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Optimal control strategies for dengue fever spread in Johor, Malaysia

Abidemi A, Aziz NAB

Comput Methods Programs Biomed, 2020 Nov;196:105585.
PMID: 32554024 DOI: 10.1016/j.cmpb.2020.105585

Background Dengue is a vector-borne viral disease endemic in Malaysia. The disease is presently a public health issue in the country. Hence, the use of mathematical model to gain insights into the transmission dynamics and derive the optimal control strategies for minimizing the spread of the disease is of great importance. Methods A model involving eight mutually exclusive compartments with the introduction of personal protection, larvicide and adulticide control strategies describing dengue fever transmission dynamics is presented. The control-induced basic reproduction number (R˜0) related to the model is computed using the next generation matrix method. Comparison theorem is used to analyse the global dynamics of the model. The model is fitted to the data related to the 2012 dengue outbreak in Johor, Malaysia, using the least-squares method. In a bid to optimally curtail dengue fever propagation, we apply optimal control theory to investigate the effect of several control strategies of combination of optimal personal protection, larvicide and adulticide controls on dengue fever dynamics. The resulting optimality system is simulated in MATLAB using fourth order Runge-Kutta scheme based on the forward-backward sweep method. In addition, cost-effectiveness analysis is performed to determine the most cost-effective strategy among the various control strategies analysed. Results Analysis of the model with control parameters shows that the model has two disease-free equilibria, namely, trivial equilibrium and biologically realistic disease-free equilibrium, and one endemic equilibrium point. It also reveals that the biologically realistic disease-free equilibrium is both locally and globally asymptotically stable whenever the inequality R˜0<1holds. In the case of model with time-dependent control functions, the optimality levels of the three control functions required to optimally control dengue disease transmission are derived. Conclusion We conclude that dengue fever transmission can be curtailed by adopting any of the several control strategies analysed in this study. Furthermore, a strategy which combines personal protection and adulticide controls is found to be the most cost-effective control strategy.

Matched MeSH terms: Aedes*
Fulltext Evaluation of Melaleuca cajuputi (Family: Myrtaceae) Essential Oil in Aerosol Spray Cans against Dengue Vectors in Low Cost Housing Flats

Abu Bakar A, Sulaiman S, Omar B, Mat Ali R

J Arthropod Borne Dis, 2012;6(1):28-35.
PMID: 23293776

Melaleuca cajuputi essential oil in aerosol spray was evaluated against the dengue vectors Aedes aegypti and Ae. albopictus at low cost housing flats in Section 10, Setapak, Kuala Lumpur, Malaysia.

Matched MeSH terms: Aedes
Fulltext The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae

Abu Hasan Z', Williams H, Ismail NM, Othman H, Cozier GE, Acharya KR, et al.

Sci Rep, 2017 03 27;7:45409.
PMID: 28345667 DOI: 10.1038/srep45409

The control of mosquitoes is threatened by the appearance of insecticide resistance and therefore new control chemicals are urgently required. Here we show that inhibitors of mosquito peptidyl dipeptidase, a peptidase related to mammalian angiotensin-converting enzyme (ACE), are insecticidal to larvae of the mosquitoes, Aedes aegypti and Anopheles gambiae. ACE inhibitors (captopril, fosinopril and fosinoprilat) and two peptides (trypsin-modulating oostatic factor/TMOF and a bradykinin-potentiating peptide, BPP-12b) were all inhibitors of the larval ACE activity of both mosquitoes. Two inhibitors, captopril and fosinopril (a pro-drug ester of fosinoprilat), were tested for larvicidal activity. Within 24 h captopril had killed >90% of the early instars of both species with 3rd instars showing greater resistance. Mortality was also high within 24 h of exposure of 1st, 2nd and 3rd instars of An. gambiae to fosinopril. Fosinopril was also toxic to Ae. aegypti larvae, although the 1st instars appeared to be less susceptible to this pro-drug even after 72 h exposure. Homology models of the larval An. gambiae ACE proteins (AnoACE2 and AnoACE3) reveal structural differences compared to human ACE, suggesting that structure-based drug design offers a fruitful approach to the development of selective inhibitors of mosquito ACE enzymes as novel larvicides.

Matched MeSH terms: Aedes/drug effects*
Emergence of dengue virus type 4 genotype IIA in Malaysia

AbuBakar S, Wong PF, Chan YF

J Gen Virol, 2002 Oct;83(Pt 10):2437-2442.
PMID: 12237425 DOI: 10.1099/0022-1317-83-10-2437

Phylogenetic analyses of the envelope (E) gene sequence of five recently isolated dengue virus type 4 (DENV-4) suggested the emergence of a distinct geographical and temporal DENV-4 subgenotype IIA in Malaysia. Four of the isolates had direct ancestral lineage with DENV-4 Indonesia 1973 and showed evidence of intra-serotypic recombination with the other recently isolated DENV-4, MY01-22713. The E gene of isolate MY01-22713 had strong evidence of an earlier recombination involving DENV-4 genotype II Indonesia 1976 and genotype I Malaysia 1969. These results suggest that intra-serotypic recombination amongst DENV-4 from independent ancestral lineages may have contributed to the emergence of DENV-4 subgenotype IIA in Malaysia.

Matched MeSH terms: Aedes
Fulltext Antigenic cell associated dengue 2 virus proteins detected in vitro using dengue fever patients sera

Abubakar S, Azila A, Suzana M, Chang LY

Malays J Pathol, 2002 Jun;24(1):29-36.
PMID: 16329553

At least three major antigenic dengue 2 virus proteins were recognized by pooled dengue fever patients' sera in infected Aedes albopictus (C6/36) mosquito cells. Dengue virus envelope (E), premembrane (PrM) and non-structural protein 1 (NS 1) dimer were detected beginning on day 3 postinfection in both the cell membrane and cytosolic fractions. Using the patients' sera, the presence of antigenic intermediate core protein (C)-PrM and NS1-non-structural protein 2a (NS2a) in the cytoplasmic fraction of dengue 2 virus infected cells was revealed. The presence of a approximately 92 and approximately 84 kDa NS 1 dimer in the membrane (NS 1m) and cytosolic (NS 1c) fractions of C6/36 cells, respectively, was also recognized. Using individual patient's serum, it was further confirmed that all patients' sera contained antibodies that specifically recognized E, NS 1 and PrM present in the dengue 2 virus-infected cell membrane fractions, suggesting that these glycosylated virus proteins were the main antigenic proteins recognized in vivo. Detection of dengue 2 virus C antibody in some patients further suggested that C could be antigenic if presented in vivo.

Matched MeSH terms: Aedes/cytology; Aedes/virology
Outlook of dengue in Malaysia: a century later

Abubakar S, Shafee N

Malays J Pathol, 2002 Jun;24(1):23-7.
PMID: 16329552

Dengue continues to be a major health threat to Malaysia a century after its first reported outbreak in 1902. Examination of the available outbreak data suggested that a major DF/DHF outbreak occurred in Malaysia in a cyclical pattern of approximately every 8 years. All four dengue virus serotypes are found co-circulating in Malaysia, but after the first and only major outbreak involving DEN-4 in 1960's, only DEN-1, DEN-2 and DEN-3 were associated with DF/DHF outbreaks. It is argued that perhaps the spread of the later dengue virus serotypes followed the pattern of spread of the mosquito vector Aedes aegypti, whereas the former was associated with Aedes albopictus, the outdoor and rural area dwelling mosquito. Estimating from the trend and pattern of dengue and the associated dengue virus serotypes, unless there is a major breakthrough in dengue vaccine development, it is likely that dengue outbreaks will continue to occur in Malaysia throughout the 21st century.

Matched MeSH terms: Aedes/cytology; Aedes/virology
Fulltext Population genetic structure of Aedes aegypti subspecies in selected geographical locations in Sudan

Abuelmaali SA, Mashlawi AM, Ishak IH, Wajidi MFF, Jaal Z, Avicor SW, et al.

Sci Rep, 2024 Feb 05;14(1):2978.
PMID: 38316804 DOI: 10.1038/s41598-024-52591-6

Although knowledge of the composition and genetic diversity of disease vectors is important for their management, this is limiting in many instances. In this study, the population structure and phylogenetic relationship of the two Aedes aegypti subspecies namely Aedes aegypti aegypti (Aaa) and Aedes aegypti formosus (Aaf) in eight geographical areas in Sudan were analyzed using seven microsatellite markers. Hardy-Weinberg Equilibrium (HWE) for the two subspecies revealed that Aaa deviated from HWE among the seven microsatellite loci, while Aaf exhibited departure in five loci and no departure in two loci (A10 and M201). The Factorial Correspondence Analysis (FCA) plots revealed that the Aaa populations from Port Sudan, Tokar, and Kassala clustered together (which is consistent with the unrooted phylogenetic tree), Aaf from Fasher and Nyala populations clustered together, and Gezira, Kadugli, and Junaynah populations also clustered together. The Bayesian cluster analysis structured the populations into two groups suggesting two genetically distinct groups (subspecies). Isolation by distance test revealed a moderate to strong significant correlation between geographical distance and genetic variations (p = 0.003, r = 0.391). The migration network created using divMigrate demonstrated that migration and gene exchange between subspecies populations appear to occur based on their geographical proximity. The genetic structure of the Ae. aegypti subspecies population and the gene flow among them, which may be interpreted as the mosquito vector's capacity for dispersal, were revealed in this study. These findings will help in the improvement of dengue epidemiology research including information on the identity of the target vector/subspecies and the arboviruses vector surveillance program.

Matched MeSH terms: Aedes*
Genetic Polymorphism of Aedes albopictus Population Inferred From ND5 Gene Variabilities In Subang Jaya, Malaysia

Adilah-Amrannudin N, Hamsidi M, Ismail NA, Ismail R, Dom NC, Ahmad AH, et al.

J Am Mosq Control Assoc, 2016 Dec;32(4):265-272.
PMID: 28206858 DOI: 10.2987/16-6579.1

This study was performed to establish the genetic variability of Aedes albopictus within Subang Jaya, Selangor, Malaysia, by using the nicotinamide adenine dinucleotide dehydrogenase 5 subunit (ND5) mitochondrial DNA (mtDNA) marker. A total of 90 samples were collected from 9 localities within an area of the Subang Jaya Municipality. Genetic variability was determined through the amplification and sequencing of a fragment of the ND5 gene. Eight distinct mtDNA haplotypes were identified. The evolutionary relationship of the local haplotypes alongside 28 reference strains was used to construct a phylogram, the analysis of which revealed low genetic differentiation in terms of both nucleotide and haplotype diversity. Bayesian method was used to infer the phylogenetic tree, revealing a unique relationship between local isolates. The study corroborates the reliability of ND5 to identify distinct lineages for polymorphism-based studies and supplements the existing body of knowledge regarding its genetic diversity. This in turn could potentially aid existing vector control strategies to help mitigate the risk and spread of the dengue virus.

Matched MeSH terms: Aedes/genetics*
The Impact of Sociological and Environmental Factors for Dengue Infection in Kuala Lumpur, Malaysia

Adnan RA, Ramli MF, Othman HF, Asha'ri ZH, Ismail SNS, Samsudin S

Acta Trop, 2021 Apr;216:105834.
PMID: 33485870 DOI: 10.1016/j.actatropica.2021.105834

BACKGROUND: Dengue incidence has grown dramatically around the world in recent years. Vector control is the only method to reduce dengue incidence due to the lack of a vaccine available. By understanding the factors contributed to the vector densities such as environmental and sociological factors, dengue prevention and control may succeed.
OBJECTIVE: This study is aimed at determining the impact of sociological and environmental factors contributing to dengue cases.
METHODS: The study surveyed 379 respondents with dengue history. The socio-environmental factors were evaluated by chi-square and binary regression.
RESULT: The chi-square results revealed sociological factors associated between family with dengue experience such as older age (p =0.012), fewer than four people in the household (p= 0.008), working people (p= 0.004) and apartment/terrace houses (p=0.023). Similarly, there is a significant association between respondent's dengue history and houses that are shaded with vegetation (p= 0.012) and the present of public playground areas near the residential (p = 0.011).
CONCLUSION: The study identified socio-environmental factors that play an important role in the abundance of Aedes mosquitoes and also for the local dengue control measures.

Matched MeSH terms: Aedes
ABSENCE OF AEDES AEGYPTI (L.) ON AN ECOLOGICAL ISLAND: COMPETITIVE EXCLUSION?

Afizah AN, Mahirah MN, Azahari AH, Asuad MK, Nazni WA, Lee HL

Southeast Asian J. Trop. Med. Public Health, 2015 Sep;46(5):850-6.
PMID: 26863856

Ovitrap surveillance was conducted in 2012 and 2006 in Malay and Aboriginal Villages on Carey Island. In each village, standard ovitraps were placed indoors and outdoors at randomly selected houses/locations. All L3 larvae recovered were identified up to species level. Results demonstrated that only larvae of Aedes albopictus were found in all the positive ovitraps placed indoors and outdoors. In 2012, a high ovitrap index (OI) of 66.7% indoor and 84.0% outdoor in the Malay Village; and 62.5% indoor and 88.0% outdoor in Aboriginal Village with an apparent absence of Aedes aegypti. In 2006, a 100% OI was recorded in all ovitraps set indoors and outdoors in both villages.

Matched MeSH terms: Aedes/classification; Aedes/growth & development; Aedes/physiology*
Water containers and the preferable conditions for laying eggs by Aedes mosquitoes in Maros Regency, South of Sulawesi, Indonesia

Agus Nurjana M, Srikandi Y, Wijatmiko TJ, Hidayah N, Isnawati R, Octaviani O, et al.

J Water Health, 2023 Nov;21(11):1741-1746.
PMID: 38017604 DOI: 10.2166/wh.2023.270

One of the factors that influence the development of mosquitoes is the water container. This study was performed to determine the relationship between the characteristics of water containers and the preferable conditions for laying eggs by Aedes sp. A single larva method was conducted during March 2019 in 300 houses in two villages (Turikale and Adatongeng) at Maros Regency, Indonesia. In total, 1,269 water containers were considered, and among them buckets were found to be the most common container. Logistic regression analysis showed that the type, container location, and weekly drainage were related to the presence of larvae/pupae in the Maros Regency (p-value < 0.05). Non-water containers, which are kept indoors and are not drained at least once a week, have a greater chance of breeding Aedes sp. More attention is given to non-water containers that are located inside the house. Prevention activities, especially draining water containers properly at least once a week ensures that they do not become breeding sites for Aedes sp. mosquitoes and helps to prevent the transmission of dengue viral fever.

Matched MeSH terms: Aedes*
Fulltext Larvicidal efficacy of different plant parts of railway creeper, Ipomoea cairica Extract Against Dengue Vector Mosquitoes, Aedes albopictus (Diptera: Culicidae) and Aedes aegypti (Diptera: Culicidae)

AhbiRami R, Zuharah WF, Thiagaletchumi M, Subramaniam S, Sundarasekar J

J Insect Sci, 2014;14:180.
PMID: 25368088 DOI: 10.1093/jisesa/ieu042

Natural insecticides from plant origin against mosquito vectors have been the main concern for research due to their high level of eco-safety. Control of mosquitoes in their larval stages are an ideal method since Aedes larvae are aquatic, thus it is easier to deal with them in this habitat. The present study was specifically conducted to explore the larvicidal efficacy of different plant parts of Ipomoea cairica (L.) or railway creeper crude extract obtained using two different solvents; methanol and acetone against late third-stage larvae of Aedes albopictus (Skuse) and Aedes aegypti (L.) (Diptera: Culicidae). Plant materials of I. cairica leaf, flower, and stem were segregated, airdried, powdered, and extracted using Soxhlet apparatus. Larvicidal bioassays were performed by using World Health Organization standard larval susceptibility test method for each species which were conducted separately for different concentration ranging from 10 to 450 ppm. Both acetone and methanol extracts showed 100% mortality at highest concentration tested (450 ppm) after 24 h of exposure. Results from factorial ANOVA indicated that there were significant differences in larvicidal effects between mosquito species, solvent used and plant parts (F=5.71, df=2, P<0.05). The acetone extract of I. cairica leaf showed the most effective larvicidal action in Ae. aegypti with LC50 of 101.94 ppm followed by Ae. albopictus with LC50 of 105.59 ppm compared with other fractions of I. cairica extract obtained from flower, stem, and when methanol are used as solvent. The larvae of Ae. aegypti appeared to be more susceptible to I. cairica extract with lower LC50 value compared with Ae. albopictus (F=8.83, df=1, P<0.05). Therefore, this study suggests that the acetone extract of I. cairica leaf can be considered as plant-derived insecticide for the control of Aedes mosquitoes. This study quantified the larvicidal property of I. cairica extract, providing information on lethal concentration that may have potential for a more eco-friendly Aedes mosquito control program.

Matched MeSH terms: Aedes*
Fulltext Oviposition deterring and oviciding potentials of Ipomoea cairica L. leaf extract against dengue vectors

Ahbirami R, Zuharah WF, Yahaya ZS, Dieng H, Thiagaletchumi M, Fadzly N, et al.

Trop Biomed, 2014 Sep;31(3):456-65.
PMID: 25382472

Bioprospecting of plant-based insecticides for vector control has become an area of interest within the last two decades. Due to drawbacks of chemical insecticides, phytochemicals of plant origin with mosquito control potential are being utilized as alternative sources in integrated vector control. In this regard, the present study aimed to investigate oviposition deterring and oviciding potentials of Ipomoea cairica (L.) (Family: Convolvulaceae) crude leaf extract against dengue vectors, Aedes aegypti and Aedes albopictus. Ipomoea cairica is an indigenous plant that has demonstrated marked toxicity towards larvae of Ae. aegypti and Ae. albopictus. Leaves of I. cairica were extracted using Soxhlet apparatus with acetone as solvent. Oviposition deterrent activity and ovicidal assay was carried out in oviposition site choice tests with three different concentrations (50, 100, 450 ppm). Acetone extract of I. cairica leaf strongly inhibited oviposition with 100% repellence to Ae. aegypti at lower concentration of 100 ppm, while for Ae. albopictus was at 450 ppm. The oviposition activity index (OAI) values which ranged from -0.69 to -1.00 revealed that I. cairica demonstrated deterrent effect. In ovicidal assay, similar trend was observed whereby zero hatchability was recorded for Ae. aegypti and Ae. albopictus eggs at 100 and 450 ppm, respectively. It is noteworthy that I. cairica leaf extract had significantly elicited dual properties as oviposition deterrent and oviciding agent in both Aedes species. Reduction in egg number through oviposition deterring activity, reduction in hatching percentage and survival rates, suggested an additional hallmark of this plant to be integrated in Aedes mosquito control. Ipomoea cairica deserved to be considered as one of the potential alternative sources for the new development of novel plant based insecticides in future.

Matched MeSH terms: Aedes/drug effects*; Aedes/physiology
Fulltext Wolbachia strain wAlbB maintains high density and dengue inhibition following introduction into a field population of Aedes aegypti

Ahmad NA, Mancini MV, Ant TH, Martinez J, Kamarul GMR, Nazni WA, et al.

Philos Trans R Soc Lond B Biol Sci, 2021 02 15;376(1818):20190809.
PMID: 33357050 DOI: 10.1098/rstb.2019.0809

Aedes aegypti mosquitoes carrying the wAlbB Wolbachia strain show a reduced capacity to transmit dengue virus. wAlbB has been introduced into wild Ae. aegypti populations in several field sites in Kuala Lumpur, Malaysia, where it has persisted at high frequency for more than 2 years and significantly reduced dengue incidence. Although these encouraging results indicate that wAlbB releases can be an effective dengue control strategy, the long-term success depends on wAlbB maintaining high population frequencies and virus transmission inhibition, and both could be compromised by Wolbachia-host coevolution in the field. Here, wAlbB-carrying Ae. aegypti collected from the field 20 months after the cessation of releases showed no reduction in Wolbachia density or tissue distribution changes compared to a wAlbB laboratory colony. The wAlbB strain continued to induce complete unidirectional cytoplasmic incompatibility, showed perfect maternal transmission under laboratory conditions, and retained its capacity to inhibit dengue. Additionally, a field-collected wAlbB line was challenged with Malaysian dengue patient blood, and showed significant blocking of virus dissemination to the salivary glands. These results indicate that wAlbB continues to inhibit currently circulating strains of dengue in field populations of Ae. aegypti, and provides additional support for the continued scale-up of Wolbachia wAlbB releases for dengue control. This article is part of the theme issue 'Novel control strategies for mosquito-borne diseases'.

Matched MeSH terms: Aedes*
Fulltext Detection of Wolbachia in Aedes albopictus and Their Effects on Chikungunya Virus

Ahmad NA, Vythilingam I, Lim YAL, Zabari NZAM, Lee HL

Am J Trop Med Hyg, 2017 Jan 11;96(1):148-156.
PMID: 27920393 DOI: 10.4269/ajtmh.16-0516

Wolbachia-based vector control strategies have been proposed as a means to augment the currently existing measures for controlling dengue and chikungunya vectors. Prior to utilizing Wolbachia as a novel vector control strategy, it is crucial to understand the Wolbachia-mosquito interactions. In this study, field surveys were conducted to screen for the infection status of Wolbachia in field-collected Aedes albopictus The effects of Wolbachia in its native host toward the replication and dissemination of chikungunya virus (CHIKV) was also studied. The prevalence of Wolbachia-infected field-collected Ae. albopictus was estimated to be 98.6% (N = 142) for females and 95.1% (N = 102) for males in the population studied. The Ae. albopictus were naturally infected with both wAlbA and wAlbB strains. We also found that the native Wolbachia has no impact on CHIKV infection and minimal effect on CHIKV dissemination to secondary organs.

Matched MeSH terms: Aedes/microbiology*; Aedes/virology*
Fulltext Detection of dengue virus from field Aedes aegypti and Aedes albopictus adults and larvae

Ahmad R, Ismail A, Saat Z, Lim LH

Southeast Asian J. Trop. Med. Public Health, 1997 Mar;28(1):138-42.
PMID: 9322296

Mosquito adults and larvae were collected from dengue high risk areas and transported to the laboratory for identification. Identified mosquitos were pooled according to the species, date and locality and stored at -70 degrees C. A total of 1,385 pools of Aedes albopictus and 267 pools of Ae. Aegypti were collected from major towns in 12 states in Peninsular Malaysia. Virus isolation was carried out using cell culture (C6/36 clone) of Ae. albopictus and detection of dengue virus by the peroxidase anti-peroxidase staining. All positive isolations were further re-confirmed by the reverse transcriptase-polymerase chain reaction (RT-PCR). Most of the pools were negative with PAP staining and RT-PCR. However, 11 mosquito pools were positive with PAP staining. On the other hand, samples from Terengganu, Pulau Pinang and Johor were positive using both methods.

Matched MeSH terms: Aedes/virology*
Effect of ten chlorophytes on larval survival, development and adult body size of the mosquito Aedes aegypti

Ahmad R, Chu WL, Ismail Z, Lee HL, Phang SM

Southeast Asian J. Trop. Med. Public Health, 2004 Mar;35(1):79-87.
PMID: 15272748

The effect of ten microalgal chlorophytes isolated from mosquito breeding containers on the survival, larval development and adult body size of the mosquito Aedes aegypti was investigated. All larvae fed with six of the microalgal isolates died after 7 days. These isolates were found to be resistant to digestion by mosquito larvae. Delayed pupation and body size reduction of the mosquitos fed with Chlorococcum UMACC 218 and Scenedesmus UMACC 220 were observed. In contrast, larvae fed with Ankistrodesmus convolutus UMACC 101 and Chlorococcum UMACC 213 were bigger in size than those fed with normal insectory feed. The present study showed that microalgal chlorophytes have the potential to be used as larvicidal agents for mosquitos.

Matched MeSH terms: Aedes/physiology*
Fulltext The biology and demographic parameters of Aedes albopictus in northern peninsular Malaysia

Aida HN, Dieng H, Ahmad AH, Satho T, Nurita AT, Salmah MR, et al.

Asian Pac J Trop Biomed, 2011 Dec;1(6):472-7.
PMID: 23569816 DOI: 10.1016/S2221-1691(11)60103-2

OBJECTIVE: To generate life table characteristics for the dengue vector Aedes albopictus (A. albopictus) under uncontrolled conditions, incorporating both the aquatic and the adult stages.
METHODS: Ten females derived from wild pupae were allowed to fully blood-feed on restrained mice. 774 eggs were hatched in seasoned water. F1 larvae were followed for development until their F2 counterparts emerged as adults. Some population parameters were monitored (F1) or estimated (F2).
RESULTS: A. albopictus exhibited increased fecundity and egg hatch success. Immature development was quick. Immature survival was high, with lowest rate in the pupal stage. Adult emergence was about 81% and sex ratio was close to 1:1. Generational mortality (K) was about 28%. A high proportion of females completed a reproductive cycle and the obtained parity rate was predicted to lead to higher fecundity in the next generation.
CONCLUSIONS: It can be concluded that natural A. albopictus populations in Penang seem largely determined by quick development in combination with low immature loss and increased oviposition.

Matched MeSH terms: Aedes/growth & development*; Aedes/physiology
Dengue hemorrhagic fever rainfall in Penninsular Malyasia: some suggested relationships

Aiken SR, Frost DB, Leigh CH

Soc Sci Med Med Geogr, 1980 Sep;14D(3):307-16.
PMID: 7455728
Matched MeSH terms: Aedes/growth & development
Fulltext Antifilarial and Antibiotic Activities of Methanolic Extracts of Melaleuca cajuputi Flowers

Al-Abd NM, Nor ZM, Mansor M, Hasan MS, Kassim M

Korean J Parasitol, 2016 Jun;54(3):273-80.
PMID: 27417081 DOI: 10.3347/kjp.2016.54.3.273

We evaluated the activity of methanolic extracts of Melaleuca cajuputi flowers against the filarial worm Brugia pahangi and its bacterial endosymbiont Wolbachia. Anti-Wolbachia activity was measured in worms and in Aedes albopictus Aa23 cells by PCR, electron microscopy, and other biological assays. In particular, microfilarial release, worm motility, and viability were determined. M. cajuputi flower extracts were found to significantly reduce Wolbachia endosymbionts in Aa23 cells, Wolbachia surface protein, and microfilarial release, as well as the viability and motility of adult worms. Anti-Wolbachia activity was further confirmed by observation of degraded and phagocytized Wolbachia in worms treated with the flower extracts. The data provided in vitro and in vivo evidence that M. cajuputi flower extracts inhibit Wolbachia, an activity that may be exploited as an alternative strategy to treat human lymphatic filariasis.

Matched MeSH terms: Aedes

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