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The influence of ball-swing on the timing and coordination of a natural interceptive task

Sarpeshkar V, Mann DL, Spratford W, Abernethy B

Hum Mov Sci, 2017 Aug;54:82-100.
PMID: 28410536 DOI: 10.1016/j.humov.2017.04.003

Successful interception relies on the use of perceptual information to accurately guide an efficient movement strategy that allows performers to be placed at the right place at the right time. Although previous studies have highlighted the differences in the timing and coordination of movement that underpin interceptive expertise, very little is known about how these movement patterns are adapted when intercepting targets that follow a curvilinear flight-path. The aim of this study was to examine how curvilinear ball-trajectories influence movement patterns when intercepting a fast-moving target. Movement timing and coordination was examined when four groups of cricket batters, who differed in their skill level and/or age, hit targets that followed straight or curvilinear flight-paths. The results revealed that when compared to hitting straight trials, (i) mixing straight with curvilinear trials altered movement coordination and when the ball was hit, (ii) curvilinear trajectories reduced interceptive performance and significantly delayed the timing of all kinematic moments, but there were (iii) larger decrease in performance when the ball swung away from (rather than in towards) the performer. Movement coordination differed between skill but not age groups, suggesting that skill-appropriate movement patterns that are apparent in adults may have fully emerged by late adolescence.

Matched MeSH terms: Movement*
Editorial: Inclusion, equity, diversity and social justice in movement disorders research

Miyasaki JM, Lim TT, Bhidayasiri R

Parkinsonism Relat Disord, 2021 04;85:114-116.
PMID: 33840573 DOI: 10.1016/j.parkreldis.2021.03.022
Matched MeSH terms: Movement Disorders*
A fuzzy logic control in adjustable autonomy of a multi-agent system for an automated elderly movement monitoring application

Mostafa SA, Mustapha A, Mohammed MA, Ahmad MS, Mahmoud MA

Int J Med Inform, 2018 04;112:173-184.
PMID: 29500017 DOI: 10.1016/j.ijmedinf.2018.02.001

Autonomous agents are being widely used in many systems, such as ambient assisted-living systems, to perform tasks on behalf of humans. However, these systems usually operate in complex environments that entail uncertain, highly dynamic, or irregular workload. In such environments, autonomous agents tend to make decisions that lead to undesirable outcomes. In this paper, we propose a fuzzy-logic-based adjustable autonomy (FLAA) model to manage the autonomy of multi-agent systems that are operating in complex environments. This model aims to facilitate the autonomy management of agents and help them make competent autonomous decisions. The FLAA model employs fuzzy logic to quantitatively measure and distribute autonomy among several agents based on their performance. We implement and test this model in the Automated Elderly Movements Monitoring (AEMM-Care) system, which uses agents to monitor the daily movement activities of elderly users and perform fall detection and prevention tasks in a complex environment. The test results show that the FLAA model improves the accuracy and performance of these agents in detecting and preventing falls.

Matched MeSH terms: Movement*
Investigation to predict patellar tendon reflex using motion analysis technique

Tham LK, Osman NA, Lim KS, Pingguan-Murphy B, Abas WA, Zain NM

Med Eng Phys, 2011 May;33(4):407-10.
PMID: 21146440 DOI: 10.1016/j.medengphy.2010.11.002

The investigation of patellar tendon reflex involves development of a reflex hammer holder, kinematic data collection and analysis of patellar reflex responses using motion analysis techniques. The main aim of this research is to explore alternative means of assessing reflexes as a part of routine clinical diagnosis. The motion analysis system was applied to provide quantitative data which is a more objective measure of the patellar tendon reflex. Kinematic data was collected from 28 males and 22 females whilst subjected to a knee jerk test. Further analysis of kinematic data was performed to predict relationships which might affect the patellar tendon reflex. All subjects were seated on a high stool with their legs hanging freely within the capture volume of the motion analysis system. Knee jerk tests were applied to all subjects, on both sides of the leg, by eliciting hypo, hyper, and normal reflexes. An additional reinforcement technique called the Jendrassik manoeuvre was also performed under the same conditions to elicit a normal patellar tendon reflex. The comparison of reflex response between genders showed that female subjects generally had a greater response compared to males. However, the difference in reflex response between the left leg and the right leg was not significant. Tapping strength to elicit a hyper-reflex produced greater knee-jerk compared to the normal clinical tapping strength. All results were in agreement with clinical findings and results found by some early researchers.

Matched MeSH terms: Movement/physiology*
Fulltext Habitat suitability and movement corridors of grey wolf (Canis lupus) in Northern Pakistan

Kabir M, Hameed S, Ali H, Bosso L, Din JU, Bischof R, et al.

PLoS One, 2017;12(11):e0187027.
PMID: 29121089 DOI: 10.1371/journal.pone.0187027

Habitat suitability models are useful to understand species distribution and to guide management and conservation strategies. The grey wolf (Canis lupus) has been extirpated from most of its historic range in Pakistan primarily due to its impact on livestock and livelihoods. We used non-invasive survey data from camera traps and genetic sampling to develop a habitat suitability model for C. lupus in northern Pakistan and to explore the extent of connectivity among populations. We detected suitable habitat of grey wolf using a maximum entropy approach (Maxent ver. 3.4.0) and identified suitable movement corridors using the Circuitscape 4.0 tool. Our model showed high levels of predictive performances, as seen from the values of area under curve (0.971±0.002) and true skill statistics (0.886±0.021). The main predictors for habitat suitability for C. lupus were distances to road, mean temperature of the wettest quarter and distance to river. The model predicted ca. 23,129 km2 of suitable areas for wolf in Pakistan, with much of suitable habitat in remote and inaccessible areas that appeared to be well connected through vulnerable movement corridors. These movement corridors suggest that potentially the wolf range can expand in Pakistan's Northern Areas. However, managing protected areas with stringent restrictions is challenging in northern Pakistan, in part due to heavy dependence of people on natural resources. The habitat suitability map provided by this study can inform future management strategies by helping authorities to identify key conservation areas.

Matched MeSH terms: Movement/physiology*
Fulltext Development and performance of a new prosthesis system using ultrasonic sensor for wrist movements: a preliminary study

Abd Razak NA, Abu Osman NA, Gholizadeh H, Ali S

Biomed Eng Online, 2014 Apr 23;13:49.
PMID: 24755242 DOI: 10.1186/1475-925X-13-49

BACKGROUND: The design and performance of a new development prosthesis system known as biomechatronics wrist prosthesis is presented in this paper. The prosthesis system was implemented by replacing the Bowden tension cable of body powered prosthesis system using two ultrasonic sensors, two servo motors and microcontroller inside the prosthesis hand for transradial user.
METHODS: The system components and hand prototypes involve the anthropometry, CAD design and prototyping, biomechatronics engineering together with the prosthetics. The modeler construction of the system develop allows the ultrasonic sensors that are placed on the shoulder to generate the wrist movement of the prosthesis. The kinematics of wrist movement, which are the pronation/supination and flexion/extension were tested using the motion analysis and general motion of human hand were compared. The study also evaluated the require degree of detection for the input of the ultrasonic sensor to generate the wrist movements.
RESULTS: The values collected by the vicon motion analysis for biomechatronics prosthesis system were reliable to do the common tasks in daily life. The degree of the head needed to bend to give the full input wave was about 45°-55° of rotation or about 14 cm-16 cm. The biomechatronics wrist prosthesis gave higher degree of rotation to do the daily tasks but did not achieve the maximum degree of rotation.
CONCLUSION: The new development of using sensor and actuator in generating the wrist movements will be interesting for used list in medicine, robotics technology, rehabilitations, prosthetics and orthotics.

Matched MeSH terms: Movement*
Effects of utterance rate and length on the spatiotemporal index in Parkinson's disease

Chu SY, Barlow SM, Lee J, Wang J

Int J Speech Lang Pathol, 2020 04;22(2):141-151.
PMID: 31213093 DOI: 10.1080/17549507.2019.1622781

Purpose: To characterise labial articulatory pattern variability using the spatiotemporal index (STI) in speakers with idiopathic Parkinson's disease (PD) across different speaking rates and syllable-sentence conditions compared to age- and sex-matched healthy controls.Method: Ten speakers with mild-severe idiopathic PD and 10 controls produced "pa" and the Rainbow Passage at slow, typical and fast speech rates. Upper lip and lower lip kinematics were digitised during a motion capture system. Data were analysed using linear mixed modelling.Result: Regardless of the participant group, a high STI value was observed in the fast speech rate for the "pa" syllable condition, particularly for movements of the lower lip. As utterance rate increased, the control group showed the highest variability, followed by PD OFF and PD ON conditions. Syllable "pa" showed a greater STI value compared to both the first and second utterance of Rainbow Passage.Conclusion: PD manifests sufficient residual capacity to achieve near-normal motor compensation to preserve the consistency of lower lip movements during speech production. The lack of a significant difference in lip STI values between ON-OFF medication states suggests that dopaminergic treatment does not influence stability of speech for individuals with mild-moderate stage PD.

Matched MeSH terms: Movement
Fulltext 3D Transparent Object Detection and Reconstruction Based on Passive Mode Single-Pixel Imaging

Mathai A, Guo N, Liu D, Wang X

Sensors (Basel), 2020 Jul 29;20(15).
PMID: 32751165 DOI: 10.3390/s20154211

Transparent object detection and reconstruction are significant, due to their practical applications. The appearance and characteristics of light in these objects make reconstruction methods tailored for Lambertian surfaces fail disgracefully. In this paper, we introduce a fixed multi-viewpoint approach to ascertain the shape of transparent objects, thereby avoiding the rotation or movement of the object during imaging. In addition, a simple and cost-effective experimental setup is presented, which employs two single-pixel detectors and a digital micromirror device, for imaging transparent objects by projecting binary patterns. In the system setup, a dark framework is implemented around the object, to create shades at the boundaries of the object. By triangulating the light path from the object, the surface shape is recovered, neither considering the reflections nor the number of refractions. It can, therefore, handle transparent objects with a relatively complex shape with the unknown refractive index. The implementation of compressive sensing in this technique further simplifies the acquisition process, by reducing the number of measurements. The experimental results show that 2D images obtained from the single-pixel detectors are better in quality with a resolution of 32×32. Additionally, the obtained disparity and error map indicate the feasibility and accuracy of the proposed method. This work provides a new insight into 3D transparent object detection and reconstruction, based on single-pixel imaging at an affordable cost, with the implementation of a few numbers of detectors.

Matched MeSH terms: Movement
Morphological patterns of the palatal rugae: A review

Chong JA, Mohamed AMFS, Pau A

J Oral Biosci, 2020 09;62(3):249-259.
PMID: 32619633 DOI: 10.1016/j.job.2020.06.003

BACKGROUND: Palatal rugae are asymmetric ridges of connective tissue located behind the incisive papilla over the anterior hard palate. They serve as stable superimposition landmarks to assess tooth movement in orthodontics and as identification aids in forensic odontology. However, the stability of palatal rugae remains controversial. This review aimed to describe the genetic, growth, and environmental factors that may influence the palatal rugae patterns. A broad search of PubMed and ScienceDirect databases was conducted. A total of 193 articles were identified, of which 73 met the selection criteria. Data were extracted into a table that presented the details of the study, sample description, and changes in the palatal rugae patterns.
HIGHLIGHT: There were conflicting results regarding sexual dimorphism and population characterization of the palatal rugae patterns. All rugae showed positional changes, increased lengths, and lower numbers, but no significant shape changes with growth. The lengths, numbers, and positions of the rugae were affected by orthodontic treatment, especially their lateral points, but their individual characteristics did not change.
CONCLUSION: The diversity in rugae patterns and their potential for sex discrimination among different populations showed differing results due to individual variations and the complex influence of genetic, growth, and environmental factors on their morphology.

Matched MeSH terms: Tooth Movement
Fulltext Standard versus real versus fake braces: design and microstructure comparison

Siti Hajjar Nasir, Noraini Abu Bakar, Rosdiyana Samad

International Medical Journal Malaysia, 2017;16(21):11-11.
MyJurnal

The growing demand for orthodontic braces among Malaysian community has led to
the development of "fake" and "real" braces. "Fake" braces refer to braces that are worn as costume
and are not bonded to teeth hence unable to produce movement of teeth. "Real" braces refer to
braces that are bonded to tooth structure and are able to produce tooth movement. The braces are
bonded by unqualified practitioners with no formal dental education and they provide braces
treatment in unlicensed premises such as hotel rooms or patients' own homes. (Copied from article).

Matched MeSH terms: Movement
MEMS switch contact bouncing mitigation using novel dual-pulse actuation voltage

Lai C, Wong W

Sains Malaysiana, 2011;40.

A novel dual-pulse actuation voltage that reduces dielectric charging in micro-electromechanical system (MEMS) switch and thus leading to a longer switch lifetime, are shown to simultaneously mitigate MEMS switch contact bouncing. A simple mass-spring-damper mathematical model is used to simulate movement of the switch contact as the excitation voltage is applied. The model shows that the novel dual-pulse voltages damped the acceleration of the switch membrane as it approaches the contact point, eventually slowing it down and minimizes the impact force. This has the effect of minimizing the occurrence of contact bouncing. Practical experiment on the commercial TeraVicta TT712-68CSP MEMS switch corroborates that the novel excitation voltages reduced bouncing.

Matched MeSH terms: Movement
Fulltext A randomised approach for enumerating migrated cells in a transwell migration assay

Kanesan, Livashini, Siti Sarah Omar Zaki, Vidyadaran, Sharmili

Malaysian Journal of Medicine and Health Sciences, 2018;14(103):50-53.
MyJurnal

The transwell migration assay is commonly used for assessing cell migration. It involves the enumeration of cells that
have migrated across a pore-containing membrane. We describe a randomised approach to quantifying migrated
cells and compare it to a conventional full cell count. We used ATP as a chemoattractant and automatic cell quantification performed on all fields (Full count; FC) or 10 randomly selected fields (Randomised count; RC). The two
methods were compared by evaluating standard deviations (SD), coefficient of variation (CV) and using the Bland-Altman analysis. The dispersion of data is higher with the RC approach (3.77-6.66% CV for control; 3.89-4.48% CV
for ATP-treated wells) compared to FC (0.27-0.46% CV for control; 0.05-0.09% CV for ATP-treated wells), but are
acceptable considering that the number of migrated cells are in the thousands. Both methods verified that an ATP
migration assay for BV2 microglia was established, demonstrating that the RC approach is reliable and comparable
to a full count.

Matched MeSH terms: Cell Movement
Dynamic Modeling of Fiber-Reinforced Soft Manipulator: A Visco-Hyperelastic Material-Based Continuum Mechanics Approach

Mustaza SM, Elsayed Y, Lekakou C, Saaj C, Fras J

Soft Robot, 2019 06;6(3):305-317.
PMID: 30917093 DOI: 10.1089/soro.2018.0032

Robot-assisted surgery is gaining popularity worldwide and there is increasing scientific interest to explore the potential of soft continuum robots for minimally invasive surgery. However, the remote control of soft robots is much more challenging compared with their rigid counterparts. Accurate modeling of manipulator dynamics is vital to remotely control the diverse movement configurations and is particularly important for safe interaction with the operating environment. However, current dynamic models applied to soft manipulator systems are simplistic and empirical, which restricts the full potential of the new soft robots technology. Therefore, this article provides a new insight into the development of a nonlinear dynamic model for a soft continuum manipulator based on a material model. The continuum manipulator used in this study is treated as a composite material and a modified nonlinear Kelvin-Voigt material model is utilized to embody the visco-hyperelastic dynamics of soft silicone. The Lagrangian approach is applied to derive the equation of motion of the manipulator. Simulation and experimental results prove that this material modeling approach sufficiently captures the nonlinear time- and rate-dependent behavior of a soft manipulator. Material model-based closed-loop trajectory control was implemented to further validate the feasibility of the derived model and increase the performance of the overall system.

Matched MeSH terms: Movement
Fulltext Inhibition of miR-141 and miR-200a Increase DLC-1 and ZEB2 Expression, Enhance Migration and Invasion in Metastatic Serous Ovarian Cancer

Wahab NA, Othman Z, Nasri NWM, Mokhtar MH, Ibrahim SF, Hamid AA, et al.

Int J Environ Res Public Health, 2020 04 17;17(8).
PMID: 32316405 DOI: 10.3390/ijerph17082766

The role of microRNA (miRNA) in ovarian cancer has been extensively studied as a regulator for its targeted genes. However, its specific role in metastatic serous ovarian cancer (SOC) is yet to be explored. This paper aims to investigate the differentially expressed miRNAs in metastatic SOC compared to normal. Locked nucleic acid PCR was performed to profile miRNA expression in 11 snap frozen metastatic SOC and 13 normal ovarian tissues. Functional analysis and regulation of their targeted genes were assessed in vitro. Forty-eight miRNAs were significantly differentially expressed in metastatic SOC as compared to normal. MiR-19a is a novel miRNA to be upregulated in metastatic SOC compared to normal. DLC1 is possibly regulated by miR-141 in SOC. MiR-141 inhibition led to significantly reduced cell viability. Cell migration and invasion were significantly increased following miRNA inhibition. This study showed the aberrantly expressed miRNAs in metastatic SOC and the roles of miRNAs in the regulation of their targeted genes and ovarian carcinogenesis.

Matched MeSH terms: Cell Movement
Fulltext The effect of resting morphological lip shape during lip movement: A three-dimensional motion analysis study

Nasir SH, Popat H, Richmond S

Heliyon, 2020 Jun;6(6):e04093.
PMID: 32514484 DOI: 10.1016/j.heliyon.2020.e04093

Purpose: The aim of this study was to determine the influence of different morphological lip shape during lip movement.
Method: A sample of 80 individuals with three-dimensional facial images at rest and during speech were recorded. Subjects were asked to pronounce four bilabial words in a relaxed manner and scanned using the 3dMDFace™ Dynamic System at 48 frames per second. Six lip landmarks were identified at rest and the landmark displacement vectors for the frame of maximal lip movement for all six visemes were recorded. Principal component analysis was applied to isolate relationship between lip traits and their registered coordinates. Eight specific resting morphological lip traits were identified for each individual. The principal component (PC) scores for each viseme were labelled by lip morphological trait and were graphically visualized as ellipses to discriminate any differences in lip movement.
Results: The first five PCs accounted for up to 95% of the total variance in lip shape during movement, with PC1 accounting for at least 38%. There was no clear discrimination between PC1, PC2 and PC3 for any of the resting morphological lip traits.
Conclusion: Lip shapes during movement are more uniform between individuals and resting morphological lip shape does not influence movement of the lips.

Matched MeSH terms: Movement
Fulltext Angular velocity and elevation angle: the proposed human model scalable tracking model using linear regression

Yong CY, Sudirman R, Chew KM

Sains Malaysiana, 2015;44(12):1661-1669.

A scalable tracking human model was proposed for recognizing human jogging and walking activities. The model aims to detect and track a particular subject by using wearable sensor. Data collected are in accelerometer readings in three axes and gyroscope readings in three axes. The development of proposed human model is based on the moderating effects on human movements. Two moderators were proposed as the moderating factors of human motion and they are angular velocity and elevation angle. Linear regression is used to investigate the relationship among inputs, moderators and outputs of the model. The result of this study showed that the angular velocity and elevation angle moderators are affecting the relation of research output. Acceleration in x-axis (Ax) and angular velocity in y-axis (Gy) are the two main components in directing
a motion. Classification between jogging and walking motions was done by measuring the magnitude of angular velocity and elevation angle. Jogging motion was classified and identified with larger angular velocity and elevation angle. The two proposed hypotheses were supported and proved by research output. The result is expected to be beneficial and able to assist researcher in investigating human motions.

Matched MeSH terms: Movement
Fulltext Modulation of POPDC1 Expression by Phenothiazine and Trifluoperazine Suppress Colon Cancer Growth and Migration

Thomas FM, Sudi S, Muhamad Salih FA, Palasuberniam P, Suali L, Mohd Sani MH, et al.

Asian Pac J Cancer Prev, 2022 Aug 01;23(8):2863-2871.
PMID: 36037145 DOI: 10.31557/APJCP.2022.23.8.2863

OBJECTIVE: The aim of this study was to investigate the effects of CaM antagonist, PTZ, and TFP on cell proliferation and migration of colon cancer cells and its impact on POPDC protein expression.
METHODS: The 50% inhibitory concentration (IC50) of PTZ and TFP in SW1116, SW480, HCT-15, and COLO205 colon cancer cell lines are measured using MTT. Western blot and immunocytochemistry were used to determine the expression of PCNA, cyclin D1 (CD1), and POPDC proteins. Cell migration was observed using a scratch wound-healing assay.
RESULTS: Treatment with PTZ and TFP inhibited colon cancer cells growth in a dose-dependent manner. PTZ and TFP significantly inhibited the activation of proliferation markers, PCNA and CD1, and the migration of colon cancer cells. Furthermore, POPDC protein was significantly suppressed in all cell types of colon cancer, particularly in SW480. Finally, the CaM antagonist upregulates the POPDC1 expression in colon cancer cells.
CONCLUSION: These findings suggest that CaM antagonists suppress colon cancer cells proliferation via downregulation of CD1 and PCNA. In addition, POPDC protein could be used as a biomarker in colon cancer, and CaM antagonist could be used to regulate POPDC1 expression. This study suggests that targeting POPDC1 with CaM inhibition could be a potential therapeutic strategy for colon cancer treatment.
.

Matched MeSH terms: Cell Movement
Fulltext Modeling the Effect of Curvature on the Collective Behavior of Cells Growing New Tissue

Alias MA, Buenzli PR

Biophys J, 2017 Jan 10;112(1):193-204.
PMID: 28076811 DOI: 10.1016/j.bpj.2016.11.3203

The growth of several biological tissues is known to be controlled in part by local geometrical features, such as the curvature of the tissue interface. This control leads to changes in tissue shape that in turn can affect the tissue's evolution. Understanding the cellular basis of this control is highly significant for bioscaffold tissue engineering, the evolution of bone microarchitecture, wound healing, and tumor growth. Although previous models have proposed geometrical relationships between tissue growth and curvature, the role of cell density and cell vigor remains poorly understood. We propose a cell-based mathematical model of tissue growth to investigate the systematic influence of curvature on the collective crowding or spreading of tissue-synthesizing cells induced by changes in local tissue surface area during the motion of the interface. Depending on the strength of diffusive damping, the model exhibits complex growth patterns such as undulating motion, efficient smoothing of irregularities, and the generation of cusps. We compare this model with in vitro experiments of tissue deposition in bioscaffolds of different geometries. By including the depletion of active cells, the model is able to capture both smoothing of initial substrate geometry and tissue deposition slowdown as observed experimentally.

Matched MeSH terms: Cell Movement
Fulltext An Assessment of the Movement and Function of Children with Specific Learning Disabilities: A Review of Five Standardised Assessment Tools

Baharudin NS, Harun D, Kadar M

Malays J Med Sci, 2020 Mar;27(2):21-36.
PMID: 32788838 MyJurnal DOI: 10.21315/mjms2020.27.2.3

Various standardised assessment tools have been used to evaluate children with disabilities. However, assessment tools that provide information on the movement and function of children with specific learning disabilities (SLD) are still limited. This article provides a narrative review of the characteristics of five movement and/or function assessment tools. The strengths and limitations of the tools will be highlighted. Empirical studies on the assessment tools used are reviewed based on three criteria: (i) standardised tools; (ii) assessment of movement and/or function; (iii) applicability to children with SLD ranging from 4-17 years of age and widely used in practice. The following instruments have been included as they have been found to fulfil the criteria: (i) the Bruininks-Oseretsky test of motor proficiency-2 (BOT-2); (ii) the movement assessment battery for children-2 (MABC-2); (iii) the pediatric balance scale (PBS); (iv) the Vineland adaptive behaviour scale-II (VABS-II) and (v) the pediatric evaluation of disability inventory-computerised adaptive test (PEDI-CAT). The article presents the characteristics, strengths and limitations of five standardised assessment tools that are currently in use, which measure the movement and/or function of children with SLD. This article concludes with a discussion of recommendations for the best approaches to evaluating the movement and functional abilities of children with SLD.

Matched MeSH terms: Movement
Fulltext A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts

Kabir TD, Leigh RJ, Tasena H, Mellone M, Coletta RD, Parkinson EK, et al.

Aging (Albany NY), 2016 08;8(8):1608-35.
PMID: 27385366 DOI: 10.18632/aging.100987

Senescent cancer-associated fibroblasts (CAF) develop a senescence-associated secretory phenotype (SASP) that is believed to contribute to cancer progression. The mechanisms underlying SASP development are, however, poorly understood. Here we examined the functional role of microRNA in the development of the SASP in normal fibroblasts and CAF. We identified a microRNA, miR-335, up-regulated in the senescent normal fibroblasts and CAF and able to modulate the secretion of SASP factors and induce cancer cell motility in co-cultures, at least in part by suppressing the expression of phosphatase and tensin homologue (PTEN). Additionally, elevated levels of cyclo-oxygenase 2 (PTGS2; COX-2) and prostaglandin E2 (PGE2) secretion were observed in senescent fibroblasts, and inhibition of COX-2 by celecoxib reduced the expression of miR-335, restored PTEN expression and decreased the pro-tumourigenic effects of the SASP. Collectively these data demonstrate the existence of a novel miRNA/PTEN-regulated pathway modulating the inflammasome in senescent fibroblasts.

Matched MeSH terms: Cell Movement/drug effects; Cell Movement/physiology

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