Displaying publications 21 - 40 of 264 in total

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  1. The Inclusion of Folic Acid in Weekly Iron-Folic Acid Supplements Confers no Additional Benefit on Anemia Reduction in Nonpregnant Women: A Randomized Controlled Trial in Malaysia
    Samson KLI, Loh SP, Lee SS, Sulistyoningrum DC, Khor GL, Mohd Shariff ZB, et al.
    J Nutr, 2021 Aug 07;151(8):2264-2270.
    PMID: 33978167 DOI: 10.1093/jn/nxab115
    BACKGROUND: Weekly iron-folic acid (IFA) supplements are recommended for all menstruating women in countries where anemia prevalence is ≥20%; however, it is unknown whether the inclusion of folic acid in weekly IFA supplements reduces anemia.

    OBJECTIVES: We examined whether the inclusion of folic acid in weekly IFA supplements conferred any benefit on hemoglobin (Hb) concentration, anemia reduction, or iron status [ferritin and soluble transferrin receptor (sTfR)], over iron alone.

    METHODS: In this secondary analysis of a randomized controlled trial in Malaysia, n = 311 nonpregnant women (18-45 y old) received 60 mg Fe with either 0, 0.4, or 2.8 mg folic acid once-weekly for 16 wk. Fasting blood was collected at baseline and 16 wk. A generalized linear model (normal distribution with identity link) was used to assess Hb concentration at 16 wk (primary outcome).

    RESULTS: At baseline, 84% of women had low folate status (plasma folate  0.05). Baseline plasma folate concentration did not modify the effect of treatment on Hb concentration at 16 wk. Among all women, the risks of anemia [risk ratio (RR): 0.65; 95% CI: 0.45, 0.96; P = 0.03] and iron deficiency based on ferritin (RR: 0.30; 95% CI: 0.20, 0.44; P 

    Matched MeSH terms: Hemoglobins/analysis
  2. Iron overload in anaemia with underlying haemoglobin constant spring in an antenatal mother in primary care
    Thew HZ, Ng CH, Loo CY
    BMJ Case Rep, 2024 Feb 17;17(2).
    PMID: 38367998 DOI: 10.1136/bcr-2023-258526
    This is the case of a gravida 3 para 1 woman in her late 20s with underlying haemoglobin constant spring who visited a healthcare clinic for an antenatal check-up. Towards the end of her second trimester, she experienced lethargy. During her antenatal booking, she was diagnosed with mild asymptomatic anaemia, high serum ferritin, T saturation of 88% and abnormal liver function tests. She was referred to a hospital where an MRI scan revealed over 2 g of iron deposits in her liver, leading to a revised diagnosis of iron overload. Treatment included deferoxamine and expectant management throughout her antenatal period, and her delivery was uncomplicated. While iron deficiency anaemia is common in pregnancy, it is crucial not to overlook iron deposition and the distinction from acute fatty liver during pregnancy to prevent treatment delays.
    Matched MeSH terms: Hemoglobins, Abnormal*
  3. Fulltext Alpha-chain thalassemia and hydrops fetalis in Malaya: report of five cases
    Lie-Injo LE
    Blood, 1962 Nov;20:581-90.
    PMID: 13930509
    Five cases of severe hydrops and erythroblastosis fetalis in association with a large amount of Hb “Bart’s,” all of Chinese origin, are described. The following characteristic clinical and hematologic symptoms were found. There were generalized hydrops, ascites and gross enlargement of the liver. The spleen, however, was not ahvays enlarged. The placenta was large and friable. Severe erythroblastosis of the blood was always found, with reticulocytosis, many target cells and thin cells. The MCV of the red cells was very high. The cells showed an interesting sickling phenomenon. No evidence of isoimmunization was found. In eight parents examined, no abnormal hemoglobin was detected, and alkali-resistant hemoglobin and hemoglobin A2 were not found to be increased. Their blood showed microcytosis of the red cells cxcept in one father and one mother. In this mother, however, the blood was examimied after a blood transfusion. It is thought probable that these were cases of homozygous alpha-chain thalassemia.
    Matched MeSH terms: Hemoglobins*; Hemoglobins, Abnormal*
  4. The differences in hemoglobin levels before and after consuming ambon bananas in students
    Sadiman S, Islamiyati I, Poddar S
    Enferm Clin, 2020 06;30 Suppl 5:115-118.
    PMID: 32713547 DOI: 10.1016/j.enfcli.2019.11.035
    The purpose of this study is to determine whether there are differences in hemoglobin levels before and after consuming ambon bananas in students of Prodi Kebidanan Metro. The specific purpose of this study was to determine hemoglobin levels before consuming ambon bananas, hemoglobin levels after consuming ambon bananas and the differences in hemoglobin levels before and after consuming ambon bananas in female students at Prodi Kebidanan Metro. This research is an intervention research with quasi experiment design with The One Group Pretest - posttest design. The population in this study were students in the first and second grade in Prodi Kebidanan Metro who lived in the dormitory as many as 149 female students. A sample of 49 people will take a portion of the population using simple random sampling technique. Data analysis used dependent sample t tests to test the mean increase in Hb levels before and after consuming ambon bananas. The results showed an average Hb level before consuming bananas at 12.51g/dl and an the average hb level after consuming bananas was 12.89g/dl, so the average increase in Hb levels was 0.39g/dl. The results of the analysis using the t-test dependent test obtained p value=0.000, which means that there are significant differences in Hb levels of students before and after consuming ambon banana.
    Matched MeSH terms: Hemoglobins
  5. Phosphoglucomutase and carbonic anhydrase in West Malaysian aborigines
    Welch QB, Lie-Injo Luan Eng, Bolton JM
    Hum. Hered., 1972;22(1):28-37.
    PMID: 4624781
    Matched MeSH terms: Hemoglobins/analysis; Hemoglobins, Abnormal/analysis
  6. Optical nitrite biosensor based on hemoglobin-immobilized polyacrylate microspheres
    Syamimi Haslan, Lee YH, Goh CT, Ling LT
    Sains Malaysiana, 2018;47:2027-2033.
    Biosensor optik berasaskan hemoglobin (Hb) terpegun pada mikrosfera poli(n-butil akrilat-co-N-akriloksisuksinimida)
    [poli(nBA-NAS)] telah dibangunkan bagi mengesan kepekatan ion nitrit (NO2
    -
    ). Kompleks HEM ferum dalam Hb
    memangkinkan tindak balas penurunan ion NO2
    -
    kepada nitrik oksida (NO) lalu bergabung dengan deoksihemoglobin
    (HbFe2+) membentuk kompleks ferum-nitrosil-hemoglobin (HbFe2+-NO) yang berwarna hijau kekuningan. Spektrofotometer
    pantulan gentian optik digunakan untuk memantau kepekatan ion NO2
    -
    secara kuantitatif berdasarkan perubahan warna
    Hb terpegun pada mikrosfera poliakrilat daripada perang kemerahan ke hijau kekuningan pada panjang gelombang
    pantulan maksimum 668 nm. Pencirian terhadap biosensor nitrit reflektometrik melibatkan ujian kesan pH, kesan
    kepekatan Hb, julat rangsangan linear, kebolehasilan, jangka hayat dan kesan gangguan ion telah dijalankan. Biosensor
    ion NO2
    - optik terbangun memaparkan julat linear dinamik daripada 5 hingga 50 mg mL-1 (R2
    =0.9894) pada pH7.0 dengan
    had pengesanan (LOD) sebanyak 3.3 mg mL-1 dan nilai sisihan piawai relatif (RSD) kebolehasilan biosensor sebanyak
    5.8%. Jangka hayat biosensor optik nitrit tersebut adalah selama 36 hari dan majoriti ion asing yang sering wujud
    bersama ion NO2
    - dalam sampel air semula jadi tidak menunjukkan kesan gangguan yang bererti terhadap penentuan
    ion NO2
    -
    menggunakan biosensor optik terbangun kecuali ion Hg2+, Ag+, Br-
    dan S2-.
    Matched MeSH terms: Hemoglobins
  7. Fulltext Distribution of alpha thalassaemia gene variants in diverse ethnic populations in malaysia: data from the institute for medical research
    Ahmad R, Saleem M, Aloysious NS, Yelumalai P, Mohamed N, Hassan S
    Int J Mol Sci, 2013;14(9):18599-614.
    PMID: 24025420 DOI: 10.3390/ijms140918599
    Alpha thalassaemia is highly prevalent in the plural society of Malaysia and is a public health problem. Haematological and molecular data from 5016 unrelated patients referred from various hospitals to the Institute for Medical Research for α thalassaemia screening from 2007 to 2010 were retrieved. The aims of this retrospective analysis were to describe the distribution of various alpha thalassaemia alleles in different ethnic groups, along with their genotypic interactions, and to illustrate the haematological changes associated with each phenotype. Amongst the patients, 51.2% (n = 2567) were diagnosed with α thalassaemia. Of the 13 α thalassaemia determinants screened, eight different deletions and mutations were demonstrated: three double gene deletions, --(SEA), --(THAI), --(FIL); two single-gene deletions, α-³·⁷ and -α⁴·²; and three non-deletion mutations, Cd59G > A (haemoglobin [Hb] Adana), Cd125T > C (Hb Quong Sze) and Cd142 (Hb Constant Spring). A high incidence of α-³·⁷ deletion was observed in Malays, Indians, Sabahans, Sarawakians and Orang Asli people. However, the --SEA deletion was the most common cause of alpha thalassaemia in Chinese, followed by the α-³·⁷ deletion. As many as 27 genotypic interactions showed 1023 α thalassaemia silent carriers, 196 homozygous α⁺ thalassaemia traits, 973 heterozygous α⁰ thalassaemia carriers and 375 patients with Hb H disease. Statistical analysis showed a significant difference in the distribution of α thalassaemia determinants amongst the various ethnic groups. Hence, the heterogeneous distribution of common determinants indicated that the introduction of an ethnicity-targeted hierarchical α thalassaemia screening approach in this multi-ethnic Malaysian population would be effective.
    Matched MeSH terms: Hemoglobins, Abnormal/genetics
  8. Fulltext Polyphenols in Barringtonia racemosa and their protection against oxidation of LDL, serum and haemoglobin
    Kong KW, Mat-Junit S, Ismail A, Aminudin N, Abdul-Aziz A
    Food Chem, 2014 Mar 1;146:85-93.
    PMID: 24176317 DOI: 10.1016/j.foodchem.2013.09.012
    The polyphenolic profiles and antioxidant activities of the water extracts of Barringtonia racemosa shoots (leaves and stems) were explored. Two methods, freeze drying and air drying, for preparation of the shoots, were also compared. Freeze drying was better as air drying caused 5-41% reduction of polyphenols. Three phenolic acids and three flavonoids were identified, using UHPLC. The descending order of polyphenols in the leaves and stems was gallic acid>ellagic acid>quercetin>protocatechuic acid>rutin>kaempferol. In vitro antioxidant analyses were performed using biological samples. In the LDL oxidation assay, B. racemosa leaf extract (IC50=73.0μg/ml) was better than stem extract (IC50=226μg/ml) at inhibiting the formation of TBARS and lipid hydroperoxides. Similar trends were observed for serum and haemoglobin oxidation. B. racemosa leaf extract was better than its stem extract in delaying the time required to oxidise haemoglobin to methaemoglobin. The high polyphenolic content of B. racemosa shoots could have contributed towards their antioxidative effects.
    Matched MeSH terms: Hemoglobins/chemistry*
  9. Fulltext Analysis of α1 and α2 globin genes among patients with hemoglobin Adana in Malaysia
    Lee TY, Lai MI, Ismail P, Ramachandran V, Tan JA, Teh LK, et al.
    Genet. Mol. Res., 2016 Apr 07;15(2).
    PMID: 27173219 DOI: 10.4238/gmr.15027400
    Hemoglobin (Hb) Adana [HBA2: c179G>A (or HBA1); p.Gly60Asp] is a non-deletional α-thalassemia variant found in Malaysia. An improvement in the molecular techniques in recent years has made identification of Hb Adana much easier. For this study, a total of 26 Hb Adana α-thalassemia intermedia and 10 Hb Adana trait blood samples were collected from patients. Common deletional and non-deletional α-thalassemia genotypes were determined using multiplex gap polymerase chain reaction (PCR) and multiplex ARMS PCR techniques. Identification of the Hb Adana location on the α-globin gene was carried out using genomic sequencing and the location of the mutation was confirmed via restriction fragment length polymorphism-PCR. Among the 36 samples, 24 (66.7%) had the -α(3.7)/α(Cd59)α mutation, while the -α(3.7)/α(Cd59)α mutation accounted for 2 samples (5.6%) and the remaining 10 (27.8%) samples were α/α(Cd59)α. All 36 samples were found to have the Hb Adana mutation on the α2-globin gene. The position of the α-globin gene mutation found in our cases was similar to that reported in Indonesia (16%) but not to that in Turkey (0.6%). Our results showed that the Hb Adana mutation was preferentially present in the α2-globin genes in Malays compared to the other ethnicities in Malaysia. Thus, the Malays might have similar ancestry based on the similarities in the Hb Adana position.
    Matched MeSH terms: Hemoglobins, Abnormal/genetics*
  10. Serum ferritin concentrations in male Malaysian blood donors
    Ton SH, Lopez CG
    Southeast Asian J. Trop. Med. Public Health, 1980 Mar;11(1):87-90.
    PMID: 7403958
    Serum ferritin and haemoglobin estimates were carried out on 78 first time blood donors with a view to determining iron store status. Of these 30 were Malays, 20 were Chinese and 28 were Indians. The ferritin level in Malay donors ranged from 16-160 mg/ml (mean 83 +/- 49.4 mg/ml in chinese donors is ranged from 36-500 mg/ml (mean 242.8 +/- 132 mg/ml), and in the Indian donors it ranged from 5 - 270 mg/ml (mean 94.6 +/- 67.9 mg/ml). The haemoglobin concentration for the whole group was 14.9 +/- 1.49 g/dl. There was no correlation of haemoglobin concentration with serum ferritin levels.
    Matched MeSH terms: Hemoglobins/analysis
  11. Fulltext Iron-deficiency anaemia and serum ferritin levels in Malaysian women
    Goh TH, Hariharan M
    Med J Malaysia, 1986 Dec;41(4):300-4.
    PMID: 3670151
    Serum ferritin and blood haemoglobin levels were studied in 229 women attending a family planning clinic. Ferritin values ranged from 2 to 438 Jlg/l and was skewed with an arithmetic mean of 41.8 and geometric mean of 23.4 flg/l; 26.6% were iron-deficient (ferritin < 12 Jlg/l). Haemoglobin values were normally distributed with a mean of 11. 7 g/dl but 59% were anaemic (Hb < 12 gjdl]. The correlation between ferritin and haemoglobin values was poor (r = 0.147) but almost all women with a haemoglobin below 10 g/dl were iron-deficient. This study reaffirms the need for monitoring iron-deficiency anaemia in apparently healthy women seeking contraception.
    Matched MeSH terms: Hemoglobins/analysis
  12. Fulltext Haemoglobin E trait: microcytosis and erythrocytosis
    George E, Sivagengei K
    Med J Malaysia, 1982 Jun;37(2):102-3.
    PMID: 7132828
    Matched MeSH terms: Hemoglobins, Abnormal/analysis*
  13. Genetic microdifferentiation in the Semai Senoi of Malaysia
    Fix AG, Lie-injo LE
    Am. J. Phys. Anthropol., 1975 Jul;43(1):47-55.
    PMID: 1155591
    Blood samples, demographic and cultural data were collected from seven settlements of Semai Senoi, a swidden farming ethnic group of Malaysia. Three genetic loci (ABO blood group, hereditary ovalcytosis, and hemoglobin) were analyzed in a total sample of 546 individuals. These data indicate a considerable degree of genetic microdifferentiation in this area of the Semai distribution. Parent-offspring birthplace data (analyzed by means of a migration matrix) and settlement histories show that settlements are not strongly isolated. Genetic differences in the study area demonstrate a reasonable correspondence with migration and the history of the settlements. Genetic convergence also occurs through the addition of migrant groups to established populations leading to new patterns of marriage between donor and recipient groups. The genetic structure of the total Semai population through time thus comprises a mosaic of shifiting allele frequencies in a series of semi-isolated local populations.
    Matched MeSH terms: Hemoglobins/analysis
  14. Studies of oxygen binding energy to hemoglobin molecule
    Chow YW, Pietranico R, Mukerji A
    Biochem Biophys Res Commun, 1975 Oct 27;66(4):1424-31.
    PMID: 6
    Matched MeSH terms: Hemoglobins*; Oxyhemoglobins
  15. Carbonyl Functionalized Single-Walled Carbon Nanotube-Hb Crosslinked Network: A Novel Platform for Studying Bio-Electrochemistry and Electrocatalysis of Hemoglobin
    Kafi AKM, Yam CCL, Azmi NS, Yusoff MM
    J Nanosci Nanotechnol, 2018 Apr 01;18(4):2422-2428.
    PMID: 29442911 DOI: 10.1166/jnn.2018.14327
    In this work, the direct electrochemistry of hemoglobin (Hb), which was immobilized on carbonyl functionalized single walled carbon nanotube (SWCNT) and deposited onto a gold (Au) electrode has been described. The synthesis of the network of crosslinked SWCNT/Hb was done with the help of crosslinking agent EDC (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide). The UV-Vis and FTIR spectroscopy of SWCNT/Hb networks showed that Hb maintained its natural structure and kept good stability. In addition with this, scanning electron microscopy (SEM) illustrated that SWCNT/Hb networks had a featured layered structure and Hb being strongly liked with SWCNT surface. Cyclic voltammetry (CV) was used to study and to optimize the performance of the resulting modified electrode. The cyclic voltammetric (CV) responses of SWCNT/Hb networks in pH 7.0 exhibit prominent redox couple for the FeIII/II redox process with a midpoint potential of -0.46 V and -0.34, cathodic and anodic respectively. Furthermore, SWCNT/Hb networks are utilized for the detection of hydrogen peroxide (H2O2). Electrochemical measurements reveal that the resulting SWCNT/Hb electrodes display high electrocatalytic activity to H2O2 with high sensitivity, wide linear range, and low detection limit. Overall, the electrochemical results are due to excellent biocompatibility and excellent electron transport efficiency of CNT as well as high Hb loading and synergistic catalytic effect of the modified electrode toward H2O2.
    Matched MeSH terms: Hemoglobins/chemistry*
  16. Hemoglobin Immobilization on Multiporous Nanofibers of SnO₂ and Chitosan Composite for Hydrogen Peroxide Sensing
    Kafi AKM, Alim S, Jose R, Yusoff MM
    J Nanosci Nanotechnol, 2019 04 01;19(4):2027-2033.
    PMID: 30486943 DOI: 10.1166/jnn.2019.15465
    A multiporous nanofiber (MPNFs) of SnO₂ and chitosan has been used for the immobilization of a redox protein, hemoglobin (Hb), onto the surface of glassy carbon electrode (GCE). The multiporous nanofiber of SnO₂ that has very high surface area is synthesized by using electrospinning technique through controlling the tin precursor concentration. Since the constructed MPNFs of SnO₂ exposes very high surface area, it increases the efficiency for biomolecule-loading. The morphology of fabricated electrodes is examined by SEM observation and the absorbance spectra of Hb/(MPNFs) of SnO₂ are studied by UV-Vis analysis. Cyclic Voltammetry and amperometry are employed to study and optimize the performance of the resulting fabricated electrode. After fabrication of the electrode with the Hb and MPNFs of SnO₂, a direct electron transfer between the protein's redox centre and the glassy carbon electrode was established. The modified electrode has showed a couple of redox peak located at -0.29 V and -0.18 V and found to be sensitive to H₂O₂. The fabricated electrode also exhibited an excellent electrocatalytic activity towards the reduction of H₂O₂. The catalysis currents increased linearly to the H₂O₂ concentration in a wide range of 5.0×10-6-1.5×10-4 M. Overall experimental results show that MPNFs of SnO₂ has a role towards the enhancement of the electroactivity of Hb at the electrode surface. Thus the MPNFs of SnO₂ is a very promising candidate for future biosensor applications.
    Matched MeSH terms: Hemoglobins*
  17. Leucocyte alkaline phosphatase, leucocyte count and haemoglobin level in malayan new-borns and young infants
    Lie-Injo Luan Eng, Govindasamy S
    Med J Malaya, 1965 Jun;19(4):263-6.
    PMID: 4220850
    Matched MeSH terms: Hemoglobins*
  18. Abnormal hemoglobins, glucose-6-phosphate dehydrogenase deficiency and hereditary ovalocytosis in the Dayaks of Sarawak
    Ganesan J, Lie-Injo LE, Ong Beng P
    Hum. Hered., 1975;25(4):258-62.
    PMID: 1184011 DOI: 10.1159/000152733
    A survey of abnormal hemoglobins, G6PD deficiency and hereditary ovalocytosis was carried out among the Dayaks of Sarawak. The only abnormal hemoglobin found was Hb Co Sp, which occurred in 0.35% of the Land Dayaks and 0.83% of the Sea Dayaks. G6PD deficiency occurred in 5.3% of the male Land Dayaks and 5.0% of the male Sea Dayaks; no electrophoretic variant of G6PD was found in any of the 285 Land Dayaks and 240 Sea Dayaks examined. Hereditary ovalocytosis was found in 12.7% of the Land Dayaks and 9.0% of the Sea Dayaks.
    Matched MeSH terms: Hemoglobins, Abnormal*
  19. Multiple fetal and adult hemoglobins in Malaysian Macaca nemestrina: consequences of a-chain variation
    Nute PE, Pataryas HA
    Am. J. Phys. Anthropol., 1974 Jan;40(1):17-25.
    PMID: 4206325
    Matched MeSH terms: Hemoglobins/analysis*
  20. Haemoglobin E-hereditary elliptocytosis in Malayan aborigines
    Lie-Injo LE, Fix A, Bolton JM, Gilman RH
    Acta Haematol., 1972;47(4):210-6.
    PMID: 4625303
    Matched MeSH terms: Hemoglobins, Abnormal*
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