MyMedR

Displaying publications 1 - 20 of 57 in total

Abstract:

Sort:

Fulltext Deceased Donor Organs: What Can Be Done to Raise Donation Rates Using Evidence From Malaysia?

Rasiah R, Manikam R, Chandrasekaran SK, Naghavi N, Mubarik S, Mustafa R, et al.

Am J Transplant, 2016 05;16(5):1540-7.
PMID: 26602367 DOI: 10.1111/ajt.13603

Organ donation rates have continued to fall seriously short of needs worldwide, with the lowest rates recorded among developing economies. This study seeks to analyze evidence from a developing economy to explore the usefulness of social psychological theory to solve the problem. The study deployed a large survey (n = 10 412) using a convenience sampling procedure targeted at increasing the number of Malaysians registered with the Ministry of Health, Malaysia who are willing to donate organs upon death. Structural equation modeling was deployed to estimate simultaneously the relative influence of cognitive and noncognitive variables on willingness to donate deceased organs. The cognitive factors of donation perception, socioeconomic status and financial incentives, and the noncognitive factors of demography and fear showed a high statistically significant (1%) relationship with willingness to donate organs after death. While financial incentives were significant, cash rewards showed the least impact. Donation perception showed the highest impact, which shows that the development of effective pedagogic programs with simultaneous improvements to the quality of services provided by medical personnel engaged in retrieving and transplanting deceased donor organs can help raise organ donation rates.

Matched MeSH terms: Tissue and Organ Procurement/statistics & numerical data*
Requirements for the development of a hand transplantation program

Gordon CR, Siemionow M

Ann Plast Surg, 2009 Sep;63(3):262-73.
PMID: 19692900 DOI: 10.1097/SAP.0b013e31818d45e9

Since 1998, 42 hand transplants in 30 patients have been performed in countries such as France, United States, China, Austria, Malaysia, Italy, Belgium, Poland, Spain, and Germany. Now, with recent improvements in immunosuppression, the clinical applicability may expand and the ethical obstacles may soon be overcome, allowing multiple US institutions to perform hand allotransplantation. The main purpose of this article is to facilitate access to pertinent details in regards to hand transplantation, such as donor/recipient selection criteria, immunosuppressive therapies, and associated complications. It is a comprehensive literature review compiled from published reports from multiple hand transplant programs throughout the world. Due to its inherent complexity, hand transplantation should only be attempted at institutions within the US capable of orchestrating a specialized multidisciplinary team, and each institution's protocol should be extremely detailed and individualized.

Matched MeSH terms: Tissue and Organ Procurement/organization & administration
Social and cultural aspects of organ donation in Asia

Woo KT

Ann Acad Med Singap, 1992 May;21(3):421-7.
PMID: 1416796

In Asian countries, it is more difficult to obtain cadaver kidneys for renal transplantation because of certain socio-cultural beliefs and customs. The issues affecting living related kidney donation are more social than cultural. This is due to the web of family pressures and personal conflicts for both donor and recipient surrounding the donation. Important misconceptions and fears are: fear of death, the belief that removal of organ violates sanctity of decreased, concern about being cut up after death, desire to be buried whole, dislike of idea of kidneys inside another person, wrong concept of brain death, and the idea of donation being against religious conviction. In Singapore, with the introduction of the Human Organ Transplant Act (HOTA) in 1988, the number of cadaveric transplants have increased, including those from the Medical Therapy Act (MTA). HOTA and education have played pivotal roles in bringing about an increased yield of cadaveric kidneys. With the availability of living unrelated donor (LUD) transplants in India, our living related donor (LRD) transplant programme has suffered, because patients would rather buy a kidney from overseas than get a relative to donate one. Patients are also going to China for overseas cadaveric transplants where the kidneys come from executed convicts. People in countries like Hong Kong, Japan and the Philippines share the same Asian tradition of not parting with their organs after death. Muslim countries like Malaysia require the deceased to have earlier pledged his kidneys for donation prior to death before they can be harvested for transplantation at death.

Matched MeSH terms: Tissue and Organ Procurement*
Do Family Members of Dialysis Patients Have a Positive Attitude Toward Organ Donation?

Tumin M, Tafran K, Zakaria RH, Satar NM, Ng KP, Lim SK

Ann. Transplant., 2015 Dec 22;20:752-6.
PMID: 26690676 DOI: 10.12659/aot.894427

BACKGROUND: Malaysia, which currently uses the informed consent system (ICS), is suffering from a severe shortage of organs for transplantation. Family members of dialysis patients (FMDPs) are expected to have a positive attitude toward deceased organ donation (DOD) because they have a close relative in need of a kidney donation. This study explores FMDPs' attitude toward DOD under the ICS and the presumed consent system (PCS).

MATERIAL/METHODS: The attitude of 350 FMDPs toward DOD under the ICS and PCS were sought between June and October 2013 in 3 dialysis institutions in Kuala Lumpur, Malaysia.

RESULTS: Under the ICS, 6.6% of respondents were registered donors, 6.6% were ready to register at the time of the survey, 38.6% were willing to donate but not ready to register at the time of the survey, and 48.2% were unwilling to donate organs upon death. If the PCS were implemented, 57.7% of respondents (28.7% of the willing donors and 88.7% of the unwilling respondents) stated that they would officially object to organ donation.

CONCLUSIONS: FMDPs' attitude toward DOD is not more positive or significantly better than that of the general public (based on earlier studies). The PCS may increase the number of donors, but it may also worsen the attitude of FMDPs toward DOD. Strategies aiming to promote DOD in Malaysia should be revised, and should perhaps be focused on enhancing trust of the medical system.

Matched MeSH terms: Tissue and Organ Procurement/organization & administration*
Fulltext Organ donation in Muslim countries: the case of Malaysia

Tumin M, Noh A, Mohd Satar N, Chin-Sieng C, Soo-Kun L, Abdullah N, et al.

Ann. Transplant., 2013;18:671-6.
PMID: 24316733 DOI: 10.12659/AOT.889194

The aim of this paper is to look into the factors influencing Malaysian Muslims' decision to become deceased organ donors in Malaysia.

Matched MeSH terms: Tissue and Organ Procurement*
Fulltext Organ donation among Malaysian Muslims: the role of mosques

Tumin M, Raja Ariffin RN, Mohd Satar N, Abdullah N, Wan Md Adnan WA, Ismail AZ, et al.

Ann. Transplant., 2015;20:206-10.
PMID: 25865792 DOI: 10.12659/AOT.892707

Malaysia, a country of Muslim majority, is suffering from a severe organ shortage due to the lack of donors. Mosques are the main gateways into the Muslim community. Hence, it is imperative to explore their role in facilitating organ donation.

Matched MeSH terms: Tissue and Organ Procurement
Review paper: Organ transplants: ethical, social, and religious issues in a multicultural society

Robson NZ, Razack AH, Dublin N

Asia Pac J Public Health, 2010 Jul;22(3):271-8.
PMID: 20460294 DOI: 10.1177/1010539509357446

Recent advances in the fields of organ donation and organ transplant have introduced new hope for the treatment of serious diseases. However, this promise has been accompanied by several issues. The most common issue raised is ethical implications, but in a multicultural society like Malaysia, additional concerns arise pertaining to social and religious issues. These concerns needs to be addressed as attitudes toward and acceptability of organ donation varies according to social, culture, and religion. The diverse cultural, religious, and traditional concepts pertaining to organ donation may hamper its acceptability and cause a lack of willingness to donate organs. The purpose of this article is to briefly explore the ethical issues involved in organ transplant and the various religious opinions on organ donation. It is hoped that this knowledge and understanding may benefit both health care providers and patients in a multicultural society like Malaysia.

Matched MeSH terms: Tissue and Organ Procurement/ethics*
Fulltext Willingness and Perceived Barriers towards Organ Donation among Student Nurses in Universiti Malaysia Sabah

R. Segaran, Mohd Amsyar Bacho, Asrani Yaco

Borneo Journal of Medical Sciences, 2018;12(101):67-68.
MyJurnal

Organ transplant has become a main stream important medical procedure commonly used in hospitals. However, for organ transplant programme to be successful, it heavily relies on the public to voluntarily register for organ procurement. Effort to promote awareness and register public as organ donors has been ongoing, but public response to commit and register as donors has been lukewarm. Arguably, healthcare personnel and nurses are in a key position to educate and advocate for organ donation but often, ironically healthcare personal themselves are reluctant or unwilling to commit as organ donors. Thus, in the context of student nurses in Universiti Malaysia Sabah (UMS), the question arises, what is their stance and views regarding organ donation.

Matched MeSH terms: Tissue and Organ Procurement
Tissue allograft coding and traceability in USM Tissue Bank, Malaysia

Sheikh Ab Hamid S, Abd Rahman MN

Cell Tissue Bank, 2010 Nov;11(4):401-5.
PMID: 20582480 DOI: 10.1007/s10561-010-9188-2

In Malaysia, tissue banking activities began in Universiti Sains Malaysia (USM) Tissue Bank in early 1990s. Since then a few other bone banks have been set up in other government hospitals and institutions. However, these banks are not governed by the national authority. In addition there is no requirement set by the national regulatory authority on coding and traceability for donated human tissues for transplantation. Hence, USM Tissue Bank has taken the initiatives to adopt a system that enables the traceability of tissues between the donor, the processed tissue and the recipient based on other international standards for tissue banks. The traceability trail has been effective and the bank is certified compliance to the international standard ISO 9001:2008.

Matched MeSH terms: Tissue and Organ Procurement/methods; Tissue and Organ Procurement/standards*
Verifying measurements of residual calcium content in demineralised cortical bone

Ariffin AF, Yusof N, Mohd S, Rahman SA, Ramalingam S, Mansor A, et al.

Cell Tissue Bank, 2019 Dec;20(4):527-534.
PMID: 31456097 DOI: 10.1007/s10561-019-09785-4

Calcium contents of demineralised human cortical bone determined by titrimetric assay and atomic absorption spectrophotometry technique were verified by comparing to neutron activation analysis which has high recovery of more than 90%. Conversion factors determined from the comparison is necessary to correct the calcium content for each technique. Femurs from cadaveric donors were cut into cortical rings and demineralised in 0.5 M hydrochloric acid for varying immersion times. Initial calcium content in the cortical bone measured by titration was 4.57%, only 21% of the measurement by neutron activation analysis; while measured by atomic absorption spectrophotometer was 13.4%, only 61% of neutron activation analysis. By comparing more readings with the measurements by neutron activation analysis with 93% recovery, a conversion factor of 4.83 was verified and applied for the readings by titration and 1.45 for atomic absorption spectrophotometer in calculating the correct calcium contents. The residual calcium content started to reduce after the cortical bone was demineralised in hydrochloric acid for 8 h and reduced to 13% after 24 h. Using the linear relationship, the residual calcium content could be reduced to less than 8% after immersion in hydrochloric acid for 40 h. Atomic absorption spectrophotometry technique is the method of choice for calcium content determination as it is more reliable compared to titrimetric assay.

Matched MeSH terms: Tissue and Organ Procurement
Living kidney donation: the importance of public education

Tumin M, Rasiah R, Noh A, Satar NM, Chong CS, Lim SK, et al.

Clin Transplant, 2014 Apr;28(4):423-7.
PMID: 24617562 DOI: 10.1111/ctr.12334

A sample of Malaysians in the Klang Valley indicating their decision on becoming unrelated living kidney donors was surveyed regarding huge amounts of financial incentives to be rewarded to them. From the 1310 respondents, 72.1% said "no" on becoming a living donor. The reason "I don't think humans can live with only one kidney" scored the highest (35.6%), and from the 27.9% of the respondents who are willing to donate their organ with the right financial incentive, most of the respondents picked the reasons "I want to do something noble in life" (50%), and monetary reason scored the lowest (6.2%), indicating that financial incentive is not a major reason guiding individuals' decision on becoming living donors. We suggest that the government should put priority at targeting public education to raise the understanding on the risk, safety and the quality of life of donation and transplantation, and improving the public trust on the donation and the surgical methods to carry out transplantation.

Matched MeSH terms: Tissue and Organ Procurement/economics; Tissue and Organ Procurement/methods*
Non-organ donors' attitudes toward incentives

Tumin M, Noh A, Chong CS, Lim SK, Abdullah N, Ng KP

Clin Transplant, 2013 May-Jun;27(3):E316-9.
PMID: 23600843 DOI: 10.1111/ctr.12132

Malaysians indicating that they did not intend to become organ donors upon their death were surveyed regarding interest in non-fungible financial incentives to be granted to surviving family members. Among the 730 (56% of the total sample of 1311) indicating unwillingness to be donors, 29.6% (216/730) subsequently indicated that they would be willing donors if the government introduced policies that, upon their death, "rewarded your (their) family with incentives for your (their) deeds." Among the 69% (504/730) who insisted that they would not become organ donor even with incentive, nearly 80% (404/501) of them were able to identify relevant incentives they thought should be provided by the state to those who make organ donations upon death. The majority of both groups preferred the state provide medical benefits to a surviving family member, suggesting this may be an attractive policy option for the state to raise the deceased organ donation pool.

Matched MeSH terms: Tissue and Organ Procurement/economics*
Knowledge, attitudes, practices and behaviors regarding deceased organ donation and transplantation in Malaysia's multi-ethnic society: a baseline study

Wong LP

Clin Transplant, 2011 Jan-Feb;25(1):E22-31.
PMID: 20718827 DOI: 10.1111/j.1399-0012.2010.01312.x

Malaysia's organ and tissue donation rates are among the lowest in the world. The study aims to explore the knowledge, attitudes, practices and behaviors regarding deceased organ donation and transplantation in the diverse ethnic communities in the state of Selangor, Malaysia.

Matched MeSH terms: Tissue and Organ Procurement/statistics & numerical data*
Fulltext Factors that hinder organ donation: religio-cultural or lack of information and trust

Tumin M, Noh A, Jajri I, Chong CS, Manikam R, Abdullah N

Exp Clin Transplant, 2013 Jun;11(3):207-10.
PMID: 23432623 DOI: 10.6002/ect.2012.0194

This paper examines factors that influence Malaysian persons with a tertiary level of education on their willingness to donate organs.

Matched MeSH terms: Tissue and Organ Procurement*
Fulltext Factors Associated with Health Care Professionals' Attitude Toward the Presumed Consent System

Tumin M, Tafran K, Mohd Satar NH, Peng NK, Manikam R, Yoong TL, et al.

Exp Clin Transplant, 2019 02;17(1):1-5.
PMID: 29766774 DOI: 10.6002/ect.2017.0214

OBJECTIVES: This paper explores health care professionals' potential attitude toward organ donation if the presumed consent system were to be implemented in Malaysia, as well as factors associated with this attitude.
MATERIALS AND METHODS: We used self-administered questionnaires to investigate the attitude of 382 health care professionals from the University of Malaya Medical Center between January and February 2014. The responses were analyzed using logistic regression.
RESULTS: Of the 382 respondents, 175 (45.8%) stated that they would officially object to organ donation if the presumed consent system were to be implemented, whereas the remaining 207 (54.2%) stated that they would not object. The logistic regression showed that health care professionals from the Malay ethnic group were more likely to object than those from Chinese (adjusted odds ratio of 0.342; P = .001) and Indian and other (adjusted odds ratio of 0.341; P = .003) ethnic groups. Health care professionals earning 3000 Malaysian Ringgit or below were more likely to object than those earning above 3000 Malaysian Ringgit (adjusted odds ratio of 1.919; P = .006). Moreover, respondents who were initially unwilling to donate organs, regardless of the donation system, were more likely to object under the presumed consent system than those who were initially willing to donate (adjusted odds ratio of 2.765; P < .001).
CONCLUSIONS: Health care professionals in Malaysia have a relatively negative attitude toward the presumed consent system, which does not encourage the implementation of this system in the country at present. To pave the way for a successful implementation of the presumed consent system, efforts should be initiated to enhance the attitude of health care professionals toward this system. In particular, these efforts should at most target the health care professionals who are Malay, earn a low income, and have a negative default attitude toward deceased donation.

Matched MeSH terms: Tissue and Organ Procurement*
Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation

Kim DS, Yoon YI, Kim BK, Choudhury A, Kulkarni A, Park JY, et al.

Hepatol Int, 2024 Apr;18(2):299-383.
PMID: 38416312 DOI: 10.1007/s12072-023-10629-3

Liver transplantation is a highly complex and challenging field of clinical practice. Although it was originally developed in western countries, it has been further advanced in Asian countries through the use of living donor liver transplantation. This method of transplantation is the only available option in many countries in the Asia-Pacific region due to the lack of deceased organ donation. As a result of this clinical situation, there is a growing need for guidelines that are specific to the Asia-Pacific region. These guidelines provide comprehensive recommendations for evidence-based management throughout the entire process of liver transplantation, covering both deceased and living donor liver transplantation. In addition, the development of these guidelines has been a collaborative effort between medical professionals from various countries in the region. This has allowed for the inclusion of diverse perspectives and experiences, leading to a more comprehensive and effective set of guidelines.

Matched MeSH terms: Tissue and Organ Procurement*
In search of the best organ donation legislative system for Hong Kong: further research is needed

Tafran K

Hong Kong Med J, 2018 06;24(3):318-319.
PMID: 29926801 DOI: 10.12809/hkmj187371
Matched MeSH terms: Tissue and Organ Procurement*
Fulltext Family response to presume consent system on organ donation from a review of literature

Makmor Tumin, Khaled Tafran, Nurul Huda Mohd Satar

International e-Journal of Science, Medicine & Education, 2015;9(3):20-26.
MyJurnal

Most countries around the world have experienced a shortage in organs needed for transplantation. Organ donation performance is widely attributed to two important factors: the legislation and the role of the family. Thus, this literature review aims to examine the willingness of people for organ donation while highlighting the importance of having a presumed consent system.

Matched MeSH terms: Tissue and Organ Procurement
Fulltext Muslims' views on the permissibility of organ donation: The case of Malaysia

Tumin M, Noh A, Mohd Satar N, Tafran K, Abdullah N, Wan Md Adnan WAH, et al.

International e-Journal of Science, Medicine & Education, 2016;10(1):41-46.
MyJurnal

Background: Some argue that Malaysia’s extremely low organ donation rate is attributed to religion, specifically Islam. Testing this argument, this study asked Malaysian Muslims their views regarding various issues on organ donation and examined whether their decisions to donate organs are framed by religious beliefs.
Materials and Methods: This study investigated the perspectives of Malaysian Muslims between October and December 2013 in Kuala Lumpur. Self-administered questionnaires were distributed to 900 people, with 829 responses collected (92% response rate). Respondents’ verbal consent was taken before proceeding with the survey.
Results: The survey found that more than half of respondents felt that organ donation is permitted in
Islam and that it is a communal responsibility. However, the same proportions were unsure on the issues of rewards for organs or on whether Islam permits the procuring of organs from brain dead patients.
Conclusions: Malaysian Muslims are not against organ donation; however, encouraging organ donation requires the state to address public concerns on Islam’s views on this sensitive issue through effective policy tools to help address these gaps in Malaysian Muslims’ understanding of organ donation. The organ donation rate could improve by using Islamic scholars as ambassadors for an organ donation drive to convey the message of Malaysia’s urgent need for organ donation.

Matched MeSH terms: Tissue and Organ Procurement*
Fulltext Prioritizing Factors Affecting Deceased Organ Donation in Malaysia: Is a New Organ Donation System Required?

Naghavi N, Mubarik MS, Rasiah R, Sharif Nia H

Int J Gen Med, 2020;13:641-651.
PMID: 32982381 DOI: 10.2147/IJGM.S253372

Purpose: The gap between the demand and the supply of human organs for transplantation is on the rise in Malaysia, despite the efforts of governments to promote donor registration. Factors affecting willingness to donate are contextual and vary from country to country. This research mainly focuses on the selection of most suitable organ donation system through factors affecting willingness to donate in Malaysia. The objectives of this study are to prioritize those factors acting as the pillars of the organ donation system and further to select the most suitable organ donation system for Malaysia.
Patients and Methods: The data were collected from 35 experts by using a bipolar questionnaire. The study applied an analytical hierarchal process (AHP) for prioritization factors contributing to willingness to donate and then selection of a suitable organ donation system based on prioritized factors.
Results: Based on the AHP results, it is evident that donation perception (0.36) has the highest priority in influencing organ donation rates, followed by socioeconomic status (0.32), demographic factors (0.23), and financial incentives (0.09). Further, our results challenge the existing opt-in donation system in Malaysia and present a presumptive approach as a suitable system for increasing deceased donation rate in Malaysia. Presumptive approach promotes the role of health-care professionals in securing the family consent.
Conclusion: This approach is a person-oriented rather than process-oriented strategy and it relies on designated requesters' skills to evoke altruism among bereaved families. Based on results, the authors recommended that relevant government agencies focus on training nurses to discuss donation with bereaved families and raising public awareness.

Matched MeSH terms: Tissue and Organ Procurement

Filters

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links