Displaying publications 1 - 20 of 28 in total

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  1. A simple method for chromium speciation analysis in contaminated water using APDC and a pre-heated glass tube followed by HPLC-PDA
    Salihu SO, Bakar NKA
    Talanta, 2018 May 01;181:401-409.
    PMID: 29426532 DOI: 10.1016/j.talanta.2018.01.041
    In this study, a simple sample preparation method was developed for the determination of tri-and hexavalent chromium in water samples. It utilizes a pre-heated customized glass tube (CGT), to supply the heat energy required for the reaction of Cr(III) with ammonium pyrrolidinedithiocarbamate (APDC). The products of the Cr complexes, tris(1-pyrrolidinecarbodithioato)chromium(III) and bis(1-pyrrolidinecarbodithioato)[1-pyrrolidinecarbodithio(thioperoxoato)]chromium(III) were chromatographed with Shimadzu LC-20AT and Zobax Eclipse C18 (150mm × 4.6mm, 5µm) column using ACN: Water, (7:3, v/v) as the mobile phase. The concentration of Cr(III) ranged from 0.06mgL-1to 0.09mgL-1and that of Cr(VI) was between 0.02mgL-1to 0.04mgL-1in the samples. Percentage recoveries from spiked real samples were between 87% (tap water) to 110% (wastewater) for Cr(III) and 92% (pond water) to 117% (tap water) for Cr(VI). The limits of detection (LODs) were 0.0029mgL-1and 0.0014mg/L-1for Cr(III) Cr(VI) respectively. While the limits of quantitation (LOQs), were 0.0098mgL-1and 0.0047mgL-1for Cr(III) and Cr(VI) respectively. Method precision (RSD (%)) was 3.3% and 3.5% for Cr(III) and Cr(VI) respectively. The developed method was applied for the speciation analysis of chromium in drinking water, tap water, wastewater, river water, and pond water samples. Our findings proved the method is simple and inexpensive. The method was validated by the analysis of a certified reference material (CRM) SLRS-4. The percentage recovery and RSD(%) from the spiked CRM were 91% and 115% and 0.32% and 1.4% for Cr(III) and Cr(VI) respectively.
    Matched MeSH terms: Thiocarbamates
  2. Agrobacterium tumefaciens mediated transformation of the proteolysis 6 (prt6) gene into cotyledons of tomato cv. Micro tom
    Intan Elya Suka, Nur Farhana Roslan, Zamri Zainal, Nurulhikma Md Isa, Bee LC
    Sains Malaysiana, 2018;47:1465-1471.
    Gen Proteolisis 6 (PRT6) merupakan gen yang memainkan peranan penting dalam tapak jalan N-end rule dan berfungsi
    sebagai enzim E3 ligase. PRT6 berperanan dalam pengenalan protein sasaran bagi proses degradasi. Objektif utama kajian
    ini adalah untuk mentransformasi konstruk RNAi PRT6 ke dalam tomato berperantarakan Agrobacterium tumefaciens.
    Ini bertujuan untuk memahami peranan tapak jalan N-end rule semasa proses pemasakan buah. Beberapa faktor yang
    memberi kesan kepada transformasi seperti masa ko-penanaman dan juga kepekatan antibiotik yang digunakan telah
    dioptimumkan. Keputusan kajian menunjukkan pengeraman kotiledon selama 48 jam pada medium ko-penanaman dapat
    meningkatkan penghasilan kalus sebanyak 61% manakala penggunaan 500 mg/L antibiotik karbenisilin dalam medium
    regenerasi pucuk dapat mengurangkan kontaminasi A. tumefaciens sehingga 5.2%. Selain itu, strain A. tumefaciens
    C58 merupakan strain A. tumefaciens yang paling sesuai digunakan sebagai perantara dalam kajian ini. Tindak balas
    berantai polimerase (PCR) telah dijalankan pada pucuk yang terhasil untuk mengesahkan integrasi fragmen PRT6 ke dalam
    genom tomato. Berdasarkan analisis PCR, kesemua tujuh pucuk putatif transgenik adalah merupakan transforman positif.
    Matched MeSH terms: Thiocarbamates
  3. Application of the artificial neural network in quantitative structure-gradient elution retention relationship of phenylthiocarbamyl amino acids derivatives
    Tham SY, Agatonovic-Kustrin S
    J Pharm Biomed Anal, 2002 May 15;28(3-4):581-90.
    PMID: 12008137
    Quantitative structure-retention relationship(QSRR) method was used to model reversed-phase high-performance liquid chromatography (RP-HPLC) separation of 18 selected amino acids. Retention data for phenylthiocarbamyl (PTC) amino acids derivatives were obtained using gradient elution on ODS column with mobile phase of varying acetonitrile, acetate buffer and containing 0.5 ml/l of triethylamine (TEA). Molecular structure of each amino acid was encoded with 36 calculated molecular descriptors. The correlation between the molecular descriptors and the retention time of the compounds in the calibration set was established using the genetic neural network method. A genetic algorithm (GA) was used to select important molecular descriptors and supervised artificial neural network (ANN) was used to correlate mobile phase composition and selected descriptors with the experimentally derived retention times. Retention time values were used as the network's output and calculated molecular descriptors and mobile phase composition as the inputs. The best model with five input descriptors was chosen, and the significance of the selected descriptors for amino acid separation was examined. Results confirmed the dominant role of the organic modifier in such chromatographic systems in addition to lipophilicity (log P) and molecular size and shape (topological indices) of investigated solutes.
    Matched MeSH terms: Thiocarbamates/analysis*
  4. Fulltext Assessment of traffic noise and the association with non auditory effect among shop lot workers in Kajang, Selangor
    Mohd Zahiruddin Zukfali, Haliza Abdul Rahman
    Malaysian Journal of Public Health Medicine, 2016;16(10):0-0.
    MyJurnal
    The objective of study is to determine traffic noise level and non-auditory effect among shop lot workers at Kajang Selangor. This cross sectional study was carried to study traffic noise exposure with annoyance and work performance level among shop lot workers in Jalan Mendaling, JalanTukang and Jalan Sulaiman at Kajang town, Selangor. This study involves 120 shop lot workers that exposed to the traffic noise during their working hours where they are randomly selected. Noise exposure was estimated using the Sound Level Meter for environmental noise. The traffic volume was recorded using video recorder and calculated using tally counter. One set questionnaire consist standard questionnaire was used to assess the annoyance level and work performance level among the respondents. Respondents were predominantly by male which are 94 and female, 26 respondents. The mean age of the respondent were ranged between 41 to 60 years old. Only 12.5% of respondent are ranged 21 until 30 years old. In total of 120 respondent, 54.2% of them are Chinese while Malay and India only 30% and 15.8% respectively. The result showed that the traffic noise level at study areas are exceeded the permissible sound limit of commercial and business area during daylight which is 70 dB(A). Regarding work performance, 94 respondents are having low work performance level and 82% of respondent high annoyance level during the exposure of traffic noise from four different sources which are noise from the traffic, speeding vehicle, high traffic volume and exhaust system. There is a significant relationship between traffic noise level with work performance level (p=0.001) and annoyance level (p=0.026). The average traffic noise (Laeq) level at Jalan Mendaling, Jalan Tukang and Jalan Sulaiman is 71.19 dB(A) which were high and exceeds permissible sound level from road traffic, commercial and business place at day time, 70 dB(A). The exposure from the traffic noise effect the annoyance level and work performance level among the shop lot worker. In order to reduce traffic noise exposure towards the shop lot workers, some recommendation are needed to control the traffic noise such as build a noise barrier, plant trees and also enforcement of legal requirement in noise level.
    Matched MeSH terms: Thiocarbamates
  5. Fulltext Assessment of using tunneling and trenchless technology for constricting twin box culvert
    Mohammad, Thamer Ahmad, Mohd. Razali Abdul Kadir, Megat Johari Megat Mohd. Noor, Ahmad Husaini Sulaiman
    Pertanika Journal of Science & Technology, 2010;18(1):-.
    MyJurnal
    Part of the Seremban flood mitigation project in the state of Negeri Sembilan, Malaysia is to mitigate
    the flood at Jalan Rasah. The mitigation is planned to be implemented in packages. Package I and Package II of River Anak Air Rasah are parts of the project work. In these packages, wider and deeper concrete sections for the river are constructed. The existing undersized culverts were replaced by bigger reinforced concrete box culverts. The size of the box culverts was based on 100-years average reoccurrence interval (ARI). One of these culverts intersected with a rail line connecting Singapore and Malaysia. Trenchless jacking technique was used to lay the box culvert. The total length of the box culvert jacked under the railway line is 33 m, whereas the total width of the twin box culvert is 7.8 m with a total height of 3 m. This was the first time that the trenchless jacking techniques were used for the urban flood mitigation purpose in Malaysia, and it is mainly used to minimise traffic disruption. This study reports the success of using jacking technique in the development of the flood mitigation program of DID in Negeri Sembilan. Among other things, it explains significant performance of the technique under local conditions and experiences gained towards the advancement of tunnelling and trenchless technology.
    Matched MeSH terms: Thiocarbamates
  6. Beberapa sifat fizik dan mekanik batuan granit berbutir kasar Kuala Kubu Bharu, Selangor
    Umar Hamzah, Lee CR, Abd. Ghani Rafek
    Sains Malaysiana, 2007;36:1-8.
    Empat puluh sampel batuan granit berbutir kasar daripada Kuala Kubu Bharu telah dikumpulkan daripada 14 lokaliti di sepanjang singkapan jalan daripada Taman Bukit Bunga hingga ke kampung Pertak. Sampel-sampel teras selinder dan blok empatsegi telah disediakan daripada sampel lapangan tersebut untuk menjalani ujian halaju sonik dan mekanik setelah pengukuran beberapa sifat fizik. Nilai purata porositi berkesan sampel-sampel tersebut ialah 1.33 % manakala purata ketumpatan kering dan tepu adalah 2542 dan 2555 kg/m3. Graviti spesifik yang dihitung berjulat 2.1-2.9. Halaju denyut ultrasonik min gelombang P dan S yang melalui bahan batuan yang diuji ialah 5359 m/s dan 2890 m/s. Ujian-ujian mampatan sepaksi menunjukkan purata kekuatan mampatan sepaksi sampel yang bernilai 138.6 MPa. Nilai purata bagi indeks kekuatan beban titik Is(50) pula ialah 5.63. Oleh itu perkaitan kekuatan mampatan sepaksi dengan kekuatan beban titik ialah dengan faktor multiplikasi 25.
    Matched MeSH terms: Thiocarbamates
  7. Fulltext Chronic gamma irradiation for crops improvement and agrobiotechnology
    Azhar Mohamad
    Buletin Persatuan Genetik Malaysia, 2011;18(1):31-32.
    MyJurnal
    The Gamma Green House (GGH) is a chronic irradiation facility located at MINT Tech Park, Nuclear Malaysia, Jalan Dengkil. GGH is used for induction of mutation in plants and other biological samples with low dose radiation over period of time depending on the nature and sensitivity of the plant species. Gamma Greenhouse facility at Malaysian Nuclear Agency comprises an open topped
    irradiation area consisting of circular green house with 30 meters radius, control room and irradiator with interlock system. The irradiation source is a REVISS RSL6050 double encapsulated 800 Ci 137Cs (half-life 30.1 years for 137Cs) pencils and allowed to be exposed only when the entire 300 m diameter site is free from personnel. The irradiator system is secured by a sophisticated interlock system, which only allows the source to be exposed when all the prerequisite safety conditions are met, and automatically returns the source to the safe
    storage position if any safety device is compromised.
    Matched MeSH terms: Thiocarbamates
  8. Cirian Halaju Seismos dan Ultrasonik Profil Luluhawa Granit Km 39.9 Lebuhraya Kuala Lumpur-Karak
    Umar Hamzah, Ibrahim Komoo
    Sains Malaysiana, 1997;26.
    A survey to characterize seismic and ultrasonic properties of a granite weathering profile have been carried out at a roadcut slope exposure along Kuala Lumpur-Karak highway at kilometres 39.9. The terraced cut slope shows a complete weathering profile beginning from fresh grade I rock to grade VI residual soil. Together with in situ seismic measurement, rock samples have been collected for ultrasonic tests in laboratory. The range of velocities representing grades and indices of weathered rocks and soils are determined from the in situ seismic surveys. The range of ultrasonic velocities and elastic moduli are obtained from the laboratory measurements.
    Satu survei untuk mencirikan sifat seismos dan ultrasonik profil luluhawa granit telah dilakukan di singkapan potongan jalan, cerun utara lebuhraya Kuala Lumpur-Karak pada lokaliti 39.9 km. Potongan berteres ini mempamirkan satu profil luluhawa lengkap iaitu mulai batuan gred 1 yang segar hingga ke tanah baki bergred VI. Di samping pengukuran seismos secara in situ, sampel batuan juga diambil untuk dibuat pengukuran halaju ultrasonik di makmal. Julat halaju yang mewakili gred dan indeks luluhawa bagi tanah dan batuan diperolehi daripada survei seismos in situ. Julat halaju trasonik dan modulus kenyal diperolehi hasil pengukuran di makmal.
    Matched MeSH terms: Thiocarbamates
  9. Copper complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin induced apoptosis in breast cancer cell
    Foo JB, Low ML, Lim JH, Lor YZ, Zainol Abidin R, Eh Dam V, et al.
    Biometals, 2018 08;31(4):505-515.
    PMID: 29623473 DOI: 10.1007/s10534-018-0096-4
    Copper complexes have been widely studied for the anti-tumour application as cancer cells are reported to take up greater amounts of copper than normal cells. Preliminary study revealed that the newly synthesised copper complex [Cu(SBCM)2] displayed marked anti-proliferative towards triple-negative MDA-MB-231 breast cancer cells. Therefore, Cu(SBCM)2 has great potential to be developed as an agent for the management of breast cancer. The present study was carried out to investigate the mode of cell death induced by Cu(SBCM)2 towards MDA-MB-231 breast cancer cells. The inhibitory and morphological changes of MDA-MB-231 cells treated with Cu(SBCM)2 was determined by using MTT assay and inverted light microscope, respectively. The safety profile of Cu(SBCM)2 was also evaluated towards human dermal fibroblast (HDF) normal cells. Confirmation of apoptosis and cell cycle arrest were determined by flow cytometry analysis. The expression of p53, Bax, Bcl-2 and MMP2 protein were detected with western blot analysis. Cu(SBCM)2 significantly inhibited the growth of MDA-MB-231 cells in a dose-dependent manner with GI50 18.7 ± 3.06 µM. Indeed, Cu(SBCM)2 was less toxic towards HDF normal cells with GI50 31.8 ± 4.0 µM. Morphological study revealed that Cu(SBCM)2-treated MDA-MB-231 cells experienced cellular shrinkage, membrane blebbing, chromatin condensation and formation of apoptotic bodies, suggesting that Cu(SBCM)2 induced apoptosis in the cells, which was confirmed by Annexin-V/PI flow cytometry analysis. It was also found that Cu(SBCM)2 induced G2/M phase cell cycle arrest towards MDA-MB-231 cells. The induction of apoptosis and cell cycle arrest in the present study is possibly due to the down-regulation of the mutant p53 and MMP2 protein. In conclusion, Cu(SBCM)2 can be developed as a targeted therapy for the treatment of triple-negative breast cancer.
    Matched MeSH terms: Thiocarbamates/pharmacology; Thiocarbamates/chemistry
  10. Cytotoxicity of triphenyltin(IV) methyl- and ethylisopropyldithiocarbamate compounds in chronic myelogenus leukemia cell line (K-562)
    Awang N, Kamaludin NF, Hamid A, Mokhtar NW, Rajab NF
    Pak J Biol Sci, 2012 Sep 01;15(17):833-8.
    PMID: 24163967
    Studies on the discovery of new cancer treatment by using metal-based compounds such as tin (Sn) has now greatly being synthesized and evaluated to identify their effectiveness and suitability to be developed as a new anticancer drug.

    APPROACH: This study was carried out to evaluate the cytotoxicity of triphenyltin(lV) methylisopropyldithiocarbamate (compound 1) and triphenyltin(IV) ethylisopropyldithiocarbamate (compound (2) on chronic myelogenus leukemia cells. The determination of their cytotoxicity (IC50) at different time of exposure and concentration was carried out through the employment of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay.

    RESULTS: The IC50 values obtained for compound 1 and 2 following treatment at 24, 48 and 72 h were 0.660, 0.223, 0.370 microM and 0.677, 0.306, 0.360 microM, respectively. Cell morphological changes such as apoptotic and necrotic features were also been observed.

    CONCLUSION: The compounds tested were found to give cytotoxic effect against chronic myelogenus leukemia (K-562) cell at a micromolar dose. Thus, further study on their specific mechanism of actions in the human cells should be carried out to elucidate their potential as an anticancer agent.

    Matched MeSH terms: Thiocarbamates/pharmacology*
  11. Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework
    Sun RW, Zhang M, Li D, Zhang ZF, Cai H, Li M, et al.
    Chemistry, 2015 Dec 14;21(51):18534-8.
    PMID: 26459298 DOI: 10.1002/chem.201503656
    A dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin-resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug-release testing, in this study, a set of transwell assay-based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn-MOF towards A2780cis.
    Matched MeSH terms: Thiocarbamates/chemistry*
  12. Kesan kadar nitrogen terhadap populasi lalat putih (bemisia tabaci) pada tanaman cili (capsicum annum L.)
    Zurina M, Idris A, Mohamad Roff M
    Sains Malaysiana, 2010;39.
    Bemisia tabaci (Gennadius) merupakan spesies lalat putih utama dan berbahaya kepada pertanian. Kajian telah dijalankan di Stesen MARDI Jalan Kebun, Klang, Selangor dari 9 September 2006 hingga 11 November 2007. Objektif kajian ini adalah untuk menilai kesan populasi lalat putih terhadap tanaman cili yang diberi kadar nitrogen yang berbeza (0, 33, 43, 53 g/pokok). Keputusan kajian menunjukkan pokok cili yang dibaja dengan kadar nitrogen yang tinggi menyebabkan peningkatan yang bererti (P<0.05) kepada populasi B. tabaci peringkat belum matang berbanding pada pokok cili yang dibajakan nitrogen pada kadar rendah. Min bilangan B. tabaci pada peringkat belum matang per aras kanopi adalah berbeza secara signifikan (P<0.05) antara aras kanopi dan antara perlakuan. Secara amnya, min bilangan telur dan larva B. tabaci adalah lebih tinggi secara bererti (P<0.05) pada aras kanopi atas berbanding tengah dan bawah. Walau bagaimanapun, min bilangan pupa B. tabaci adalah tinggi secara signifikan (P<0.05) pada aras kanopi bawah berbanding aras kanopi atas dan tengah. Min bilangan B. tabaci pada peringkat belum matang adalah berbeza secara bererti (P<0,05) mengikut minggu selepas pokok cili ditanam pada semua perlakuan. Secara amnya, populasi B. tabaci lebih tinggi semasa awal musim penanaman dan menurun selepasnya hingga ke akhir musim kecuali pada minggu ketiga dan ketujuh selepas pokok cili di tanam.
    Matched MeSH terms: Thiocarbamates
  13. Our recent experiences with sarin poisoning cases in Japan and pesticide users with references to some selected chemicals
    Yokoyama K
    Neurotoxicology, 2007 Mar;28(2):364-73.
    PMID: 16730798
    Attention has been paid to neurobehavioral effects of occupational and environmental exposures to chemicals such as pesticides, heavy metals and organic solvents. The area of research that includes neurobehavioral methods and effects in occupational and environmental health has been called "Occupational and Environmental Neurology and Behavioral Medicine." The methods, by which early changes in neurological, cognitive and behavioral function can be assessed, include neurobehavioral test battery, neurophysiological methods, questionnaires and structured interview, biochemical markers and imaging techniques. The author presents his observations of neurobehavioral and neurophysiological effects in Tokyo subway sarin poisoning cases as well as in pesticide users (tobacco farmers) in Malaysia in relation to Green Tobacco Sickness (GTS). In sarin cases, a variety effects were observed 6-8 months after exposure, suggesting delayed neurological effects. Studies on pesticide users revealed that organophosphorus and dithiocarbamate affected peripheral nerve conduction and postural balance; subjective symptoms related to GTS were also observed, indicating the effects of nicotine absorbed from wet tobacco leaves. In addition, non-neurological effects of pesticides and other chemicals are presented, in relation to genetic polymorphism and oxidative stress.
    Matched MeSH terms: Thiocarbamates/adverse effects
  14. Fulltext Pembangunan wakaf pendidikan di University College Bestari, Terengganu
    Mutiara Dwi Sari, Ab. Aziz Yusof, Ahmad Shaifful Anuar Ahmad Shukor
    Malaysian Journal of Social Sciences and Humanities, 2016;1(4):1-17.
    MyJurnal
    Salah satu syarat untuk menjadi sebuah negara maju adalah tersedianya modal insan yang unggul yang
    lahir daripada Institusi Pengajian Tinggi. Kerajaan Malaysia telah memberikan peruntukan yang besar
    untuk mencapai matlamat tersebut. Walau bagaimanupun, terdapat kekangan dan keterhadan kewangan
    Kerajaan untuk memenuhi keseluruhan biaya Institusi Pengajian Tinggi. Oleh itu, semua pihak terkait
    perlulah mencari alternatif dan jalan keluar bagi mengatasi masalah ini. Wakaf merupakan salah satu
    sistem ekonomi Islam yang dikatakan sangat berpotensi bagi membangunkan pendidikan. Kertas kerja
    ini mempunyai dua tujuan. Pertama, untuk mengenal pasti pembangunan wakaf pendidikan dengan
    kajian kes di Universiti College Bestari (UCB), Terengganu, Malaysia. Kedua, menganalisis isu
    kelestaraian wakaf dan kaedah-kaedah yang digunakan UCB dalam mempastikan kelestarian wakaf
    tersebut. Bagi mencapai kedua-dua tujuan ini kaedah kualitatif yang melibatkan temu bual mendalam
    dua orang responden telah dijalankan. Data yang diperolehi di analisis menggunakan kaedah analisis
    kandungan. Hasil kajian mendapati bahawa pembangunan wakaf di UCB sudah bermula sejak tahun
    1998. Pengurusan dan pentadbiran wakaf UCB dilakukan di bawah tiga agensi (joint venture) yang
    setiapnya merupakan pemegang saham iaitu PEYATIM (Pertubuhan Kebajikan Anak Yatim Malaysia)
    (50%), PERKAYA (Pertubuhan Kebajikan Anak Yatim) Terengganu (30%) dan YAKIN (Yayasan
    Kebajikan Negeri Terengganu) (20%). Antara kaedah yang digunakan untuk melestarikan wakaf
    pengajian tinggi di UCB adalah penjagaan dan pengelolaan aset yang telus dengan kepimpinan yang
    kuat, sistem pemasaran dan kaedah wakaf yang mudah. Sumbangan kerajaan dan juga peranan alumni
    dikatakan juga membantu pembangunan wakaf tersebut. Kajian ini membuktikan bahawa sistem wakaf
    memiliki potensi untuk membantu membangunkan pendidikan yang lestari.
    Matched MeSH terms: Thiocarbamates
  15. Pencirian geomekanik jasad batuan dengan menggunakan kaedah seismos: nisbah poisson
    Goh T, Ghani Rafek A, Rahim Samsudin A, Hariri Ariffin M, Baizura Yunus N
    Sains Malaysiana, 2011;40:1123-1127.
    Parameter mekanik seperti nisbah Poisson merupakan parameter input kejuruteraan batuan terutamanya dalam perisian komputer model berangka. Kaedah seismos digunakan untuk menentukan nisbah Poisson jasad batuan segar (gred I), terluluhawa sedikit (gred II), terluluhawa sederhana (gred III) dan tinggi (gred IV). Nisbah Poisson setiap lapisan jasad batuan dikira berdasarkan nilai purata halaju gelombang mampatan (Vp) dan gelombang ricih (Vs) pada kedalaman tertentu. Halaju gelombang mampatan (Vp) diperoleh daripada survei seismos biasan dan halaju gelombang ricih (Vs) diperoleh daripada survei analisis spektral gelombang permukaan (SASW) atau analisis gelombang permukaan berbilang saluran (MASW). Sebanyak 66 ujian seismos telah dijalankan pada 9 cerun jasad batuan iaitu 6 ujian di atas 1 cerun jasad batuan granit di JKR kuari Bukit Penggorak, Kuantan, Pahang; 26 ujian di atas 4 cerun jasad batuan granit di Kuari Kajang Rock, Semenyih, Ulu Langat, Selangor; 12 ujian di atas 1 cerun jasad batuan granit di Lebuhraya Silk Kajang (km 14.6) Selangor; 14 ujian di atas 2 cerun jasad batuan syis di Jalan Kuala Kubu Baru-Bukit Fraser (km 15), Selangor dan 8 ujian di atas 1 cerun jasad batuan kuarzit di Section U10, Bukit Cherakah, Shah Alam, Selangor. Daripada ujian seismos, nilai maksimum nisbah Poisson jasad batuan yang bergred I, II, III dan IV ialah 0.295, 0.335, 0.355 dan 0.364. Nilai minimum nisbah Poisson jasad batuan yang mempunyai gred I, II, III dan IV ialah 0.215, 0.299, 0.334 dan 0.337. Nilai purata nisbah Poisson untuk jasad batuan bergred I, II, III dan IV ialah 0.274, 0.320, 0.345 dan 0.345. Nilai nisbah Poisson jasad batuan menjadi semakin besar apabila gred terluluhawa menjadi semakin besar. Nilai purata nisbah Poisson jasad batuan gred II, III dan IV bertambah sebanyak 16.8%, 25.9% dan 25.9% jika dibandingkan dengan jasad batuan gred I. Keadaan ini berlaku kerana perubahan retakan pada jasad batuan gred I adalah lebih besar apabila mengalami proses terluluhawa. Perubahan retakan menjadi semakin kecil apabila mengalami proses terluluhawa seterusnya. Tiada perubahan retakan berlaku pada jasad batuan gred III apabila menjadi jasad batuan gred IV.
    Matched MeSH terms: Thiocarbamates
  16. Pengenalpastian dan profil pengekspresan gen biosintesis asid amino yis psikrofil, glaciozyma antarctica
    Izwan Bharudin, Radziah Zolkefli, Shazilah Kamaruddin, Farah Diba Abu Bakar, Abdul Munir Abdul Murad, Mohd Faizal Abu Bakar, et al.
    Sains Malaysiana, 2018;47:1675-1684.
    Mekanisme pengambilan dan penghasilan asid amino bagi mikroorganisma psikrofil yang bermandiri dan berpoliferasi
    pada persekitaran sejuk melampau masih belum difahami sepenuhnya. Objektif kajian ini ialah untuk mengenal pasti
    gen yang terlibat dalam penjanaan asid amino bagi yis psikrofil, Glaciozyma antarctica serta menentukan pengekspresan
    gen tersebut semasa kehadiran dan kekurangan asid amino dalam medium pertumbuhan. Pengenalpastian gen telah
    dilakukan melalui penjanaan penanda jujukan terekspres (ESTs) daripada dua perpustakaan cDNA yang dibina daripada
    sel yang dikultur dalam medium pertumbuhan kompleks dan medium pertumbuhan minimum tanpa asid amino. Sebanyak
    3552 klon cDNA daripada setiap perpustakaan dipilih secara rawak untuk dijujuk menghasilkan 1492 transkrip unik
    (medium kompleks) dan 1928 transkrip unik (medium minimum). Analisis pemadanan telah mengenl pasti gen mengekod
    protein yang terlibat di dalam pengambilan asid amino bebas, biosintesis asid amino serta gen yang terlibat dengan
    kitar semula asid amino berdasarkan tapak jalan yang digunakan oleh yis model, Saccharomyces cerevisiae. Analisis
    pengekspresan gen menggunakan kaedah RT-qPCR menunjukkan pengekspresan gen mengekod protein yang terlibat di
    dalam pengambilan asid amino bebas iaitu permease adalah tinggi pada medium kompleks manakala pengekspresan
    kebanyakan gen mengekod protein yang terlibat dalam kitar semula dan biosintesis asid amino adalah tinggi di dalam
    medium minimum. Kesimpulannya, gen yang terlibat dalam penjanaan dan pengambilan asid amino bagi mikroorganisma
    psikrofil adalah terpulihara seperti mikroorganisma mesofil dan pengekspresan gen-gen ini adalah diaruh oleh kehadiran
    atau ketiadaan asid amino bebas pada persekitaran.
    Matched MeSH terms: Thiocarbamates
  17. Fulltext Penggunaan aplikasi GIS dalam penyakit tuberkulosis di Cheras, Kuala Lumpur, Malaysia
    Shamsul Azhar Shah, Md. Idris Mohd. Nor, Abdul Hadi Harman Shah, Tahir Aris
    Malaysian Journal of Public Health Medicine, 2002;2(2):15-26.
    MyJurnal
    Tuberkulosis merupakan penyakit yang masih meigadi masalah kesihatan di seluruh dunia amnya dan di Malaysia khasnya. Kajian telah dilakukan ali Cheras, Kuala Lumpur menggunakan aplikasi GIS untuk mengenalpasti taburan geografi dan tren tuberkulosis daripada tahun 1996 sehingga tahun 2000. Kajian ini juga dilakukan untuk melihat kebolehan GIS sebagai alat surveilan penyakit beyangkit. Hasil kajian dengan menggunakan aplikasi GIS mendapati tren peningkatan tuberkulosis di kawasan·kawasan yang tertentu di Cheras. Penumpuan kes-kes tuberkulosis dapat dilihat di kawasan taburan penduduk yang kepadatan tinggi dan sederhana tinggi terutama di kawasan Kampung Pandan, kawasan penempatan Jalan Cheras dan Bandar Tun Razak. Kes—kes tersebut juga kebanyakannya adalah dalam lingkungan 100 meter ke 200 meter di antara satu sama lain. Kesimpulannya secara am, aplikasi GIS memberikan dimensi baru dalam kawalan penyakit dan ia pasti dapat digunakan dalam membantu aktiviti surveilan penyakit tuberkulosis.
    Matched MeSH terms: Thiocarbamates
  18. Penilaian Kualiti Jasad Batuan di Terowong Kedua Genting Sempah, Selangor Darul Ehsan (Rock Mass Quality Evaluation of the Second Tunnel at Genting Sempah, Selangor Darul Ehsan)
    Abdul Ghani Rafek, Khairuddin Nordin
    Sains Malaysiana, 1997;26.
    The new Genting Sempah tunnel represents an important part of the widening and upgrading of the main east-west road link between Kuala Lumpur on the west coast and Kuantan on the east coast of Peninsular Malaysia. The new tunnel is located between 18m to 30m north of the existing (old) tunnel which was constructed in 1975 and has a similar alignment. Engineering geological investigations and site characterization for the construction of the new tunnel were carried out in 1994 with drilling, aerial photograph interpretation, surface geological mapping, geophysical surveys and laboratory testing. Rock mass classification was carried out based on the Q classification system of Barton et at. (1974). Based on this classification, it was predicted that for the tunnel zone, 8.6 % of the length of the tunnel consisted of rock mass classified as very poor i.e. type two, 82.8% as extremely poor, i.e. type three and the remaining 8.6% as exceptionally poor, i.e. type four. Excavation of the tunnel between March 1995 and September 1996 together with engineering geological logging and rock mass classification revealed the following; type two, very poor 6.3%, type three, extremely poor 89.9%, type four, exceptionally poor 3.8%. These results show the general validity of the prediction of the rock mass quality.
    Terowong kedua Genting Sempah merupakan suatu bahagian utama dalam pembesaran dan peningkatan taraf jalan timur-barat utama yang menghubungi Kuala Lumpur di pantai barat dan Kuantan di pantai timur Semenanjung Malaysia. Terowong kedua berkedudukan 18 m hingga 30 m ke utara terowong lama yang dibina pada tahun 1975 dan mempunyai penjajaran yang sama. Penyiasatan geologi kejuruteraan dan pemeriksaan tapak pembinaan terowong kedua dilaksanakan pada tahun 1994 dengan penggerudian, pentafsiran fotograf udara, pemetaan geologi permukaan, survei geofizik dan ujian makmal. Pengelasan kualiti jasad batuan dilakukan berdasarkan sistem pengelasan Q oleh Barton et al. (1974). Hasil pengelasan ini di zon terowong meramalkan 8.6% panjang terowong baru terdiri daripada jasad batuan berkualiti sangat rendah, iaitu jenis dua, 82.8% berkualiti tersangat rendah, iaitu jenis tiga manakala 8.6% panjang terowong terdiri daripada jasad batuan berkualiti luarbiasa rendah, iaitu jenis empat. Penggalian terowong di antara Mac 1995 dan September 1996 dengan rakaman geologi kejuruteraan dan pengelasan jasad batuan semasa penggalian menghasilkan keputusan seperti berikut; jenis dua, berkualiti sangat rendah 6.3%, jenis tiga, berkualiti tersangat rendah 89.9%, jenis empat, berkualiti luar biasa rendah 3.8%. Keputusan
    Matched MeSH terms: Thiocarbamates
  19. Penilaian kualiti subgred turapan menggunakan kaedah analisis spektrum gelombang permukaan
    Rosyidi S, Taha M, Ismail A, Chik Z
    Sains Malaysiana, 2009;38.
    Dalam hal yang berkaitan dengan pengurusan turapan jalan raya, keupayaan galas lapisan subgred banyak mempengaruhi keadaan struktur turapan secara keseluruhan. Oleh itu, penilaian kualiti subgred diperlukan dari masa ke masa bagi mengawal kualiti turapan supaya ianya boleh dilalui kenderaan tanpa mengalami kerosakan. Kaedah Analisis Spektrum Gelombang Permukaan (lebih dikenali dengan Spectral Analysis of Surface Wave-SASW) merupakan suatu teknik uji kaji seismos tanpa musnah di lapangan yang boleh digunakan untuk penilaian kekukuhan dan kedalaman struktur turapan jalan termasuk lapisan subgred turapan dengan cepat dan menjimatkan. Makalah ini bertujuan untuk menunjukkan keupayaan kaedah SASW bagi menilai kualiti lapisan subgred turapan. Kaedah SASW dilakukan berdasarkan kaedah perambatan gelombang R. Berasaskan data beza fasa gelombang R yang merambat di permukaan turapan, lengkung eksperimen serakan halaju fasa diperolehi. Selanjutnya melalui proses songsangan, parameter dinamik bahan seperti halaju ricih yang mewakili modulus elastik dan ricih dinamik bahan turapan jalan boleh ditentukan. Hasil kajian menunjukkan bahawa kaedah SASW berupaya menghasilkan parameter dinamik bahan lapisan subgred turapan yang boleh diguna pakai. Beberapa model empirik dengan korelasi yang baik berjaya diterbitkan daripada kajian ini yang boleh digunakan dengan mudah di lapangan untuk penilaian kekukuhan lapisan subgred secara tepat.
    Matched MeSH terms: Thiocarbamates
  20. Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N((i)Pr)CH2CH2OH] for R = Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways
    Jamaludin NS, Goh ZJ, Cheah YK, Ang KP, Sim JH, Khoo CH, et al.
    Eur J Med Chem, 2013 Sep;67:127-41.
    PMID: 23856069 DOI: 10.1016/j.ejmech.2013.06.038
    The synthesis and characterisation of R3PAu[S2CN((i)Pr)CH2CH2OH], for R = Ph (1), Cy (2) and Et (3)4, is reported. Compounds 1-3 are cytotoxic against the doxorubicin-resistant breast cancer cell line, MCF-7R, with 1 exhibiting greater potency and cytotoxicity than either of doxorubicin and cisplatin. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis by 1, and necrosis by 2 and 3, are demonstrated, by both extrinsic and intrinsic pathways. Compound 1 activates the p53 gene, 2 activates only the p73 gene, whereas 3 activates both the p53 and p73 genes. Compounds 1 and 3 activate NF-κB, and each inhibits topoisomerase I.
    Matched MeSH terms: Thiocarbamates/chemistry*
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