MyMedR

This study aimed to determine the proportions of normothermic infants who remained normothermic, and hypothermic infants who became normothermic following the use of a heated water-filled mattress (HWM) in the labour room.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/prevention & control*

Fulltext C-reactive protein/albumin ratio is a prognostic indicator for predicting surgical intervention and mortality in neonates with necrotizing enterocolitis

Mohd Amin AT, Zaki RA, Friedmacher F, Sharif SP

Pediatr Surg Int, 2021 Jul;37(7):881-886.

PMID: 33779823 DOI: 10.1007/s00383-021-04879-1

PURPOSE: The role of hypoalbuminemia and raised C-reactive protein (CRP) levels in predicting critical prognosis has been described extensively in adult literature. However, there are limited studies in pediatrics, particularly neonates. The CRP/albumin (CRP/ALB) ratio is often associated with higher mortality, organ failure and prolonged hospital stay. We hypothesized that the serum CRP/ALB ratio has a prognostic value in predicting surgery and mortality in neonates with necrotizing enterocolitis (NEC).

METHODS: Retrospective review of all neonates with clinical and radiological evidence of non-perforated NEC that were treated in a tertiary-level referral hospital between 2009 and 2018. General patient demographics, laboratory parameters and outcomes were recorded. Receiver operating characteristics analysis was performed to evaluated optimal cut-offs and area under the curve (AUC) with 95% confidence intervals (CI).

RESULTS: A total of 191 neonates were identified. Of these, 103 (53.9%) were born at ≤ 28 weeks of gestation and 101 (52.9%) had a birth weight of ≤ 1000 g. Eighty-four (44.0%) patients underwent surgical intervention for NEC. The overall survival rate was 161/191 (84.3%). A CRP/ALB ratio of ≥ 3 on day 2 of NEC diagnosis was associated with a statistically significant higher likelihood for surgery [AUC 0.71 (95% CI 0.63-0.79); p

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/blood*; Infant, Newborn, Diseases/mortality; Infant, Newborn, Diseases/surgery

Fulltext Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in three Malay children

Ngu HL, Zabedah MY, Kobayashi K

Malays J Pathol, 2010 Jun;32(1):53-7.

PMID: 20614727 MyJurnal

Citrin deficiency is an autosomal recessive disorder caused by mutation in the SLC25AJ3 gene. It has two major phenotypes: adult-onset type II citrullinemia (CTLN2) and neonatal intrahepatic cholestatic caused by citrin deficiency (NICCD). NICCD is characterized by neonatal/infantile-onset cholestatic hepatitis syndrome associated with multiple amino acidemia and hypergalactosemia. NICCD is self-limiting in most patients. However, some patients may develop CTLN2 years later, which manifests as fatal hyperammonemia coma. We report three unrelated Malay children with genetically confirmed NICCD characterised by an insertion mutation IVS16ins3kb in SLC25A13 gene. All 3 patients presented with prolonged neonatal jaundice which resolved without specific treatment between 5 to 10 months. Of note was the manifestation of a peculiar dislike of sweet foods and drinks. Elevated plasma citrulline was an important biochemical marker. NICCD should be considered in the differential diagnosis of cholestatic jaundice in Malaysian infants regardless of ethnic origin.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/genetics

Rickettsia tsutsugamushi antibody in mother/cord pairs of sera

Shirai A, Brown GW, Gan E, Huxsoll DL, Groves MG

Jpn. J. Med. Sci. Biol., 1981 Feb;34(1):37-9.

PMID: 6790744

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/epidemiology

Tetanus neonatorum in West Malaysia

Chen ST

J Trop Med Hyg, 1974 Sep;77(9):204-7.

PMID: 4416077

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/epidemiology*

Smallpox vaccination: complications and present role

Balasundram R

Med J Malaya, 1972 Dec;27(2):89-94.

PMID: 4145716

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/etiology

To breast feed or not?

Nutr Rev, 1972 May;30(5):112-4.

PMID: 4554312

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/etiology

Recurrent candidaemia in a neonate with Hirschsprung's disease: fluconazole resistance and genetic relatedness of eight Candida tropicalis isolates

Chong PP, Chieng DC, Low LY, Hafeez A, Shamsudin MN, Seow HF, et al.

J Med Microbiol, 2006 Apr;55(Pt 4):423-428.

PMID: 16533990 DOI: 10.1099/jmm.0.46045-0

The incidence of candidaemia among immunocompromised patients in Malaysia is increasing at an alarming rate. Isolation of clinical strains that are resistant to fluconazole has also risen markedly. We report here the repeated isolation of Candida tropicalis from the blood of a neonatal patient with Hirschsprung's disease. In vitro fluconazole susceptibility tests of the eight isolates obtained at different time points showed that seven of the isolates were resistant and one isolate was scored as susceptible dose-dependent. Random amplification of polymorphic DNA fingerprinting of the isolates using three primers and subsequent phylogenetic analysis revealed that these isolates were highly similar strains having minor genetic divergence, with a mean pairwise similarity coefficient of 0.893+/-0.041. The source of the infectious agent was thought to be the central venous catheter, as culture of its tip produced fluconazole-resistant C. tropicalis. This study demonstrates the utility of applying molecular epidemiology techniques to complement traditional mycological culture and drug susceptibility tests for accurate and appropriate management of recurrent candidaemia and highlights the need for newer antifungals that can combat the emergence of fluconazole-resistant C. tropicalis strains.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/microbiology*

Metabolic acidosis and renal solute load in relation to the protein intake of low birth weight Malaysian neonates

Johnson RO, Johnson BH, Raman A, Lee EL, Lam KL

Aust Paediatr J, 1979 Jun;15(2):101-6.

PMID: 485988

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/etiology*

Neonatal outcomes and its association among gestational diabetes mellitus with and without depression, anxiety and stress symptoms in Malaysia: A cross-sectional study

Lee KW, Ching SM, Hoo FK, Ramachandran V, Chong SC, Tusimin M, et al.

Midwifery, 2020 Feb;81:102586.

PMID: 31830674 DOI: 10.1016/j.midw.2019.102586

OBJECTIVE: Prevalence of depression, anxiety and stress symptoms in gestational diabetes mellitus ranges from 10.2% to 39.9% based on previous studies in Malaysia. Presence of depression, anxiety or stress in pregnancy may increase the risk of neonatal morbidity and mortality. The aim of this study was to determine the prevalence of neonatal outcomes and its association among mothers with gestational diabetes mellitus with and without the presence of depression, anxiety and stress symptoms in Malaysia.

DESIGN: This was a cross-sectional study.

SETTING: Tertiary hospitals in Malaysia.

PARTICIPANTS: Mothers with gestational diabetes mellitus (n = 418) who deliver their neonates at two major tertiary hospitals in Malaysia.

MEASUREMENTS: Neonatal outcomes, such as low birth weight, preterm birth, macrosomia, metabolic and electrolyte disorders, neonatal respiratory distress and congenital anomalies were determined.

FINDINGS: Prevalence of low birth weight in neonates born to mothers with gestational diabetes mellitus was 14.6%, followed by metabolic and electrolyte disorders 10.5%, preterm birth 9.1%, macrosomia 4.8%, neonatal respiratory distress 5.8% and congenital anomalies (2.4%). Among the adverse neonatal outcomes, neonatal respiratory distress was significantly associated with the presence of depression symptoms in mothers with gestational diabetes mellitus using univariate analysis (p = 0.010). After controlling for confounding factors, predictors for neonatal respiratory distress at delivery were the presence of depression symptoms in mothers with gestational diabetes mellitus (Adjusted OR = 3.87, 95% CI = 1.32-11.35), living without a husband (Adjusted OR = 9.74, 95% CI = 2.04-46.51), preterm delivery (Adjusted OR = 7.20, 95% CI = 2.23-23.30), caesarean section (Adjusted OR = 3.33, 95% CI = 1.09-10.15), being nulliparous and primiparous (Adjusted OR = 3.62, 95% CI = 1.17-11.17) and having family history of diabetes (Adjusted OR = 3.20, 95% CI = 1.11-9.21).

KEY CONCLUSIONS: The findings of this study demonstrate the positive association of neonatal respiratory distress with the presence of depression symptoms in mothers with gestational diabetes mellitus.

IMPLICATIONS FOR PRACTICE: It is therefore important to identify depression symptoms after a diagnosis of gestational diabetes mellitus in pregnant mothers is made to enable early referral and interventions.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/epidemiology*

Fulltext Oesophageal intubation and ventilation as initial airway support of newborn infant with tracheal agenesis

Wong AC, Khoo CS, Ee YS, Sidhu JK, Chan LG

Med J Malaysia, 2014 Aug;69(4):189-90.

PMID: 25500849 MyJurnal

Tracheal agenesis is a rare congenital airway anomaly which presents as an airway emergency at birth. We report a case of late premature Chinese infant with tracheal agenesis type II (by Floyd's classification) who presented with severe respiratory distress at birth. He had multiple failed attempts at intubations with accidental oesophageal intubation and ventilation. Tracheal agenesis with tracheo-oesophageal fistula was suspected from an emergency optical laryngoesophagoscopy done. The infant was subsequently stabilized on oesophageal ventilation. The diagnosis was confirmed on CT scan and parents were counseled regarding the poor outcome and decided for withdrawal at day 7 of life.