Displaying publications 1 - 20 of 111 in total

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  1. Tan MK, Siddiqi A, Yeo LY
    Sci Rep, 2017 07 27;7(1):6652.
    PMID: 28751783 DOI: 10.1038/s41598-017-07025-x
    The Miniaturised Lab-on-a-Disc (miniLOAD) platform, which utilises surface acoustic waves (SAWs) to drive the rotation of thin millimeter-scale discs on which microchannels can be fabricated and hence microfluidic operations can be performed, offers the possibility of miniaturising its larger counterpart, the Lab-on-a-CD, for true portability in point-of-care applications. A significant limitation of the original miniLOAD concept, however, is that it does not allow for flexible control over the disc rotation direction and speed without manual adjustment of the disc's position, or the use of multiple devices to alter the SAW frequency. In this work, we demonstrate the possibility of achieving such control with the use of tapered interdigitated transducers to confine a SAW beam such that the localised acoustic streaming it generates imparts a force, through hydrodynamic shear, at a specific location on the disc. Varying the torque that arises as a consequence by altering the input frequency to the transducers then allows the rotational velocity and direction of the disc to be controlled with ease. We derive a simple predictive model to illustrate the principle by which this occurs, which we find agrees well with the experimental measurements.
    Matched MeSH terms: Hydrodynamics
  2. Toh KY, Liang YY, Lau WJ, Fimbres Weihs GA
    Membranes (Basel), 2020 Oct 15;10(10).
    PMID: 33076290 DOI: 10.3390/membranes10100285
    Simulation via Computational Fluid Dynamics (CFD) offers a convenient way for visualising hydrodynamics and mass transport in spacer-filled membrane channels, facilitating further developments in spiral wound membrane (SWM) modules for desalination processes. This paper provides a review on the use of CFD modelling for the development of novel spacers used in the SWM modules for three types of osmotic membrane processes: reverse osmosis (RO), forward osmosis (FO) and pressure retarded osmosis (PRO). Currently, the modelling of mass transfer and fouling for complex spacer geometries is still limited. Compared with RO, CFD modelling for PRO is very rare owing to the relative infancy of this osmotically driven membrane process. Despite the rising popularity of multi-scale modelling of osmotic membrane processes, CFD can only be used for predicting process performance in the absence of fouling. This paper also reviews the most common metrics used for evaluating membrane module performance at the small and large scales.
    Matched MeSH terms: Hydrodynamics
  3. Sadri R, Hosseini M, Kazi SN, Bagheri S, Abdelrazek AH, Ahmadi G, et al.
    J Colloid Interface Sci, 2018 Jan 01;509:140-152.
    PMID: 28898734 DOI: 10.1016/j.jcis.2017.07.052
    In this study, we synthesized covalently functionalized graphene nanoplatelet (GNP) aqueous suspensions that are highly stable and environmentally friendly for use as coolants in heat transfer systems. We evaluated the heat transfer and hydrodynamic properties of these nano-coolants flowing through a horizontal stainless steel tube subjected to a uniform heat flux at its outer surface. The GNPs functionalized with clove buds using the one-pot technique. We characterized the clove-treated GNPs (CGNPs) using X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). We then dispersed the CGNPs in distilled water at three particle concentrations (0.025, 0.075 and 0.1wt%) in order to prepare the CGNP-water nanofluids (nano-coolants). We used ultraviolet-visible (UV-vis) spectroscopy to examine the stability and solubility of the CGNPs in the distilled water. There is significant enhancement in thermo-physical properties of CGNPs nanofluids relative those for distilled water. We validated our experimental set-up by comparing the friction factor and Nusselt number for distilled water obtained from experiments with those determined from empirical correlations, indeed, our experimental set-up is reliable and produces results with reasonable accuracy. We conducted heat transfer experiments for the CGNP-water nano-coolants flowing through the horizontal heated tube in fully developed turbulent condition. Our results are indeed promising since there is a significant enhancement in the Nusselt number and convective heat transfer coefficient for the CGNP-water nanofluids, with only a negligible increase in the friction factor and pumping power. More importantly, we found that there is a significant increase in the performance index, which is a positive indicator that our nanofluids have potential to substitute conventional coolants in heat transfer systems because of their overall thermal performance and energy savings benefits.
    Matched MeSH terms: Hydrodynamics
  4. Ismail Z, Fitt AD, Please CP
    Math Med Biol, 2013 Dec;30(4):339-55.
    PMID: 23054933 DOI: 10.1093/imammb/dqs028
    Descemet membrane detachment (DMD) is a rare but potentially serious surgical complication that arises most often during cataract surgery. A recent study (Couch, S. M. & Baratz, K. H. (2009) Cornea, 28, 1160-1163) cited the case of a patient with DMDs in both eyes, noting that though one detachment was surgically repaired, the other spontaneously reattached and needed no further treatment. A fluid mechanical model of buoyancy-driven aqueous humour flow in the anterior chamber around a DMD is developed to explain this phenomenon. The analytical model is based on the lubrication theory limit of the Navier-Stokes equations. The flow is determined for a fixed geometry and the possible motion of the DMD is then analysed. Numerical calculations are also carried out (using COMSOL© Multiphysics) to confirm the lubrication theory results. The analytical and numerical results both show that, under the correct conditions, either spontaneous reattachment or worsening of the tear may occur. We conclude that it is possible that clinical outcomes for DMDs may be controlled by adjusting the temperature difference across the eye and/or the orientation of the patient.
    Matched MeSH terms: Hydrodynamics
  5. Tong CY, Li HZ, Derek CJC
    Lab Chip, 2023 Sep 13;23(18):4052-4066.
    PMID: 37609763 DOI: 10.1039/d3lc00415e
    In attached microalgae cultivation systems, cell detachment due to fluid hydrodynamic flow is not a subject matter that is commonly looked into. However, this phenomenon is of great relevance to optimizing the operating parameters of algae cultivation and feasible reactor design. Hence, this current work miniaturizes traditional benchtop assays into a microfluidic platform to study the cell detachment of green microalgae, Chlorella vulgaris, from porous substrates during its early cultivation stage under precisely controlled conditions. As revealed by time lapse microscopy, an increase in bulk flow velocity facilitated nutrient transport but also triggered cell detachment events. At a flow rate of 1000 μL min-1 of growth medium for 120 min, the algal cell coverage was up to 5% lower than those at 5 μL min-1 and 50 μL min-1. In static seeding, the evolution of attached cell resistance toward liquid flows was dependent on hydrodynamic zones. The center zone of the microchannel was shown to be a "comfortable zone" of the attached cells to sequester nutrients effectively at lower medium flow rates but there was a profile transition where outlet zones favored cell attachment the most at higher flow rates (1.13 times higher than the center zone for 1000 μL min-1). Besides, computational fluid dynamics (CFD) simulations illustrated that the focusing band varied between cross-sections and depths, while the streamline was the least concentrated along the side walls and bottom plane of the microfluidic devices. It was intriguing to learn that cell detachment was not primarily happening along the symmetry streamline. Insight gained from this study could be further applied in the optimization of operating conditions of attached cultivation systems whilst preserving laminar flow conditions.
    Matched MeSH terms: Hydrodynamics
  6. Faizal WM, Ghazali NNN, Badruddin IA, Zainon MZ, Yazid AA, Ali MAB, et al.
    Comput Methods Programs Biomed, 2019 Oct;180:105036.
    PMID: 31430594 DOI: 10.1016/j.cmpb.2019.105036
    Obstructive sleep apnea is one of the most common breathing disorders. Undiagnosed sleep apnea is a hidden health crisis to the patient and it could raise the risk of heart diseases, high blood pressure, depression and diabetes. The throat muscle (i.e., tongue and soft palate) relax narrows the airway and causes the blockage of the airway in breathing. To understand this phenomenon computational fluid dynamics method has emerged as a handy tool to conduct the modeling and analysis of airflow characteristics. The comprehensive fluid-structure interaction method provides the realistic visualization of the airflow and interaction with the throat muscle. Thus, this paper reviews the scientific work related to the fluid-structure interaction (FSI) for the evaluation of obstructive sleep apnea, using computational techniques. In total 102 articles were analyzed, each article was evaluated based on the elements related with fluid-structure interaction of sleep apnea via computational techniques. In this review, the significance of FSI for the evaluation of obstructive sleep apnea has been critically examined. Then the flow properties, boundary conditions and validation of the model are given due consideration to present a broad perspective of CFD being applied to study sleep apnea. Finally, the challenges of FSI simulation methods are also highlighted in this article.
    Matched MeSH terms: Hydrodynamics*
  7. Semail NF, Noordin SS, Keyon ASA, Waras MN, Saad B, Kamaruzaman S, et al.
    Biomed Chromatogr, 2021 May;35(5):e5050.
    PMID: 33314228 DOI: 10.1002/bmc.5050
    A simple and sensitive preconcentration strategy using sequential electrokinetic and hydrodynamic injection modes in micellar electrokinetic chromatography with diode array detection was developed and applied for the separation and determination of anticancer agent, 5-fluorouracil and its metabolite, 5-fluoro-2'-deoxyuridine, in human plasma. Sequential injection modes with increased analyte loading capacity using the anionic pseudo-stationary phase facilitated collection of the dispersed neutral and charged analytes into narrow zones and improved sensitivity. Several important parameters affecting sample enrichment performance were evaluated and optimized in this study. Under the optimized experimental conditions, 614- and 643-fold and 782- and 803-fold sensitivity improvement were obtained for 5-fluorouracil and its metabolite when compared with normal hydrodynamic and electrokinetic injection, respectively. The method has good linearity (1-1,000 ng/ml) with acceptable coefficient of determination (r2  > 0.993), low limits of detection (0.11-0.14 ng/ml) and satisfactory analyte relative recovery (97.4-99.7%) with relative standard deviations of 4.6-9.3% (n = 6). Validation results as well as the application to analysis of human plasma samples from cancer patients demonstrate the applicability of the proposed method to clinical studies.
    Matched MeSH terms: Hydrodynamics
  8. Ng, C. S., Leman, A. M., N. Asmuin
    MyJurnal
    Local exhaust ventilation (LEV) is used in industries to capture contaminants such as gases, dusts, mists, vapours or fumes out of workstations to protect occupants’ exposure to contaminants. LEV is allocated and installed by employers, however it doesn’t work accordingly. LEV design is often overlooked and underappreciated. Effectiveness of LEV system can be achieved if more attention is focused to proper design of LEV system. To solve this issue, computational fluid dynamics (CFD) can be performed. CFD is a software tool to predict and simulate fluid dynamic phenomena. CFD is used to forecast or reconstruct the behaviour of an engineering product under assumed or measure boundary conditions. However, CFD is just a prediction tool, which can lead to inaccuracy of predicting airflow due to problems with pre-processing, solver and post-processing with parameter from actual experimental results. Therefore, validation is needed to help minimizing percentage error of CFD methods. In this research, measurements of airflow parameter of LEV system at National Institute of Occupational Safety and Health (NIOSH) Bangi, Selangor were conducted. Control Speed panel found at NIOSH Bangi, which is used to increase or decrease speed of fan, was performed using Control Speed of 20%, 40% 60% and 80%. Upon validation, average absolute error obtained from four different control speeds ranges from 3.372% to 4.862%. Validity of CFD modelling is acceptable, which is less than 5% and good agreement is achieved between actual experimental results and CFD simulation results. Therefore, it can be concluded that CFD software tool can be performed to simulate air velocity in LEV system. CFD methods can save labour costs and time consumption when it is used during earliest stage of LEV design, before actual construction is implemented. The outcome of this paper can be used as a baseline for factories equipped with LEV system to protect occupants’ exposure to contaminants.
    Matched MeSH terms: Hydrodynamics
  9. Azraf Azman, Mohd Rizal Mamat@Ibrahim, Anwar Abdul Rahman, Megat Harun Al Rashid Megat Ahmad, Abdul Aziz Mohamed, Muhammad Rawi Mohd Zin, et al.
    MyJurnal
    The temperature profile of a cryogenic system for cooling of beryllium filter of a small-angle neutron scattering (SANS) instrument of TRIGA MARK II PUSPATI research reactor was investigated using computational fluid dynamics (CFD) modeling and simulation. The efficient cooling of beryllium filter is important for obtaining higher cold neutron transmission for the SANS instrument. This paper presents the transient CFD results of temperature distributions via the thermal link to the beryllium and simulation of heat
    flux. The temperature simulation data are also compared with the experimental results for the cooling time and distribution to the beryllium.
    Matched MeSH terms: Hydrodynamics
  10. Rasedee AFN, Abdul Sathar MH, Othman KI, Hamzah SR, Ishak N
    PLoS One, 2021;16(2):e0246904.
    PMID: 33577619 DOI: 10.1371/journal.pone.0246904
    Differential equations are commonly used to model various types of real life applications. The complexity of these models may often hinder the ability to acquire an analytical solution. To overcome this drawback, numerical methods were introduced to approximate the solutions. Initially when developing a numerical algorithm, researchers focused on the key aspect which is accuracy of the method. As numerical methods becomes more and more robust, accuracy alone is not sufficient hence begins the pursuit of efficiency which warrants the need for reducing computational cost. The current research proposes a numerical algorithm for solving initial value higher order ordinary differential equations (ODEs). The proposed algorithm is derived as a three point block multistep method, developed in an Adams type formulae (3PBCS) and will be used to solve various types of ODEs and systems of ODEs. Type of ODEs that are selected varies from linear to nonlinear, artificial and real life problems. Results will illustrate the accuracy and efficiency of the proposed three point block method. Order, stability and convergence of the method are also presented in the study.
    Matched MeSH terms: Hydrodynamics
  11. Fulazzaky MA
    Bioprocess Biosyst Eng, 2013 Jan;36(1):11-21.
    PMID: 22622964 DOI: 10.1007/s00449-012-0756-7
    Anaerobic treatment processes to remove organic matter from palm oil mill effluent (POME) have been used widely in Malaysia. Still the amounts of total organic and total mineral released from POME that may cause degradation of the receiving environment need to be verified. This paper proposes the use of the hydrodynamic equations to estimate performance of the cascaded anaerobic ponds (CAP) and to calculate amounts of total organic matter and total mineral released from POME. The CAP efficiencies to remove biochemical oxygen demands, chemical oxygen demands, total solids and volatile solids (VS) as high as 94.5, 93.6, 96.3 and 98.2 %, respectively, are estimated. The amounts of total organic matter and total mineral as high as 538 kg VS/day and 895 kg FS/day, respectively, released from POME to the receiving water are calculated. The implication of the proposed hydrodynamic equations contributes to more versatile environmental assessment techniques, sometimes replacing laboratory analysis.
    Matched MeSH terms: Hydrodynamics
  12. Ul-Haque A, Asrar W, Omar AA, Sulaeman E, Mohamed Ali JS
    J Exp Biol, 2015 Apr 15;218(Pt 8):1270-1.
    PMID: 25911735 DOI: 10.1242/jeb.117556
    Matched MeSH terms: Hydrodynamics
  13. Mohd Hafez Mohd Isa, Frazier AR, Jauregi P
    Sains Malaysiana, 2012;41:1117-1124.
    Biosurfactants are microbially produced surface active agents that offer better biodegradability and lower toxicity than chemically synthesized surfactants because of their biogenetic origin. One of the most surface-active biosurfactants known is surfactin, a cyclic lipopeptide produced by various strains of Bacillus subtilis. In this study, the cleaning potential of surfactin on ultrafiltration (UF) membranes fouled with BSA was studied using centrifugal UF devices of 50 kDa and 100 kDa MWCO polyethersulfone (PES) membranes. Mechanisms of bovine serum albumin (BSA) displacement by surfactin on fouled UF membranes were studied using dynamic light scattering (DLS) technique and surface tension measurements. Hydrodynamic diameter and surface tension measurements of BSA-surfactin mixtures showed that the surfactin was efficient in displacing BSA fouled on UF membranes due to strong electrostatic repulsive interactions involved at pH8.5. This study demonstrated that surfactin can be used to effectively clean fouled UF membranes.
    Matched MeSH terms: Hydrodynamics
  14. Jusoh, M.Z.M., Nur Ain, A.R, Muhammad Wafi Md Nor
    ESTEEM Academic Journal, 2020;16(2):65-74.
    MyJurnal
    A computational fluid dynamic analysis (CFD) is presented in the study of low Reynolds number fluid flow moving past bluff bodies. The study is focusing on the understanding of the effects of the apex-angles orientation on the flow structure and related occurring force. The apex-angle both facing upstream and downstream were computationally investigated. The simulation results of the cylinder solid are compared with available experimental data to justify the results and the model used. Results obtained in the present work were Strouhal number, drag coefficient, and Fast Fourier Transform (FFT). The study had found that the value of the drag force is increasing directly proportional to the apex angle. In contrast, the value of Strouhal number inversely proportional to the increasing of the apex angle. This was due to the flow over a cylinder creating a vortex shedding in the wake region which influenced the flow separation of fluid. Through the changing on orientation of the apex angle, it was also found that the characteristic linear dimension of the geometry will also be changed, thus affecting the flow pattern.
    Matched MeSH terms: Hydrodynamics
  15. Al-Atabi M, Ooi RC, Luo XY, Chin SB, Bird NC
    Med Eng Phys, 2012 Oct;34(8):1177-83.
    PMID: 22217515 DOI: 10.1016/j.medengphy.2011.12.006
    Computational fluid dynamic (CFD) simulations of the three-dimensional flow structures in realistic cystic ducts have been performed to obtain quantitative readings of the flow parameters to compare with clinical measurements. Resin casts of real patients' cystic ducts lumen that possess representative anatomical features were scanned to obtain three-dimensional flow domains that were used in the numerical analysis. The convoluting nature of the studied cystic ducts resulted in strong secondary flow that contributed towards a dimensionless pressure drop that is four times higher than those of a straight circular tube of an equivalent length and average diameter. The numerical pressure drop results across the cystic duct compared very well with those obtained from clinical observations which indicate that CFD is an appropriate tool to investigate the flow and functions of the biliary system. From the hydrodynamic point of view, the cystic duct lumen seems to serve as a passive resistor that strives to provide a constant amount of resistance to control the flow of bile out of the gallbladder. This is mainly achieved by the coupling of the secondary flow effects and bile rheology to provide flow resistance.
    Matched MeSH terms: Hydrodynamics*
  16. Faizal WM, Ghazali NNN, Khor CY, Badruddin IA, Zainon MZ, Yazid AA, et al.
    Comput Methods Programs Biomed, 2020 Nov;196:105627.
    PMID: 32629222 DOI: 10.1016/j.cmpb.2020.105627
    BACKGROUND AND OBJECTIVE: Human upper airway (HUA) has been widely investigated by many researchers covering various aspects, such as the effects of geometrical parameters on the pressure, velocity and airflow characteristics. Clinically significant obstruction can develop anywhere throughout the upper airway, leading to asphyxia and death; this is where recognition and treatment are essential and lifesaving. The availability of advanced computer, either hardware or software, and rapid development in numerical method have encouraged researchers to simulate the airflow characteristics and properties of HUA by using various patient conditions at different ranges of geometry and operating conditions. Computational fluid dynamics (CFD) has emerged as an efficient alternative tool to understand the airflow of HUA and in preparing patients to undergo surgery. The main objective of this article is to review the literature that deals with the CFD approach and modeling in analyzing HUA.

    METHODS: This review article discusses the experimental and computational methods in the study of HUA. The discussion includes computational fluid dynamics approach and steps involved in the modeling used to investigate the flow characteristics of HUA. From inception to May 2020, databases of PubMed, Embase, Scopus, the Cochrane Library, BioMed Central, and Web of Science have been utilized to conduct a thorough investigation of the literature. There had been no language restrictions in publication and study design of the database searches. A total of 117 articles relevant to the topic under investigation were thoroughly and critically reviewed to give a clear information about the subject. The article summarizes the review in the form of method of studying the HUA, CFD approach in HUA, and the application of CFD for predicting HUA obstacle, including the type of CFD commercial software are used in this research area.

    RESULTS: This review found that the human upper airway was well studied through the application of computational fluid dynamics, which had considerably enhanced the understanding of flow in HUA. In addition, it assisted in making strategic and reasonable decision regarding the adoption of treatment methods in clinical settings. The literature suggests that most studies were related to HUA simulation that considerably focused on the aspects of fluid dynamics. However, there is a literature gap in obtaining information on the effects of fluid-structure interaction (FSI). The application of FSI in HUA is still limited in the literature; as such, this could be a potential area for future researchers. Furthermore, majority of researchers present the findings of their work through the mechanism of airflow, such as that of velocity, pressure, and shear stress. This includes the use of Navier-Stokes equation via CFD to help visualize the actual mechanism of the airflow. The above-mentioned technique expresses the turbulent kinetic energy (TKE) in its result to demonstrate the real mechanism of the airflow. Apart from that, key result such as wall shear stress (WSS) can be revealed via turbulent kinetic energy (TKE) and turbulent energy dissipation (TED), where it can be suggestive of wall injury and collapsibility tissue to the HUA.

    Matched MeSH terms: Hydrodynamics*
  17. Low WS, Kadri NA, Abas WA
    ScientificWorldJournal, 2014;2014:961301.
    PMID: 25136701 DOI: 10.1155/2014/961301
    We propose a strategy for optimizing distribution of flow in a typical benchtop microfluidic chamber for dielectrophoretic application. It is aimed at encouraging uniform flow velocity along the whole analysis chamber in order to ensure DEP force is evenly applied to biological particle. Via the study, we have come up with a constructive strategy in improving the design of microfluidic channel which will greatly facilitate the use of DEP system in laboratory and primarily focus on the relationship between architecture and cell distribution, by resorting to the tubular structure of blood vessels. The design was validated by hydrodynamic flow simulation using COMSOL Multiphysics v4.2a software. Simulations show that the presence of 2-level bifurcation has developed portioning of volumetric flow which produced uniform flow across the channel. However, further bifurcation will reduce the volumetric flow rate, thus causing undesirable deposition of cell suspension around the chamber. Finally, an improvement of microfluidic design with rounded corner is proposed to encourage a uniform cell adhesion within the channel.
    Matched MeSH terms: Hydrodynamics
  18. Ali F, Khan I, Samiulhaq, Shafie S
    PLoS One, 2013;8(6):e65223.
    PMID: 23840321 DOI: 10.1371/journal.pone.0065223
    The aim of this study is to present an exact analysis of combined effects of radiation and chemical reaction on the magnetohydrodynamic (MHD) free convection flow of an electrically conducting incompressible viscous fluid over an inclined plate embedded in a porous medium. The impulsively started plate with variable temperature and mass diffusion is considered. The dimensionless momentum equation coupled with the energy and mass diffusion equations are analytically solved using the Laplace transform method. Expressions for velocity, temperature and concentration fields are obtained. They satisfy all imposed initial and boundary conditions and can be reduced, as special cases, to some known solutions from the literature. Expressions for skin friction, Nusselt number and Sherwood number are also obtained. Finally, the effects of pertinent parameters on velocity, temperature and concentration profiles are graphically displayed whereas the variations in skin friction, Nusselt number and Sherwood number are shown through tables.
    Matched MeSH terms: Hydrodynamics
  19. Che HX, Yeap SP, Osman MS, Ahmad AL, Lim J
    ACS Appl Mater Interfaces, 2014 Oct 8;6(19):16508-18.
    PMID: 25198872 DOI: 10.1021/am5050949
    The synthesis of nanocomposite with controlled surface morphology plays a key role for pollutant removal from aqueous environments. The influence of the molecular size of the polyelectrolyte in synthesizing silica-iron oxide core-shell nanocomposite with open shell structure was investigated by using dynamic light scattering, atomic force microscopy, and quartz crystal microbalance with dissipation (QCM-D). Here, poly(diallydimethylammonium chloride) (PDDA) was used to promote the attachment of iron oxide nanoparticles (IONPs) onto the silica surface to assemble a nanocomposite with magnetic and catalytic bifunctionality. High molecular weight PDDA tended to adsorb on silica colloid, forming a more extended conformation layer than low molecular weight PDDA. Subsequent attachment of IONPs onto this extended PDDA layer was more randomly distributed, forming isolated islands with open space between them. By taking amoxicillin, an antibiotic commonly found in pharmaceutical waste, as the model system, better removal was observed for silica-iron oxide nanocomposite with a more extended open shell structure.
    Matched MeSH terms: Hydrodynamics
  20. Liyana Mohd Ali Napia, Faizal Mohamed, Hur Munawar Kabir Mohd, Intan Syakeela Ahmad Bastamam, Shamellia Sharin, Norsyahidah Mohd Hidzir, et al.
    Sains Malaysiana, 2018;47:1235-1240.
    Unilamellar liposomes composed of dipalmitoylphosphatidylcholine (DPPC) were prepared by the reverse-phase
    evaporation method and extrusion through a polycarbonate membrane filter. Liposomes at 0.7 mg/mL lipid concentration
    in deionized water were exposed to gamma irradiation at a dose in the range 0.5 to 25 kGy. Gamma irradiation of
    liposomes resulted in the degradation of DPPC lipids into free fatty acids, lysophosphatidylcholine and 1,2-palmitoylphosphatidic
    acid (DPPA). The effect of gamma irradiation towards the physical stability of liposomes was investigated
    by means of dynamic light scattering (DLS), transmission electron microscopy (TEM) and zeta potential analysis. From
    the DLS analysis, no significant changes were observed in the hydrodynamic size of liposomes. TEM images indicate that
    the liposomes surface became smoother and rounder as higher irradiation doses were applied. Zeta potential analysis
    showed that gamma irradiation of DPPC liposomes at radiation doses as low as 0.5 kGy resulted in a drastic rise in the
    magnitude of the zeta potential. The results also demonstrate that gamma irradiation of liposomes suspension enhanced
    the overall stability of liposomes. Hence, it can be concluded that gamma irradiation on DPPC liposomes may potentially
    produce liposomes with higher stability.
    Matched MeSH terms: Hydrodynamics
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