MyMedR

Fulltext Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Saifullah B, Hussein MZ, Hussein-Al-Ali SH, Arulselvan P, Fakurazi S

Chem Cent J, 2013;7(1):72.

PMID: 23601852 DOI: 10.1186/1752-153X-7-72

Tuberculosis (TB), is caused by the bacteria, Mycobacterium tuberculosis and its a threat to humans since centuries. Depending on the type of TB, its treatment can last for 6-24 months which is a major cause for patients non-compliance and treatment failure. Many adverse effects are associated with the currently available TB medicines, and there has been no new anti-tuberculosis drug on the market for more than 50 year, as the drug development is very lengthy and budget consuming process.Development of the biocompatible nano drug delivery systems with the ability to minimize the side effects of the drugs, protection of the drug from enzymatic degradation. And most importantly the drug delivery systems which can deliver the drug at target site would increase the therapeutic efficacy. Nanovehicles with their tendency to release the drug in a sustained manner would result in the bioavalibilty of the drugs in the body for a longer period of time and this would reduce the dosing frequency in drug administration. The biocompatible nanovehicles with the properties like sustained release of drug of the target site, protection of the drug from physio-chemical degradation, reduction in dosing frequency, and prolong bioavailability of drug in the body would result in the shortening of the treatment duration. All of these factors would improve the patient compliance with chemotherapy of TB.

Fulltext Retraction: Luciferase-transfected colon adenocarcinoma cell line (DLD-1) for use in Orthotopic Xenotransplantation studies

Siddique MR, Shynder S, Ashraf MA, Yusoff I, Wajid A

Chem Cent J, 2012 10 22;6(1):121.

PMID: 23088540 DOI: 10.1186/1752-153X-6-121

Fulltext Selectively increasing of polyunsaturated (18:2) and monounsaturated (18:1) fatty acids in Jatropha curcas seed oil by crystallization using D-optimal design

Salimon J, Abdullah BM, Salih N

Chem Cent J, 2012;6(1):65.

PMID: 22747574 DOI: 10.1186/1752-153X-6-65

Fulltext Chemical composition and molecular structure of polysaccharide-protein biopolymer from Durio zibethinus seed: extraction and purification process

Amid BT, Mirhosseini H, Kostadinović S

Chem Cent J, 2012 Oct 14;6(1):117.

PMID: 23062269 DOI: 10.1186/1752-153X-6-117

BACKGROUND: The biological functions of natural biopolymers from plant sources depend on their chemical composition and molecular structure. In addition, the extraction and further processing conditions significantly influence the chemical and molecular structure of the plant biopolymer. The main objective of the present study was to characterize the chemical and molecular structure of a natural biopolymer from Durio zibethinus seed. A size-exclusion chromatography coupled to multi angle laser light-scattering (SEC-MALS) was applied to analyze the molecular weight (Mw), number average molecular weight (Mn), and polydispersity index (Mw/Mn).

RESULTS: The most abundant monosaccharide in the carbohydrate composition of durian seed gum were galactose (48.6-59.9%), glucose (37.1-45.1%), arabinose (0.58-3.41%), and xylose (0.3-3.21%). The predominant fatty acid of the lipid fraction from the durian seed gum were palmitic acid (C16:0), palmitoleic acid (C16:1), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), and linolenic acid (C18:2). The most abundant amino acids of durian seed gum were: leucine (30.9-37.3%), lysine (6.04-8.36%), aspartic acid (6.10-7.19%), glycine (6.07-7.42%), alanine (5.24-6.14%), glutamic acid (5.57-7.09%), valine (4.5-5.50%), proline (3.87-4.81%), serine (4.39-5.18%), threonine (3.44-6.50%), isoleucine (3.30-4.07%), and phenylalanine (3.11-9.04%).

CONCLUSION: The presence of essential amino acids in the chemical structure of durian seed gum reinforces its nutritional value.

Fulltext Antibacterial activity of silver bionanocomposites synthesized by chemical reduction route

Bin Ahmad M, Lim JJ, Shameli K, Ibrahim NA, Tay MY, Chieng BW

Chem Cent J, 2012;6(1):101.

PMID: 22967920 DOI: 10.1186/1752-153X-6-101

Fulltext Interactions between photodegradation components

Abdollahi Y, Zakaria A, Matori KA, Shameli K, Jahangirian H, Rezayi M, et al.

Chem Cent J, 2012;6(1):100.

PMID: 22967885 DOI: 10.1186/1752-153X-6-100

The interactions of p-cresol photocatalytic degradation components were studied by response surface methodology. The study was designed by central composite design using the irradiation time, pH, the amount of photocatalyst and the p-cresol concentration as variables. The design was performed to obtain photodegradation % as actual responses. The actual responses were fitted with linear, two factor interactions, cubic and quadratic model to select an appropriate model. The selected model was validated by analysis of variance which provided evidences such as high F-value (845.09), very low P-value (

Fulltext Design, synthesis and structural studies of meta-xylyl linked bis-benzimidazolium salts: potential anticancer agents against 'human colon cancer'

Haque RA, Iqbal MA, Khadeer Ahamed MB, Majid AA, Abdul Hameed ZA

Chem Cent J, 2012;6(1):68.

PMID: 22809051 DOI: 10.1186/1752-153X-6-68

Fulltext Immobilization of tris(2 pyridyl) methylamine in a PVC-Membrane Sensor and Characterization of the Membrane Properties

Rezayi M, Heng LY, Kassim A, Ahmadzadeh S, Abdollahi Y, Jahangirian H

Chem Cent J, 2012;6(1):40.

PMID: 22564322 DOI: 10.1186/1752-153X-6-40

Due to the increasing industrial use of titanium compounds, its determination is the subject of considerable efforts. The ionophore or membrane active recognition is the most important component of any polymeric membrane sensor. The sensor's response depends on the ionophore and bonding between the ionophore and the target ion. Ionophores with molecule-sized dimensions containing cavities or semi-cavities can surround the target ion. The bond between the ionophore and target ion gives different selectivity and sensitivity toward the other ions. Therefore, ionophores with different binding strengths can be used in the sensor.

Fulltext Distribution and fate of HCH isomers and DDT metabolites in a tropical environment-case study Cameron Highlands-Malaysia

Saadati N, Abdullah MP, Zakaria Z, Rezayi M, Hosseinizare N

Chem Cent J, 2012;6(1):130.

PMID: 23130650 DOI: 10.1186/1752-153X-6-130

Fulltext Investigation of antibacterial properties silver nanoparticles prepared via green method

Shameli K, Ahmad MB, Jazayeri SD, Shabanzadeh P, Sangpour P, Jahangirian H, et al.

Chem Cent J, 2012;6(1):73.

PMID: 22839208 DOI: 10.1186/1752-153X-6-73

Fulltext Cyclic Tetrapyrrolic Photosensitisers from the leaves of Phaeanthus ophthalmicus

Tan PJ, Ong CY, Danial A, Yusof HM, Neoh BK, Lee HB

Chem Cent J, 2011;5:32.

PMID: 21682931 DOI: 10.1186/1752-153X-5-32

Twenty-seven extracts from 26 plants were identified as photo-cytotoxic in the course of our bioassay guided screening program for photosensitisers from 128 extracts prepared from 64 terrestrial plants in two different collection sites in Malaysia - Royal Belum Forest Reserve in the State of Perak and Gunung Nuang in the State of Selangor. One of the photo-cytotoxic extracts from the leaves of Phaeanthus ophtalmicus was further investigated.

Fulltext Correlation between Fischer-Tropsch catalytic activity and composition of catalysts

Ali S, Mohd Zabidi NA, Subbarao D

Chem Cent J, 2011;5:68.

PMID: 22047220 DOI: 10.1186/1752-153X-5-68

This paper presents the synthesis and characterization of monometallic and bimetallic cobalt and iron nanoparticles supported on alumina. The catalysts were prepared by a wet impregnation method. Samples were characterized using temperature-programmed reduction (TPR), temperature-programmed oxidation (TPO), CO-chemisorption, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM-EDX) and N2-adsorption analysis. Fischer-Tropsch synthesis (FTS) was carried out in a fixed-bed microreactor at 543 K and 1 atm, with H2/CO = 2 v/v and space velocity, SV = 12L/g.h. The physicochemical properties and the FTS activity of the bimetallic catalysts were analyzed and compared with those of monometallic cobalt and iron catalysts at similar operating conditions.H2-TPR analysis of cobalt catalyst indicated three temperature regions at 506°C (low), 650°C (medium) and 731°C (high). The incorporation of iron up to 30% into cobalt catalysts increased the reduction, CO chemisorption and number of cobalt active sites of the catalyst while an opposite trend was observed for the iron-riched bimetallic catalysts. The CO conversion was 6.3% and 4.6%, over the monometallic cobalt and iron catalysts, respectively. Bimetallic catalysts enhanced the CO conversion. Amongst the catalysts studied, bimetallic catalyst with the composition of 70Co30Fe showed the highest CO conversion (8.1%) while exhibiting the same product selectivity as that of monometallic Co catalyst. Monometallic iron catalyst showed the lowest selectivity for C5+ hydrocarbons (1.6%).

Fulltext Hydrolysis optimization and characterization study of preparing fatty acids from Jatropha curcas seed oil

Salimon J, Abdullah BM, Salih N

Chem Cent J, 2011;5:67.

PMID: 22044685 DOI: 10.1186/1752-153X-5-67

Fatty acids (FAs) are important as raw materials for the biotechnology industry. Existing methods of FAs production are based on chemical methods. In this study potassium hydroxide (KOH)-catalyzed reactions were utilized to hydrolysis Jatropha curcas seed oil.

Fulltext Electrodeposition of quaternary alloys in the presence of magnetic field

Ebadi M, Basirun WJ, Alias Y, Mahmoudian M

Chem Cent J, 2010;4:14.

PMID: 20604934 DOI: 10.1186/1752-153X-4-14

Electrodeposition of Ni-Co-Fe-Zn alloys was done in a chloride ion solution with the presence and absence of a Permanent Parallel Magnetic Field (PPMF). The PPMF was applied parallel to the cathode surface. The deposition profile was monitored chronoamperometrically. It was found that the electrodeposition current was enhanced in the presence of PPMF (9 T) compared to without PPMF. The percentage of current enhancement (Gamma%) was increased in the presence of PPMF, with results of Gamma% = 11.9%, 16.7% and 18.5% at -1.1, -1.2 and -1.3 V respectively for a 2400 sec duration. In chronoamperometry, the Composition Reference Line (CRL) for Ni was around 57%, although the nobler metals (i.e. Ni, Co) showed anomalous behaviour in the presence of Zn and Fe. The anomalous behaviour of the Ni-Co-Fe-Zn electrodeposition was shown by the Energy Dispersive X-Ray (EDX) results. From Atomic Force Microscopy (AFM) measurements, it was found that the surface roughness of the Ni-Co-Fe-Zn alloy films decreased in the presence of a PPMF.

Fulltext Potential of silver against human colon cancer: (synthesis, characterization and crystal structures of xylyl (Ortho, meta, &Para) linked bis-benzimidazolium salts and Ag(I)-NHC complexes: In vitro anticancer studies)

Iqbal MA, Haque RA, Nasri SF, Majid AA, Ahamed MB, Farsi E, et al.

Chem Cent J, 2013;7(1):27.

PMID: 23391345 DOI: 10.1186/1752-153X-7-27

Since the first successful synthesis of Ag(I)-N-heterocyclic carbene complex in 1993, this class of compounds has been extensively used for transmetallation reactions where the direct synthesis using other metal ions was either difficult or impossible. Initially, silver(I)-NHC complexes were tested for their catalytic potential but could not get fame because of lower potential compare to other competent compounds in this field; however, these compounds proved to have vital antimicrobial activities. These encouraging biomedical applications further convinced researchers to test these compounds against cancer. The current work has been carried out with this aim.

Fulltext Effect of different drying techniques on flowability characteristics and chemical properties of natural carbohydrate-protein Gum from durian fruit seed

Mirhosseini H, Amid BT

Chem Cent J, 2013 Jan 04;7(1):1.

PMID: 23289739 DOI: 10.1186/1752-153X-7-1

BACKGROUND: A natural carbohydrate biopolymer was extracted from the agricultural biomass waste (durian seed). Subsequently, the crude biopolymer was purified by using the saturated barium hydroxide to minimize the impurities. Finally, the effect of different drying techniques on the flow characteristics and functional properties of the purified biopolymer was investigated. The present study elucidated the main functional characteristics such as flow characteristics, water- and oil-holding capacity, solubility, and foaming capacity.

RESULTS: In most cases except for oven drying, the bulk density decreased, thus increasing the porosity. This might be attributed to the increase in the inter-particle voids of smaller sized particles with larger contact surface areas per unit volume. The current study revealed that oven-dried gum and freeze-dried gum had the highest and lowest compressibility index, thus indicating the weakest and strongest flowability among all samples. In the present work, the freeze-dried gum showed the lowest angle of repose, bulk, tapped and true density. This indicates the highest porosity degree of freeze dried gum among dried seed gums. It also exhibited the highest solubility, and foaming capacity thus providing the most desirable functional properties and flow characteristics among all drying techniques.

CONCLUSION: The present study revealed that freeze drying among all drying techniques provided the most desirable functional properties and flow characteristics for durian seed gum.

Fulltext Synthesis of (cinnamate-zinc layered hydroxide) intercalation compound for sunscreen application

Mohsin SM, Hussein MZ, Sarijo SH, Fakurazi S, Arulselvan P, Hin TY

Chem Cent J, 2013 Feb 06;7(1):26.

PMID: 23383738 DOI: 10.1186/1752-153X-7-26

BACKGROUND: Zinc layered hydroxide (ZLH) intercalated with cinnamate, an anionic form of cinnamic acid (CA), an efficient UVA and UVB absorber, have been synthesized by direct method using zinc oxide (ZnO) and cinnamic acid as the precursor.

RESULTS: The resulting obtained intercalation compound, ZCA, showed a basal spacing of 23.9 Å as a result of cinnamate intercalated in a bilayer arrangement between the interlayer spaces of ZLH with estimated percentage loading of cinnamate of about 40.4 % w/w. The UV-vis absorption spectrum of the intercalation compound showed excellent UVA and UVB absorption ability. Retention of cinnamate in ZLH interlayers was tested against media usually came across with sunscreen usage to show low release over an extended period of time. MTT assay of the intercalation compound on human dermal fibroblast (HDF) cells showed cytotoxicity of ZCA to be concentration dependent and is overall less toxic than its precursor, ZnO.

CONCLUSIONS: (Cinnamate-zinc layered hydroxide) intercalation compound is suitable to be used as a safe and effective sunscreen with long UV protection effect.

Fulltext Biosynthesis of silver nanoparticles using Artocarpus elasticus stem bark extract

Abdullah NI, Ahmad MB, Shameli K

Chem Cent J, 2015;9:61.

PMID: 26528373 DOI: 10.1186/s13065-015-0133-0

Green approach in synthesizing metal nanoparticles has gain new interest from the researchers as metal nanoparticles were widely applied in medical equipment and household products. The use of plants in the synthesis of nanoparticles emerges as a cost effective and eco-friendly approach. A green synthetic route for the production of stable silver nanoparticles (Ag-NPs) by using aqueous silver nitrate as metal precursor and Artocarpus elasticus stem bark extract act both as reductant and stabilizer is being reported for the first time.

Fulltext Determination of heavy metals in the soils of tea plantations and in fresh and processed tea leaves: an evaluation of six digestion methods

Rashid MH, Fardous Z, Chowdhury MA, Alam MK, Bari ML, Moniruzzaman M, et al.

Chem Cent J, 2016;10:7.

PMID: 26900397 DOI: 10.1186/s13065-016-0154-3

BACKGROUND: The aim of this study was to determine the levels of cadmium (Cd), chromium (Cr), lead (Pb), arsenic (As) and selenium (Se) in (1) fresh tea leaves, (2) processed (black) tea leaves and (3) soils from tea plantations originating from Bangladesh.

METHODS: Graphite furnace atomic absorption spectrometry (GF-AAS) was used to evaluate six digestion methods, (1) nitric acid, (2) nitric acid overnight, (3) nitric acid-hydrogen peroxide, (4) nitric-perchloric acid, (5) sulfuric acid, and (6) dry ashing, to determine the most suitable digestion method for the determination of heavy metals in the samples.

RESULTS: The concentration ranges of Cd, Pb, As and Se in fresh tea leaves were from 0.03-0.13, 0.19-2.06 and 0.47-1.31 µg/g, respectively while processed tea contained heavy metals at different concentrations: Cd (0.04-0.16 µg/g), Cr (0.45-10.73 µg/g), Pb (0.07-1.03 µg/g), As (0.89-1.90 µg/g) and Se (0.21-10.79 µg/g). Moreover, the soil samples of tea plantations also showed a wide range of concentrations: Cd (0.11-0.45 µg/g), Pb (2.80-66.54 µg/g), As (0.78-4.49 µg/g), and Se content (0.03-0.99 µg/g). Method no. 2 provided sufficient time to digest the tea matrix and was the most efficient method for recovering Cd, Cr, Pb, As and Se. Methods 1 and 3 were also acceptable and can be relatively inexpensive, easy and fast. The heavy metal transfer factors in the investigated soil/tea samples decreased as follows: Cd > As > Se > Pb.

CONCLUSION: Overall, the present study gives current insights into the heavy metal levels both in soils and teas commonly consumed in Bangladesh.

Fulltext Promising upshot of silver nanoparticles primed from Gracilaria crassa against bacterial pathogens

Lavakumar V, Masilamani K, Ravichandiran V, Venkateshan N, Saigopal DV, Ashok Kumar CK, et al.

Chem Cent J, 2015;9:42.

PMID: 26251669 DOI: 10.1186/s13065-015-0120-5

The study on newer antimicrobial agent from metal based nano materials has augmented in recent years for the management of multidrug resistance microorganisms. In our present investigation, we synthesized silver nanoparticles (AgNP's) from red algae, Gracilaria crassa as beginning material which effectively condensed the silver ions to silver nanoparticles with less price tag and no risk.

Displaying publications 21 - 40 of 92 in total