Displaying publications 81 - 100 of 608 in total

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  1. Francis Paul, Kent Kong Kian Keong, Jennifer Tan, Anna Lee En Moi, Alen Lim Chung Chieh
    MyJurnal
    Introduction: Maternal death is a sensitive health indicator being monitored closely by the Ministry of Health. Obstetric emergency (OE) protocol is introduced to manage OE and to improve maternal outcome. However, there is no national OE guideline available and the OE protocol varies among different institutions. The current audit aims to evaluate the service quality during OE in Duchess of Kent Hospital (DOKH) in accordance with OE protocol DOKH revision-2017.
    Matched MeSH terms: Maternal Death
  2. Kelkar SK
    A case of intra-uterine normal pregnancy with an extra-uterine abdominal full term dead foetus (lithopaedion) is described. The impossibility of differentiation from twin uterine pregnancy until after birth of first baby is pointed out.
    Matched MeSH terms: Fetal Death
  3. Koshy M, Bushra Johari, Mohd Farhan Hamdan, Mohammad Hanafiah
    Hypertrophic cardiomyopathy (HCM) is a global disease affecting people of various ethnic origins and both genders. HCM is a genetic disorder with a wide range of symptoms, including the catastrophic presentation of sudden cardiac death. Proper diagnosis and treatment of this disorder can relieve symptoms and prolong life. Non-invasive imaging is essential in diagnosing HCM. We present a review to deliberate the potential use of cardiac magnetic resonance (CMR) imaging in HCM assessment and also identify the risk factors entailed with risk stratification of HCM based on Magnetic Resonance Imaging (MRI).
    Matched MeSH terms: Death, Sudden, Cardiac
  4. Wu M, Lu Y, Yang W, Wong SY
    Front Comput Neurosci, 2020;14:564015.
    PMID: 33469423 DOI: 10.3389/fncom.2020.564015
    Cardiovascular diseases (CVDs) are the leading cause of death today. The current identification method of the diseases is analyzing the Electrocardiogram (ECG), which is a medical monitoring technology recording cardiac activity. Unfortunately, looking for experts to analyze a large amount of ECG data consumes too many medical resources. Therefore, the method of identifying ECG characteristics based on machine learning has gradually become prevalent. However, there are some drawbacks to these typical methods, requiring manual feature recognition, complex models, and long training time. This paper proposes a robust and efficient 12-layer deep one-dimensional convolutional neural network on classifying the five micro-classes of heartbeat types in the MIT- BIH Arrhythmia database. The five types of heartbeat features are classified, and wavelet self-adaptive threshold denoising method is used in the experiments. Compared with BP neural network, random forest, and other CNN networks, the results show that the model proposed in this paper has better performance in accuracy, sensitivity, robustness, and anti-noise capability. Its accurate classification effectively saves medical resources, which has a positive effect on clinical practice.
    Matched MeSH terms: Cause of Death
  5. Rahimi R, Singh MKC, Noor NM, Omar E, Noor SM, Mahmood MS, et al.
    J Atheroscler Thromb, 2018 May 01;25(5):405-409.
    PMID: 29118310 DOI: 10.5551/jat.39107
    AIMS: The present study aimed to determine the epidemiological aspects of medico-legal autopsies and manifestation of coronary atherosclerosis.

    METHODS: This was a cross sectional study involving 222 cases recruited from National Institute of Forensic Medicine (NIFM) Hospital Kuala Lumpur (HKL) and Department of Forensic Medicine Hospital Sungai Buloh (HSgB) for a period of 15 months, from December 2012 to April 2014. Sociodemographic and autopsy findings, including the cause and manner of death were documented.

    RESULTS: Male and female subjects aged 18-70 years were recruited. Males contributed to 86% of the total subjects and comprised 61% of young adults. Road traffic accidents were the primary cause of death, contributing almost 50% of the subjects. One third of the cases comprised of death due to natural causes, wherein almost 75% of the subjects within this category succumbed to sudden cardiac death. Coronary artery disease (CAD) contributed to 60% of the sudden cardiac death (SCD). Single and double-vessel diseases were the most common pattern of atherosclerosis. In almost 80% of CAD cases, atherosclerosis affected the left anterior descending artery (LAD).

    CONCLUSION: Cardiovascular diseases were the most significant natural cause of sudden death with a staggering figure of 75%. CAD was the single most commonly encountered pathology within the SCD. Most cases presented with single and double-vessel diseases, observed in all subjects, as well as the young adult population.

    Matched MeSH terms: Cause of Death; Death, Sudden, Cardiac/etiology*; Death, Sudden, Cardiac/epidemiology
  6. Makmor, T., Abdillah, N., NurulHuda, M.S., Raja Noriza, R.A., Roza Hazli, Z.
    JUMMEC, 2015;18(1):1-4.
    MyJurnal
    The family is an important factor that influences an individual’s decision for organ donation. The number of studies addressing the family’s role in organ donation is limited. It is imperative to explore these studies and offer recommendations that may help in addressing organ shortage. 15 studies with more than 2100 participants were selected for a systematic review. The studies were accessed by searching three databases: MEDLINE, Elsevier, and PsycINFO. This systematic review indicates that knowledge about brain death and the circumstances surrounding organ donation and transplantation are the most important factors that affect a family’s decision regarding organ donation. Educational efforts targeting the family should be initiated, which can then guide the family’s decision on organ donation. We suggest that educational efforts be consistent with other factors such as religious beliefs that influence the family’s decision.
    Matched MeSH terms: Brain Death
  7. Sasongko, Teguh Haryo, Zilfalil Alwi
    MyJurnal
    Spinal muscular atrophy (SMA), a leading genetic cause of death in childhood, is caused by deletion of the SMN1 gene, located at chromosome 5q13. The molecular pathogenesis, which results in motor neuron degeneration within the anterior horn of spinal cord, is a focus of debate among scientists. The unique nature of the duplicative 5q chromosomal region provides considerable yet challenging opportunity for disease correction as well as complication in performing molecular diagnosis and understanding the molecular pathogenesis. This article reviewed recent findings in the molecular pathogenesis of SMA as well as the research advances in the molecular diagnosis and therapeutic approaches.
    Matched MeSH terms: Cause of Death
  8. Helenna M Hisham Hashim, Lee, Mei-Li, Ng, Chong Guan
    MyJurnal
    Objective: Individuals deal with dying and death differently and may not experience the same journey. We investigated Kübler-Ross' Five Stages of Grief on terminally ill patients to review the current applicability of the model among this population. The aims of this paper is to share information regarding the Five Stages of Grief, the emotions associated with the stages, and the challenges that terminally ill patients, namely those diagnosed with cancer, experience. Methods: Non-structured interviews were conducted among terminally ill patients located at the palliative ward for two years. Results: We found that terminally ill patients at the palliative ward were undergoing the Five Stages of Grief, and that the emotions associated with the stages were reported to be similar to the emotions proposed in the model and among the patients. Conclusion: Kübler-Ross' Five Stages of Grief is still applicable among terminally ill patients. The thoughts regarding dying and death still remain negative, therefore, the change in the myths of dying and death are required to help improve the journey towards death. ASEAN Journal of Psychiatry, Vol. 14 (1): January - June 2013: XX XX.
    Matched MeSH terms: Death
  9. Levin, K.B, Das, S.
    MyJurnal
    In this article, we speculate the reasons behind the death of Achilles during the Trojan war. Roots of Medicine can be traced to ancient Greek history. From the Hippocrates Oath to the Achilles tendon, it all has a long story to tell. In the history of ancient Greece, Gods played an important role in their lives and the immortals existed.
    Matched MeSH terms: Death
  10. Mardiana Mansor
    MyJurnal
    The article review was to identify, discuss, explore, critically analyze and evaluate the scenario of Human ImmunodeficiencyVirus (HIV) among women in nursing perspective taking into account global perspective. The current aim is to reduce the number of HIV globally, especially among women. Acquired immune deficiency syndrome (AIDS) is considered as a disease state of hopelessness and imminent death. HIV and AIDS status demotivate the women emotionally in physical, social, and emotional perspectives. HIV-positive women portray of AIDS is deeply discrediting; with physical failure, moral failure, and social ostracism.
    Matched MeSH terms: Death
  11. Khoo SB
    Asia Pac Fam Med, 2003;2(3):143-147.
    The concept of palliative care is still quite new in Malaysia. Through the experience of delivering palliative care in both the hospital and community settings, the author has realized that there are many false beliefs among the medical and nursing professionals, as well as patients and their caregivers. By exploring and providing factual explanations to these beliefs, the present article highlights the differences in approach between acute and palliative management and the importance of good communication skills, as well as correcting the myths of patients and their caregivers, with the aim of improving the understanding of palliative care., (C) 2003 Blackwell Science Ltd
    Matched MeSH terms: Death
  12. Sansom CL
    J Trop Med Hyg, 1916;19:69-86.
    Contents:
    Vital statistics
    Principal causes of death
    Return op diseases and deaths, 1914 in the Hospitals in Perak, Selangor, Negri Sembilan and Pahang
    Smallpox
    Veneral diseases
    Quarantine station, Port Swettenham
    Estates
    Veterinary
    Quarantine stations
    Metereology
    General
    Perak
    Malaria advisor board
    Institute for Medical Research
    Malaria board bureau, Kuala Lumpur, F.M.S., March 1, 1915. By C. Strickland, Travelling Medical Entomologist, F.M.S.
    An outbreak of fever at Morib in the Federated Malay States
    Matched MeSH terms: Cause of Death
  13. Shahrom AW, Md Azman AB, Hasnah H, Md Yusof M
    Family Physician, 1991;3:28-29.
    Blood alcohol levels from 155 UKM forensic postmortem cases of various causes of death from August 1988 to mid-September 1989 were studied. 59 cases (38%) were related to fatal road traffic accidents. 13 of these 59 cases (22%) showed blood alcohol levels of more than 50 mg/dl. 11 of these 13 cases (84.6%) revealed blood alcohol levels of more than 100 mg/dl after correction. Further analysis showed 53.8% were Indian, 76.9% aged between 20 and 40 years, 84.6% of the accidents occurred between 8.00 p.m. and 4.00 a.m. and all the alcohol related fatal road traffic accident victims studied in this series were males. This study provides helpful information.
    Matched MeSH terms: Death
  14. Ahmad NS, Abdullah N, Yasin FM
    Toxicol Rep, 2020;7:693-699.
    PMID: 32528857 DOI: 10.1016/j.toxrep.2020.04.015
    Toxicity effect of reduced graphene oxide (rGO) and titanium dioxide (TiO2) nanomaterials (NMs) on Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacteria was assessed. For both strains, study demonstrated that the toxicity was time and concentration dependent which led to reduction in growth rate and cell death. Upon NMs exposure, an instantaneous cell death in E. coli culture was observed. This is in contrast with B. subtilis, in which the culture growth remained in the log phase; however their growth rate constant,

    μ
    g

    was reduced by ∼70%. The discrepancy between E. coli and B. subtilis was due to strain-specific response upon contact with NMs. TEM, SEM and EDX analysis revealed direct physical surface-surface interaction, as evidence from the adherence of NMs on the cell surface.
    Matched MeSH terms: Cell Death
  15. Dasrilsyah RA, Ahmad S, Tan GC, Lim PS
    MyJurnal
    Congenital leukemia is an extremely rare disease but frequently fatal. We report a case of intrauterine death (IUD) secondary to congenital erythroid leukaemia associated with maternal Parvovirus B19 infection. Further research is needed to ascertain the association between maternal Parvovirus B19 infection and congenital leukemia.
    Matched MeSH terms: Fetal Death
  16. Fazel MF, Mohamad MHN, Sahar MA, Juliana N, Abu IF, Das S
    Int J Environ Res Public Health, 2022 Sep 02;19(17).
    PMID: 36078684 DOI: 10.3390/ijerph191710968
    Early cardiopulmonary resuscitation (CPR) is a strong link in the of survival for sudden cardiac arrest. Hence, bystander CPR (BPCR) plays an important role in curbing mortality and morbidity from out-of-hospital sudden cardiac arrest. However, the recent global Coronavirus disease 2019 (COVID-19) pandemic has impacted both public training and confidence in performing out-of-hospital CPR. This paper reviews detailed information from databases including Google Scholar, Scopus, PubMed and Web of Science on the readiness of BCPR during the pandemic. We also discussed the challenges bystanders encountered during the COVID-19 pandemic and the precautions to follow. Finally, we also highlighted the limitations which would benefit future endeavours in establishing well-planned and sustainable CPR training programs for the public. Therefore, regardless of the existing COVID-19 pandemic, BCPR must be emphasised to curb out-of-hospital cardiac arrest (OHCA) mortality.
    Matched MeSH terms: Death, Sudden, Cardiac
  17. Law D, Abdulkareem Najm A, Chong JX, K'ng JZY, Amran M, Ching HL, et al.
    PeerJ, 2023;11:e15651.
    PMID: 37483971 DOI: 10.7717/peerj.15651
    A previous study has shown that synthetic antimicrobial peptides (AMPs) derived from Anabas testudineus (ATMP1) could in-vitro inhibit the progression of breast cancer cell lines. In this study, we are interested in studying altered versions of previous synthetic AMPs to gain some insight into the peptides functions. The AMPs were altered and subjected to bioinformatics prediction using four databases (ADP3, CAMP-R3, AMPfun, and ANTICP) to select the highest anticancer activity. The bioinformatics in silico analysis led to the selection of two AMPs, which are ATMP5 (THPPTTTTTTTTTTTYTAAPATTT) and ATMP6 (THPPTTTTTTTTTTTTTAAPARTT). The in silico analysis predicted that ATMP5 and ATMP6 have anticancer activity and lead to cell death. The ATMP5 and ATMP6 were submitted to deep learning databases (ToxIBTL and ToxinPred2) to predict the toxicity of the peptides and to (AllerTOP & AllergenFP) check the allergenicity. The results of databases indicated that AMPs are non-toxic to normal human cells and allergic to human immunoglobulin. The bioinformatics findings led to select the highest active peptide ATMP5, which was synthesised and applied for in-vitro experiments using cytotoxicity assay MTT Assay, apoptosis detection using the Annexin V FTIC-A assay, and gene expression using Apoptosis PCR Array to evaluate the AMP's anticancer activity. The antimicrobial activity is approved by the disc diffusion method. The in-vitro experiments analysis showed that ATMP5 had the activity to inhibit the growth of the breast cancer cell line (MDA-MB-231) after 48 h and managed to arrest the cell cycle of the MDA-MB-231, apoptosis induction, and overexpression of the p53 by interaction with the related apoptotic genes. This research opened up new opportunities for developing potential and selective anticancer agents relying on antimicrobial peptide properties.
    Matched MeSH terms: Cell Death
  18. Jorfi S, Ansa-Addo EA, Mariniello K, Warde P, Bin Senian AA, Stratton D, et al.
    J Gen Virol, 2023 Sep;104(9).
    PMID: 37665326 DOI: 10.1099/jgv.0.001884
    Like most non-enveloped viruses, CVB1 mainly uses cell lysis to spread. Details of a nonlytic virus transmission remain unclear. Extracellular Vesicles (EVs) transfer biomolecules between cells. We show that CVB1 entry into HeLa cells results in apoptosis and release of CVB1-induced 'medium-sized' EVs (CVB1i-mEVs). These mEVs (100-300 nm) harbour CVB1 as shown by immunoblotting with anti-CVB1-antibody; viral capsids were detected by transmission electron microscopy and RT-PCR revealed CVB1 RNA. The percentage of mEVs released from CVB1-infected HeLa cells harbouring virus was estimated from TEM at 34 %. Inhibition of CVB1i-mEV production, with calpeptin or siRNA knockdown of CAPNS1 in HeLa cells limited spread of CVB1 suggesting these vesicles disseminate CVB1 virions to new host cells by a nonlytic EV-to-cell mechanism. This was confirmed by detecting CVB1 virions inside HeLa cells after co-culture with CVB1i-mEVs; EV release may also prevent apoptosis of infected cells whilst spreading apoptosis to secondary sites of infection.
    Matched MeSH terms: Cell Death
  19. Sanusi SB, Abu Bakar MF, Mohamed M, Sabran SF, Mainasara MM
    PMID: 29081822 DOI: 10.1155/2017/7185649
    Despite all of the control strategies, tuberculosis (TB) is still a major cause of death globally and one-third of the world's population is infected with TB. The drugs used for TB treatment have drawbacks of causing adverse side effects and emergence of resistance strains. Plant-derived medicines have since been used in traditional medical system for the treatment of numerous ailments worldwide. There were nine major review publications on antimycobacteria from plants in the last 17 years. However, none is focused on Southeast Asian medicinal plants. Hence, this review is aimed at highlighting the medicinal plants of Southeast Asian origin evaluated for anti-TB. This review is based on literatures published in various electronic database. A total of 132 plants species representing 45 families and 107 genera were reviewed; 27 species representing 20.5% exhibited most significant in vitro anti-TB activity (crude extracts and/or bioactive compounds 0-<10 µg/ml). The findings may motivate various scientists to undertake the project that may result in the development of crude extract that will be consumed as complementary or alternative TB drug or as potential bioactive compounds for the development of novel anti-TB drug.
    Matched MeSH terms: Cause of Death
  20. Subramaniam S, Boo K
    Malays J Pathol, 1992 Jun;14(1):49-51.
    PMID: 1469919
    A healthy 17-year-old Chinese male suddenly collapsed and died during a game of badminton. The autopsy examination revealed a solitary calcified aneurysm of the left common coronary artery with marked stenosis of the orifices of the anterior descending and circumflex branches. Histology of the aneurysm was non-specific with hyalinised scar tissue and foci of calcification. The only illness of significance in the past was an episode of 'pyrexia of unknown origin' at the age of 8 months. A review of the notes of that hospital admission revealed that the illness was most probably Kawasaki disease.
    Matched MeSH terms: Death, Sudden, Cardiac/etiology*; Death, Sudden, Cardiac/pathology
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