Displaying publications 21 - 40 of 324 in total

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  1. Renjhen P, Kumar A, Pattanshetty S, Sagir A, Samarasinghe CM
    J Turk Ger Gynecol Assoc, 2010;11(2):78-81.
    PMID: 24591903 DOI: 10.5152/jtgga.2010.03
    To assess the knowledge, attitude and practice of contraception among the college students.
  2. Kumar A, Goel S, Arora J, Mehta V, Pakhiddey R, Suri RK, et al.
    Clin Ter, 2015;166(3):118-20.
    PMID: 26152619 DOI: 10.7417/CT.2015.1841
    The use of muscles of scapular region in transposition and reparative surgery has made the anatomical knowledge of axillary artery and its branches imperative. The subscapular arterial tree is frequently used as a source of microvascular grafts to replace damaged or diseased portion of arteries especially in upper and lower limbs. This investigation is aimed to study the variation in branching pattern of the third part of axillary artery.
  3. Prakash A, Kumar A, Ming LC, Mani V, Majeed AB
    J Mol Neurosci, 2015 Jul;56(3):739-50.
    PMID: 25854775 DOI: 10.1007/s12031-015-0508-7
    Alzheimer's disease (AD) is a neurodegenerative disease characterized by impaired memory function and oxidative damage. NO is a major signaling molecule produced in the central nervous system to modulate neurological activity through modulating nitric oxide synthase. Recently, PPAR-γ agonists have shown neuroprotective effects in neurodegenerative disorders. However, there have been only a few studies identifying mechanisms through which cognitive benefits may be exerted. The present study was designed to investigate the possible nitric oxide mechanism in the protective effect of pioglitazone against streptozotocin (STZ)-induced memory dysfunction. Wistar rats were intracerebroventricularly (ICV) injected with STZ. Then rats were treated with pioglitazone, NO modulators [L-arginine and nitro-L-arginine methyl ester (L-NAME)] for 21 days. Behavioral alterations were assessed in between the study period. Animals were sacrificed immediately after behavioral session, and mito-oxidative parameters, TNF-α, IL-6, and caspase-3 activity were measured. STZ-treated rats showed a memory deficit and significantly increased in mito-oxidative damage and inflammatory mediators and apoptosis in the hippocampus. Chronic treatment of pioglitazone significantly improved memory retention and attenuated mito-oxidative damage parameters, inflammatory markers, and apoptosis in STZ-treated rats. However, L-arginine pretreatment with lower dose of pioglitazone has not produced any protective effect as compared to per se. Furthermore, pretreatment of L-NAME significantly potentiated its protective effect, which indicates the involvement of nitric oxide for activation of PPAR-γ action. These results demonstrate that pioglitazone offers protection against STZ-induced memory dysfunction possibly due to its antioxidant, anti-inflammatory, and anti-apoptotic action mediating nitric oxide pathways and, therefore, could have a therapeutic potential in AD.
  4. Navaratnam V, Mohamad M, Hussain S, Kumar A, Jamaludin A, Sulaiman I, et al.
    Trans R Soc Trop Med Hyg, 1989 11 1;83(6):755-9.
    PMID: 2694509
    Malaria, particularly that due to chloroquine-resistant Plasmodium falciparum, which requires management with antimalarial drugs capable of protecting against multiresistant strains, has emerged in Malaysia. A study was carried out to assess the efficacy and tolerability of 2 dosages of mefloquine/sulfadoxine/pyrimethamine (MSP; RO 13-5112) compared to Fansidar in a malaria endemic area. 914 subjects in 3 random groups were studied. Occurrence of malaria was assessed both clinically as well as by blood films. Plasma drug levels were also measured. The results showed that the low dose of MSP was completely effective in suppressing parasitaemia. 2.7% of the study population reported adverse drug reactions, the lowest incidence being in subjects on the low dose; their blood chemical profiles were also the least affected. The plasma levels of pyrimethamine and sulfadoxine achieved in the low dose group were slightly higher than expected, but there was no significant difference in bioavailability. The study showed that, for chemoprophylaxis, a low dose of MSP provided effective protection with minimal side effects.
  5. Kurup VP, Kumar A, Kelly KJ, Fink JN
    J Allergy Clin Immunol, 1993 Nov;92(5):638-43.
    PMID: 8227854 DOI: 10.1016/0091-6749(93)90005-z
    Several hybridomas were produced against antigens extracted from the latex sap of Hevea brasiliensis. One of the monoclonal antibodies (LA-E3) reacted with antigens demonstrating binding to patient sera on crossed enzyme immunoelectrophoresis. This monoclonal antibody reacted with 2 of 10 glove extracts studied and with both Malaysian and Indian latex plant extracts. The antigens purified with monoclonal antibody affinity chromatography demonstrated specific IgE in the sera of patients with latex allergy as determined by ELISA. This monoclonal antibody can thus be utilized to obtain reliable antigens useful in the diagnosis of latex sensitivity, although additional antigens will likely be necessary to enhance sensitivity and specificity.
  6. Uthaya Kumar A, Kadiresen K, Gan WC, Ling APK
    Clin Exp Vaccine Res, 2021 Jan;10(1):13-23.
    PMID: 33628750 DOI: 10.7774/cevr.2021.10.1.13
    The primary outbreak of severe acute respiratory syndrome coronavirus 2, causing pneumonia-like symptoms in patients named coronavirus disease 2019 (COVID-19) had evolved into a global pandemic. COVID-19 has surpassed Middle East respiratory syndrome and severe acute respiratory syndrome in terms of rate and scale causing more than one million deaths. Development of an effective vaccine to fight against the spread of COVID-19 is the main goal of many countries around the world and plant-based vaccines are one of the available methods in vaccine developments. Plant-based vaccine has gained its reputation among researchers for its known effective manufacturing process and cost effectiveness. Many companies around the world are participating in the race to develop an effective vaccine by using the plant system. This review discusses different approaches used as well as highlights the challenges faced by various companies and research groups in developing the plant-based COVID-19 vaccine.
  7. Fatiha Muhammad E, Kumar A, Wahab HA, Zhang KYJ
    Mol Inform, 2021 08;40(8):e2100020.
    PMID: 34060234 DOI: 10.1002/minf.202100020
    Acetylcholinesterase (AChE) inhibitors are the most effective drugs for Alzheimer's disease treatment. However, considering the potential and failure rates of AChE inhibitors, chemical scaffolds targeting cholinesterase specifically are still very limited. Herein, we report a new class of AChE inhibitors identified by employing a virtual screening approach that combines shape similarity with molecular docking calculations. Virtual screening followed by the evaluation of AChE inhibitory activity allowed us to identify 1,2,4-triazolylthioethanones as a novel class of AChE inhibitors. Thirteen compounds with 1,2,4-triazolylthiothanone core and IC50 values in the range of 0.15±0.07 to 3.32±0.92 μM have been reported here. Our findings shed light into a class of AChE inhibitors that could be useful starting point for the development of novel therapeutics to tackle Alzheimer's disease.
  8. Mansor SM, Navaratnam V, Mohamad M, Hussein S, Kumar A, Jamaludin A, et al.
    Br J Clin Pharmacol, 1989 Mar;27(3):381-6.
    PMID: 2785812
    A single dose pharmacokinetic study of a combined antimalarial formulation of mefloquine, sulphadoxine and pyrimethamine (Fansimef) has been performed in 10 healthy adult male Malaysian volunteers. The dose consisted of two tablets containing 250 mg mefloquine base, 500 mg sulphadoxine base and 25 mg pyrimethamine base each. Plasma concentrations of mefloquine and pyrimethamine were measured by GC-ECD, those of sulphadoxine by h.p.l.c. Time to peak concentrations (mean +/- s.d. for mefloquine (5.70 +/- 0.95 h), sulphadoxine (3.75 +/- 2.03 h) and pyrimethamine (3.30 +/- 1.98 h) were similar to those observed by others after administration of the single compounds. This was also true for elimination half-lives (t1/2). The t1/2s for mefloquine, sulphadoxine and pyrimethamine were 387 +/- 98 h, 255 +/- 61 h and 114 +/- 42 h, respectively.
  9. Sampath Kumar A, Arun Maiya G, Shastry BA, Vaishali K, Maiya S, Umakanth S
    Diabetes Metab Syndr, 2018 10 10;13(1):344-348.
    PMID: 30641723 DOI: 10.1016/j.dsx.2018.10.005
    BACKGROUND: Basal Metabolic Rate (BMR) means the amount of energy utilized by body in physical and psychological resting rate, after a night sleep, awake without any previous physical activity post meal (10 h after last meal) & neutral environment. In people with type 2 diabetes mellitus (T2DM) there is an increase in BMR which is said to be associated with the level of glycaemic control. So, the objective of the study was to find out the correlation between BMR, Insulin resistance and Visceral fat in T2DM with peripheral neuropathy.

    MATERIALS & METHODS: A total of 50 participants with T2DM with peripheral neuropathy were included. Age group of 30-75 years were selected for the study. Participants with a known history of neurological disease, locomotor disability, and pregnancy were excluded from the study. Demographic details of the participants like duration of diabetes mellitus, age, Fasting Blood Glucose, Fasting Insulin, HOMA-IR, Glycated Haemoglobin (HBA1c), Neuropathy and Blood pressure values were noted. We measured Basal Metabolic Rate (BMR) by using Mifflin-St Jeor predictive equation in T2DM with peripheral neuropathy.

    RESULTS: The mean age of the participants is 60.16 ± 10.62. The mean duration of T2DM 13.44 ± 11.92. In the present study we found a statistical significant correlation between BMR and HOMA IR (r = 0.913*; p = 0.000), BMR & Fasting blood sugar (FBS) (r = 0.281*; p = 0.048), BMR and Visceral fat (VF) (r = 0.332*; p = 0.018).

    CONCLUSION: Basal metabolic rate is correlated to Homa-IR, visceral fat, fasting blood sugar and musculoskeletal mass among T2DM with peripheral neuropathy.

  10. Bhandarkar AM, Pandey AK, Nayak R, Pujary K, Kumar A
    Med J Armed Forces India, 2021 Feb;77(Suppl 1):S37-S41.
    PMID: 33612930 DOI: 10.1016/j.mjafi.2020.10.021
    Background: Social media has become an integral part in the life of every individual in the 21st century. Social media addiction in the younger age group is a major problem. The objective of this study was to find a correlation between academic performance and social media use.

    Methods: This was a cross-sectional questionnaire-based study conducted in a medical school over a period of 3 months (Nov 2018-Jan 2019), where 400 medical undergraduates who use social media participated in the study. Data collected from the questionnaire included the academic performance in terms of university examination marks, the duration of social media use per day and the social media addiction score. Data correlation was done using the Pearson's correlation factor.

    Results: 41.5% of students used social media for upto 3 h per day. Whatsapp (98.25%) and Youtube (91.75%) were the most commonly used social media applications. 73.5% used social media to read health-related news, 71.5% used it to complete assignments and more than 50% used it for seminar preparation, test preparation and research-related purposes. Academic performance of female students was better than male students. There was a significantly higher use of social media among academically low-performing medical students compared with high-performing medical students. There was a weak negative correlation between academic performance and social media usage and a strong positive correlation between social media usage and the social media addiction score.

    Conclusions: Social media has a negative impact on the academic performance of 21st-century undergraduate medical students.

  11. Kumar R, Shafiq N, Kumar A, Jhatial AA
    Environ Sci Pollut Res Int, 2021 Sep;28(35):49074-49088.
    PMID: 33928510 DOI: 10.1007/s11356-021-13918-2
    Research for alternative binders has become a necessity due to cement's embodied carbon, climate change, and depletion of natural resources. These binders could potentially reduce our reliance on cement as the sole binder for concrete while simultaneously enhancing the functional characteristics of concrete. Theoretically, the use of finer particles in the cement matrix densifies the pore structure of concrete and results in improved properties. To validate this hypothesis, current research was designed to investigate how the value-added benefits of nano-silica (NS) and metakaolin (MK) in fly ash (FA)-blended cement affect the mechanical and durability characteristics of concrete when used as ternary and quaternary blends. Additionally, the cost-benefit analysis and environmental impact assessment were conducted. It was observed that the synergy of MK and NS used in FA-blended cement had a greater impact on enhancing the functional characteristics of concrete, while 10% MK as ordinary Portland cement (OPC) replacement and 1% NS as an additive in FA-blended OPC concrete was the optimum combination which achieved 94-MPa compressive strength at the age of 91 days and showed more than 25% increment in the flexural and splitting tensile strengths compared to the control mix (MS00). The ultrasonic pulse velocity and dynamic modulus of elasticity were significantly improved, while a significant reduction in chloride migration of 50% was observed. In terms of environmental impact, MS100 (30% FA and 10% MK) exhibited the least embodied CO2 emissions of 319.89 kgCO2/m3, while the highest eco-strength efficiency of 0.268 MPa/kgCO2·m-3 with respect to 28-day compressive strength was exhibited by MS101. In terms of cost-benefit, MS00 was determined the cheapest, while the addition of MK and NS increased the cost. The lowest cost of producing 1 MPa was exhibited by MS01 with a merely 0.04-$/MPa/m3 reduction compared to MS00.
  12. Bheel N, Sohu S, Jhatial AA, Memon NA, Kumar A
    Environ Sci Pollut Res Int, 2022 Jan;29(4):5207-5223.
    PMID: 34420161 DOI: 10.1007/s11356-021-16034-3
    This experimental research was conducted to study the combined effect of agricultural by-product wastes on the properties of concrete. The coconut shell ash (CSA) was utilized to substitute cement content ranging from 0 to 20% by weight of total binder and sugarcane bagasse ash (SCBA) to substitute fine aggregates (FA) ranging from 0 to 40% by weight of total FA. In this regard, a total of 300 concrete specimens (cylinders and cubes) were prepared using 1:1.5:3 mix proportions with a 0.52 water-binder ratio. The study investigated the workability, density, permeability, and mechanical properties in terms of compressive and splitting tensile strengths. Additionally, the total embodied carbon for all mix proportions was calculated. It was observed that with an increase in CSA and SCBA contents, the workability, density, and permeability reduced significantly. Due to CSA and SCBA being pozzolanic materials, a gain in compressive and splitting tensile strengths was observed for certain concrete mixes, after which the strength decreased. The increase in embodied carbon of SCBA increased the total embodied carbon of concrete; however, it can be said that C15S40 which consists of 15% CSA and 40% SCBA is the optimum mix that achieved 28.75 MPa and 3.05 MPa compressive and tensile strength, respectively, a reduction of 4% total embodied carbon.
  13. Keerio MA, Saand A, Kumar A, Bheel N, Ali K
    Environ Sci Pollut Res Int, 2021 Nov;28(42):60000-60018.
    PMID: 34151404 DOI: 10.1007/s11356-021-14960-w
    The carbon dioxide emissions from Portland cement production have increased significantly, and Portland cement is the main binder used in self-compacting concrete, so there is an urgent need to find environmentally friendly materials as alternative resources. In most developing countries, the availability of huge amounts of agricultural waste has paved the way for studying how these materials can be processed into self-compacting concrete as binders and aggregate compositions. Therefore, this experimental program was carried out to study the properties of self-compacting concrete (SCC) made with local metakaolin and coal bottom ash separately and combined. Total 25 mixes were prepared with four mixes as 5, 10, 15, and 20% replacement of cement with metakaolin; four mixes as 10, 20, 30, and 40% of coal bottom ash as partial replacement of fine aggregates separately; and 16 mixes prepared combined with metakaolin and coal bottom ash. The fresh properties were explored by slump flow, T50 flow, V-funnel, L-box, and J-ring sieve segregation test. Moreover, the hardened properties of concrete were performed for compressive, splitting tensile and flexural strength and permeability of SCC mixtures. Fresh concrete test results show that even if no viscosity modifier is required, satisfactory fresh concrete properties of SCC can be obtained by replacing the fine aggregate with coal bottom ash content. At 15% replacement of cement with local metakaolin is optimum and gave better results as compared to control SCC. At 30% replacement of fine aggregate is optimum and gave better results as compared to control SCC. In the combined mix, 10% replacement of cement with metakaolin combined with 30% replacement of fine aggregate with coal bottom ash is optimum and gave better results as compared to control SCC.
  14. Mohandas S, Shete A, Sarkale P, Kumar A, Mote C, Yadav P
    Virulence, 2023 Dec;14(1):2224642.
    PMID: 37312405 DOI: 10.1080/21505594.2023.2224642
    Nipah virus (NiV) is a high-risk pathogen which can cause fatal infections in humans. The Indian isolate from the 2018 outbreak in the Kerala state of India showed ~ 4% nucleotide and amino acid difference in comparison to the Bangladesh strains of NiV and the substitutions observed were mostly not present in the region of any functional significance except for the phosphoprotein gene. The differential expression of viral genes was observed following infection in Vero (ATCC® CCL-81™) and BHK-21 cells. Intraperitoneal infection in the 10-12-week-old, Syrian hamster model induced dose dependant multisystemic disease characterized by prominent vascular lesions in lungs, brain, kidney and extra vascular lesions in brain and lungs. Congestion, haemorrhages, inflammatory cell infiltration, thrombosis and rarely endothelial syncitial cell formation were seen in the blood vessels. Intranasal infection resulted in respiratory tract infection characterised by pneumonia. The model showed disease characteristics resembling the human NiV infection except that of myocarditis similar to that reported by NiV-Malaysia and NiV-Bangladesh isolates in hamster model. The variation observed in the genome of the Indian isolate at the amino acid levels should be explored further for any functional significance.
  15. Khan PA, Johl SK, Kumar A, Luthra S
    Environ Sci Pollut Res Int, 2023 Apr;30(19):55237-55254.
    PMID: 36882655 DOI: 10.1007/s11356-023-26262-4
    The current production and conception have impacted the environmental hazards. Green innovation (GI) is the ideal solution for sustainable production, consumption, and ecological conservation. The objective of the study is to compare comprehensive green innovation (green product, process, service, and organization) impact on firm financial performance in Malaysia and Indonesia, along with the first study to measure the moderation role of the corporate governance index. This study has addressed the gap by developing the green innovation and corporate governance index. Collected panel data from the top 188 publicly listed firms for 3 years and analyzed it using the general least square method. The empirical evidence demonstrates that the green innovation practice is better in Malaysia, and the outcome also shows that the significance level is higher in Indonesia. This study also provides empirical evidence that board composition has a positive moderation relationship betwixt GI and business performance in Malaysia but is insignificant in Indonesia. This comparative study provides new insights to the policymakers and practitioners of both countries to monitor and manage green innovation practices.
  16. Paul A, Kini SB, Kumar A, Mallya SD
    PMID: 37449276 DOI: 10.51866/oa.308
    INTRODUCTION: Optimum blood pressure (BP) control is essential to prevent complications and improve the quality of life of patients with hypertension. This study aimed to explore the determinants of BP control in patients with hypertension on treatment without any other comorbidities.

    METHOD: The study was conducted among 429 patients with essential hypertension aged > 30 years residing in four villages of a taluk/tahsil in a South Indian state. A pre-tested semi-structured questionnaire was used to collect data on socio-demographic characteristics, diagnosis and treatment of hypertension, lifestyle factors (e.g. diet and substance use), facilitators and barriers of BP control and anthropometric measurements. BP was measured using World Health Organization standards and classified using the Joint National Committee 8 Guidelines. Descriptive statistics were measured in terms of numbers and percentages. Univariate and multivariate logistic regression analyses were used to determine the significant determinants of BP control.

    RESULTS: Approximately 64.3% of the participants had their BP under control. The participants aged 46-59 years were more likely to have uncontrolled BP than those aged ≥60 years. The participants with <80% adherence to medication (non-adherent) had a five fold higher odds of having uncontrolled BP than those with >80% adherence.

    CONCLUSION: Adherence to medication was the only significant factor for BP control in the present study. Hence, adherence to medication should be addressed with interventions targeted to improve BP control in patients with hypertension.

  17. Kumar A, Kumari S, Mustapha KA, Chakladar S, Chakravarty S
    Environ Geochem Health, 2023 Oct;45(10):6967-6983.
    PMID: 36626075 DOI: 10.1007/s10653-023-01475-1
    The borehole coal samples of Dhulia North Block from the Rajmahal Basin, Eastern India, were systematically analyzed based on the chemical composition and concentration of major and trace elements (including rare earth elements, REEs) to assess the distribution of REEs and their environmental implications with utilization potential. The Dhulia North Block coals are characterized by the predominant major oxides of SiO2, Al2O3, and Fe2O3, accounting for 94% of the total ash composition, indicating the presence of quartz, clay-rich minerals, and pyrite. Compared with the average world coal ash, the total REE content in the analyzed samples ranged from 341.0 to 810.4 ppm, which is substantially higher. Hot humid climate conditions with intermediate igneous source rocks of the basin were demonstrated by the major oxide ratios (Al2O3/TiO2 < 20) and plots of TiO2 with Al2O3 and Zr. The redox-sensitive elements such as V, Ni, Cr, and Co found in the Dhulia North Block coal indicate that an oxic sedimentary environment existed in the basin when coal was formed. The low sulfur content (1% in most samples) indicates freshwater conditions in the basin at the time of organic matter deposition. The outlook coefficient (Coutl) varies between 0.7 and 1.6, indicating that the Dhulia North Block coals are a prospective source of REEs. The Dhulia North Block coals are characterized by low H/C and O/C atomic ratios ranging from 0.56 to 0.90 and 0.10 to 0.22, respectively, and contain type-III kerogens, indicating gas-prone source rock. Further, the basic-to-acid oxide ratio suggested that Dhulia North Block coals were suitable for utilization during combustion processes.
  18. Kumar B, Kumar L, Kumar A, Kumari R, Tagar U, Sassanelli C
    Environ Dev Sustain, 2023 May 17.
    PMID: 37362997 DOI: 10.1007/s10668-023-03361-3
    Developing markets are using sustainable development potential to reach zero-carbon goals. Due to the limitation of natural resources, companies need to use environmentally friendly manufacturing to develop a circular economy (CE). Green finance (GF) and the CE are linked in a systematic and complex approach; therefore, it was essential to employ the coupling coordination-level framework to explain their relationship and feedback. Any study linking green financing and CE together has been found. The objective of this research is to explore this twofold domain and determine its main characteristics. To address this objective, a comprehensive review of the literature was conducted, supplemented by a bibliometric analysis. The results confirm that GF has the potential to help society, sustainability, and the prevention to climate shifts, investing in the CE. There are many hurdles to overcome, including inadequate knowledge about CE and GF, ambiguous definitions, a lack of coherence between legal frameworks on CE and green financing, unclear laws, and a lack of financially viable motivation for investors and financial institutions that are ready to promote in sustainability. This study explores CE and GF domains. Managers may readily increase their understanding of methods, strategies, and technical solutions beneficial to assist their operations toward a green economy depending on various CE and GF elements. Finally, based on a categorization of GF types, the assessment identifies future investment potential consequences of green financing in the CE.
  19. Kumar A, Chong YT, Jamil K, Rusli E
    BMJ Case Rep, 2021 Nov 05;14(11).
    PMID: 34740908 DOI: 10.1136/bcr-2021-245415
    Osteoglophonic dwarfism, also known as osteoglophonic dysplasia (OD), is an uncommon skeletal dysplasia with an autosomal dominant mode of inheritance, which equally affects boys and girls. OD is saliently featured by craniosynostosis, dysmorphic facial features, impacted mandibular teeth, rhizomelic limb shortening and non-ossifying fibromas habitually at the metaphyseal regions, which usually disappear after skeletal maturity. The long bones in OD are portrayed by this distinguishable 'hollowed-out' appearance with metaphyseal cystic defects that have a natural history of spontaneous resolution. We report a case of a rare and unusual presentation of OD in a 23-year-old woman whom has been diagnosed with OD during her early childhood. She presented with a progressively enlarging right thigh swelling associated with pain for the past 1 year. Her right femur plain radiograph revealed diffuse lysis of the whole femur with cortical thinning. MRI revealed multiple bilateral femur benign cystic lesion synonymous with a severe spectrum of OD. She was started on a trial of oral bisphosphonates, which led to a significant improvement in pain.
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