkan pengekspresan gen mengekod protein yang terlibat di
    dalam pengambilan asid amino bebas iaitu permease adalah tinggi pada medium kompleks manakala pengekspresan
    kebanyakan gen mengekod protein yang terlibat dalam kitar semula dan biosintesis asid amino adalah tinggi di dalam
    medium minimum. Kesimpulannya, gen yang terlibat dalam penjanaan dan pengambilan asid amino bagi mikroorganisma
    psikrofil adalah terpulihara seperti mikroorganisma mesofil dan pengekspresan gen-gen ini adalah diaruh oleh kehadiran
    atau ketiadaan asid amino bebas pada persekitaran.
    Matched MeSH terms: Thiocarbamates
  10. Kesan kadar nitrogen terhadap populasi lalat putih (bemisia tabaci) pada tanaman cili (capsicum annum L.)
    Zurina M, Idris A, Mohamad Roff M
    Sains Malaysiana, 2010;39.
    Bemisia tabaci (Gennadius) merupakan spesies lalat putih utama dan berbahaya kepada pertanian. Kajian telah dijalankan di Stesen MARDI Jalan Kebun, Klang, Selangor dari 9 September 2006 hingga 11 November 2007. Objektif kajian ini adalah untuk menilai kesan populasi lalat putih terhadap tanaman cili yang diberi kadar nitrogen yang berbeza (0, 33, 43, 53 g/pokok). Keputusan kajian menunjukkan pokok cili yang dibaja dengan kadar nitrogen yang tinggi menyebabkan peningkatan yang bererti (P<0.05) kepada populasi B. tabaci peringkat belum matang berbanding pada pokok cili yang dibajakan nitrogen pada kadar rendah. Min bilangan B. tabaci pada peringkat belum matang per aras kanopi adalah berbeza secara signifikan (P<0.05) antara aras kanopi dan antara perlakuan. Secara amnya, min bilangan telur dan larva B. tabaci adalah lebih tinggi secara bererti (P<0.05) pada aras kanopi atas berbanding tengah dan bawah. Walau bagaimanapun, min bilangan pupa B. tabaci adalah tinggi secara signifikan (P<0.05) pada aras kanopi bawah berbanding aras kanopi atas dan tengah. Min bilangan B. tabaci pada peringkat belum matang adalah berbeza secara bererti (P<0,05) mengikut minggu selepas pokok cili ditanam pada semua perlakuan. Secara amnya, populasi B. tabaci lebih tinggi semasa awal musim penanaman dan menurun selepasnya hingga ke akhir musim kecuali pada minggu ketiga dan ketujuh selepas pokok cili di tanam.
    Matched MeSH terms: Thiocarbamates
  11. Synthesis, characterization and crystal structure of organotin(IV) N-butyl-N-phenyldithiocarbamate compounds and their cytotoxicity in human leukemia cell lines
    Kamaludin NF, Awang N, Baba I, Hamid A, Meng CK
    Pak J Biol Sci, 2013 Jan 01;16(1):12-21.
    PMID: 24199481
    Organotin complexes are recognized as the biologically active compounds in inducing cancerous cells death at very low doses. To date, organotin compounds currently appear among the most potent candidates in research related to the new anticancer drugs. In this study, new organotin(IV) N-butyl-N-phenyldithiocarbamate compounds have been successfully synthesized between the reaction of N-butylaniline amine with organotin(IV) chloride in 1:2/1:1 molar ratio. All compounds were characterized using the elemental analysis, FT-IR and NMR spectroscopy. The single crystal structure was determined by X-ray single crystal analysis. The elemental analysis showed good agreement with the suggested formula (C4H9)2Sn[S2CN(C4H9)(C6H5)]2 (Compound 1 and 2), (C6H5)2Sn[S2CN(C4H9)(C6H5)]2 (Compound 3) and (C6H5)3Sn[S2CN(C4H9)(C6H5)] (Compound 4). The important infrared absorbance peaks, v (C = N) and v(C = S) were detected in range between 1457-1489 cm(-1) and 951-996 cm(-1), respectively. The chemical shift of carbon in NCS2 group obtained from 13C NMR was found in range 198.86-203.53 ppm. The crystal structure of compound 4 showed that the dithiocarbamate ligand coordinates in a monodentate fashion. It crystallized in monoclinic P2(1)/n space group with the crystal cell parameter: a = 10.0488(1) angstroms, b = 18.0008(2) angstroms, c = 15.2054(2) angstroms, beta = 102.442(1) degrees and R = 0.044. The cytotoxicity (IC50) of these compounds against Jurkat E6.1 and K-562 leukemia cells were in the range between 0.4-0.8 and 1.8-5.3 microM, respectively as assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazholium bromide (MTT) assay. In conclusion, our study demonstrate that all compounds showed potent cytotoxicity towards both cell lines tested with the triphenyltin(IV) compound displayed the greatest effect.
    Matched MeSH terms: Thiocarbamates/chemical synthesis; Thiocarbamates/pharmacology*; Thiocarbamates/chemistry
  12. Taste-thresholds for phenylthiocarbamide of some population groups. II. The thresholds of two uncivilized ethnic groups living in Malaya
    LUGG JW
    Ann. Hum. Genet., 1957 Mar;21(3):244-53.
    PMID: 13411870
    Matched MeSH terms: Thiocarbamates*
  13. Two new monofunctional platinum(II) dithiocarbamate complexes: phenanthriplatin-type axial protection, equatorial-axial conformational isomerism, and anticancer and DNA binding studies
    Imran M, Rehman ZU, Hogarth G, Tocher DA, Chaudhry GE, Butler IS, et al.
    Dalton Trans, 2020 Nov 10;49(43):15385-15396.
    PMID: 33140800 DOI: 10.1039/d0dt03018j
    The syntheses of two platinum(ii) dithiocarbamate complexes (1 and 2) that show quinoplatin- and phenanthriplatin-type axial protection of the Pt-plane are described. The Pt-plane of complex 2 is axially more protected than that of complex 1. Furthermore, both complexes adopt two different stereochemical conformations in the solid state (based on single-crystal X-ray structures) owing to the structurally flexible piperazine backbone; i.e., C-e,e-Anti (1) and C-e,a-Syn (2), where "C" stands for the chair configuration, "e" and "a" stand for the equatorial and axial positions and "Anti" (opposite side) and "Syn" (same side) represent the relative orientations in space of the terminal substituents on the piperazine ring. In complex 2, the C-e,a-Syn conformation may provide additional steric hindrance to the Pt-plane. Despite the lower lipophilicity of 2 as compared to that of 1, the in vitro anticancer action against selected cancer cell lines is better for the former revealing the superior role of the axial protection over lipophilicity in modulating anticancer activity. The activity against the cancer promoting protein NF-κB signifies that the mode of cancer cell death may be the result of hindering the activity of NF-κB in the initiation of apoptosis. The apoptotic mode of cell death has been established earlier in a study using Annexin V-FITC. Finally, DNA binding studies revealed that the complex-DNA adduct formation is spontaneous and the mode of interaction is non-intercalative (electrostatic/covalent).
    Matched MeSH terms: Thiocarbamates/chemistry*
  14. Penilaian Kualiti Jasad Batuan di Terowong Kedua Genting Sempah, Selangor Darul Ehsan (Rock Mass Quality Evaluation of the Second Tunnel at Genting Sempah, Selangor Darul Ehsan)
    Abdul Ghani Rafek, Khairuddin Nordin
    Sains Malaysiana, 1997;26.
    The new Genting Sempah tunnel represents an important part of the widening and upgrading of the main east-west road link between Kuala Lumpur on the west coast and Kuantan on the east coast of Peninsular Malaysia. The new tunnel is located between 18m to 30m north of the existing (old) tunnel which was constructed in 1975 and has a similar alignment. Engineering geological investigations and site characterization for the construction of the new tunnel were carried out in 1994 with drilling, aerial photograph interpretation, surface geological mapping, geophysical surveys and laboratory testing. Rock mass classification was carried out based on the Q classification system of Barton et at. (1974). Based on this classification, it was predicted that for the tunnel zone, 8.6 % of the length of the tunnel consisted of rock mass classified as very poor i.e. type two, 82.8% as extremely poor, i.e. type three and the remaining 8.6% as exceptionally poor, i.e. type four. Excavation of the tunnel between March 1995 and September 1996 together with engineering geological logging and rock mass classification revealed the following; type two, very poor 6.3%, type three, extremely poor 89.9%, type four, exceptionally poor 3.8%. These results show the general validity of the prediction of the rock mass quality.
    Terowong kedua Genting Sempah merupakan suatu bahagian utama dalam pembesaran dan peningkatan taraf jalan timur-barat utama yang menghubungi Kuala Lumpur di pantai barat dan Kuantan di pantai timur Semenanjung Malaysia. Terowong kedua berkedudukan 18 m hingga 30 m ke utara terowong lama yang dibina pada tahun 1975 dan mempunyai penjajaran yang sama. Penyiasatan geologi kejuruteraan dan pemeriksaan tapak pembinaan terowong kedua dilaksanakan pada tahun 1994 dengan penggerudian, pentafsiran fotograf udara, pemetaan geologi permukaan, survei geofizik dan ujian makmal. Pengelasan kualiti jasad batuan dilakukan berdasarkan sistem pengelasan Q oleh Barton et al. (1974). Hasil pengelasan ini di zon terowong meramalkan 8.6% panjang terowong baru terdiri daripada jasad batuan berkualiti sangat rendah, iaitu jenis dua, 82.8% berkualiti tersangat rendah, iaitu jenis tiga manakala 8.6% panjang terowong terdiri daripada jasad batuan berkualiti luarbiasa rendah, iaitu jenis empat. Penggalian terowong di antara Mac 1995 dan September 1996 dengan rakaman geologi kejuruteraan dan pengelasan jasad batuan semasa penggalian menghasilkan keputusan seperti berikut; jenis dua, berkualiti sangat rendah 6.3%, jenis tiga, berkualiti tersangat rendah 89.9%, jenis empat, berkualiti luar biasa rendah 3.8%. Keputusan
    Matched MeSH terms: Thiocarbamates
  15. Fulltext Preliminary survey on potential slope instability and soil physico-chemical characteristic in Cameron Highlands, Pahang. (Tinjauan awal potensi ketidakstabilan cerun dan cirian fiziko-kimia tanah di Cameron Highlands, Pahang)
    Zulfahmi Ali Rahman, Sahibin Abd. Rahim, Wan Muhd Razi Idris, Jasni Yaakob
    Sains Malaysiana, 2007;36(2):105-116.
    Secara geologi, kawasan Cameron Highland terdiri daripada batuan granit batolit yang merejah ke dalam batuan sedimen yang lebih tua. Rejahan jasad igneus asidik ini menyebabkan pembentukan batuan meta-sedimen dan batuan metamorfik lain sebagai sisa bumbung. Sekis sering ditemui telah mengalami luluhawa tinggi hingga sepenuhnya, berwarna kelabu cerah hingga gelap dengan butiran halus hingga sederhana dan struktur foliasi yang ketara. Manakala batuan granit mengandungi mineral kuarza, felspar dan butiran biotit dan/atau turmalin. Kebanyakan cerun potongan jalan raya yang dibina merentasi jasad batuan ini dan survei ketidakstabilan cerun dilakukan berdasarkan jenis, geometri dan cirian fiziko-kimia tanah cerun. Hasil cerapan lapangan menunjukkan bahawa jenis cerun yang gagal adalah jenis cerun tanah yang terdiri daripada jenis gelinciran cetek dan dalam. Antara faktor yang menyumbang kepada ketidakstabilan cerun adalah geometri cerun seperti cerun yang tinggi dan sudut muka cerun yang curam, sifat keperoian tanah pada cerun dan kekurangan litupan vegetasi permukaan. Ini menyebabkan permukaan cerun terdedah kepada hentaman terus hujan. Kesan daripada air larian permukaan juga menyebabkan pembentukan alur-alur hakisan pada muka cerun tanah. Sifat fiziko-kimia bahan cerun (tanah) seperti taburan saiz partikel, pH, kandungan ferum oksida, bahan organik, kandungan air, ketumpatan pukal dan sebenar serta keporosan juga didapati memainkan peranan sebagai faktor yang dalaman dalam mempengaruhi kestabilan cerun tertentu yang dikaji. Julat pH tanah yang rendah (sifat asidik) pada semua cerun mengurangkan kandungan ferum oksida dalam tanah yang bertindak sebagai bahan penyimen tanah. Ini menyebabkan agregatan tanah menjadi lemah dan mudah terhakis.
    Matched MeSH terms: Thiocarbamates
  16. Pollution levels of thiobencarb, propanil, and pretilachlor in rice fields of the muda irrigation scheme, Kedah, Malaysia
    Sapari P, Ismail BS
    Environ Monit Assess, 2012 Oct;184(10):6347-56.
    PMID: 22089624 DOI: 10.1007/s10661-011-2424-9
    The purpose of this study was to investigate the potential risk of pretilachlor, thiobencarb, and propanil pollutants in the water system of the rice fields of the Muda area. The study included two areas that used different irrigation systems namely non-recycled (N-RCL) and recycled (RCL) water. Regular water sampling was carried out at the drainage canals during the weeding period from September to October 2006 in the main season of 2006/2007 and April-May 2007 in off season of 2007. The herbicides were extracted by the solid-phase extraction method and identified using a GC-ECD. Results showed that the procedure for identification of the three herbicides was acceptable based on the recovery test values, which ranged from 84.1% to 96.9%. A wide distribution pattern where more than 79% of the water samples contained the herbicide pollutants was observed at both the areas where N-RCL and RCL water was supplied for the two seasons. During September to October 2006, high weedicide residue concentration was observed at the N-RCL area and it ranged from 0.05 to 1.00 μg/L for pretilachlor and propanil and 10-25 μg/L for thiobencarb. In the case of the area with RCL water, the weedicide residue ranged from 1 to 5 μg/L for pretilachlor and propanil and 10-25 μg/L for thiobencarb. The highest residue level reached was 25-50, 50-100, and 100-200 μg/L for pretilachlor, propanil, and thiobencarb, respectively. During April to May 2007, high residue concentration frequently occurred at the area supplied with N-RCL irrigation water and it ranged from 0.05 to 1.00, 10 to 25, and 25 to 50 μg/L for pretilachlor, propanil, and thiobencarb, respectively. The highest residue level reached was 25-50 μg/L for pretilachlor and 100-200 μg/L for propanil and thiobencarb. There was an accelerated increase in the concentration of the herbicide residues, with the maximum levels reached at the early period of weedicide application, followed by a sharp decrease after the rice fields were completely covered with the rice crop. During the main season of 2006/2007, the concentration of propanil residue gradually rose, although that of the other herbicides declined.
    Matched MeSH terms: Thiocarbamates/analysis*
  17. Cirian Halaju Seismos dan Ultrasonik Profil Luluhawa Granit Km 39.9 Lebuhraya Kuala Lumpur-Karak
    Umar Hamzah, Ibrahim Komoo
    Sains Malaysiana, 1997;26.
    A survey to characterize seismic and ultrasonic properties of a granite weathering profile have been carried out at a roadcut slope exposure along Kuala Lumpur-Karak highway at kilometres 39.9. The terraced cut slope shows a complete weathering profile beginning from fresh grade I rock to grade VI residual soil. Together with in situ seismic measurement, rock samples have been collected for ultrasonic tests in laboratory. The range of velocities representing grades and indices of weathered rocks and soils are determined from the in situ seismic surveys. The range of ultrasonic velocities and elastic moduli are obtained from the laboratory measurements.
    Satu survei untuk mencirikan sifat seismos dan ultrasonik profil luluhawa granit telah dilakukan di singkapan potongan jalan, cerun utara lebuhraya Kuala Lumpur-Karak pada lokaliti 39.9 km. Potongan berteres ini mempamirkan satu profil luluhawa lengkap iaitu mulai batuan gred 1 yang segar hingga ke tanah baki bergred VI. Di samping pengukuran seismos secara in situ, sampel batuan juga diambil untuk dibuat pengukuran halaju ultrasonik di makmal. Julat halaju yang mewakili gred dan indeks luluhawa bagi tanah dan batuan diperolehi daripada survei seismos in situ. Julat halaju trasonik dan modulus kenyal diperolehi hasil pengukuran di makmal.
    Matched MeSH terms: Thiocarbamates
  18. Fulltext Assessment of traffic noise and the association with non auditory effect among shop lot workers in Kajang, Selangor
    Mohd Zahiruddin Zukfali, Haliza Abdul Rahman
    Malaysian Journal of Public Health Medicine, 2016;16(10):0-0.
    MyJurnal
    The objective of study is to determine traffic noise level and non-auditory effect among shop lot workers at Kajang Selangor. This cross sectional study was carried to study traffic noise exposure with annoyance and work performance level among shop lot workers in Jalan Mendaling, JalanTukang and Jalan Sulaiman at Kajang town, Selangor. This study involves 120 shop lot workers that exposed to the traffic noise during their working hours where they are randomly selected. Noise exposure was estimated using the Sound Level Meter for environmental noise. The traffic volume was recorded using video recorder and calculated using tally counter. One set questionnaire consist standard questionnaire was used to assess the annoyance level and work performance level among the respondents. Respondents were predominantly by male which are 94 and female, 26 respondents. The mean age of the respondent were ranged between 41 to 60 years old. Only 12.5% of respondent are ranged 21 until 30 years old. In total of 120 respondent, 54.2% of them are Chinese while Malay and India only 30% and 15.8% respectively. The result showed that the traffic noise level at study areas are exceeded the permissible sound limit of commercial and business area during daylight which is 70 dB(A). Regarding work performance, 94 respondents are having low work performance level and 82% of respondent high annoyance level during the exposure of traffic noise from four different sources which are noise from the traffic, speeding vehicle, high traffic volume and exhaust system. There is a significant relationship between traffic noise level with work performance level (p=0.001) and annoyance level (p=0.026). The average traffic noise (Laeq) level at Jalan Mendaling, Jalan Tukang and Jalan Sulaiman is 71.19 dB(A) which were high and exceeds permissible sound level from road traffic, commercial and business place at day time, 70 dB(A). The exposure from the traffic noise effect the annoyance level and work performance level among the shop lot worker. In order to reduce traffic noise exposure towards the shop lot workers, some recommendation are needed to control the traffic noise such as build a noise barrier, plant trees and also enforcement of legal requirement in noise level.
    Matched MeSH terms: Thiocarbamates
  19. Penilaian kualiti subgred turapan menggunakan kaedah analisis spektrum gelombang permukaan
    Rosyidi S, Taha M, Ismail A, Chik Z
    Sains Malaysiana, 2009;38.
    Dalam hal yang berkaitan dengan pengurusan turapan jalan raya, keupayaan galas lapisan subgred banyak mempengaruhi keadaan struktur turapan secara keseluruhan. Oleh itu, penilaian kualiti subgred diperlukan dari masa ke masa bagi mengawal kualiti turapan supaya ianya boleh dilalui kenderaan tanpa mengalami kerosakan. Kaedah Analisis Spektrum Gelombang Permukaan (lebih dikenali dengan Spectral Analysis of Surface Wave-SASW) merupakan suatu teknik uji kaji seismos tanpa musnah di lapangan yang boleh digunakan untuk penilaian kekukuhan dan kedalaman struktur turapan jalan termasuk lapisan subgred turapan dengan cepat dan menjimatkan. Makalah ini bertujuan untuk menunjukkan keupayaan kaedah SASW bagi menilai kualiti lapisan subgred turapan. Kaedah SASW dilakukan berdasarkan kaedah perambatan gelombang R. Berasaskan data beza fasa gelombang R yang merambat di permukaan turapan, lengkung eksperimen serakan halaju fasa diperolehi. Selanjutnya melalui proses songsangan, parameter dinamik bahan seperti halaju ricih yang mewakili modulus elastik dan ricih dinamik bahan turapan jalan boleh ditentukan. Hasil kajian menunjukkan bahawa kaedah SASW berupaya menghasilkan parameter dinamik bahan lapisan subgred turapan yang boleh diguna pakai. Beberapa model empirik dengan korelasi yang baik berjaya diterbitkan daripada kajian ini yang boleh digunakan dengan mudah di lapangan untuk penilaian kekukuhan lapisan subgred secara tepat.
    Matched MeSH terms: Thiocarbamates
  20. Agrobacterium tumefaciens mediated transformation of the proteolysis 6 (prt6) gene into cotyledons of tomato cv. Micro tom
    Intan Elya Suka, Nur Farhana Roslan, Zamri Zainal, Nurulhikma Md Isa, Bee LC
    Sains Malaysiana, 2018;47:1465-1471.
    Gen Proteolisis 6 (PRT6) merupakan gen yang memainkan peranan penting dalam tapak jalan N-end rule dan berfungsi
    sebagai enzim E3 ligase. PRT6 berperanan dalam pengenalan protein sasaran bagi proses degradasi. Objektif utama kajian
    ini adalah untuk mentransformasi konstruk RNAi PRT6 ke dalam tomato berperantarakan Agrobacterium tumefaciens.
    Ini bertujuan untuk memahami peranan tapak jalan N-end rule semasa proses pemasakan buah. Beberapa faktor yang
    memberi kesan kepada transformasi seperti masa ko-penanaman dan juga kepekatan antibiotik yang digunakan telah
    dioptimumkan. Keputusan kajian menunjukkan pengeraman kotiledon selama 48 jam pada medium ko-penanaman dapat
    meningkatkan penghasilan kalus sebanyak 61% manakala penggunaan 500 mg/L antibiotik karbenisilin dalam medium
    regenerasi pucuk dapat mengurangkan kontaminasi A. tumefaciens sehingga 5.2%. Selain itu, strain A. tumefaciens
    C58 merupakan strain A. tumefaciens yang paling sesuai digunakan sebagai perantara dalam kajian ini. Tindak balas
    berantai polimerase (PCR) telah dijalankan pada pucuk yang terhasil untuk mengesahkan integrasi fragmen PRT6 ke dalam
    genom tomato. Berdasarkan analisis PCR, kesemua tujuh pucuk putatif transgenik adalah merupakan transforman positif.
    Matched MeSH terms: Thiocarbamates
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