MyMedR

Stress among parents of children with attention deficit hyperactivity disorder, a Malaysian experience

Narkunam N, Hashim AH, Sachdev MK, Pillai SK, Ng CG

Asia Pac Psychiatry, 2014 Jun;6(2):207-16.

PMID: 23857633 DOI: 10.1111/j.1758-5872.2012.00216.x

Attention deficit hyperactivity disorder (ADHD) is a chronic debilitating illness with onset in early childhood. The objective of this study was to look at the impact of children with ADHD on their parents.

Clinical features of depression in Asia: results of a large prospective, cross-sectional study

Srisurapanont M, Hong JP, Tian-Mei S, Hatim A, Liu CY, Udomratn P, et al.

Asia Pac Psychiatry, 2013 Dec;5(4):259-67.

PMID: 24038919 DOI: 10.1111/appy.12104

The objective of this study was to investigate the clinical features of depression in Asian patients.

Pattern of suicides in 2009: data from the National Suicide Registry Malaysia

Ali NH, Zainun KA, Bahar N, Haniff J, Hamid AM, Bujang MA, et al.

Asia Pac Psychiatry, 2014 Jun;6(2):217-25.

PMID: 23857761 DOI: 10.1111/j.1758-5872.2012.00227.x

The National Suicide Registry Malaysia (NSRM) is a nationwide system that captures data on completed suicides in Malaysia from all forensic departments under the purview of the Ministry of Health Malaysia.

Use of antidepressants in the treatment of depression in Asia: guidelines, clinical evidence, and experience revisited

Treuer T, Liu CY, Salazar G, Kongsakon R, Jia F, Habil H, et al.

Asia Pac Psychiatry, 2013 Dec;5(4):219-30.

PMID: 23857712 DOI: 10.1111/appy.12090

Major depressive disorder is prevalent worldwide, and only about half of those affected will experience no further episodes or symptoms. Additionally, depressive symptoms can be challenging to identify, with many patients going undiagnosed despite a wide variety of available treatment options. Antidepressants are the cornerstone of depression treatment; however, a large number of factors must be considered in selecting the treatment best suited to the individual. To help support physicians in this process, international and national treatment guidelines have been developed. This review evaluates the current use of antidepressant treatment for major depressive disorder in six Asian countries (China, Korea, Malaysia, Philippines, Taiwan, and Thailand). No remarkable differences were noted between Asian and international treatment guidelines or among those from within Asia as these are adapted from western guidelines, although there were some local variations. Importantly, a shortage of evidence-based information at a country level is the primary problem in developing guidelines appropriate for Asia, so most of the guidelines are consensus opinions derived from western research data utilized in western guidelines. Treatment guidelines need to evolve from being consensus based to evidence based when evidence is available, taking into consideration cost/effectiveness or cost/benefit with an evidence-based approach that more accurately reflects clinical experience as well as the attributes of each antidepressant. In everyday practice, physicians must tailor their treatment to the patient's clinical needs while considering associated external factors; better tools are needed to help them reach the best possible prescribing decisions which are of maximum benefit to patients.

Depression and coping in adults undergoing dialysis for end-stage renal disease

Ibrahim N, Kong NCT, Desa A, Razali R

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:35-40.

PMID: 23857835 DOI: 10.1111/appy.12042

Introduction: Research on depression in local patients with end-stage renal disease (ESRD) is sparse. Thus, this study aims to examine the frequency and severity of depression among ESRD patients and relate depression with their coping skills.
Methods: A cross-sectional study using universal sampling method was conducted at several dialysis centers in Kuala Lumpur, Selangor and Johor, Malaysia. The Beck Depression Inventory II (BDI-II) and the Brief COPE scale were used to measure depression and coping skill, respectively.
Results: The study involved 274 ESRD patients, comprising of 183 hemodialysis and 91 continuous ambulatory peritoneal dialysis patients. The result showed that 21.1% of the patients experienced moderate to severe depression. Several components of coping skill were associated with depression. However, only two components in the Brief COPE (behavioral disengagement and self-blame) were identified as predictors.
Discussion: This study showed that depression is common in ESRD patients and is related to the types of coping skills adopted by patients. Hence, this study provides some insight into ESRD patients with depression. Appropriate counseling should be given to these patients to empower them to cope with the illness so as to enhance their quality of life.

Externalizing and internalizing syndromes in relation to school truancy among adolescents in high-risk urban schools

Nik Jaafar NR, Tuti Iryani MD, Wan Salwina WI, Fairuz Nazri AR, Kamal NA, Prakash RJ, et al.

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:27-34.

PMID: 23857834 DOI: 10.1111/appy.12072

To examine the relationship between externalizing/internalizing syndromes and school truancy among Form Four (10th grade) students attending "high-risk" schools in Kuala Lumpur.

Risk and associated factors of female sexual orgasmic disorder in women with hypertension in Malaysia

Abdul Latif R, Muhamad R, Kanagasundram S, Sidi H, Nik Jaafar NR, Midin M, et al.

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:21-6.

PMID: 23857833 DOI: 10.1111/appy.12039

The objective of this study was to examine the risk of female sexual orgasmic disorder among a group of women with hypertension in Malaysia. The associated factors were also examined.

Sexual desire disorder in female healthcare personnel in Malaysia

Grewal GS, Gill JS, Sidi H, Gurpreet K, Jambunathan ST, Suffee NJ

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:14-20.

PMID: 23857832 DOI: 10.1111/appy.12037

INTRODUCTION: The aim of this study was to determine the prevalence and risk factors for female sexual desire disorder (FSDD) among healthcare personnel at selected healthcare facilities in Malaysia.
METHODS: Two hundred and one female healthcare workers from three large tertiary hospitals were selected by stratified random sampling to participate in this cross-sectional study. Validated questionnaires were used to assess depression, anxiety, and sexual function in women and erectile dysfunction (ED) in their partners.
RESULTS: The prevalence of FSDD was 18.9%. Women with low sexual desire were more likely to have higher educational attainment (OR = 3.06; 95% CI; 1.22-7.66), lower frequency of sexual intercourse (OR = 12.81; 95% CI; 4.43-37.83), two or more children (OR = 3.05; 95% CI; 1.02-9.09), duration of marriage of 20 years or more (OR = 2.62; 95% CI; 1.27-5.40), and a spouse with ED (OR = 2.86; 95% CI; 1.08-7.56).
DISCUSSION: FSDD is common among female healthcare personnel in Malaysia, affecting nearly one in five women. The implication of low sexual desire is important in terms of contributing to a meaningful sexual relationship, and indirectly affects the quality of life of the healthcare personnel.
KEYWORDS: Malaysia; healthcare personnel; prevalence; risk factor; sexual desire disorder

Phases of female sexual response cycle among Malaysian women with infertility: a factor analysis study

Seen Heng Y, Sidi H, Nik Jaafar NR, Razali R, Ram H

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:50-4.

PMID: 23857837 DOI: 10.1111/appy.12044

This cross-sectional study aimed to determine the construct of the phases of the female sexual response cycle (SRC) among women attending an infertility clinic in a Malaysian tertiary center.

Association between 5HT2A polymorphism and selective serotonin re-uptake inhibitor (SSRI)-induced sexual desire disorder (SDD) among Malaysian women

Masiran R, Sidi H, Mohamed Z, Mohamed Saini S, Nik Jaafar NR

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:41-9.

PMID: 23857836 DOI: 10.1111/appy.12043

SSRIs are known for their sexual side-effects with a variable rate of sexual dysfunction (SD). 5HT2A (rs6311) single nucleotide polymorphism (SNP) was found to have significant association with SD. The purpose of this study was to determine the prevalence of female SDD, its clinical correlates and association with 5HT2A (rs6311) SNP in patients with major depressive disorder (MDD) treated with SSRIs.

Risk factors for depression and anxiety among pregnant women in Hospital Tuanku Bainun, Ipoh, Malaysia

Fadzil A, Balakrishnan K, Razali R, Sidi H, Malapan T, Japaraj RP, et al.

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:7-13.

PMID: 23857831 DOI: 10.1111/appy.12036

Anxiety and depression are prevalent during pregnancy. Estimates of the prevalence of anxiety and depression during pregnancy vary according to the criteria used, variable methodologies and population characteristics.

Perspectives in Malaysian psychiatry

Maniam T, Sidi H, Razali R

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:2-3.

PMID: 23857829 DOI: 10.1111/appy.12035

Welcome from the editors of Asia Pacific Psychiatry

Tasman A, Alcaron RD, Chiu HF, Herrman H, Ng CH

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:1.

PMID: 23857828 DOI: 10.1111/appy.12071

Quality of life of patients with epilepsy in Malaysia

Mohamed S, Gill JS, Tan CT

Asia Pac Psychiatry, 2014 Mar;6(1):105-9.

PMID: 23857866 DOI: 10.1111/j.1758-5872.2012.00192.x

To determine the quality of life of patients with epilepsy and its relationship with depression, and the clinical and sociodemographic variables.

Treating heroin addiction: bridging the past and future--a Malaysian experience

Robson N, Rashid R, Nazar M, Habil H

Asia Pac Psychiatry, 2015 Mar;7(1):121-5.

PMID: 23857876 DOI: 10.1111/j.1758-5872.2012.00194.x

Mental health literacy: A cross-cultural study from Britain, Hong Kong and Malaysia

Loo PW, Wong S, Furnham A

Asia Pac Psychiatry, 2012 Jun;4(2):113-25.

PMID: 26767355 DOI: 10.1111/j.1758-5872.2012.00198.x

A cross-cultural study was conducted on the identification of psychiatric problems comparing British, Hong Kong and Malaysian participants.

Prevalence of postpartum depression in a hospital setting among Malaysian mothers

Zainal NZ, Kaka AS, Ng CG, Jawan R, Singh Gill J

Asia Pac Psychiatry, 2012 Jun;4(2):144-9.

PMID: 26767359 DOI: 10.1111/j.1758-5872.2011.00173.x

Postpartum depression (PPD) is a disorder that affects not only mothers, but also can lead to family, social, economic and vocational breakdown. The objective of this study was to determine the prevalence and factors associated with postpartum depression among mothers in an urban hospital setting in Malaysia.

Polymorphism of the serotonin transporter gene (5-HTTLPR) in major depressive disorder patients in Malaysia

Mohamed Saini S, Muhamad Radzi A, Abdul Rahman AH

Asia Pac Psychiatry, 2012 Jun;4(2):126-30.

PMID: 26767356 DOI: 10.1111/j.1758-5872.2012.00190.x

The serotonin transporter promoter (5-HTTLPR) is a potential susceptibility locus in the pathogenesis of major depressive disorder. However, data from Malaysia is lacking. The present study aimed to determine the association between the homozygous short variant of the serotonin transporter promoter gene (5-HTTLPR) with major depressive disorder.

Psychometric properties of the revised Malay version Medical Outcome Study Social Support Survey using confirmatory factor analysis among postpartum mothers

Norhayati MN, Aniza AA, Nik Hazlina NH, Azman MY

Asia Pac Psychiatry, 2015 Dec;7(4):398-405.

PMID: 25808643 DOI: 10.1111/appy.12184

Social support is an essential component for the physical and emotional well-being of postpartum mothers. The objective of this study is to determine the psychometric properties of the revised Malay version Medical Outcome Study (MOS) Social Support Survey using a confirmatory validity approach.

Safety and effectiveness of lurasidone for the treatment of schizophrenia in Asian patients: Results of a 26-week open-label extension study

Higuchi T, Ishigooka J, Iyo M, Hagi K

Asia Pac Psychiatry, 2020 Mar;12(1):e12377.

PMID: 31837113 DOI: 10.1111/appy.12377

INTRODUCTION: This study was designed to evaluate the long-term safety and effectiveness of lurasidone in the treatment of schizophrenia among Asian patients.

METHODS: Patients (N = 281) with schizophrenia who had completed a randomized, double-blind (DB), 6-week comparison of lurasidone (40 and 80 mg/day) and placebo were enrolled in a 26-week extension study in which all patients received open-label (OL), flexible doses of lurasidone (40 or 80 mg/day). Effectiveness was measured using the Positive and Negative Syndrome Scale (PANSS) scale.

RESULTS: Fifty-seven percent of patients completed the OL extension study; 16.7% discontinued early due to lack of effectiveness; and 10.3% due to adverse events. The most common adverse events were insomnia (11.3%), akathisia (11.0%), and nasopharyngitis (10.6%). Adverse events related to weight gain, metabolic parameters, prolactin, and ECG measures were uncommon. Mean change in the PANSS total score from the DB baseline to OL endpoint was -28.4, with mean improvement of -7.5 observed from baseline to OL endpoint, and with a PANSS responder rate of 73.7%.

DISCUSSION: The results of the current 26-week extension study found lurasidone to be a generally safe, well-tolerated, and effective long-term treatment for schizophrenia in Asian patients.

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