Displaying publications 21 - 40 of 332 in total

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  1. Tuygunov N, Zakaria MN, Yahya NA, Abdul Aziz A, Cahyanto A
    J Mech Behav Biomed Mater, 2023 Oct;146:106099.
    PMID: 37660446 DOI: 10.1016/j.jmbbm.2023.106099
    Bone regeneration is a rapidly growing field that seeks to develop new biomaterials to regenerate bone defects. Conventional bone graft materials have limitations, such as limited availability, complication, and rejection. Glass ionomer cement (GIC) is a biomaterial with the potential for bone regeneration due to its bone-contact biocompatibility, ease of use, and cost-effectiveness. GIC is a two-component material that adheres to the bone and releases ions that promote bone growth and mineralization. A systematic literature search was conducted using PubMed-MEDLINE, Scopus, and Web of Science databases and registered in the PROSPERO database to determine the evidence regarding the efficacy and bone-contact biocompatibility of GIC as bone cement. Out of 3715 initial results, thirteen studies were included in the qualitative synthesis. Two tools were employed in evaluating the Risk of Bias (RoB): the QUIN tool for assessing in vitro studies and SYRCLE for in vivo. The results indicate that GIC has demonstrated the ability to adhere to bone and promote bone growth. Establishing a chemical bond occurs at the interface between the GIC and the mineral phase of bone. This interaction allows the GIC to exhibit osteoconductive properties and promote the growth of bone tissue. GIC's bone-contact biocompatibility, ease of preparation, and cost-effectiveness make it a promising alternative to conventional bone grafts. However, further research is required to fully evaluate the potential application of GIC in bone regeneration. The findings hold implications for advancing material development in identifying the optimal composition and fabrication of GIC as a bone repair material.
    Matched MeSH terms: Biocompatible Materials/pharmacology
  2. Md Razak Daud, Wan Nor Shela Ezwane Wan Jusoh, Syahrullail Samion
    MyJurnal
    This study investigates metal removal rate (MRR) of the biomaterial by using discharge machine Neuar CNC A50 Electrical Discharge Machine Die Sinking (EDM DS). The purpose of this study is to compare machining curvature cup for material SKD 11 and stainless steel with shape curvature cup acetabular. The result showed that electrode wear is higher when high current is applied. For each applied current 0.5A and 3.0A could result electrode wear of 0.236 mm, 0.246 mm and 0.269 mm respectively. Mean time of complete discharged for each pit with 0.3mm depth with supply 0. 5A is 6.51 minutes; 1. 5A is 3.54 minutes and 3A is 1.52 minutes. The biggest mean parameter of the pit is 0.356 mm, with 3A of current is applied. From this study, it can be concluded that low current set may give lower electrode copper wear. The experiment will help a researcher to discharge biomaterial types of metal with small size of copper electrode use of EDM DS Neuar for discharge multi hole or micro pit.
    Matched MeSH terms: Biocompatible Materials
  3. Udenni Gunathilake TMS, Ching YC, Ching KY, Chuah CH, Abdullah LC
    Polymers (Basel), 2017 Apr 29;9(5).
    PMID: 30970839 DOI: 10.3390/polym9050160
    Extensive employment of biomaterials in the areas of biomedical and microbiological applications is considered to be of prime importance. As expected, oil based polymer materials were gradually replaced by natural or synthetic biopolymers due to their well-known intrinsic characteristics such as biodegradability, non-toxicity and biocompatibility. Literature on this subject was found to be expanding, especially in the areas of biomedical and microbiological applications. Introduction of porosity into a biomaterial broadens the scope of applications. In addition, increased porosity can have a beneficial effect for the applications which exploit their exceptional ability of loading, retaining and releasing of fluids. Different applications require a unique set of pore characteristics in the biopolymer matrix. Various pore morphologies have different characteristics and contribute different performances to the biopolymer matrix. Fabrication methods for bio-based porous materials more related to the choice of material. By choosing the appropriate combination of fabrication technique and biomaterial employment, one can obtain tunable pore characteristic to fulfill the requirements of desired application. In our previous review, we described the literature related to biopolymers and fabrication techniques of porous materials. This paper we will focus on the biomedical and microbiological applications of bio-based porous materials.
    Matched MeSH terms: Biocompatible Materials
  4. S E, G A, A F I, P S G, Y LT
    Environ Res, 2021 06;197:111177.
    PMID: 33864792 DOI: 10.1016/j.envres.2021.111177
    Membrane technology, especially nanofiltration (NF) has great attention to provide an imperative solution for water issues. The membrane is considered to be the heart in the separation plant. Understanding the membrane characteristics could allow predicting and optimizing the membrane performance namely flux, rejection and reduced fouling. The membrane development using biomaterials and nanomaterials provides a remarkable opportunity in the water application. This review focuses on the membrane characteristics of biomaterials and nanomaterials based nanofiltration. In this review, recent researches based on biomaterials and nanomaterials loaded membrane for salt rejection have been analyzed. Membrane fouling depends on the membrane characteristics and this review defined fouling as a ubiquitous bottleneck challenge that hampers the NF blooming applications. Fouling mitigation strategies via membrane modification using biomaterial (chitosan, curcumin and vanillin) and various other nanomaterials are critically reviewed. This review also highlights the membrane cleaning and focuses on concentrates disposal methods with zero liquid discharge system for resource recovery. Finally, the conclusion and future prospects of membrane technology are discussed. From this current review, it is apparent that the biomaterial and various other nanomaterials acquire exclusive properties that facilitate membrane advancement with improved capability for water treatment. Regardless of membrane material developments, still exist considerable difficulties in membrane commercialization. Thus, additional studies related to this field are needed to produce membranes with better performance for large‒scale applications.
    Matched MeSH terms: Biocompatible Materials
  5. Isa, Z.M., Hobkirk, J.A.
    Ann Dent, 2000;7(1):-.
    MyJurnal
    Currently many dental implant systems with varied and numerous components are available commercially, and with new implant systems and designs emerging, it is essential that the user understands that any system selected should be based on sound scientific principles and capable of osseoil!tegration. This has been defined in many different ways, with biomaterial, biological and biomechanical factors being the main considerations. The final restoration is based on both biological tissue and mechanical components. As the success of osseointegration is based on the clinical outcome, clinicians must ensure that the stresses that the superstructure, implant, and surrounding bone are subjected to are within the tolerable limits of the various components, even though the degree of tolerance has not yet been fully defined.
    Matched MeSH terms: Biocompatible Materials
  6. Meor Yusoff Meor Sulaiman, Masliana Muslimin
    MyJurnal
    A process to produce calcium phosphate biomaterial was done using an organic based diethylhexyl phosphoric acid (DEHPA) as its starting material. The gel obtained from this reaction was used to study calcium phosphate transformation using in-situ XRD with temperature ranges from room temperature to 1300 o C. The results obtained from this analysis show the following phase transformation sequence gel > β-Ca2P2O7 > β-TCP + HA > α-TCP + HA. β-Ca2P2O7 was formed at 400 o C and the sample when heated up to 1000 o C, peaks of β- TCP and HA appeared showing the transformation of the β-Ca2P2O7 phase. When the sample was heated up further to 1200 o C, β-TCP transformed into α-TCP.
    Matched MeSH terms: Biocompatible Materials
  7. Ahmady A, Abu Samah NH
    Int J Pharm, 2021 Oct 25;608:121037.
    PMID: 34438009 DOI: 10.1016/j.ijpharm.2021.121037
    Bioadhesive polymers offer versatility to medical and pharmaceutical inventions. The incorporation of such materials to conventional dosage forms or medical devices may confer or improve the adhesivity of the bioadhesive systems, subsequently prolonging their residence time at the site of absorption or action and providing sustained release of actives with improved bioavailability and therapeutic outcomes. For decades, much focus has been put on scientific works to replace synthetic polymers with biopolymers with desirable functional properties. Gelatine has been considered one of the most promising biopolymers. Despite its biodegradability, biocompatibility and unique biological properties, gelatine exhibits poor mechanical and adhesive properties, limiting its end-use applications. The chemical modification and blending of gelatine with other biomaterials are strategies proposed to improve its bioadhesivity. Here we discuss the classical approaches involving a variety of polymer blends and composite systems containing gelatine, and gelatine modifications via thiolation, methacrylation, catechol conjugation, amination and other newly devised strategies. We highlight several of the latest studies on these strategies and their relevant findings.
    Matched MeSH terms: Biocompatible Materials
  8. Low SS, Yew M, Lim CN, Chai WS, Low LE, Manickam S, et al.
    Ultrason Sonochem, 2022 Jan;82:105887.
    PMID: 34954629 DOI: 10.1016/j.ultsonch.2021.105887
    Ultrasound (US) demonstrates remarkable potential in synthesising nanomaterials, particularly nanobiomaterials targeted towards biomedical applications. This review briefly introduces existing top-down and bottom-up approaches for nanomaterials synthesis and their corresponding synthesis mechanisms, followed by the expounding of US-driven nanomaterials synthesis. Subsequently, the pros and cons of sono-nanotechnology and its advances in the synthesis of nanobiomaterials are drawn based on recent works. US-synthesised nanobiomaterials have improved properties and performance over conventional synthesis methods and most essentially eliminate the need for harsh and expensive chemicals. The sonoproduction of different classes and types of nanobiomaterials such as metal and superparamagnetic nanoparticles (NPs), lipid- and carbohydrate-based NPs, protein microspheres, microgels and other nanocomposites are broadly categorised based on the physical and/or chemical effects induced by US. This review ends on a good note and recognises US-driven synthesis as a pragmatic solution to satisfy the growing demand for nanobiomaterials, nonetheless some technical challenges are highlighted.
    Matched MeSH terms: Biocompatible Materials
  9. Hild F, Nguyen NT, Deng E, Katrib J, Dimitrakis G, Lau PL, et al.
    Macromol Rapid Commun, 2016 Aug;37(15):1295-9.
    PMID: 27315130 DOI: 10.1002/marc.201600149
    The use of dielectric property measurements to define specific trends in the molecular structures of poly(caprolactone) containing star polymers and/or the interbatch repeatability of the synthetic procedures used to generate them is demonstrated. The magnitude of the dielectric property value is shown to accurately reflect: (a) the number of functional groups within a series of materials with similar molecular size when no additional intermolecular order is present in the medium, (b) the polymer molecular size for a series of materials containing a fixed core material and so functional group number, and/or (c) the batch to batch repeatability of the synthesis method. The dielectric measurements are validated by comparison to spectroscopic/chromatographic data.
    Matched MeSH terms: Biocompatible Materials/chemical synthesis*
  10. Hazmi AJ, Zuki AB, Noordin MM, Jalila A, Norimah Y
    Med J Malaysia, 2008 Jul;63 Suppl A:93-4.
    PMID: 19025000
    This study was conducted based on the hypothesis that mineral and physicochemical properties of cockle shells similarly resemble the properties of corals (Porites sp.). Hence, the mineral and physicochemical evaluations of cockle shells were conducted to support the aforementioned hypothesis. The results indicated that cockle shells and coral exoskeleton shared similar mineral and physicochemical properties.
    Matched MeSH terms: Biocompatible Materials/chemistry
  11. Mel M, Sopyan I, Nor YA
    Med J Malaysia, 2008 Jul;63 Suppl A:18-20.
    PMID: 19024963
    Tricalcium phosphate ceramic microcarrier has been developed and introduced to a new possibility for the culture of anchorage dependent animal cells of DF1. It was observed that the number of attached cells was increased with shorter time for both spinner vessel and stirred tank (ST) bioreactor. For those bioreactors, the total viable cell number that had been obtained is about 1.2 x 10(5) cell/ml.
    Matched MeSH terms: Biocompatible Materials*
  12. Zarina O, Radzali O
    Med J Malaysia, 2004 May;59 Suppl B:160-1.
    PMID: 15468867
    Hydroxyapatite powder was mechanochemically synthesized from calcium pyrophosphate (Ca2P2O7) and calcium carbonate (CaCO3) using a solid-state reaction. The two powders were mixed in distilled water, milled for 8 hours, dried and calcined at 1100 degrees C for 1 hour. The phase(s) formed was analyzed by x-ray diffraction (XRD). It was found that hydroxyapatite was not the only one formed. This result will be used as the starting point to produce a single-phase hydroxyapatite in terms of excess hydroxyl group in a mechanochemical reaction.
    Matched MeSH terms: Biocompatible Materials/chemical synthesis*
  13. Azlina A, Samsudin AR
    Med J Malaysia, 2004 May;59 Suppl B:166-7.
    PMID: 15468870
    In Malaysia, the field of genomics in toxicology is still in infancy. The purpose of this study is to focus on the use of toxicogenomics for determination of gene expressions changes in cultured human fibroblast cells treated with genotoxicology free biomaterial (using Ames test), a locally produced hyroxyapatite. Dose and time response is similar to Ames test with time interval up to 21 days. mRNA is extracted, followed with RT-PCR and polyacrilamide gel electrophoresis. Changes of the gene expressions compared to the non-treated fibroblast mRNA would suggest some gene interactions in the molecule level associated with the exposure of the fibroblast cell line to the biomaterials. Further analysis (cloning & sequencing) shall be carried out to investigate the genes involved as simple changes might not signified toxicity.
    Matched MeSH terms: Biocompatible Materials/toxicity*
  14. Khalid K
    Med J Malaysia, 2004 May;59 Suppl B:133-4.
    PMID: 15468854
    Matched MeSH terms: Biocompatible Materials*
  15. Shah RK, Fahmi MN, Mat AH, Zainal AA
    Med J Malaysia, 2004 May;59 Suppl B:75-6.
    PMID: 15468826
    Hydroxyapatite (HA) has been earmarked as suitable for implantation within the human of its chemical makeup to human bone. In this paper, HA powders were synthesized via the precipitation method where phosphoric acid (H3PO4) was titrated into calcium hydroxide solution [Ca(OH)2]. Two parameters such as temperature and stirring rate were identified as factors that influenced the amount and purity of HA powder. Phase identification of the synthesized powder was done using X-Ray Diffraction (XRD). The results show that HA phase can be synthesized from this titration process of Ca(OH)2 and H3PO4 with yield amount of HA powder around 45 - 61 grams but with less than hundred percent purity. In order to study the effect of heat treatment to HA crystals structure, HA powder was calcined at 850 degrees C for 2 hours. It's found that the degree of crystallinity increases after calcination because of lattice expansion when the materials were heated at higher temperature
    Matched MeSH terms: Biocompatible Materials/chemical synthesis*
  16. Nik Mohd Polo Kinin NM, Wan Mohd Arif WI, Zainal Arifm A
    Med J Malaysia, 2004 May;59 Suppl B:23-4.
    PMID: 15468800
    The appearance of dental porcelains is comparable to natural teeth. This study discusses the effect of Y2O3 addition to the fluorescent property of dental porcelains. The composition of dental porcelains contained Y2O3 as the fluorescent agent and base frit. The combinations of Y2O3 added consist of a series with 0.5, 1.0, 1.5, 2.0 and 2.5 wt% respectively, based on the total composition. In the extreme condition, fluorescent agents are added from 5.0 up to 10.0 wt%. In order to enhance the fluorescent property of dental porcelains, an opacifiying agent, cerium oxide (CeO2) was also added to dental porcelains composition. The fluorescent property was determined using Spectroline EF-1400C/F that emits 240 nm wavelength ultraviolet light. The microstructure was examined by Scanning Electron Microscope (SEM). The result shows that, the fluorescent properties displayed are similar to natural teeth when subjected to ultraviolet light. SEM micrograph was able to show the fluorescent agent dispersed in glass phase. Increasing additions of Y2O3 gave the fluorescent properties near to natural teeth.
    Matched MeSH terms: Biocompatible Materials*
  17. Sudesh K
    Med J Malaysia, 2004 May;59 Suppl B:55-6.
    PMID: 15468816
    Among the various biomaterials available for tissue engineering and therapeutic applications, microbial polyhydroxyalkanoates (PHAs) offer the most diverse range of thermal and mechanical properties. Of particular interest are the PHAs that contain 4-hydroxybutyrate such as poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB) and poly(4-hydroxybutyrate) [P(4HB)]. These polyesters can only be synthesized by a few types of bacteria, among which Comamonas acidovorans has the most efficient metabolic pathways to channel 4HB monomers. The resulting polyesters are bioabsorbable and are being developed as a new biomaterial for medical applications. By controlling the molar ratio of the monomers, it is possible to produce materials that are as tough and elastic as rubber.
    Matched MeSH terms: Biocompatible Materials*
  18. Konduk BA, Ucisik AH
    Med J Malaysia, 2004 May;59 Suppl B:53-4.
    PMID: 15468815
    The effect of hemodialysis on the mechanical behavior of a cellulosic Hemophane ME-IOH and one Polysulfone type hollow fibers was investigated. Mechanical tests showed that the deformation of polysulfone type of hollow fibers is entirely different than that of the other dialyser for the samples used and unused in hemodialysis. All the samples exposed to the dialysis showed decreased in ductility. Fracture surface studies proved that there was some alignment on the fracture surface. XRD and DSC experiments revealed structural changes had occurred.
    Matched MeSH terms: Biocompatible Materials*
  19. Raouf AA, Samudin AR, Samian R, Akool K, Abdullah N
    Med J Malaysia, 2004 May;59 Suppl B:49-50.
    PMID: 15468813
    This study was designed to investigate the surface properties especially surface porosity of polyhydroxybutyrate (PHB) using scanning electron microscopy. PHB granules were sprinkled on the double-sided sticky tape attached on a SEM aluminium stub and sputtered with gold(10nm thickness) in a Polaron SC515 Coater, following which the samples were placed into the SEM specimen chamber for viewing and recording. Scanning electron micrographs with different magnification of PHB surface revealed multiple pores with different sizes.
    Matched MeSH terms: Biocompatible Materials/analysis*
  20. Mohamed MH
    Med J Malaysia, 2004 May;59 Suppl B:19-20.
    PMID: 15468798
    One of the emerging technologies in the area of plasma processing is plasma immersion ion implantation (PSII). The paper addresses the merits offered by the PSII technique especially in the area of biomaterial processing. Worldwide development status as well as the drive towards commercial applications is elaborated in an attempt to draw the attention to the importance of the process for Malaysia as well as south East Asia.
    Matched MeSH terms: Biocompatible Materials*
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