Displaying publications 41 - 60 of 353 in total

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  1. Fulltext Tianeptine dependence: a case report
    Syed Nabil, Ng, Chong Guan, Rusdi Abd Rashid
    Malaysian Journal of Psychiatry, 2018;27(1):0-0.
    MyJurnal
    Tianeptine is an atypical tricyclic antidepressant that is prescribed mainly for the treatment of depression and anxiety disorder. There have been scattered reported cases of tianeptine dependence and abuse in the literature. We report the case of a 32-year-old gentleman with resistant major depressive disorder that was initially successfully treated with Tianeptine. When his depression relapse due to work-related issue, he step-up his dosages without supervision. He developed tolerance and withdrawal to tianeptine making it difficult for him to stop without help. This case highlights the possibility of tianeptine abuse to its high tolerability and easy access for purchase.
    Matched MeSH terms: Depressive Disorder, Major
  2. Fulltext Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients
    Aldoghachi AF, Tor YS, Redzun SZ, Lokman KAB, Razaq NAA, Shahbudin AF, et al.
    PLoS One, 2019;14(1):e0211241.
    PMID: 30677092 DOI: 10.1371/journal.pone.0211241
    BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a neurotrophin found in abundance in brain regions such as the hippocampus, cortex, cerebellum and basal forebrain. It has been associated with the risk of susceptibility to major depressive disorder (MDD). This study aimed to determine the association of three BDNF variants (rs6265, rs1048218 and rs1048220) with Malaysian MDD patients.

    METHODS: The correlation of these variants to the plasma BDNF level among Malaysian MDD patients was assessed. A total of 300 cases and 300 matched controls recruited from four public hospitals within the Klang Valley of Selangor State, Malaysia and matched for age, sex and ethnicity were screened for BDNF rs6265, rs1048218 and rs1048220 using high resolution melting (HRM).

    FINDINGS: BDNF rs1048218 and BDNF rs1048220 were monomorphic and were excluded from further analysis. The distribution of the alleles and genotypes for BDNF rs6265 was in Hardy-Weinberg equilibrium for the controls (p = 0.13) but was in Hardy Weinberg disequilibrium for the cases (p = 0.011). Findings from this study indicated that having BDNF rs6265 in the Malaysian population increase the odds of developing MDD by 2.05 folds (95% CI = 1.48-3.65). Plasma from 206 cases and 206 controls were randomly selected to measure the BDNF level using enzyme-linked immunosorbent assay (ELISA). A significant decrease in the plasma BDNF level of the cases as compared to controls (p<0.0001) was observed. However, there was no evidence of the effect of the rs6265 genotypes on the BDNF level indicating a possible role of other factors in modulating the BDNF level that warrants further investigation.

    CONCLUSION: The study indicated that having the BDNF rs6265 allele (A) increase the risk of developing MDD in the Malaysian population suggesting a possible role of BDNF in the etiology of the disorder.

    Matched MeSH terms: Depressive Disorder, Major/blood; Depressive Disorder, Major/etiology; Depressive Disorder, Major/genetics*
  3. Fulltext The prevalence of depression and its relationship to health related quality of life among Prostate cancer patients in tertiary centres, Kuala Lumpur
    Mohamad Rodi Isa, Moy FM, Azad Hassan Abdul Razack, Zulkifli Mohd Zainuddin, Nur Zuraida Zainal
    Journal of Clinical and Health Sciences, 2016;1:36-45.
    To determine the prevalence of depression and its relationship with health related quality of life among prostate cancer patients in tertiary medical centres, Kuala Lumpur.
    Matched MeSH terms: Depressive Disorder
  4. Positive effects of Individual Cognitive Behavior Therapy for patients with unipolar mood disorders with suicidal ideation in Malaysia: A randomised controlled trial
    Sinniah A, Oei TPS, Maniam T, Subramaniam P
    Psychiatry Res, 2017 08;254:179-189.
    PMID: 28463716 DOI: 10.1016/j.psychres.2017.04.026
    The aim of this study was to investigate the effectiveness of Individual Cognitive Behavior Therapy (ICBT) in treating patients with mood disorders with suicidal ideation. A total of 69 patients (48 females, 21 males) with the diagnoses above were randomly allocated to either the group of Treatment As Usual (TAU)+ICBT (n=33) or the TAU group (n=36). All participants completed the Beck Depression Inventory (BDI), Beck Scale for Suicide Ideation (BSS), Positive and Negative Suicide Ideation Inventory (PANSI), Beck Hopelessness Scale (BHS), and Depression Anxiety Stress Scale-21 (DASS-21). These questionnaires were administered at pre-treatment, midway through treatment (week 4), post-treatment (week 8), and at follow-ups after three months (week 20) and six months (week 32). Factorial ANOVA results showed that the TAU+ICBT patients improved significantly and at faster rate as compared to the TAU group, which showed improvement only from pre to mid treatment on DASS-D and BHS-T measures. The effect size (Cohen's d), for the TAU+ICBT group showed large effect (1.47) for depressive symptoms and suicidal ideation (1.00). These findings suggest that ICBT used in addition to the TAU, was effective in enhancing treatment outcome of patients with unipolar mood disorders as well as, reducing risk for suicide behavior.
    Matched MeSH terms: Depressive Disorder/epidemiology; Depressive Disorder/psychology*; Depressive Disorder/therapy*
  5. Fulltext Psychological distress among cancer patients on chemotherapy
    Nor Zuraida, Z., Ng, C.G.
    JUMMEC, 2010;13(1):12-18.
    MyJurnal
    Distress has become a major issue in cancer population. Patients may suffer from either physical,psychological distress or both. Cancer patients who are undergoing chemotherapy are more likely to experience psychological distress. This could be due to the negative effects of chemotherapy agents, the uncertainty of post-treatment, and the occurrence of psychosocial problems. As a result, the patient may experience a normal reaction such as sadness or may develop common psychiatric disorders such as depression and anxiety.
    Matched MeSH terms: Depressive Disorder
  6. Fulltext Hospital-based pulmonary rehabilitation program is more effective than home-based pulmonary rehabilitation in improving the quality of life of chronic obstructive pulmonary disease (COPD) patients. [Program rehabilitasi pulmonari di hospital lebih berkesan daripada program rehabilitasi pulmonari di rumah dalam meningkatkan kualiti hidup pesakit obstruksi pulmonari kronik (COPD)]
    Ayiesah Ramli, Nor Azlin Mohd Nordin, Asfarina Zanudin, Wong, Judy
    Jurnal Sains Kesihatan Malaysia, 2009;7(2):47-58.
    MyJurnal
    This study identified the effectiveness between home-based and hospital-based pulmonary rehabilitation program on the quality of life of chronic obstructive pulmonary disease (COPD) patients. Thirty five patients who met the inclusion criteria were referred by physicians and randomized to either hospital-based pulmonary rehabilitation (PRPH) or home-based pulmonary rehabilitation (PRPR). The PRPH program was scheduled twice a week for eight weeks at the Physiotherapy Department, Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Whilst, the PRPR group was required to attend sessions at the Physiotherapy Department twice to learn the exercise regimens before carrying out the exercises themselves at home. Subjects were asked to record activitites in a diary and a telephone call was made once every two weeks to ensure compliance towards the exercise regimens. The SF-36 questionnaire and Geriatric Depression Scale were outcome measures used in assessing status of patients prior to treatment and after intervention at the 8th week Seventeen (48.6%) subjects completed the PRPH and 15 (43%), the PRPR. Results indicated that in the PRPH group there were significant improvements in some of the domains of SF-36, i.e., role physical (p = 0.012) body pain (p = 0.040), general health (p = 0.008) and role emotional (p = 0.012). In the PRPR group, the Geriatric Depression Scale mean score was 1.8 ± 0.41 at baseline compared to 1.69 ± 0.48 following intervention (p > 0.05). Whilst, among the PRPH group, the mean was 1.87 ± 0.35 at baseline and 1.53 ± 0.52 after eight week (p < 0.05). In conclusion, hospital-based pulmonary rehabilitation is more effective than the home-based pulmonary rehabilitation in improving the quality of life and reducing depression among patients with COPD.
    Keywords: Home Based Pulmonary Rehabilitation Program (PRPR); Hospital based Pulmonary Rehabilitation Program (PRPH); COPD; Quality of life (QOL).
    Matched MeSH terms: Depressive Disorder
  7. Fulltext A case report of a patient involved in an alleged homicide-attempted suicide case - a theoretical discussion on the theory of homicide-suicide
    Ahmad Nabil, M.R., Suarn, S.
    Medicine & Health, 2015;10(2):141-145.
    MyJurnal
    This case report stresses the role of depression in the manifestation of a homicide-attempted suicide. We report the case of a man who allegedly murdered his partner and then attempted suicide. Previously, he had several failures and rejections in relationships in addition to work-related stress. He was diagnosed with major depressive disorder and treated with antidepressant. The scarcity of homicide-attempted suicide as exemplified in this case could give an insight to the Psychiatrist for better understading and possible prevention.
    Matched MeSH terms: Depressive Disorder, Major
  8. Fulltext The psychological impact of diabetic limb problems
    Bahari R
    International Medical Journal Malaysia, 2015;14(2):3-8.
    MyJurnal
    Limb problem is a common complication for patients with diabetes. While the impact of diabetic limb problems
    on physical health is well known, the psychological impact of the condition is still largely unknown. People with
    diabetes with or without foot ulcers frequently suffer from major depressive disorder, and this is made worse
    by the presence of limb complications. Furthermore, depression itself can have negative consequences on the
    person’s diabetes. Hence, in caring for people with diabetic foot problem, the psychological sequelae must not
    be overlooked but managed accordingly
    Matched MeSH terms: Depressive Disorder, Major
  9. Fulltext Anxiety-depression psychopathology of a patient with voyeurism, major depression and premature ejaculation
    Ismail N, Husain R, Sidi H
    ASEAN Journal of Psychiatry, 2017;18(2):278-280.
    MyJurnal
    Objective: This case report highlights a case of young male referred for psychiatric evaluation due to paraphilic disorder. This 27-year old single male working as an assistant accountant was noted to have voyeuristic behaviour and presented with depressive symptoms since his teenage age. He has poor coping whenever he experiences stress in life. He started to watch pornographic videos and subsequently get involved by peeping pre-pubescent’s undergarments. These activities are followed by a compulsive behaviour such as masturbation to gratify his sexual arousal.
    Results: The patient undergone several psychotherapy sessions, and medical report was furnished for the court's purpose. Our assessment revealed that he was suffering from a lifetime major depressive disorder,and he was prescribed with Tablet Sertraline 50mg/daily.He also has premature ejaculation, severe in nature. He regretted his voyeuristic urge and psychotherapyfocused on how to channel his sexual needs.
    Conclusion: Mood disorder is seen in paraphilic disorder and has to be dealt with in order to establish good management care.
    Matched MeSH terms: Depressive Disorder, Major
  10. Fulltext A diagnostic dilemma: catatonia, serotonin syndrome and Parkinsonism
    Mohd Miharbeim M.F., Ahmad Zafri, A.B., Suhaila, M.Z.
    Malaysian Journal of Psychiatry, 2017;26(1):0-0.
    MyJurnal
    Catatonia may concomitantly occur with other psychiatric diagnoses such as
    Major Depressive Disorder, however problem in diagnosis may arise due to
    the overlapping features with other problems such as serotonin syndromes,
    neuroleptic malignant syndromes and Parkinsonism. Despite the diagnostic
    dilemma and lack of diagnostic tools, the clinical correlation between the
    carbon monoxide poisoning and the late-onset development of the
    Parkinsonian features is the highlight of this report.
    Matched MeSH terms: Depressive Disorder, Major
  11. Fulltext Understanding trypophobia: the fear of holes
    Aminuddin, I., Lotfi, H.A.
    Malaysian Journal of Psychiatry, 2016;25(2):0-0.
    MyJurnal
    The sight of clustered holes can bring about uneasiness in people, and the disgust response towards it is called trypophobia. Reactions in humans vary from nausea to severe depression. We explore the possible causes of this unique phenomenon, such as evolutionary adaptation and spectral features. We also uncover the clinical features and its relationship to other psychological conditions for example, obsessive-compulsive disorder.
    Matched MeSH terms: Depressive Disorder, Major
  12. Cognitive dysfunction in Malaysian patients with major depressive disorder: A subgroup analysis of a multicountry, cross-sectional study
    Zainal NZ, Kalita P, Herr KJ
    Asia Pac Psychiatry, 2019 Mar;11(1):e12346.
    PMID: 30511420 DOI: 10.1111/appy.12346
    INTRODUCTION: Cognitive dysfunction has been significantly associated with functional impairment in patients with major depressive disorder (MDD).

    METHODS: This is a subgroup analysis of 211 Malaysian patients recruited from the multicountry, multicenter, cross-sectional Cognitive Dysfunction in Asian patients with Depression (CogDAD) study. Depression severity, cognitive dysfunction, and functional disability were assessed and compared with the overall CogDAD study population. Factors associated with functional disability were also evaluated in this Malaysian patient population.

    RESULTS: Approximately half of the Malaysian patients were in their first depressive episode, with the majority being treated for mild-to-moderate depression. Furthermore, Malaysian patients experienced cognitive dysfunction, with self-reported Perceived Deficits Questionnaire (PDQ-D) scores falling within the third quartile of PDQ-D severity. Malaysian patients also reported functional disability evidenced by a mean total Sheehan Disability Scale (SDS) score of 11.47 ± 6.68, with the highest SDS score reported in the "Social Life/Leisure Activities" domain. Compared with the overall CogDAD study population, the Malaysian patient population had comparable patient demographics in terms of marital and working status; outcome scores for PHQ-9 (9-item Patient Health Questionnaire for self-reported depression severity), PDQ-D and SDS; and worst perceived cognitive dysfunction reported in the "Attention/Concentration" domain. Factors found to be significantly associated with functional disability were PDQ-D score, sick leave taken, and antidepressant treatment (P 
    Matched MeSH terms: Depressive Disorder, Major/complications*; Depressive Disorder, Major/epidemiology; Depressive Disorder, Major/physiopathology
  13. Fulltext Depression and its relationship to loneliness and life events among urban poor in the federal territory, Kuala Lumpur, Malaysia
    Siti Nor Radhiah Muhammad Y, Nor Ba’yah Abdul K
    Jurnal Psikologi Malaysia, 2016;30:133-141.
    This study examines the relationship between loneliness, life events and depression among 178 adults in the disadvantage community of Malaysia and to determine predictors of depression. A set of standardized questionnaires was used to measure depression, loneliness and stressful life events. The results showed that loneliness and stressful life events were related to depression. Results also showed that loneliness was a predictor of depression. Implications of the study in terms of theory and practice are also discussed.
    Matched MeSH terms: Depressive Disorder
  14. Manic-Depressive Psychosis (MDP): Western and Islamic approach
    Alias J, Mat N
    Jurnal Psikologi Malaysia, 2011;olume 25:22-25.
    Personal ups and downs are appropriate responses to the ups and downs of life. However, some experiences emotional extremes in moods and disturbed their normal life. Individuals who have depression at times and mania or hypomania at others are called manic-depressive; and the combination is known as manic-depressive psychosis (MDP). This paper attempts to look at manic-depressive psychosis (MDP) from the western approaches as well as from the Islamic point of view. The treatments proposed by both streams are also provided.
    Matched MeSH terms: Depressive Disorder
  15. Fulltext Preliminary study: effects of social instability stress on depressive behaviours in ovariectomised rats
    Al-Rahbi B, Zakaria R, Muthuraju S, Othman Z, Hassan A
    Malays J Med Sci, 2013 Mar;20(2):35-40.
    PMID: 23983575 MyJurnal
    Depression is one of the common post-menopausal symptoms. In addition to estrogen deficiency, social instability stress may contribute as an additional underlying factor in the development of depressive behaviour in females. Therefore, this study was aimed at examining the influence of social instability stress on depressive behaviour in ovariectomized rats.
    Matched MeSH terms: Depressive Disorder
  16. Anhedonia among patients with Major Depressive Disorder: A comparison between patients on escitalopram and healthy controls
    Ng CG, Wong SK, Loh HS, Yee A
    Clin Ter, 2014;165(6):e384-90.
    PMID: 25524191 DOI: 10.7417/CT.2014.1778
    BACKGROUND AND AIMS: Escitalopram has widely been recognized as one of the most frequently used antidepressants, with superior tolerability and great efficacy in preventing major depressive disorder (MDD) relapse and recurrence. However, anhedonia, which is a core symptom of MDD, remains difficult to treat. This study investigates the hedonic levels of MDD patients treated with Escitalopram.

    MATERIALS AND METHODS: A total of 108 participants, 26 of whom with MDD on Escitalopram, were recruited in this cross sectional study. They were evaluated using the Snaith-Hamilton Pleasure Scale (SHAPS) and Beck Depression Inventory (BDI) questionnaires to assess their hedonic state, general mental health condition and level of depression.

    RESULTS: Our study shows that most items in the SHAPS scores are significantly different between MDD patients on Escitalopram and the controls.

    CONCLUSIONS: The hedonic capacity remains different between the two groups despite patients with MDD are put on Escitalopram treatment. Escitalopram fails to alleviate the hedonic state of MDD patients. Antidepressants that improve both depressive symptoms and hedonic states should be considered when treating MDD patients in clinical settings.
    Matched MeSH terms: Depressive Disorder, Major/drug therapy*; Depressive Disorder, Major/psychology*
  17. Depression and psychosocial correlates of liver transplant candidates: a systematic review
    Mohamed S, Sabki ZA, Zainal NZ
    Asia Pac Psychiatry, 2014 Dec;6(4):447-53.
    PMID: 25132651 DOI: 10.1111/appy.12145
    Liver transplant candidates are vulnerable to develop depression. This paper aims to ascertain the prevalence of depression in liver transplant candidates and its psychosocial factors in a systematic review.
    Matched MeSH terms: Depressive Disorder/etiology*; Depressive Disorder/epidemiology
  18. Public knowledge and beliefs about depression among urban and rural Chinese in Malaysia
    Loo PW, Furnham A
    Asian J Psychiatr, 2012 Sep;5(3):236-45.
    PMID: 22981052 DOI: 10.1016/j.ajp.2012.02.003
    The study compared knowledge and beliefs about depression among urban and rural Chinese in a Malaysian sample. A total of 409 participants were asked to identify cases of depression varying in intensity from two vignettes and rate their beliefs regarding a list of possible causes and treatments for depression. The urban Chinese were more likely to identify depression as the problem in the vignette. Beliefs about causes of depression were factored into five components, whereas beliefs about treatment for depression factored into four components. The results indicated that the causes most strongly endorsed were stress and pressure, and standard treatments rated the highest as treatments for depression. Overall, depression literacy was moderate for Chinese Malaysians. The results are discussed in relation to Chinese cultural beliefs about depression. Limitations of this preliminary study were acknowledged.
    Matched MeSH terms: Depressive Disorder/ethnology*; Depressive Disorder/epidemiology
  19. Depression risks in mothers of children with developmental disabilities: a cross-cultural comparison of Brazil, Colombia, Malaysia and Thailand
    Osada H, Coelho de Amorim A, Velosa A, Wan WP, Lotrakul P, Hara H
    Int J Soc Psychiatry, 2013 Jun;59(4):398-400.
    PMID: 22408120 DOI: 10.1177/0020764012438477
    Compared with US or European countries, there are fewer mental health services for mothers of children with developmental disabilities in Latin American and/or Southeast Asian countries.
    Matched MeSH terms: Depressive Disorder/epidemiology*; Depressive Disorder/psychology*
  20. Fulltext Coping styles in patients with haematological cancer in a Malaysian hospital
    Priscilla D, Hamidin A, Azhar MZ, Noorjan KO, Salmiah MS, Bahariah K
    East Asian Arch Psychiatry, 2011 Jun;21(2):44-51.
    PMID: 21838206
    Objectives: To determine the relationship between major depressive disorder, anxiety disorders and the quality of life of haematological cancer patients.
    Methods: This cross-sectional study was conducted at Ampang Hospital Kuala Lumpur, Malaysia, a tertiary referral centre hospital for haematological cancer. The Mini-International Neuropsychiatric Interview was used for the diagnosis of major depressive disorder and anxiety disorders. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire was utilised to measure patients’ quality of life.
    Results: A total of 105 haematological cancer patients ere included in the study with response rate of 100%. Major depressive disorder correlated with almost all domains of the quality of life, except the pain scores. Logistic regression showed that insomnia and financial difficulties were related to major depressive disorder. Different anxiety disorders also correlated with quality of life in specific domains. The leading anxiety disorders that correlated mostly with quality﹣of life scales were generalised anxiety disorder, followed by obsessive-compulsive disorder, social anxiety disorder, as well as post-traumatic stress disorder and panic disorder with agoraphobia (p < 0.05).
    Conclusions: Psychological treatment along with medication and intervention should be implemented to improve the overall quality of life and psychiatric disorder symptoms among the haematological cancer patients.
    Key words: Anxiety; Depression; Hematologic neoplasms; Quality of life
    Matched MeSH terms: Depressive Disorder, Major/complications; Depressive Disorder, Major/psychology
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