MyMedR

Synchronous cancers are defined as malignant tumours that occur simultaneously, each of which must be distinct with no possibility of one being the metastasis of the other. A 65 year old gentleman presented to us with two month history of epigastric pain associated with anaemia, loss of appetite and weight. He has no history of malignancy in his family. Colonoscopy revealed tumours at transverse colon and caecum. Intra-operatively, tumours were sited at caecum, transverse colon and jejunum. Tumours were diagnosed as synchronous adenocarcinoma histopathologically with loss of expression of MLH1 and MSH2. From literature search, this is the first reported triple synchronous tumours of the caecum, transverse colon and jejunum. We believe that this gentleman developed triple synchronous tumour through the sporadic MSI pathway.

Matched MeSH terms: Cecal Neoplasms/pathology*; Colonic Neoplasms/pathology*; Jejunal Neoplasms/pathology*; Neoplasms, Multiple Primary/pathology*

Fulltext Nasopharyngeal carcinoma in Oman and Malaysia: is there any difference?

Mohamad I, Nadarajah S

Oman Med J, 2015 Sep;30(5):397-8.

PMID: 26421124 DOI: 10.5001/omj.2015.79

Matched MeSH terms: Nasopharyngeal Neoplasms*

Fulltext Crocodiles and alligators: physicians' answer to cancer?

Khan NA, Soopramanien M, Siddiqui R

Curr Oncol, 2019 06;26(3):186.

PMID: 31285664 DOI: 10.3747/co.26.4855

Matched MeSH terms: Neoplasms*

Fulltext Adapting Cancer Civil Society Organizations to Accelerate COVID-19 Vaccinations in People Living With Cancer in Low- and Middle-Income Countries-A Commentary

Munisamy M, Ndoh K, Abdelbadee A, Espejo I, Manjuh F, Tamas A, et al.

JCO Glob Oncol, 2021 07;7:1194-1198.

PMID: 34292779 DOI: 10.1200/GO.21.00195

Matched MeSH terms: Neoplasms*

Fossa of Rosenmuller and nasopharyngeal carcinoma

Prasad U

Med J Malaysia, 1979 Mar;33(3):222-5.

PMID: 522726

Matched MeSH terms: Nasopharyngeal Neoplasms/diagnosis*

Carcinoid tumour: a report of 4 cases with unusual sites of origin

Dutt AK, Kutty MK, Balasegaram M, Omar-Ahmad U

Med J Malaya, 1969 Mar;23(3):216-9.

PMID: 4240078

Matched MeSH terms: Bronchial Neoplasms*; Duodenal Neoplasms*; Esophageal Neoplasms*; Intestinal Neoplasms*

The value of cytological examination of serous effusions in the diagnosis of malignant disease

LUCAS JK, CHAN KE

Med J Malaya, 1961 Jun;15:237-46.

PMID: 14467086

Matched MeSH terms: Neoplasms/diagnosis*

Lung cancer: I. Presenting clinical features

Ashoka Menon M, Saw Huat Seong

Med J Malaysia, 1979 Mar;33(3):230-4.

PMID: 522728

Matched MeSH terms: Lung Neoplasms/diagnosis*

The ripple effect: Cancer-related financial toxicity for family members and caregivers

Dee EC, Robredo JPG, Eala MAB, Suanes PN, Bhoo-Pathy N

Psychooncology, 2023 Jan;32(1):155-159.

PMID: 36383435 DOI: 10.1002/pon.6067

Matched MeSH terms: Neoplasms*

Image collection and annotation platforms to establish a multi-source database of oral lesions

Rajendran S, Lim JH, Yogalingam K, Kallarakkal TG, Zain RB, Jayasinghe RD, et al.

Oral Dis, 2023 Jul;29(5):2230-2238.

PMID: 35398971 DOI: 10.1111/odi.14206

OBJECTIVE: To describe the development of a platform for image collection and annotation that resulted in a multi-sourced international image dataset of oral lesions to facilitate the development of automated lesion classification algorithms.

MATERIALS AND METHODS: We developed a web-interface, hosted on a web server to collect oral lesions images from international partners. Further, we developed a customised annotation tool, also a web-interface for systematic annotation of images to build a rich clinically labelled dataset. We evaluated the sensitivities comparing referral decisions through the annotation process with the clinical diagnosis of the lesions.

RESULTS: The image repository hosts 2474 images of oral lesions consisting of oral cancer, oral potentially malignant disorders and other oral lesions that were collected through MeMoSA® UPLOAD. Eight-hundred images were annotated by seven oral medicine specialists on MeMoSA® ANNOTATE, to mark the lesion and to collect clinical labels. The sensitivity in referral decision for all lesions that required a referral for cancer management/surveillance was moderate to high depending on the type of lesion (64.3%-100%).

CONCLUSION: This is the first description of a database with clinically labelled oral lesions. This database could accelerate the improvement of AI algorithms that can promote the early detection of high-risk oral lesions.

Matched MeSH terms: Mouth Neoplasms*

Appendiceal Tie Syndrome

Ng ZQ, Tan HCL, Tan JH

J Gastrointest Surg, 2023 Apr;27(4):836-837.

PMID: 36658386 DOI: 10.1007/s11605-023-05597-w

Matched MeSH terms: Appendiceal Neoplasms*

Fulltext Challenges in the management of nasopharyngeal carcinoma: a review

Abdullah B, Alias A, Hassan S

Malays J Med Sci, 2009 Oct;16(4):50-4.

PMID: 22135512 MyJurnal

Nasopharyngeal carcinoma (NPC) is a non-lymphomatous, squamous cell carcinoma that occurs in the epithelial lining of the nasopharynx, an area that shows varying degrees of differentiation. Although relatively rare worldwide, NPC has substantial incidence and mortality in populations in Southeast Asia and in people with Southern Chinese ancestry. In Malaysia, NPC is a leading cancer type. In the clinic, NPC presents on a very wide spectrum. Therefore, a high degree of suspicion on the part of the clinician and an increased awareness by the patient is essential for the recognition of an early lesion. Early detection of the cancer is important as it affects the patient's prognosis and the mode of treatment. Managing patients with NPC is very challenging as patients usually present late when the cancer is already in an advanced stage. Here, we review the challenges in the management of NPC.

Matched MeSH terms: Nasopharyngeal Neoplasms*

Fulltext Expression trend of selected ribosomal protein genes in nasopharyngeal carcinoma

Ma XR, Sim EU, Ling TY, Tiong TS, Subramaniam SK, Khoo AS

Malays J Med Sci, 2012 Oct;19(4):23-30.

PMID: 23613646 MyJurnal

Ribosomal proteins are traditionally associated with protein biosynthesis until recent studies that implicated their extraribosomal functions in human diseases and cancers. Our previous studies using GeneFishing™ DEG method and microarray revealed underexpression of three ribosomal protein genes, RPS26, RPS27, and RPL32 in cancer of the nasopharynx. Herein, we investigated the expression pattern and nucleotide sequence integrity of these genes in nasopharyngeal carcinoma to further delineate their involvement in tumourigenesis. The relationship of expression level with clinicopathologic factors was also statistically studied.

Matched MeSH terms: Nasopharyngeal Neoplasms*

Fulltext eComment. Pulmonary metastasectomy of colorectal carcinoma in patients with intra-thoracic lymph node involvement: a step too far?

Sachithanandan A

Interact Cardiovasc Thorac Surg, 2015 Feb;20(2):221.

PMID: 25605822 DOI: 10.1093/icvts/ivu415

Matched MeSH terms: Lung Neoplasms/mortality*; Colorectal Neoplasms/mortality*

Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer

Jabbarzadeh Kaboli P, Rahmat A, Ismail P, Ling KH

Eur J Pharmacol, 2014 Oct 5;740:584-95.

PMID: 24973693 DOI: 10.1016/j.ejphar.2014.06.025

Breast cancer is the most common cancer among women worldwide and novel therapeutic agents are needed to treat this disease. The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways regulated by this compound is needed to define the mechanism of its action in cancer treatment. In this review, the molecular targets of berberine in various cancers, particularly breast cancer, are discussed. Berberine was shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells. Some signaling pathways affected by berberine, including the MAP (mitogen-activated protein) kinase and Wnt/β-catenin pathways, are critical for reducing cellular migration and sensitivity to various growth factors. This review will discuss recent studies and consider the application of new prospective approaches based on microRNAs and other crucial regulators for use in future studies to define the action of berberine in cancer. The effects of berberine on cancer cell survival and proliferation are also outlined.

Matched MeSH terms: Neoplasms/drug therapy*; Neoplasms/genetics; Neoplasms/metabolism

Fulltext Ultrasound and abdominal masses

Md Alif AK

Med J Malaysia, 1982 Mar;37(1):82-7.

PMID: 7121355

Matched MeSH terms: Abdominal Neoplasms/diagnosis*; Liver Neoplasms/diagnosis

Displaying publications 21 - 40 of 6237 in total