Displaying publications 41 - 60 of 2383 in total

Abstract:
Sort:
  1. Kwa SK
    Family Physician, 2001;11:20-3.
    Asthma is a chronic reversible respiratory problem commonly seen by Family Physicians. Pregnancy can produce physiological and physical changes that can affect the severity of asthma and its management. Conversely poorly controlled asthmatic attacks can result in adverse obstetric outcome: prematurity, low birth weight babies, foetal hypoxia and increased maternal and foetal morbidity and mortality. It is important that Family Physicians should be able to manage competently and provide appropriate counseling for women with asthma in pregnancy, labour and lactation. Assessment of asthma control using a peak flow meter is recommended. The use of the usual inhaled and oral corticosteroids, beta 2 agonists, cromones and anticholinergics are generally safe in pregnancy, labour and lactation. But methylxanthines should be used with caution. Women should be advised that asthma medication would not adversely affect their unborn babies and the birth outcome of well-controlled asthmatic women approaches that of the normal population but uncontrolled asthma would be detrimental to the health of mother and child.
    Matched MeSH terms: Pregnancy
  2. Sivalingam N
    Family Physician, 1992;4:23-26.
    Matched MeSH terms: Pregnancy
  3. Wong YP, Tan GC, Khong TY
    Int J Mol Sci, 2023 Feb 25;24(5).
    PMID: 36901979 DOI: 10.3390/ijms24054550
    The outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global public health crisis, causing substantial concern especially to the pregnant population. Pregnant women infected with SARS-CoV-2 are at greater risk of devastating pregnancy complications such as premature delivery and stillbirth. Irrespective of the emerging reported cases of neonatal COVID-19, reassuringly, confirmatory evidence of vertical transmission is still lacking. The protective role of the placenta in limiting in utero spread of virus to the developing fetus is intriguing. The short- and long-term impact of maternal COVID-19 infection in the newborn remains an unresolved question. In this review, we explore the recent evidence of SARS-CoV-2 vertical transmission, cell-entry pathways, placental responses towards SARS-CoV-2 infection, and its potential effects on the offspring. We further discuss how the placenta serves as a defensive front against SARS-CoV-2 by exerting various cellular and molecular defense pathways. A better understanding of the placental barrier, immune defense, and modulation strategies involved in restricting transplacental transmission may provide valuable insights for future development of antiviral and immunomodulatory therapies to improve pregnancy outcomes.
    Matched MeSH terms: Pregnancy; Pregnancy Complications, Infectious*; Pregnancy Outcome
  4. Ramly F, Mahamooth MIJ, Abidin HAZ, Sani H, Hassan J
    Int J Gynaecol Obstet, 2023 Feb;160(2):710-712.
    PMID: 36200647 DOI: 10.1002/ijgo.14493
    Matched MeSH terms: Pregnancy
  5. Sirasanagandla SR, Ranganath Pai KS, Potu BK, Bhat KM
    J Ayurveda Integr Med, 2014 Jan;5(1):25-32.
    PMID: 24812472 DOI: 10.4103/0975-9476.128852
    Delayed fetal skeletal ossification is one of the known complications of maternal diabetes.
    Matched MeSH terms: Pregnancy; Pregnancy in Diabetics
  6. Loh KY, Sivalingam N
    Med J Malaysia, 2005 Aug;60(3):394-9; quiz 400.
    PMID: 16379204
    Nausea and vomiting are common in early pregnancy affecting 70-80 percent of pregnant mothers. In a majority of women vomiting begins between 4-7 weeks of pregnancy. Nausea and vomiting are usually mild and self-limiting, however some of the mothers have a more profound course which lead to hyperemesis gravidarum. Careful clinical evaluation is necessary to exclude underlying medical illnesses or non pregnancy related causes of severe vomiting. Hyperemesis gravidarum poses health risk to both mother and baby, therefore prompt treatment should be initiated without delay. Non pharmacotherapy such as dietary modification and emotional support are useful. Pharmacotherapy with antiemetics, pyridoxine, methylprednisolone are effective and relatively safe. Severe hyperemesis with dehydration and electrolyte imbalance may need hospitalisation for electrolyte and fluid replacement.
    Matched MeSH terms: Pregnancy; Pregnancy Trimester, First
  7. Mohd Azri MS, Adibah HI, Haliza G
    Med J Malaysia, 2015 Aug;70(4):214-9.
    PMID: 26358016 MyJurnal
    OBJECTIVE: To summarise the published research on teenage pregnancy in Malaysia, discuss the impact of the findings on clinical practice, and identify gaps in teenage pregnancy research in Malaysia.
    METHODS: There were 31 articles related to teen pregnancy found after searching a database dedicated to indexing all original clinical research data published in Malaysia from year 2000 to 2014. Twenty-seven articles (including reports from the National Obstetrics Registry) were selected and reviewed on the basis of clinical relevance and future research implications. This literature review has been divided into eight sections: epidemiology, age at first marriage, adolescent fertility rate, unmarried childbearing, risk factors, maternal risks and neonatal outcome, future plan after delivery, and contraceptive use.
    RESULTS: More than 19,000 births to teenage mothers were recorded each year between 2009 and 2011. Adolescent fertility rates were recorded at 6 births per 1000 women ages 15-19 years in 2013. Many of these births were from unwed pregnancies, which accounted for 1.99% of total deliveries. A majority of young mothers were willing to take care of their baby, although some of them planned to put their baby up for adoption. Risk factors for teenage pregnancy were found to be similar to those published in studies worldwide.
    CONCLUSION: More research is needed to better understand the issue of teen pregnancy. For the best results, collaborative studies among nationwide hospitals and institutions should be the way forward.
    Matched MeSH terms: Pregnancy in Adolescence*
  8. Nalliah S
    Family Practitioner, 1985;8(1):59-62.
    Matched MeSH terms: Pregnancy; Pregnancy in Adolescence
  9. Yong SL, Ng BK, Mohd Yassin MAJ, Syed Zakaria SZ, Mohamed Ismail NA
    J Obstet Gynaecol, 2018 May;38(4):461-465.
    PMID: 29390907 DOI: 10.1080/01443615.2017.1372397
    This study was to assess the relationship between late pregnancy haemoglobin A1C (HbA1C) at 29-30 weeks of gestation and adverse pregnancy outcomes (APOs) in 272 pregnant women with pre-existing diabetes. HbA1C ≥6.1% was associated with significantly increased risk of preterm delivery, Caesarean section, large for gestational age (LGA), neonatal respiratory distress, neonatal hypoglycaemia, and composite adverse neonatal outcome (p  5.6% (p = .039). Reduction of HbA1C cut-off from 6.1% to 5.6% improved the sensitivity but reduced the specificity for prediction of APOs. Overall, the receiver operating characteristic (ROC) curves demonstrated the moderate predictive value of late pregnancy HbA1C for APOs. In conclusion, elevated late pregnancy HbA1C levels at 29-30 gestational weeks had a negative impact on APOs in pregnant women with pre-existing diabetes. However, HbA1C cut-off levels of neither ≥6.1% nor >5.6% were ideal for predicting APOs. Impact statement What is already known on this subject: Poorly controlled diabetes is associated with adverse pregnancy outcomes (APOs). Periconceptual haemoglobin A1C (HbA1C) correlates well with the risk of foetal anomaly but is not predictive of APOs at time of delivery. New evidence suggested that late pregnancy HbA1C is predictive of APOs but the definitions of a late pregnancy gestational week and target HbA1C cutpoint remain in doubt. What the results of this study add: This study investigated the relationship between late pregnancy HbA1C levels at 29-30 weeks of gestation and the APOs among pregnant women with pre-existing diabetes. Late pregnancy HbA1C ≥ 6.1% correlated with the risk of APOs but the increased risk of pre-eclampsia only became significant at the lower cut-off of >5.6%. Reducing HbA1C cut-off from 6.1% to 5.6% improved the sensitivity but reduced the specificity for prediction of APOs. Overall, late pregnancy HbA1C had a moderate predictive value for APOs. What the implications are of these findings for clinical practice and/or further research: HbA1C cut-off levels of neither ≥6.1% nor >5.6% were ideal in predicting APOs among pregnant women with pre-existing diabetes. As HbA1C levels tend to drop in pregnancy, caution should be taken when interpreting HbA1C in pregnancy. More multi-centred studies are required to explore the respective glycaemic target for each APO and to determine the ideal timing for late pregnancy HbA1C measurement.
    Matched MeSH terms: Pregnancy; Pregnancy in Diabetics/blood*; Pregnancy in Diabetics/epidemiology; Pregnancy Outcome/epidemiology*; Pregnancy Trimester, Third/blood*
  10. W Adnan WF, Nik Mahmood NMZ, Ismail MP, Mohamad Zon E, Othman MS, Kamaludin Z
    Cancer Treat Res Commun, 2022;33:100660.
    PMID: 36455511 DOI: 10.1016/j.ctarc.2022.100660
    BACKGROUND: Endometrial cancer in young women (less than 40-year-old) is associated with anovulatory menses, polycystic ovarian syndrome (PCOS) and subfertility. Endometrial cancer occurring in a miscarriage is rare. We highlight a case of endometrial cancer occurring during miscarriage of a non-viable pregnancy, its management and the outcome.

    CASE: A 32-year-old woman, Gravida 1 Para 0, was referred to our center at 7 weeks gestation in 2018 for uncontrolled diabetes mellitus diagnosed during investigation for subfertility. Her poor compliance with the treatment is consistent with an HbA1c of 8%. During the assessment, she was already complaining of lower abdominal pain. Ultrasound showed irregular IUGS with no fetal echo. She had a miscarriage soon; however, due to ultrasound evidence of thickened and irregular endometrium (17 mm) with mixed echogenicity, dilatation and curettage (D + C) were commenced. The first and second tissues were reported as the product of conception (POC) and well differentiated endometrioid adenocarcinoma, respectively. The first hysteroscopy showed foci area of polypoidal growth at the right posterior endometrium, obscuring the right ostium, with similar histology report. She was commenced on high-dose progestogen with hysteroscopy surveillance 6 months later, which showed disease regression. After two normal hysteroscopies and endometrial biopsies with continuous progestogen therapy for 12 months, cyclical progestogen for 12 months and follow-up for another 6 months, she had spontaneous conception and is currently pregnant at 16 weeks gestation.

    CONCLUSION: Endometrial cancer should be suspected in high-risk patients with first-trimester miscarriage. Individualized treatment with high dose progestogen and follow-up with the proper patient and partner counselling and education has high successful regressionand later on, pregnancy rate.

    Matched MeSH terms: Pregnancy; Pregnancy Trimester, First
  11. Naim NM, Ahmad S, Siraj HH, Ng P, Mahdy ZA, Razi ZR
    Obstet Gynecol, 2008 Feb;111(2 Pt 2):502-4.
    PMID: 18239000 DOI: 10.1097/01.AOG.0000279451.51446.c1
    Advanced abdominal pregnancy is rare, and one that occurs after uterine rupture with delivery of a viable fetus is exceptional.
    Matched MeSH terms: Pregnancy; Pregnancy, Abdominal/diagnosis*; Pregnancy, Abdominal/etiology*; Pregnancy, Abdominal/surgery
  12. Vela V, Teo J
    Aust N Z J Obstet Gynaecol, 2001 Aug;41(3):344-5.
    PMID: 11592558 DOI: 10.1111/j.1479-828x.2001.tb01245.x
    Matched MeSH terms: Pregnancy; Pregnancy Outcome*; Pregnancy, Abdominal*
  13. Wong CM, Ganesh R, Ng KY
    Med J Malaysia, 1999 Mar;54(1):117-9.
    PMID: 10972015
    Diagnosis of ectopic pregnancy prior to rupture is an arduous task even with the availability of many new investigative methods and imaging modalities. Above all, a high index of suspicion is necessary when dealing with women who present in early pregnancy with abdominal pain and vaginal bleeding. With the increased use of ovulation induction agents, the probability of heterotropic pregnancy should be kept in mind. The use of transvaginal ultrasonography (TVS) will help in earlier diagnosis because of its advantages over transabdominal ultrasonography (TAS).
    Matched MeSH terms: Pregnancy; Pregnancy, Ectopic/diagnosis*; Pregnancy, Ectopic/surgery; Pregnancy, Ectopic/ultrasonography
  14. Leong KW, Teh A, Bosco JJ, Lim J
    Postgrad Med J, 1995 Oct;71(840):625-7.
    PMID: 8545293
    Pregnancy following idiopathic aplastic anaemia is rare and is difficult to manage because of life-threatening episodes of bleeding and infections. Only a handful of cases has been reported in the literature. The pregnancies were unsuccessful in the majority. The present report describes a patient with moderately severe idiopathic aplastic anaemia who was managed with intensive haematological support leading to delivery of a healthy infant by caesarean section. Despite platelet transfusion refractoriness as a result of transfusions prior to pregnancy, adequate platelet transfusions prevented excessive bleeding. The literature is reviewed and management with platelet transfusions is discussed.
    Matched MeSH terms: Pregnancy*; Pregnancy Complications, Hematologic/etiology*; Pregnancy Complications, Hematologic/therapy
  15. Cheah SH, Sivanesaratnam V
    Aust N Z J Obstet Gynaecol, 1989 May;29(2):143-5.
    PMID: 2803125
    In this series the incidence of pregnancy in women in the reproductive age group admitted to hospital with burns was 7.8% (9 of 116). The maternal and perinatal outcome is related to the extent, presence or absence of complications of burns and to the gestational age of the fetus. Two maternal deaths in this series occurred in patients with burns involving more than 85% of the skin surface; in both instances stillbirths occurred less than 48 hours after the burns. In view of the high perinatal mortality, patients with extensive burns who are more than 32 weeks' pregnant should be delivered soon after admission. The extensively burned anterior abdominal wall can make assessment of uterine size difficult. An assessment in such a situation would be useful.
    Matched MeSH terms: Pregnancy; Pregnancy Complications*; Pregnancy Outcome*
  16. Sivalingam N
    Med J Malaysia, 1981 Dec;36(4):254-8.
    PMID: 7334965
    Forty patients with tubal ectopic pregnancies seen over an 18 month period are studied. Epidemiological parameters in the three major groups are compared. The diagnostic problems, signs and symptoms are discussed. Aetiological factors in this area are compared with changing trends in other centres. Pelvic inflammatory disease remains an important cause. The role of conservative approach in surgical treatment of ectopic pregnancy Z5 discussed. The crude incidence rate of ectopic pregnancy in Johore Baru Hospital between January 1978 and June 1979 is 1:358 deliveries.
    Matched MeSH terms: Pregnancy; Pregnancy, Tubal/diagnosis; Pregnancy, Tubal/epidemiology*; Pregnancy, Tubal/pathology
  17. Lim MA
    Med J Malaysia, 1974 Mar;28(3):171-5.
    PMID: 4278064
    Matched MeSH terms: Pregnancy; Pregnancy, Ectopic/diagnosis*; Pregnancy, Ectopic/etiology; Pregnancy, Ectopic/surgery
  18. Ariffin Bin Marzuki, Thambu JA
    Med J Malaysia, 1973 Mar;27(3):203-6.
    PMID: 4268925
    Matched MeSH terms: Pregnancy; Pregnancy Complications, Hematologic/mortality; Pregnancy Complications, Infectious/mortality
  19. Lee BS, Sathar J, Sivapatham L, Lee LI
    Malays J Pathol, 2018 Aug;40(2):149-152.
    PMID: 30173232 MyJurnal
    INTRODUCTION: Non-transfusion dependent thalassaemia (NTDT) is a term used for thalassaemia patients who do not require lifelong regular transfusions for survival. Pregnancy in these women, whether spontaneous or through assisted reproductive technology, represents a challenge for the physician.
    MATERIALS AND METHODS: The maternal and foetal outcomes of patients with NTDT followed up in a tertiary haematology centre over 6 months period were studied. A total of 36 pregnancies in 26 pregnant women with NTDT were analysed.
    RESULTS: Among these women, all of the pregnancies resulted in successful delivery of singleton live-born neonates. There were four clinically distinct forms of NTDT among these women which include Hb E/β-thalassemia (mild and moderate forms), HbH disease, HbH-Constant Spring, and homozygous δβ-thalassemia. No blood transfusion was needed in 15 of the 36 pregnancies (41.6%). The lowest mean Hb level in which no blood transfusion was given was 8.21 g/dL. The mean of packed-cell units received during pregnancy was 6.95 units per pregnancy. There was no worsening of serum ferritin observed during pregnancy with mean serum ferritin pre- and post-pregnancy of 409.35 ug/L and 418.18 ug/L respectively. The mean gestational age at delivery was 38.6 weeks with no preterm delivery reported. The mean foetal birth weight was 2729 grams. There was no intrauterine growth restriction (IUGR) or congenital malformation. There was a case of small for gestational age (SGA) and a case of oligohydramnios.
    CONCLUSION: This study showed that pregnancy was possible, safe and has a favourable outcome in patients with NTDT with multidisciplinary care.
    Matched MeSH terms: Pregnancy; Pregnancy Complications, Hematologic*; Pregnancy Outcome*
  20. Jan Mohamed HJ, Rowan A, Fong B, Loy SL
    PLoS One, 2014;9(7):e100705.
    PMID: 24992199 DOI: 10.1371/journal.pone.0100705
    Vitamin D deficiency has become a global health issue in pregnant women. This study aimed to assess the adequacy of maternal vitamin D status by measuring maternal serum and breast milk 25-hydroxyvitamin D [25(OH)D] levels and to determine the association between maternal serum and milk 25(OH)D levels.
    Matched MeSH terms: Pregnancy; Pregnancy Complications/blood*; Pregnancy Trimester, Second/blood*; Pregnancy Trimester, Third/blood*
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links