Displaying publications 21 - 40 of 533 in total

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  1. Ahmad Munir Che Muhamed, Thompson, Martin William
    Movement Health & Exercise, 2012;1(1):11-23.
    MyJurnal
    The combined metabolic and thermoregulatory demands experienced during exercise in the heat impose an exceptional stress on the circulatory system. To date, much of what is known about circulatory stress during exercise in the heat has focused on primarily dry environment (~ 40% rh)
    with limited studies carried in higher humidity (> 60% rh) conditions. This study was designed to investigate the influence of humid condition on circulatory responses during prolonged intense running exercise among elite runners. On separate days, 11 male elite runners ran for 60 minutes at
    an intensity of 70% max across three different humidity levels of HH (71% rh), NH (43% rh) and LH (26.2% rh) with the ambient temperature set at 300C. Thermal stress was found to increase during exercise in the HH condition as both Tre and Tsk steadily rise across time. Circulatory stress markedly increased during exercise in higher humidity levels. Heart rate was significantly higher in the HH condition with its level increasing to 92% of HRmax. The upwards drift in HR was significantly higher in HH within the last ten minutes of exercise. Contrary, stroke volume recorded a
    steady decline during exercise with a significantly lower SV in the HH as compared with the NH and LH. Results implicate rising humidity level will impose greater circulatory stress during prolonged intense exercise. The consequence from this circulatory stress will result in limited ability for an athlete to sustain his exercise capacity when HR reaches maximal level.
    Matched MeSH terms: Environment
  2. Ahmad N, Shah SA, Abdul Gafor AH, Abdul Murad NA, Kamaruddin MA, Abd Jalal N, et al.
    Diabet Med, 2020 11;37(11):1890-1901.
    PMID: 32012348 DOI: 10.1111/dme.14257
    AIM: To examine the possible gene-environment interactions between 32 single nucleotide polymorphisms and environmental factors that could modify the probability of chronic kidney disease.

    METHODS: A case-control study was conducted involving 600 people with type 2 diabetes (300 chronic kidney disease cases, 300 controls) who participated in The Malaysian Cohort project. Retrospective subanalysis was performed on the chronic kidney disease cases to assess chronic kidney disease progression from the recruitment phase. We genotyped 32 single nucleotide polymorphisms using mass spectrometry. The probability of chronic kidney disease and predicted rate of newly detected chronic kidney disease progression were estimated from the significant gene-environment interaction analyses.

    RESULTS: Four single nucleotide polymorphisms (eNOS rs2070744, PPARGC1A rs8192678, KCNQ1 rs2237895 and KCNQ1 rs2283228) and five environmental factors (age, sex, smoking, waist circumference and HDL) were significantly associated with chronic kidney disease. Gene-environment interaction analyses revealed significant probabilities of chronic kidney disease for sex (PPARGC1A rs8192678), smoking (eNOS rs2070744, PPARGC1A rs8192678 and KCNQ1 rs2237895), waist circumference (eNOS rs2070744, PPARGC1A rs8192678, KCNQ1 rs2237895 and KCNQ1 rs2283228) and HDL (eNOS rs2070744 and PPARGC1A rs8192678). Subanalysis indicated that the rate of newly detected chronic kidney disease progression was 133 cases per 1000 person-years (95% CI: 115, 153), with a mean follow-up period of 4.78 (SD 0.73) years. There was a significant predicted rate of newly detected chronic kidney disease progression in gene-environment interactions between KCNQ1 rs2283228 and two environmental factors (sex and BMI).

    CONCLUSIONS: Our findings suggest that the gene-environment interactions of eNOS rs2070744, PPARGC1A rs8192678, KCNQ1 rs2237895 and KCNQ1 rs2283228 with specific environmental factors could modify the probability for chronic kidney disease.

    Matched MeSH terms: Gene-Environment Interaction
  3. Ahmad, Z., Rohana, H., Md Tahir, P.
    ASM Science Journal, 2013;7(1):37-58.
    MyJurnal
    This study investigated the thermal properties of three room temperature curing adhesives containing nano particles which were thixotropic and shear thinning which allowed injection into overhead holes when exposed to different environmental conditions. Viscosity and shear stress of the adhesives were measured as a function of shear rate. The thermal behaviour of the adhesives were measured using dynamic mechanical thermal anylisis following exposures to different temperatures and humidities which included temperatures of 20 degrees Celcius, 30 degrees Celcius and 50 degrees Celcius, relative humidities of 65% RH, 75% RH 95% RH soaked in water at 20 degrees Celcius and placed in the oven at 50 degrees Celcius. The dynamic thermal properties reported include storage and loss modulus, the loss tangent and the glass transition temperature ( Tg ). For nano- and micro-particles filled adhesives, the Tg increased with the temperature increase, even though the adhesives was subjected to high humidity and this was due to further cross-linking. The results showed that room temperature cured epoxies were only partially cured at room temperature.
    Matched MeSH terms: Environment
  4. Ahmed F, Rafii MY, Ismail MR, Juraimi AS, Rahim HA, Asfaliza R, et al.
    Biomed Res Int, 2013;2013:963525.
    PMID: 23484164 DOI: 10.1155/2013/963525
    Submergence or flood is one of the major harmful abiotic stresses in the low-lying countries and crop losses due to waterlogging are considerably high. Plant breeding techniques, conventional or genetic engineering, might be an effective and economic way of developing crops to grow successfully in waterlogged condition. Marker assisted selection (MAS) is a new and more effective approach which can identify genomic regions of crops under stress, which could not be done previously. The discovery of comprehensive molecular linkage maps enables us to do the pyramiding of desirable traits to improve in submergence tolerance through MAS. However, because of genetic and environmental interaction, too many genes encoding a trait, and using undesirable populations the mapping of QTL was hampered to ensure proper growth and yield under waterlogged conditions Steady advances in the field of genomics and proteomics over the years will be helpful to increase the breeding programs which will help to accomplish a significant progress in the field crop variety development and also improvement in near future. Waterlogging response of soybean and major cereal crops, as rice, wheat, barley, and maize and discovery of QTL related with tolerance of waterlogging, development of resistant variety, and, in addition, future prospects have also been discussed.
    Matched MeSH terms: Gene-Environment Interaction*
  5. Airiken M, Zhang F, Chan NW, Kung HT
    Environ Sci Pollut Res Int, 2022 Feb;29(8):12282-12299.
    PMID: 34564811 DOI: 10.1007/s11356-021-16579-3
    In the current context of rapid development and urbanization, land use and land cover (LULC) types have undergone unprecedented changes, globally and nationally, leading to significant effects on the surrounding ecological environment quality (EEQ). The urban agglomeration in North Slope of Tianshan (UANST) is in the core area of the Silk Road Economic Belt of China. This area has experienced rapid development and urbanization with equally rapid LULC changes which affect the EEQ. Hence, this study quantified and assessed the spatial-temporal changes of LULC on the UANST from 2001 to 2018 based on remote sensing analysis. Combining five remote sensing ecological factors (WET, NDVI, IBI, TVDI, LST) that met the pressure-state-response(PSR) framework, the spatial-temporal distribution characteristics of EEQ were evaluated by synthesizing a new Remote Sensing Ecological Index (RSEI), with the interaction between land use change and EEQ subsequently analyzed. The results showed that LULC change dominated EEQ change on the UANST: (1) From 2001 to 2018, the temporal and spatial pattern of the landscape on the UANST has undergone tremendous changes. The main types of LULC in the UANST are Barren land and Grassland. (2) During the study period, RSEI values in the study area were all lower than 0.5 and were at the [good] levels, reaching 0.31, 0.213, 0.362, and 0346, respectively. In terms of time and space, the overall EEQ on the UANST experienced three stages of decline-rise-decrease. (3) The estimated changes in RSEI were highly related to the changes of LULC. During the period 2001 to 2018, the RSEI value of cropland showed a trend of gradual increase. However, the rest of the LULC type's RSEI values behave differently at different times. As the UANST is the core area of Xinjiang's urbanization and economic development, understanding and balancing the relationship between LULC and EEQ in the context of urbanization is of practical application in the planning and realization of sustainable ecological, environmental, urban, and social development in the UANST.
    Matched MeSH terms: Environment; Environmental Monitoring*
  6. Aisyah HA, Paridah MT, Sapuan SM, Ilyas RA, Khalina A, Nurazzi NM, et al.
    Polymers (Basel), 2021 Feb 02;13(3).
    PMID: 33540731 DOI: 10.3390/polym13030471
    Over the last decade, the progressive application of natural fibres in polymer composites has had a major effect in alleviating environmental impacts. Recently, there is a growing interest in the development of green materials in a woven form by utilising natural fibres from lignocellulosic materials for many applications such as structural, non-structural composites, household utilities, automobile parts, aerospace components, flooring, and ballistic materials. Woven materials are one of the most promising materials for substituting or hybridising with synthetic polymeric materials in the production of natural fibre polymer composites (NFPCs). These woven materials are flexible, able to be tailored to the specific needs and have better mechanical properties due to their weaving structures. Seeing that the potential advantages of woven materials in the fabrication of NFPC, this paper presents a detailed review of studies related to woven materials. A variety of factors that influence the properties of the resultant woven NFRC such as yarn characteristics, fabric properties as well as manufacturing parameters were discussed. Past and current research efforts on the development of woven NFPCs from various polymer matrices including polypropylene, polylactic acid, epoxy and polyester and the properties of the resultant composites were also compiled. Last but not least, the applications, challenges, and prospects in the field also were highlighted.
    Matched MeSH terms: Environment
  7. Al-Naggar RA, Al-Dubai SA, Al-Naggar TH, Chen R, Al-Jashamy K
    Asian Pac J Cancer Prev, 2011;12(3):619-24.
    PMID: 21627354
    OBJECTIVE: The objectives were to determine the prevalence and associated factors for smoking among university students in Malaysia.
    METHODOLOGY: A cross-sectional study was conducted among 199 students in the period from December of academic year 2009 until April of academic year 2010 in Management and Science University (MSU), Shah Alam, Selangor, Malaysia. The questionnaire was distributed randomly to all faculties of MSU by choosing one of every 3 lecture rooms, as well as the library and cafeterias of the campus randomly by choosing one from every 3 tables. Questions concerned socio-demographic variables, knowledge, attitudes and practice toward smoking. Participant's consent was obtained and ethical approval was provided by the ethics committee of the University. Data entry and analysis were performed using descriptive statistics, chi square test, Student t- test and logistic multiple regression with the SPSS version 13.0, statistical significance being concluded at p < 0.05.
    RESULTS: About one third of students were smokers (29%). The most important reason of smoking was stress (20%) followed by 'influenced by friends' (16 %). Prevalence of smoking was significantly higher among male and those in advanced semesters (p = >0.001, p = 0.047). Smokers had low level of knowledge (p < 0.05), had wrong beliefs on smoking (p < 0.05), and negative attitude toward tobacco control policies compared to non smokers (p < 0.05). On multiple logistic regression, significant predictors of smoking in the model were gender (p = 0.025), age (p = 0.037), semester of study (p = 0.025) and attitude toward smoking (p < 0.001).
    CONCLUSION: This study found that 29% of university students were smokers. Males and students in advanced semesters were more likely to smoke. The results provide baseline data to develop an anti-smoking program to limit smoking in the university by implementing policies against smoking.
    Matched MeSH terms: Social Environment
  8. Al-Naggar RA, Bobryshev YV
    Asian Pac J Cancer Prev, 2012;13(11):5627-32.
    PMID: 23317228
    BACKGROUND: The aim of the study was to determine the prevalence of shisha smoking and associated factors among medical students in Malaysia.

    MATERIALS AND METHODS: A cross-sectional study was conducted at the Management and Science University from December 2011 until March 2012. The questionnaire consisted of five sections including socio-demographic, social environment, knowledge about shisha, psychosocial factors, and personal shisha smoking behavior. Obtained data were analyzed using Statistical Package for the Social Sciences (SPSS 13). T-test was used to determine the relationships between shisha smoking and socio-demographic characteristic.

    RESULTS: A total number of 300 medical students participated in this study. Mean age was 22.5±2.5 years. The majority were female, Malay, single, from urban areas (67%, 54%, 97%, 73%; respectively). The prevalence of shisha smoking among medical students was found to be 20%. The study revealed that many students believed that shisha does not contains nicotine, carbon monoxide, does not lead to lung cancer, dental problems and does not lead to cardiovascular diseases (25%, 20.7%, 22.3%, 29%, 26.7%; respectively). Age and sex were found to be significantly associated with smoking shisha status among medical students (p=0.029, p<0.001; respectively). Furthermore, having parents, siblings and friends smokers of shisha were found to be significantly associated with shisha smoking status (p<0.001, p<0.001, p<0.001; respectively). Furthermore, family problems, problems with friends, financial problems and university life were found to significantly associated with shisha smoking status among medical students (p<0.001, p=0.002, p<0.001, p=0.002; respectively).

    CONCLUSIONS: There is a high prevalence of shisha smoking and a poor knowledge about its impact on health among medical students. More attention is needed to focus on medical education in this regard. The policies that are currently employed in order to reduce the cigarettes smoking should be applied to shisha smoking and shisha products.
    Matched MeSH terms: Social Environment
  9. Al-Samman AM, Rahman TA, Azmi MH, Hindia MN, Khan I, Hanafi E
    PLoS One, 2016 Sep 21;11(9):e0163034.
    PMID: 27654703 DOI: 10.1371/journal.pone.0163034
    This paper presents an experimental characterization of millimeter-wave (mm-wave) channels in the 6.5 GHz, 10.5 GHz, 15 GHz, 19 GHz, 28 GHz and 38 GHz frequency bands in an indoor corridor environment. More than 4,000 power delay profiles were measured across the bands using an omnidirectional transmitter antenna and a highly directional horn receiver antenna for both co- and cross-polarized antenna configurations. This paper develops a new path-loss model to account for the frequency attenuation with distance, which we term the frequency attenuation (FA) path-loss model and introduce a frequency-dependent attenuation factor. The large-scale path loss was characterized based on both new and well-known path-loss models. A general and less complex method is also proposed to estimate the cross-polarization discrimination (XPD) factor of close-in reference distance with the XPD (CIX) and ABG with the XPD (ABGX) path-loss models to avoid the computational complexity of minimum mean square error (MMSE) approach. Moreover, small-scale parameters such as root mean square (RMS) delay spread, mean excess (MN-EX) delay, dispersion factors and maximum excess (MAX-EX) delay parameters were used to characterize the multipath channel dispersion. Multiple statistical distributions for RMS delay spread were also investigated. The results show that our proposed models are simpler and more physically-based than other well-known models. The path-loss exponents for all studied models are smaller than that of the free-space model by values in the range of 0.1 to 1.4 for all measured frequencies. The RMS delay spread values varied between 0.2 ns and 13.8 ns, and the dispersion factor values were less than 1 for all measured frequencies. The exponential and Weibull probability distribution models best fit the RMS delay spread empirical distribution for all of the measured frequencies in all scenarios.
    Matched MeSH terms: Environment
  10. Alam A, Azam M, Abdullah AB, Malik IA, Khan A, Hamzah TA, et al.
    Environ Sci Pollut Res Int, 2015 Jun;22(11):8392-404.
    PMID: 25537287 DOI: 10.1007/s11356-014-3982-5
    Environmental quality indicators are crucial for responsive and cost-effective policies. The objective of the study is to examine the relationship between environmental quality indicators and financial development in Malaysia. For this purpose, the number of environmental quality indicators has been used, i.e., air pollution measured by carbon dioxide emissions, population density per square kilometer of land area, agricultural production measured by cereal production and livestock production, and energy resources considered by energy use and fossil fuel energy consumption, which placed an impact on the financial development of the country. The study used four main financial indicators, i.e., broad money supply (M2), domestic credit provided by the financial sector (DCFS), domestic credit to the private sector (DCPC), and inflation (CPI), which each financial indicator separately estimated with the environmental quality indicators, over a period of 1975-2013. The study used the generalized method of moments (GMM) technique to minimize the simultaneity from the model. The results show that carbon dioxide emissions exert the positive correlation with the M2, DCFC, and DCPC, while there is a negative correlation with the CPI. However, these results have been evaporated from the GMM estimates, where carbon emissions have no significant relationship with any of the four financial indicators in Malaysia. The GMM results show that population density has a negative relationship with the all four financial indicators; however, in case of M2, this relationship is insignificant to explain their result. Cereal production has a positive relationship with the DCPC, while there is a negative relationship with the CPI. Livestock production exerts the positive relationship with the all four financial indicators; however, this relationship with the CPI has a more elastic relationship, while the remaining relationship is less elastic with the three financial indicators in a country. Energy resources comprise energy use and fossil fuel energy consumption, both have distinct results with the financial indicators, as energy demand have a positive and significant relationship with the DCFC, DCPC, and CPI, while fossil fuel energy consumption have a negative relationship with these three financial indicators. The results of the study are of value to both environmentalists and policy makers.
    Matched MeSH terms: Environment*
  11. Alara OR, Abdurahman NH
    J Food Sci Technol, 2019 Feb;56(2):580-588.
    PMID: 30906015 DOI: 10.1007/s13197-018-3512-4
    Recently, unconventional methods especially microwave-assisted hydrodistillation extraction (MAHE) is being used as an alternative technique for extracting bioactive compounds from plant materials due to its advantages over conventional methods such as Soxhlet extraction (SE). In this study, bioactive compounds were extracted from Vernonia cinerea leaf using both MAHE and SE methods. In addition, the kinetic study of MAHE and SE methods were carried out using first- and second-order kinetic models. The results obtained showed that MAHE can extract higher yield of bioactive compounds from V. cinerea leaf in a shorter time and reduced used of extracting solvent compared with SE method. Based on the results obtained, second-order kinetic models can actually describe the extraction of bioactive compounds from V. cinerea leaf through MAHE with extraction rate coefficient of 0.1172 L/gmin and extraction capacity of 1.0547 L/g as compared to SE with 0.0157 L/gmin and 1.1626 L/g of extraction rate coefficient and extraction capacity, respectively. The gas chromatography-mass spectrometry analysis of the oil showed the presence of numerous heavy fractions in the oil obtained through MAHE as compared with the SE method. Moreover, the electric consumption and environmental impacts analysis of the oil suggested that MAHE can be a suitable green technique for extracting bioactive compounds from V. cinerea leaf.
    Matched MeSH terms: Environment
  12. Ali Ghahraei, Nurul Amziah Md Yunus, Izhal Abdul Halin, Nasri Sulaiman
    MyJurnal
    Controlled humidity environment is of significance in many scientific researches and experiments. In most laboratory-scale atmospheric chambers, an electrical temperature-based control system is used to adjust humidity. Since these chambers are not affordable in every laboratory, other low cost chambers using nitrogen gas or silica gel are used to adjust humidity. In this paper, a mechanism was developed to control the relative humidity in closed lab-scale chambers. Humidification is done by spraying water through a blower fan while de-humidification is by pumping air through silica gel as well as nitrogen gas injection. A Mamdani type fuzzy controller was designed to control the components and relative humidity. The results show the proposed system and controller can adjust and maintain relative humidity from 41% to 100% with maximum overshoot of 1% and the maximum range of error of steady state of 1.2 %.
    Matched MeSH terms: Environment, Controlled
  13. Ali Q, Parveen S, Yaacob H, Zaini Z, Sarbini NA
    Environ Sci Pollut Res Int, 2021 Oct;28(40):56199-56218.
    PMID: 34050516 DOI: 10.1007/s11356-021-14612-z
    Despite a profound evidence of the human unsustainable behaviours' impact on the environment, stark disparities prevail on this narrative especially in the context of the current epidemiological situation ushered by the COVID-19. The ongoing pandemic is a global public health concern due to its sagacious impacts on environmental sustainability, social responsibility and people's quality of life. This study primarily focuses on analysing the impact of COVID-19 (COV) on the environmental awareness (EA), sustainable consumption (SC) and social responsibility (SR). Additionally, we aspire to investigate the impact of demographics of generations and religion on the proposed nexus in this study. The data was collected from 700 participants of different age groups and religious backgrounds in Malaysia, and structural equation modelling (SEM) was used to analyse this data and test the hypotheses. The findings indicate that COVID-19 has a significantly positive impact on EA, SC and SR, and the generations and religiosity moderate the relationship between COVID-19 and its impact on sustainable behaviours. This study contributes to analyse the difference in the perception of EA, SC and SR among the people that eventually will stimulate the scientific reasoning among the governments, policymakers and scientists to develop a holistic framework to combat unprecedented event such as COVID-19 and ensure the authentication of sustainable environment and exceptional quality of life. The policymakers in Malaysia may use the findings of this study to inspect the social and environmental aspects of the people during the transformation events.
    Matched MeSH terms: Environment
  14. Ambu, Stephen, Chu, Wan-Loy, Mak, Joon-Wah, Wong, Shew-Fung, Chan, Li-Li, Wong, Siew-Tung
    MyJurnal
    Malaysia has good environmental laws to protect the outdoor environment and public health. However there are no laws governing indoor air quality (IAQ) and the knowledge among the public about its importance is also lacking. Environmental professionals think it is not a priority and this influences the policy decisions in the country. Therefore there is a need to create awareness by way of research, education and other promotional activities. What is much needed at this time is the establishment of standards for the conduct of risk assessment studies. To establish standards we need reliable data which can be used to develop appropriate guidelines for the purpose of mitigation and adaptation programmes. IAQ can have significant influence on health resulting in drop in productivity and economy of a country. It has been estimated that in the US, building related illnesses (BRI) symptoms have a relationship with decrease (3 to 5%) in work performance in an affected population resulting in an annual loss of US$60 billion in revenue. However, based on efficient management programmes they have also projected that the potential annual savings can be in the region of US$10 to 30 billion. This establishes that fact that good management programmes based on efficient guidelines is of economic value to a country and wellbeing of the population. The IMU has embarked on a research programme to collect the much-needed data for the framing of a good IAQ guideline for Malaysia.
    Matched MeSH terms: Environment
  15. Ambu, Stephen
    MyJurnal
    Climate change is a product of human actions. The extreme events such as flash floods, droughts, heat waves, earthquakes, volcano eruptions and tsunamis seen in the world today are the result of indiscriminate human intrusion into the environment. Vulnerable countries and populations are the most affected by these climatic events. This places a burden on the resources of these countries. The Kyoto Protocol is a milestone in environmental management and the impetus created by it must be maintained by carrying out the much needed research into appropriate mitigating measures that will alleviate the climate
    change impact globally. A paradigm shift is needed in addressing the associated risks on human health to assess socioeconomic determinants and the related impacts on disease burden. Some wealthy nations emphasize economic benefits and downplay sustainability goals, health and equality. However the rising cost of energy is beginning to influence their outlook towards this issue. The implications on economics, human health and wellbeing are implicit. In order to strike a balance between disadvantaged and privileged nations, many
    international agencies are spearheading various research agenda to improve adaptation programmes on effects of changing climatic conditions on health. Malaysia too has such programmes initiated under its 5-year development plans.
    Matched MeSH terms: Environment
  16. Amini H, Farzaneh B, Azimifar F, Sarhan AAD
    ISA Trans, 2016 Sep;64:293-302.
    PMID: 27329852 DOI: 10.1016/j.isatra.2016.05.006
    This paper establishes a novel control strategy for a nonlinear bilateral macro-micro teleoperation system with time delay. Besides position and velocity signals, force signals are additionally utilized in the control scheme. This modification significantly improves the poor transparency during contact with the environment. To eliminate external force measurement, a force estimation algorithm is proposed for the master and slave robots. The closed loop stability of the nonlinear micro-micro teleoperation system with the proposed control scheme is investigated employing the Lyapunov theory. Consequently, the experimental results verify the efficiency of the new control scheme in free motion and during collision between the slave robot and the environment of slave robot with environment, and the efficiency of the force estimation algorithm.
    Matched MeSH terms: Environment
  17. Amiruzehan Kassim, Raja Nur Adilah Raja Abdul Rahman, Mohd Faizal Hafez Hidayat, Budi Aslinie Md Sabri
    Compendium of Oral Science, 2016;3(1):25-32.
    MyJurnal
    Objectives: To assess the prevalence of handedness and its impact on the perceived difficulty in clinical training amongst undergraduate dental students in Malaysia. Materials and Methods: A cross-sectional survey using a self-administered questionnaire was conducted in 5 dental schools around the Klang Valley. Samples consisted of year 4 and year 5 clinical undergraduate dental students. Information on the socio-demographic data, the determination of handedness and assesment of perceived difficulty in carrying out certain clinical procedures were collected. Results: A total sample of 347 participants of which 76.9% were females was obtained. The distribution of year 4 and year 5 students in the sample were equal. Eighty five percent of the samples were right-handed, 9.5% were ambidextrous and 5.5% were left-handed. Statistically significant difference was found between handedness groups for the combined clinical procedures variable: F (2.100), P
    Matched MeSH terms: Environment
  18. Ananthakrishnan AN, Bernstein CN, Iliopoulos D, Macpherson A, Neurath MF, Ali RAR, et al.
    Nat Rev Gastroenterol Hepatol, 2018 Jan;15(1):39-49.
    PMID: 29018271 DOI: 10.1038/nrgastro.2017.136
    A number of environmental factors have been associated with the development of IBD. Alteration of the gut microbiota, or dysbiosis, is closely linked to initiation or progression of IBD, but whether dysbiosis is a primary or secondary event is unclear. Nevertheless, early-life events such as birth, breastfeeding and exposure to antibiotics, as well as later childhood events, are considered potential risk factors for IBD. Air pollution, a consequence of the progressive contamination of the environment by countless compounds, is another factor associated with IBD, as particulate matter or other components can alter the host's mucosal defences and trigger immune responses. Hypoxia associated with high altitude is also a factor under investigation as a potential new trigger of IBD flares. A key issue is how to translate environmental factors into mechanisms of IBD, and systems biology is increasingly recognized as a strategic tool to unravel the molecular alterations leading to IBD. Environmental factors add a substantial level of complexity to the understanding of IBD pathogenesis but also promote the fundamental notion that complex diseases such as IBD require complex therapies that go well beyond the current single-agent treatment approach. This Review describes the current conceptualization, evidence, progress and direction surrounding the association of environmental factors with IBD.
    Matched MeSH terms: Environment*
  19. Ancrenaz M, Gimenez O, Ambu L, Ancrenaz K, Andau P, Goossens B, et al.
    PLoS Biol, 2005 Jan;3(1):e3.
    PMID: 15630475
    Great apes are threatened with extinction, but precise information about the distribution and size of most populations is currently lacking. We conducted orangutan nest counts in the Malaysian state of Sabah (North Borneo), using a combination of ground and helicopter surveys, and provided a way to estimate the current distribution and size of the populations living throughout the entire state. We show that the number of nests detected during aerial surveys is directly related to the estimated true animal density and that a helicopter is an efficient tool to provide robust estimates of orangutan numbers. Our results reveal that with a total estimated population size of about 11,000 individuals, Sabah is one of the main strongholds for orangutans in North Borneo. More than 60% of orangutans living in the state occur outside protected areas, in production forests that have been through several rounds of logging extraction and are still exploited for timber. The role of exploited forests clearly merits further investigation for orangutan conservation in Sabah.
    Matched MeSH terms: Environment*
  20. Ang RP, Tan KA, Talib Mansor A
    J Interpers Violence, 2011 Sep;26(13):2619-34.
    PMID: 21156699 DOI: 10.1177/0886260510388286
    The current study examined normative beliefs about aggression as a mediator between narcissistic exploitativeness and cyberbullying using two Asian adolescent samples from Singapore and Malaysia. Narcissistic exploitativeness was significantly and positively associated with cyberbullying and normative beliefs about aggression and normative beliefs about aggression were significantly and positively associated with cyberbullying. Normative beliefs about aggression were a significant partial mediator in both samples; these beliefs about aggression served as one possible mechanism of action by which narcissistic exploitativeness could exert its influence on cyberbullying. Findings extended previous empirical research by showing that such beliefs can be the mechanism of action not only in offline but also in online contexts and across cultures. Cyberbullying prevention and intervention efforts should include modification of norms and beliefs supportive of the legitimacy and acceptability of cyberbullying.
    Matched MeSH terms: Social Environment
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